Author results

6HPR
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CRYSTAL STRUCTURE OF CIAP1 RING DOMAIN BOUND TO UBCH5B-UB AND A NON-COVALENT UB
Descriptor:Baculoviral IAP repeat-containing protein 2, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ...
Authors:Patel, A., Huang, D.T.
Deposit date:2018-09-21
Release date:2018-12-12
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex.
J. Biol. Chem., 294, 2019
5O6S
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UBV.B4R, A DIMERIC UBIQUITIN VARIANT BINDING TO BIRC4 RING
Descriptor:Polyubiquitin-B
Authors:Gabrielsen, M., Buetow, L., Huang, D.T.
Deposit date:2017-06-07
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O6T
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BIRC4 RING IN COMPLEX WITH DIMERIC UBIQUITIN VARIANT
Descriptor:E3 ubiquitin-protein ligase XIAP, Polyubiquitin-B, ZINC ION, ...
Authors:Gabrielsen, M., Buetow, L., Huang, D.T.
Deposit date:2017-06-07
Release date:2017-11-01
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O75
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UBE4B U-BOX DOMAIN
Descriptor:Ubiquitin conjugation factor E4 B, SULFATE ION
Authors:Gabrielsen, M., Buetow, L., Nakasone, M.A., Huang, D.T.
Deposit date:2017-06-08
Release date:2017-11-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.483 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O76
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STRUCTURE OF PHOSPHOY371 C-CBL IN COMPLEX WITH ZAP70-PEPTIDE AND UBV.PCBL UBIQUITIN VARIANT
Descriptor:E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, UbV.pCBL ubiquitin variant, ...
Authors:Gabrielsen, M., Buetow, L., Huang, D.T.
Deposit date:2017-06-08
Release date:2017-11-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.473 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5MNJ
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STRUCTURE OF MDM2-MDMX-UBCH5B-UBIQUITIN COMPLEX
Descriptor:Ubiquitin-conjugating enzyme E2 D2, Polyubiquitin-B, E3 ubiquitin-protein ligase Mdm2, ...
Authors:Klejnot, M., Huang, D.T.
Deposit date:2016-12-13
Release date:2017-05-31
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Nat. Struct. Mol. Biol., 24, 2017
5J3X
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STRUCTURE OF C-CBL Y371F
Descriptor:E3 ubiquitin-protein ligase CBL, ZINC ION, CALCIUM ION
Authors:Huang, D.T., Buetow, L., Dou, H.
Deposit date:2016-03-31
Release date:2016-09-21
Method:X-RAY DIFFRACTION (2.822 Å)
Cite:Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
Bmc Biol., 14, 2016
5E5B
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CRYSTAL STRUCTURE OF HUMAN SPT16 N-TERMINAL DOMAIN
Descriptor:FACT complex subunit SPT16
Authors:Marciano, G., Huang, D.T.
Deposit date:2015-10-08
Release date:2016-02-10
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure of the human histone chaperone FACT Spt16 N-terminal domain.
Acta Crystallogr.,Sect.F, 72, 2016
4V3K
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RNF38-UBCH5B-UB COMPLEX
Descriptor:UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
Authors:Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T.
Deposit date:2014-10-20
Release date:2015-04-08
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
4V3L
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RNF38-UB-UBCH5B-UB COMPLEX
Descriptor:UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
Authors:Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T.
Deposit date:2014-10-20
Release date:2015-04-08
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
3ZNI
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STRUCTURE OF PHOSPHOTYR363-CBL-B - UBCH5B-UB - ZAP-70 PEPTIDE COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE CBL-B, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
Authors:Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T.
Deposit date:2013-02-14
Release date:2013-07-10
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3.
Nat.Struct.Mol.Biol., 20, 2013
4AUQ
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STRUCTURE OF BIRC7-UBCH5B-UB COMPLEX.
Descriptor:UBIQUITIN-CONJUGATING ENZYME E2 D2, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7, POLYUBIQUITIN-C, ...
Authors:Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T.
Deposit date:2012-05-21
Release date:2012-08-15
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.176 Å)
Cite:Birc7-E2 Ubiquitin Conjugate Structure Reveals the Mechanism of Ubiquitin Transfer by a Ring Dimer.
Nat.Struct.Mol.Biol., 19, 2012
4A49
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STRUCTURE OF PHOSPHOTYR371-C-CBL-UBCH5B COMPLEX
Descriptor:E3 ubiquitin-protein ligase CBL, Ubiquitin-conjugating enzyme E2 D2, ZINC ION, ...
