Author results

2Q3F
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X-RAY CRYSTAL STRUCTURE OF PUTATIVE HUMAN RAS-RELATED GTP BINDING D IN COMPLEX WITH GMPPNP
Descriptor:Ras-related GTP-binding protein D, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Mulichak, A.M., Rabeh, W.M., Tempel, W., Nedyalkova, L., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Keefe, L.J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-05-30
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human Ras-related GTP-binding D.
To be published
3MSE
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CRYSTAL STRUCTURE OF C-TERMINAL DOMAIN OF PF110239.
Descriptor:Calcium-dependent protein kinase, putative, CALCIUM ION, ...
Authors:Wernimont, A.K., Artz, J.D., Hutchinson, A., Sullivan, H., Weadge, J., Tempel, W., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Hui, R., Lin, Y.H., Neculai, A.M., Amani, M., Structural Genomics Consortium (SGC)
Deposit date:2010-04-29
Release date:2010-06-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of C-terminal domain of PF110239
To be Published
3OZ6
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CRYSTAL STRUCTURE OF MAPK FROM CRYPTOSPORIDIUM PARVUM, CGD2_1960
Descriptor:Mitogen-activated protein kinase 1, serine/threonine protein kinase, GLYCEROL
Authors:Wernimont, A.K., Lew, J., Lin, Y.H., Sullivan, H., Hassanali, A., Kozieradzki, I., Cossar, D., Arrowsmith, C.H., Bochkarev, A., Bountra, C., Edwards, A.M., Weigelt, J., Hui, R., Neculai, A.M., Hutchinson, A., Structural Genomics Consortium (SGC)
Deposit date:2010-09-24
Release date:2010-12-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystal structure of MapK from Cryptosporidium Parvum, cgd2_1960
To be Published
3P1W
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CRYSTAL STRUCTURE OF RAB GDI FROM PLASMODIUM FALCIPARUM, PFL2060C
Descriptor:RabGDI protein
Authors:Wernimont, A.K., Neculai, A.M., Weadge, J., MacKenzie, F., Cossar, D., Tempel, W., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Langsley, G., Bosch, J., Hui, R., Pizzaro, J.C., Hutchinson, A., Structural Genomics Consortium (SGC)
Deposit date:2010-09-30
Release date:2010-12-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of RAB GDI from Plasmodium Falciparum, PFL2060c
To be published
3Q5I
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CRYSTAL STRUCTURE OF PBANKA_031420
Descriptor:Protein kinase, CALCIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Wernimont, A.K., Hutchinson, A., Sullivan, H., Panico, E., Crombet, L., Cossar, D., Hassani, A., Vedadi, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Hui, R., Neculai, A.M., Amani, M., Structural Genomics Consortium (SGC)
Deposit date:2010-12-28
Release date:2011-06-01
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of CDPK1 from Plasmodium Bergheii, PBANKA_031420
To be Published
5FET
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CRYSTAL STRUCTURE OF PVX_084705 IN PRESENCE OF COMPOUND 2
Descriptor:cGMP-dependent protein kinase, putative, 4-[7-[(dimethylamino)methyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine
Authors:Wernimont, A.K., Tempel, W., Walker, J.R., He, H., Seitova, A., Hills, T., Neculai, A.M., Baker, D.A., Flueck, C., Kettleborough, C.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Hutchinson, A., El Bakkouri, M., Structural Genomics Consortium (SGC)
Deposit date:2015-12-17
Release date:2016-01-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Crystal Structure of PVX_084705 in presence of Compound 2
To be published
5OCH
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THE CRYSTAL STRUCTURE OF HUMAN ABCB8 IN AN OUTWARD-FACING STATE
Descriptor:ATP-binding cassette sub-family B member 8, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Faust, B., Pike, A.C.W., Shintre, C.A., Quiqley, A.M., Chu, A., Barr, A., Shrestha, L., Mukhopadhyay, S., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The crystal structure of human ABCB8 in an outward-facing state
To Be Published
1HV2
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SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE
Descriptor:ELONGIN C, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR
Authors:Botuyan, M.V., Mer, G., Yi, G.-S., Koth, C.M., Case, D.A., Edwards, A.M., Chazin, W.J., Arrowsmith, C.H.
