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7C7A
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BU of 7c7a by Molmil
Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1
Descriptor: Internal Transcribed Spacer 1, MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, ...
Authors:Lan, P, Wu, J, Lei, M.
Deposit date:2020-05-24
Release date:2020-07-08
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural insight into precursor ribosomal RNA processing by ribonuclease MRP.
Science, 369, 2020
7C79
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BU of 7c79 by Molmil
Cryo-EM structure of yeast Ribonuclease MRP
Descriptor: MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease MRP RNA subunit NME1, ...
Authors:Lan, P, Wu, J, Lei, M.
Deposit date:2020-05-24
Release date:2020-07-08
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural insight into precursor ribosomal RNA processing by ribonuclease MRP.
Science, 369, 2020
6AH3
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BU of 6ah3 by Molmil
Cryo-EM structure of yeast Ribonuclease P with pre-tRNA substrate
Descriptor: MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, ...
Authors:Lan, P, Tan, M, Wu, J, Lei, M.
Deposit date:2018-08-16
Release date:2018-10-17
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
6AGB
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BU of 6agb by Molmil
Cryo-EM structure of yeast Ribonuclease P
Descriptor: RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, Ribonuclease P protein subunit RPR2, ...
Authors:Lan, P, Tan, M, Wu, J, Lei, M.
Deposit date:2018-08-10
Release date:2018-10-17
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
5VX0
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BU of 5vx0 by Molmil
Bak in complex with Bim-h3Glg
Descriptor: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ...
Authors:Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VWX
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BU of 5vwx by Molmil
Bak core latch dimer in complex with Bim-h0-h3Glt
Descriptor: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11
Authors:Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.489 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
6K0B
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BU of 6k0b by Molmil
cryo-EM structure of archaeal Ribonuclease P with mature tRNA
Descriptor: 50S ribosomal protein L7Ae, RPR, Ribonuclease P protein component 1, ...
Authors:Wan, F, Lan, P, Wu, J, Lei, M.
Deposit date:2019-05-05
Release date:2019-06-19
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019
6K0A
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BU of 6k0a by Molmil
cryo-EM structure of an archaeal Ribonuclease P
Descriptor: 50S ribosomal protein L7Ae, RPR, Ribonuclease P protein component 1, ...
Authors:Wan, F, Lan, P, Wu, J, Lei, M.
Deposit date:2019-05-05
Release date:2019-06-19
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019
7WTA
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BU of 7wta by Molmil
Cryo-EM structure of human pyruvate carboxylase in apo state
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTC
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BU of 7wtc by Molmil
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ...
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTD
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BU of 7wtd by Molmil
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ...
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTE
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BU of 7wte by Molmil
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2
Descriptor: ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, Pyruvate carboxylase, ...
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTB
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BU of 7wtb by Molmil
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
6AHU
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BU of 6ahu by Molmil
Cryo-EM structure of human Ribonuclease P with mature tRNA
Descriptor: H1 RNA, Ribonuclease P protein subunit p14, Ribonuclease P protein subunit p20, ...
Authors:Wu, J, Niu, S, Tan, M, Lan, P, Lei, M.
Deposit date:2018-08-20
Release date:2018-12-05
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
6AHV
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BU of 6ahv by Molmil
Crystal structure of human RPP40
Descriptor: Ribonuclease P protein subunit p40
Authors:Wu, J, Niu, S, Tan, M, Lan, P, Lei, M.
Deposit date:2018-08-20
Release date:2018-12-05
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
6AHR
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BU of 6ahr by Molmil
Cryo-EM structure of human Ribonuclease P
Descriptor: H1 RNA, Ribonuclease P protein subunit p14, Ribonuclease P protein subunit p20, ...
Authors:Wu, J, Niu, S, Tan, M, Lan, P, Lei, M.
Deposit date:2018-08-20
Release date:2018-12-05
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
7D59
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BU of 7d59 by Molmil
cryo-EM structure of human RNA polymerase III in apo state
Descriptor: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ...
Authors:Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M.
Deposit date:2020-09-25
Release date:2021-02-17
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into transcriptional regulation of human RNA polymerase III.
Nat.Struct.Mol.Biol., 28, 2021
7D58
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BU of 7d58 by Molmil
cryo-EM structure of human RNA polymerase III in elongating state
Descriptor: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ...
Authors:Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M.
Deposit date:2020-09-25
Release date:2021-02-17
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insights into transcriptional regulation of human RNA polymerase III.
Nat.Struct.Mol.Biol., 28, 2021
7SVM
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BU of 7svm by Molmil
DPP8 IN COMPLEX WITH LIGAND ICeD-2
Descriptor: (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one, Dipeptidyl peptidase 8, trimethylamine oxide
Authors:Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:2021-11-19
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Acs Chem.Biol., 17, 2022
7SVN
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BU of 7svn by Molmil
DPP9 IN COMPLEX WITH LIGAND ICeD-1
Descriptor: (2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile, Dipeptidyl peptidase 9
Authors:Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:2021-11-19
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Acs Chem.Biol., 17, 2022
7SVO
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BU of 7svo by Molmil
DPP8 IN COMPLEX WITH LIGAND ICeD-1
Descriptor: (2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile, Dipeptidyl peptidase 8, trimethylamine oxide
Authors:Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:2021-11-19
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Acs Chem.Biol., 17, 2022
7SVL
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BU of 7svl by Molmil
DPP9 IN COMPLEX WITH LIGAND ICeD-2
Descriptor: (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one, Dipeptidyl peptidase 9
Authors:Lammens, A, Hollenstein, K, Klein, D.J.
Deposit date:2021-11-19
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Acs Chem.Biol., 17, 2022
4QMF
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BU of 4qmf by Molmil
Structure of the Krr1 and Faf1 complex from Saccharomyces cerevisiae
Descriptor: KRR1 small subunit processome component, Protein FAF1
Authors:Zheng, S, Ye, K.
Deposit date:2014-06-16
Release date:2014-07-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast
J.Biol.Chem., 289, 2014
8H69
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BU of 8h69 by Molmil
Cryo-EM structure of influenza RNA polymerase
Descriptor: Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3'), ...
Authors:Li, H, Wu, Y, Liang, H, Liu, Y.
Deposit date:2022-10-16
Release date:2023-06-28
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles.
Nat.Struct.Mol.Biol., 30, 2023
5VWV
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BU of 5vwv by Molmil
Bak core latch dimer in complex with Bim-BH3 - Cubic
Descriptor: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ...
Authors:Brouwer, J.M, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017

 

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