Authors:Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
Deposit date:2011-10-07
Release date:2012-01-25
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.214 Å)
Cite:Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Nat. Struct. Mol. Biol., 19, 2012
4A4B
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STRUCTURE OF MODIFIED PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
Authors:Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
Deposit date:2011-10-08
Release date:2012-01-25
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.789 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
4A4C
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STRUCTURE OF PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
Authors:Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
Deposit date:2011-10-08
Release date:2012-01-25
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
2Y1M
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STRUCTURE OF NATIVE C-CBL
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION, CALCIUM ION
Authors:Dou, H., Sibbet, G.J., Huang, D.T.
Deposit date:2010-12-08
Release date:2012-01-18
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
2Y1N
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STRUCTURE OF C-CBL-ZAP-70 PEPTIDE COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, SYK-RELATED TYROSINE KINASE, ...
Authors:Dou, H., Sibbet, G.J., Huang, D.T.
Deposit date:2010-12-08
Release date:2012-01-18
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
3ONG
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CRYSTAL STRUCTURE OF UBA2UFD-UBC9: INSIGHTS INTO E1-E2 INTERACTIONS IN SUMO PATHWAYS
Descriptor:Ubiquitin-activating enzyme E1-like, SUMO-conjugating enzyme UBC9
Authors:Wang, J., Taherbhoy, A.M., Hunt, H.W., Seyedin, S.N., Miller, D.W., Huang, D.T., Schulman, B.A.
Deposit date:2010-08-28
Release date:2011-01-12
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways.
Plos One, 5, 2010
3ONH
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CRYSTAL STRUCTURE OF UBA2UFD-UBC9: INSIGHTS INTO E1-E2 INTERACTIONS IN SUMO PATHWAYS
Descriptor:Ubiquitin-activating enzyme E1-like
Authors:Wang, J., Taherbhoy, A.M., Hunt, H.W., Seyedin, S.N., Miller, D.W., Huang, D.T., Schulman, B.A.
Deposit date:2010-08-28
Release date:2011-01-12
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways.
Plos One, 5, 2010
3FN1
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E2-RING EXPANSION OF THE NEDD8 CASCADE CONFERS SPECIFICITY TO CULLIN MODIFICATION.
Descriptor:NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F
Authors:Huang, D.T., Ayrault, O., Hunt, H.W., Taherbhoy, A.M., Duda, D.M., Scott, D.C., Borg, L.A., Neale, G., Murray, P.J., Roussel, M.F., Schulman, B.A.
Deposit date:2008-12-22
Release date:2009-03-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
2NVU
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STRUCTURE OF APPBP1-UBA3~NEDD8-NEDD8-MGATP-UBC12(C111A), A TRAPPED UBIQUITIN-LIKE PROTEIN ACTIVATION COMPLEX
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, NEDD8-conjugating enzyme Ubc12, ...
Authors:Huang, D.T., Hunt, H.W., Zhuang, M., Ohi, M.D., Holton, J.M., Schulman, B.A.
Deposit date:2006-11-13
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Nature, 445, 2007
1Y8X
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STRUCTURAL BASIS FOR RECRUITMENT OF UBC12 BY AN E2-BINDING DOMAIN IN NEDD8'S E1
Descriptor:Ubiquitin-conjugating enzyme E2 M, Ubiquitin-activating enzyme E1C
Authors:Huang, D.T., Paydar, A., Zhuang, M., Waddell, M.B., Holton, J.M., Schulman, B.A.
Deposit date:2004-12-13
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
Mol.Cell, 17, 2005
1TT5
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STRUCTURE OF APPBP1-UBA3-UBC12N26: A UNIQUE E1-E2 INTERACTION REQUIRED FOR OPTIMAL CONJUGATION OF THE UBIQUITIN-LIKE PROTEIN NEDD8
Descriptor:amyloid protein-binding protein 1, ubiquitin-activating enzyme E1C isoform 1, Ubiquitin-conjugating enzyme E2 M, ...
Authors:Huang, D.T., Miller, D.W., Mathew, R., Cassell, R., Holton, J.M., Roussel, M.F., Schulman, B.A.
Deposit date:2004-06-21
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
Nat.Struct.Mol.Biol., 11, 2004
1R4M
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APPBP1-UBA3-NEDD8, AN E1-UBIQUITIN-LIKE PROTEIN COMPLEX
Descriptor:amyloid beta precursor protein-binding protein 1, ubiquitin-activating enzyme E1C, Ubiquitin-like protein NEDD8, ...
Authors:Walden, H., Podgorski, M.S., Holton, J.M., Schulman, B.A.
Deposit date:2003-10-07
Release date:2003-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003
1R4N
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APPBP1-UBA3-NEDD8, AN E1-UBIQUITIN-LIKE PROTEIN COMPLEX WITH ATP
Descriptor:amyloid beta precursor protein-binding protein 1, ubiquitin-activating enzyme E1C, Ubiquitin-like protein NEDD8, ...
Authors:Walden, H., Podgorski, M.S., Holton, J.M., Schulman, B.A.
Deposit date:2003-10-07
Release date:2003-12-23
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003