Deposit date:2001-01-05
Release date:2001-09-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide.
J.Mol.Biol., 312, 2001
1QUQ
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COMPLEX OF REPLICATION PROTEIN A SUBUNITS RPA14 AND RPA32
Descriptor:PROTEIN (REPLICATION PROTEIN A 32 KD SUBUNIT), PROTEIN (REPLICATION PROTEIN A 14 KD SUBUNIT)
Authors:Bochkarev, A., Bochkareva, E., Frappier, L., Edwards, A.M.
Deposit date:1999-07-02
Release date:1999-08-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding.
EMBO J., 18, 1999
6CNH
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HUMAN PRPF4B IN COMPLEX WITH REBASTINIB
Descriptor:Serine/threonine-protein kinase PRP4 homolog, 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, SULFATE ION
Authors:Godoi, P.H.C., Santiago, A.S., Ramos, P.Z., Fala, A.M., Salmazo, A.P.T., Counago, R.M., Righetto, G.L., Silva, P.N.B., Gileadi, O., Guimaraes, C.R.W., Massirer, K.B., Arruda, P., Elkins, J.M., Edwards, A.M., Structural Genomics Consortium (SGC)
Deposit date:2018-03-08
Release date:2018-03-28
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the human PRPF4B in complex with Rebastinib
To be Published
1DPU
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SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN RPA32 COMPLEXED WITH UNG2(73-88)
Descriptor:REPLICATION PROTEIN A (RPA32) C-TERMINAL DOMAIN, URACIL DNA GLYCOSYLASE (UNG2)
Authors:Mer, G., Edwards, A.M., Chazin, W.J.
Deposit date:1999-12-27
Release date:2000-11-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA.
Cell(Cambridge,Mass.), 103, 2000
1EF4
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SOLUTION STRUCTURE OF THE ESSENTIAL RNA POLYMERASE SUBUNIT RPB10 FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor:DNA-DIRECTED RNA POLYMERASE, ZINC ION
Authors:Mackereth, C.D., Arrowsmith, C.H., Edwards, A.M., Mcintosh, L.P., Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-02-07
Release date:2000-06-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum.
Proc.Natl.Acad.Sci.USA, 97, 2000
1EIJ
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NMR ENSEMBLE OF METHANOBACTERIUM THERMOAUTOTROPHICUM PROTEIN 1615
Descriptor:HYPOTHETICAL PROTEIN MTH1615
Authors:Christendat, D., Booth, V., Gernstein, M., Arrowsmith, C.H., Edwards, A.M., Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-02-25
Release date:2000-11-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural proteomics of an archaeon.
Nat.Struct.Biol., 7, 2000
1EIK
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SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT RPB5 FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor:RNA POLYMERASE SUBUNIT RPB5
Authors:Yee, A., Booth, V., Dharamsi, A., Engel, A., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-02-25
Release date:2000-06-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum.
Proc.Natl.Acad.Sci.USA, 97, 2000
1EJ2
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CRYSTAL STRUCTURE OF METHANOBACTERIUM THERMOAUTOTROPHICUM NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE WITH BOUND NAD+
Descriptor:NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE, SULFATE ION, SODIUM ION, ...
Authors:Saridakis, V., Christendat, D., Kimber, M.S., Edwards, A.M., Pai, E.F., Midwest Center for Structural Genomics (MCSG), Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-02-29
Release date:2001-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into ligand binding and catalysis of a central step in NAD+ synthesis: structures of Methanobacterium thermoautotrophicum NMN adenylyltransferase complexes.
J.Biol.Chem., 276, 2001
1EJE
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CRYSTAL STRUCTURE OF AN FMN-BINDING PROTEIN
Descriptor:FMN-BINDING PROTEIN, NICKEL (II) ION, SULFATE ION, ...
Authors:Christendat, D., Saridakis, V., Bochkarev, A., Arrowsmith, C., Edwards, A.M., Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-03-02
Release date:2000-10-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural proteomics of an archaeon.
