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Initial Stuctural Analysis of Leishmania major Threonine Aldolase
Descriptor:	THREONINE ALDOLASE, UNKNOWN LIGAND
Authors:	Hol, W.G.J, Robien, M.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-03-30
Release date:	2004-08-17
Last modified:	2018-01-31
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Initial Structural Analysis of Leishmania major Threonine Aldolase To be Published

1RHD

STRUCTURE OF BOVINE LIVER RHODANESE. I. STRUCTURE DETERMINATION AT 2.5 ANGSTROMS RESOLUTION AND A COMPARISON OF THE CONFORMATION AND SEQUENCE OF ITS TWO DOMAINS
Descriptor:	RHODANESE
Authors:	Hol, W.G.J, Ploegman, J.H, Kalk, K.H, Drent, G.
Deposit date:	1977-11-23
Release date:	1978-01-16
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structure of bovine liver rhodanese. I. Structure determination at 2.5 A resolution and a comparison of the conformation and sequence of its two domains. J.Mol.Biol., 123, 1978

6TIM

THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
Descriptor:	SN-GLYCEROL-3-PHOSPHATE, TRIOSEPHOSPHATE ISOMERASE
Authors:	Noble, M.E.M, Wierenga, R.K, Hol, W.G.J.
Deposit date:	1991-04-23
Release date:	1992-10-15
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes. Proteins, 10, 1991

4TIM

CRYSTALLOGRAPHIC AND MOLECULAR MODELING STUDIES ON TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: A CRITICAL ASSESSMENT OF THE PREDICTED AND OBSERVED STRUCTURES OF THE COMPLEX WITH 2-PHOSPHOGLYCERATE
Descriptor:	2-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:	Nobel, M.E.M, Wierenga, R.K, Hol, W.G.J.
Deposit date:	1991-04-11
Release date:	1992-10-15
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate. J.Med.Chem., 34, 1991

5TIM

REFINED 1.83 ANGSTROMS STRUCTURE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE, CRYSTALLIZED IN THE PRESENCE OF 2.4 M-AMMONIUM SULPHATE. A COMPARISON WITH THE STRUCTURE OF THE TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE-GLYCEROL-3-PHOSPHATE COMPLEX
Descriptor:	2,3-DIHYDROXY-1,4-DITHIOBUTANE, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE
Authors:	Wierenga, R.K, Hol, W.G.J.
Deposit date:	1991-04-23
Release date:	1992-10-15
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.83 Å)
Cite:	Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex. J.Mol.Biol., 220, 1991

6MES

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1907)
Descriptor:	1-[(1H-benzimidazol-2-yl)methyl]-4-[(2,4-dichlorophenyl)methyl]-1,3-dihydro-2H-imidazol-2-one, GLYCEROL, METHIONINE, ...
Authors:	Barros-Alvarez, X, Hol, W.G.J.
Deposit date:	2018-09-07
Release date:	2019-09-18
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei Rsc Med Chem, 2020

2MAD

THE ACTIVE SITE STRUCTURE OF METHYLAMINE DEHYDROGENASE: HYDRAZINES IDENTIFY C6 AS THE REACTIVE SITE OF THE TRYPTOPHAN DERIVED QUINONE COFACTOR
Descriptor:	METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT)
Authors:	Huizinga, E.G, Vellieux, F.M.D, Hol, W.G.J.
Deposit date:	1992-05-20
Release date:	1994-01-31
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor. Biochemistry, 31, 1992

2W7V

periplasmic domain of EpsL from Vibrio parahaemolyticus
Descriptor:	1,2-ETHANEDIOL, GENERAL SECRETION PATHWAY PROTEIN L, PHOSPHATE ION
Authors:	Abendroth, J, Kreger, A.C, Abendroth, H, Sandkvist, M, Hol, W.G.J.
Deposit date:	2009-01-06
Release date:	2010-03-31
Last modified:	2017-06-28
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	The Dimer Formed by the Periplasmic Domain of Epsl from the Type 2 Secretion System of Vibrio Parahaemolyticus. J.Struct.Biol., 168, 2009

2PHH

THE COENZYME ANALOGUE ADENOSINE 5-DIPHOSPHORIBOSE DISPLACES FAD IN THE ACTIVE SITE OF P-HYDROXYBENZOATE HYDROXYLASE. AN X-RAY CRYSTALLOGRAPHIC INVESTIGATION
Descriptor:	ADENOSINE-5-DIPHOSPHORIBOSE, P-HYDROXYBENZOATE HYDROXYLASE, P-HYDROXYBENZOIC ACID
Authors:	Van Derlaan, J.M, Drenth, J, Hol, W.G.J.
Deposit date:	1989-06-19
Release date:	1990-10-15
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	The coenzyme analogue adenosine 5-diphosphoribose displaces FAD in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation. Biochemistry, 28, 1989

5V49

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1917)
Descriptor:	GLYCEROL, METHIONINE, Methionyl-tRNA synthetase, ...
Authors:	Barros-Alvarez, X, Hol, W.G.J.
Deposit date:	2017-03-08
Release date:	2017-07-26
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors. Bioorg. Med. Chem. Lett., 27, 2017

