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1KI1
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BU of 1ki1 by Molmil
Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42
Descriptor: G25K GTP-binding protein, placental isoform, SULFATE ION, ...
Authors:Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J.
Deposit date:2001-12-02
Release date:2002-05-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
1LB1
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BU of 1lb1 by Molmil
Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA
Descriptor: Guanine nucleotide exchange factor DBS, Transforming protein RhoA
Authors:Snyder, J.T, Worthylake, D.K, Rossman, K.L, Betts, L, Pruitt, W.M, Siderovski, D.P, Der, C.J, Sondek, J.
Deposit date:2002-04-01
Release date:2002-05-29
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
6CU6
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BU of 6cu6 by Molmil
Crystal structure of GMPPNP-bound G12R mutant of human KRAS4b
Descriptor: GLYCEROL, GTPase KRas, MAGNESIUM ION, ...
Authors:Tran, T.H, Simanshu, D.K.
Deposit date:2018-03-23
Release date:2019-09-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Atypical KRASG12RMutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
Cancer Discov, 10, 2020
2PZ1
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BU of 2pz1 by Molmil
Crystal Structure of Auto-inhibited Asef
Descriptor: Rho guanine nucleotide exchange factor 4
Authors:Betts, L, Sondek, J, Rossman, K.L.
Deposit date:2007-05-17
Release date:2007-08-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
1WQ1
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BU of 1wq1 by Molmil
RAS-RASGAP COMPLEX
Descriptor: ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, H-RAS, ...
Authors:Scheffzek, K, Ahmadian, M.R, Kabsch, W, Wiesmueller, L, Lautwein, A, Schmitz, F, Wittinghofer, A.
Deposit date:1997-07-03
Release date:1998-07-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Science, 277, 1997

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