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4TWA
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BU of 4twa by Molmil
Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum
Descriptor: CHLORIDE ION, Proline--tRNA ligase, SULFATE ION
Authors:Jain, V, Yogavel, M, Sharma, A.
Deposit date:2014-06-30
Release date:2014-08-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.
J. Struct. Funct. Genomics, 15, 2014
4YDQ
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BU of 4ydq by Molmil
Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum in complex with Halofuginone and AMPPNP
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Yogavel, M, Sharma, A.
Deposit date:2015-02-23
Release date:2015-05-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis
Structure, 23, 2015
5JLD
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BU of 5jld by Molmil
Crystal Structure of Arginyl-tRNA Synthetase from Plasmodium falciparum (PfRRS)
Descriptor: Arginyl-tRNA synthetase, putative
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2016-04-27
Release date:2016-08-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum
Structure, 24, 2016
5XIF
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BU of 5xif by Molmil
Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Toxoplasma gondii
Descriptor: CHLORIDE ION, Prolyl-tRNA synthetase (ProRS)
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIQ
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BU of 5xiq by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Halofuginone
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XII
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BU of 5xii by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 6
Descriptor: 1,2-ETHANEDIOL, 6-chloranyl-7-fluoranyl-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIL
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BU of 5xil by Molmil
Crystal Structure of Leishmania major Prolyl-tRNA Synthetase (LmPRS)
Descriptor: ACETATE ION, MAGNESIUM ION, Putative prolyl-tRNA synthetase, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIG
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BU of 5xig by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 1
Descriptor: 3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIP
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BU of 5xip by Molmil
Crystal Structure of Eimeria tenella Prolyl-tRNA Synthetase (EtPRS) in complex with Halofuginone
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIK
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BU of 5xik by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with tetrahydro quinazolinone febrifugine
Descriptor: 3-[2-oxidanylidene-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]-5,6,7,8-tetrahydroquinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIJ
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BU of 5xij by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9
Descriptor: 3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIH
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BU of 5xih by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 5
Descriptor: 6,7-bis(fluoranyl)-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIO
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BU of 5xio by Molmil
Crystal Structure of Cryptosporidium parvum Prolyl-tRNA Synthetase (CpPRS) in complex with Halofuginone
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proline-tRNA synthetase class II aaRS (Ybak RNA binding domain plus tRNA synthetase), ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5ZDK
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BU of 5zdk by Molmil
Crystal Structure Analysis of TtQRS in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CESIUM ION, CHLORIDE ION, ...
Authors:Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J.
Deposit date:2018-02-23
Release date:2018-12-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes
Int. J. Biol. Macromol., 120, 2018
5ZDO
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BU of 5zdo by Molmil
Crystal Structure Analysis of TtQRS in co-crystallised with ATP
Descriptor: CHLORIDE ION, Glutamine-tRNA ligase
Authors:Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J.
Deposit date:2018-02-23
Release date:2018-12-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes
Int. J. Biol. Macromol., 120, 2018
5ZG8
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BU of 5zg8 by Molmil
Crystal Structure of TtNRS
Descriptor: Asparagine--tRNA ligase
Authors:Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J.
Deposit date:2018-03-08
Release date:2019-03-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of TtNRS
To be published
5ZDL
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BU of 5zdl by Molmil
Crystal Structure Analysis of TtQRS in co-crystallised with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Glutamine--tRNA ligase
Authors:Mutharasappan, N, Jain, V, Sharma, A, Manickam, Y, Jeyaraman, J.
Deposit date:2018-02-23
Release date:2018-12-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes
Int. J. Biol. Macromol., 120, 2018
6FKK
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BU of 6fkk by Molmil
Drosophila Semaphorin 1b, extracellular domains 1-2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MIP07328p, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Rozbesky, D, Harlos, K, Jones, E.Y.
Deposit date:2018-01-24
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.
Nat Commun, 10, 2019
6S9F
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BU of 6s9f by Molmil
Drosophila OTK, extracellular domains 3-5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tyrosine-protein kinase-like otk
Authors:Rozbesky, D, Jones, E.Y.
Deposit date:2019-07-12
Release date:2020-03-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.969 Å)
Cite:Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility.
Structure, 28, 2020
5Z79
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BU of 5z79 by Molmil
Crystal Structure Analysis of the HPPK-DHPS in complex with substrates
Descriptor: 4-AMINOBENZOIC ACID, 5'-DEOXYADENOSINE, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, ...
Authors:Manickam, Y, Karl, H, Sharma, A.
Deposit date:2018-01-27
Release date:2018-08-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance
J. Biol. Chem., 293, 2018
6GGM
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BU of 6ggm by Molmil
HLA-E*01:03 in complex with the Mtb44 peptide variant: Mtb44*P2-Phe.
Descriptor: Beta-2-microglobulin, MHC class I antigen, Mtb44*P2-Phe peptide variant (ARG-PHE-PRO-ALA-LYS-ALA-PRO-LEU-LEU), ...
Authors:Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K.
Deposit date:2018-05-03
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.734 Å)
Cite:Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
6GH4
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BU of 6gh4 by Molmil
HLA-E*01:03 in complex with the Mtb44 peptide variant: Mtb44*P2-Gln.
Descriptor: ARG-GLN-PRO-ALA-LYS-ALA-PRO-LEU-LEU, Beta-2-microglobulin, MHC class I antigen, ...
Authors:Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K.
Deposit date:2018-05-04
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
6GH1
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BU of 6gh1 by Molmil
HLA-E*01:03 in complex with Mtb44
Descriptor: Beta-2-microglobulin, Enoyl-[acyl-carrier-protein] reductase [NADH], MHC class I antigen, ...
Authors:Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K.
Deposit date:2018-05-04
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
6GHN
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BU of 6ghn by Molmil
HLA-E*01:03 in complex with the Mtb44 peptide variant: Mtb44*P9-Phe.
Descriptor: ARG-LEU-PRO-ALA-LYS-ALA-PRO-LEU-PHE, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
Authors:Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K.
Deposit date:2018-05-08
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.542 Å)
Cite:Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
6GL1
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BU of 6gl1 by Molmil
HLA-E*01:03 in complex with the HIV epitope, RL9HIV
Descriptor: ARG-MET-TYR-SER-PRO-THR-SER-ILE-LEU, Beta-2-microglobulin, MHC class I antigen, ...
Authors:Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K.
Deposit date:2018-05-22
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.623 Å)
Cite:Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018

 

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