5USF

Leishmania donovani tyrosyl-tRNA synthetase in complex with nanobody and inhibitor
Descriptor:	5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, Immunoglobulin heavy chain variable region, Tyrosyl-tRNA synthetase, ...
Authors:	Barros-Alvarez, X, Hol, W.G.J.
Deposit date:	2017-02-13
Release date:	2017-05-17
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. Biochimie, 138, 2017

6AX8

Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate
Descriptor:	Methionine-tRNA ligase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate
Authors:	Barros-Alvarez, X, Hol, W.G.J.
Deposit date:	2017-09-06
Release date:	2018-04-11
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate. Acta Crystallogr F Struct Biol Commun, 74, 2018

6BQM

Secreted serine protease VesC from Vibrio cholerae
Descriptor:	serine protease VesC
Authors:	Park, Y.J, Korotkov, K.V, Delarosa, J.R, Turley, S, DiMaio, F, Hol, W.G.J.
Deposit date:	2017-11-28
Release date:	2018-11-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease. Msphere, 5, 2020

6CML

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 2093)
Descriptor:	1-[(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]-4-[(2-chloro-4-methoxyphenyl)methyl]-3-ethyl-1,3-dihydro-2H-imidazol-2-one, GLYCEROL, METHIONINE, ...
Authors:	Barros-Alvarez, X, Hol, W.G.J.
Deposit date:	2018-03-05
Release date:	2019-03-13
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei Rsc Med Chem, 11, 2020

1CHQ

SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:	CHOLERA TOXIN B PENTAMER
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1996-03-08
Last modified:	2021-11-03
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. Structure, 3, 1995

1CHP

SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:	CHLORIDE ION, CHOLERA TOXIN B PENTAMER
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1996-03-08
Last modified:	2021-11-03
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. Structure, 3, 1995

1PBD

CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING
Descriptor:	4-AMINOBENZOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOATE HYDROXYLASE
Authors:	Schreuder, H.A, Mattevi, A, Hol, W.G.J.
Deposit date:	1994-07-06
Release date:	1994-09-30
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring Biochemistry, 33, 1994

1PBB

CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING
Descriptor:	2,4-DIHYDROXYBENZOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOATE HYDROXYLASE
Authors:	Schreuder, H.A, Mattevi, A, Hol, W.G.J.
Deposit date:	1994-07-06
Release date:	1994-09-30
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring Biochemistry, 33, 1994

1HC1

CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION
Descriptor:	ARTHROPODAN HEMOCYANIN, COPPER (II) ION
Authors:	Volbeda, A, Hol, W.G.J.
Deposit date:	1991-05-15
Release date:	1994-01-31
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution. J.Mol.Biol., 209, 1989

1HCY

CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARTHROPODAN HEMOCYANIN, COPPER (II) ION
Authors:	Volbeda, A, Hol, W.G.J.
Deposit date:	1991-05-15
Release date:	1994-01-31
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution. J.Mol.Biol., 209, 1989

1PBE

CRYSTAL STRUCTURE OF THE P-HYDROXYBENZOATE HYDROXYLASE-SUBSTRATE COMPLEX REFINED AT 1.9 ANGSTROMS RESOLUTION. ANALYSIS OF THE ENZYME-SUBSTRATE AND ENZYME-PRODUCT COMPLEXES
Descriptor:	FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOATE HYDROXYLASE, P-HYDROXYBENZOIC ACID
Authors:	Schreuder, H.A, Hol, W.G.J, Drenth, J.
Deposit date:	1994-07-06
Release date:	1994-09-30
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes. J.Mol.Biol., 208, 1989

3TEC

CALCIUM BINDING TO THERMITASE. CRYSTALLOGRAPHIC STUDIES OF THERMITASE AT 0, 5 AND 100 MM CALCIUM
Descriptor:	CALCIUM ION, EGLIN C, THERMITASE
Authors:	Gros, P, Kalk, K.H, Hol, W.G.J.
Deposit date:	1990-10-26
Release date:	1992-01-15
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Calcium binding to thermitase. Crystallographic studies of thermitase at 0, 5, and 100 mM calcium. J.Biol.Chem., 266, 1991

2SBT

A COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SUBTILISIN BPN AND SUBTILISIN NOVO
Descriptor:	ACETONE, SUBTILISIN NOVO
Authors:	Drenth, J, Hol, W.G.J, Jansonius, J.N, Koekoek, R.
Deposit date:	1976-09-07
Release date:	1976-10-06
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	A comparison of the three-dimensional structures of subtilisin BPN' and subtilisin novo. Cold Spring Harbor Symp.Quant.Biol., 36, 1972

2BP2

THE STRUCTURE OF BOVINE PANCREATIC PROPHOSPHOLIPASE A2 AT 3.0 ANGSTROMS RESOLUTION
Descriptor:	PHOSPHOLIPASE A2
Authors:	Dijkstra, B.W, Vannes, G.J.H, Kalk, K.H, Brandenburg, N.P, Hol, W.G.J, Drenth, J.
Deposit date:	1981-06-05
Release date:	1981-07-16
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	The Structure of Bovine Pancreatic Prophospholipase A2 at 3.0 Angstroms Resolution Acta Crystallogr.,Sect.B, 38, 1982

1HTL

MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
Descriptor:	HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1995-04-20
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli. Nat.Struct.Biol., 2, 1995

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