Nat.Struct.Biol., 7, 2000
1ENW
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ELONGATION FACTOR TFIIS DOMAIN II
Descriptor:TRANSCRIPTION ELONGATION FACTOR S-II
Authors:Morin, P.E., Awrey, D.E., Edwards, A.M., Arrowsmith, C.H.
Deposit date:2000-03-21
Release date:2000-04-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Elongation factor TFIIS contains three structural domains: solution structure of domain II.
Proc.Natl.Acad.Sci.USA, 93, 1996
1EO0
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CONSERVED DOMAIN COMMON TO TRANSCRIPTION FACTORS TFIIS, ELONGIN A, CRSP70
Descriptor:TRANSCRIPTION ELONGATION FACTOR S-II
Authors:Booth, V., Koth, C., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-03-21
Release date:2000-05-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70
J.Biol.Chem., 275, 2000
1EP0
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HIGH RESOLUTION CRYSTAL STRUCTURE OF DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor:DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE
Authors:Christendat, D., Saridakis, V., Bochkarev, A., Pai, E.F., Arrowsmith, C.H., Edwards, A.M., Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-03-24
Release date:2000-12-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
J.Biol.Chem., 275, 2000
1EPZ
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CRYSTAL STRUCTURE OF DTDP-6-DEOXY-D-XYLO-4-HEXULOASE 3,5-EPIMERASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM WITH BOUND LIGAND.
Descriptor:DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE, THYMIDINE-5'-DIPHOSPHATE
Authors:Christendat, D., Saridakis, V., Bochkarev, A., Pai, E.F., Arrowsmith, C., Edwards, A.M.
Deposit date:2000-03-30
Release date:2000-12-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
J.Biol.Chem., 275, 2000
1HYB
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CRYSTAL STRUCTURE OF AN ACTIVE SITE MUTANT OF METHANOBACTERIUM THERMOAUTOTROPHICUM NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE
Descriptor:NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE, SULFATE ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Saridakis, V., Christendat, D., Kimber, M.S., Edwards, A.M., Pai, E.F.
Deposit date:2001-01-18
Release date:2001-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into ligand binding and catalysis of a central step in NAD+ synthesis: structures of Methanobacterium thermoautotrophicum NMN adenylyltransferase complexes.
J.Biol.Chem., 276, 2001
1IIO
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NMR-BASED STRUCTURE OF THE CONSERVED PROTEIN MTH865 FROM THE ARCHEA METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor:conserved hypothetical protein MTH865
Authors:Lee, G.M., Edwards, A.M., Arrowsmith, C.H., McIntosh, L.P.
Deposit date:2001-04-23
Release date:2001-10-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum.
J.Biomol.NMR, 21, 2001
1JW2
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SOLUTION STRUCTURE OF HEMOLYSIN EXPRESSION MODULATING PROTEIN HHA FROM ESCHERICHIA COLI. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET EC0308_1_72; NORTHEAST STRUCTURAL GENOMICS TARGET ET88
Descriptor:HEMOLYSIN EXPRESSION MODULATING PROTEIN Hha
Authors:Chang, X., Yee, A., Savchenko, A., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-09-02
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics
Proc.Natl.Acad.Sci.USA, 99, 2002
1JW3
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SOLUTION STRUCTURE OF METHANOBACTERIUM THERMOAUTOTROPHICUM PROTEIN 1598. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET MTH1598_1_140; NORTHEAST STRUCTURAL GENOMICS TARGET TT6
Descriptor:Conserved Hypothetical Protein MTH1598
Authors:Chang, X., Connelly, G., Yee, A., Kennedy, M.A., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-09-02
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1K3R
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CRYSTAL STRUCTURE OF THE METHYLTRANSFERASE WITH A KNOT FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor:conserved protein MT0001
Authors:Zarembinski, T.I., Kim, Y., Peterson, K., Christendat, D., Dharamsi, A., Arrowsmith, C.H., Edwards, A.M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2001-10-03
Release date:2002-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Deep trefoil knot implicated in RNA binding found in an archaebacterial protein.
Proteins, 50, 2003