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3KTM
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BU of 3ktm by Molmil
Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)
Descriptor: (3R)-butane-1,3-diol, ACETATE ION, Amyloid beta A4 protein, ...
Authors:Dahms, S.O, Hoefgen, S, Roeser, D, Schlott, B, Guhrs, K.H, Than, M.E.
Deposit date:2009-11-25
Release date:2010-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
4RD9
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BU of 4rd9 by Molmil
X-RAY STRUCTURE OF THE APO FORM OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN
Descriptor: Amyloid-like protein 1
Authors:Dahms, S.O, Than, M.E.
Deposit date:2014-09-18
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
Acta Crystallogr.,Sect.D, 71, 2015
4RDA
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BU of 4rda by Molmil
X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, Amyloid-like protein 1, ...
Authors:Dahms, S.O, Than, M.E.
Deposit date:2014-09-18
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
Acta Crystallogr.,Sect.D, 71, 2015
5JXI
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BU of 5jxi by Molmil
Structure of the unliganded form of the proprotein convertase furin in presence of EDTA.
Descriptor: CALCIUM ION, CHLORIDE ION, Furin, ...
Authors:Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXG
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BU of 5jxg by Molmil
Structure of the unliganded form of the proprotein convertase furin.
Descriptor: CALCIUM ION, CHLORIDE ION, Furin, ...
Authors:Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5MIM
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BU of 5mim by Molmil
Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n
Descriptor: 1-[(1~{R},2~{R},4~{S},5~{S})-2,4-bis(4-carbamimidamidophenoxy)-5-[(4-carbamimidamidophenyl)amino]cyclohexyl]guanidine, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Guan-Sheng, J, Than, M.E.
Deposit date:2016-11-28
Release date:2017-05-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
ACS Chem. Biol., 12, 2017
6EQX
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BU of 6eqx by Molmil
X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Arg-Arg-Arg-Val-Arg-Amba
Descriptor: Arg-Arg-Arg-Val-Arg-00S, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Than, M.E.
Deposit date:2017-10-16
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
6EQW
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BU of 6eqw by Molmil
X-ray structure of the proprotein convertase furin bound with the competitive inhibitor 4-aminomethyl-phenylacetyl-Arg-Val-Arg-Amba
Descriptor: AMA-ARG-TBG-ARG-00S, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Than, M.E.
Deposit date:2017-10-16
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
6EQV
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BU of 6eqv by Molmil
X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Phac-Cit-Val-Arg-Amba
Descriptor: CALCIUM ION, CHLORIDE ION, Furin, ...
Authors:Dahms, S.O, Than, M.E.
Deposit date:2017-10-16
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
7QXZ
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BU of 7qxz by Molmil
X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 5
Descriptor: 2-[(3S)-1-[[2-[3,5-bis(chloranyl)phenyl]-6-[2-(4-methylpiperazin-4-ium-1-yl)pyrimidin-5-yl]oxy-pyridin-4-yl]methyl]pyrrolidin-1-ium-3-yl]oxyethanoic acid, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Brandstetter, H, Pautsch, A.
Deposit date:2022-01-27
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.
Acs Chem.Biol., 17, 2022
7QY0
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BU of 7qy0 by Molmil
X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Brandstetter, H, Pautsch, A.
Deposit date:2022-01-27
Release date:2022-04-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.
Acs Chem.Biol., 17, 2022
7QY1
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BU of 7qy1 by Molmil
X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyridin-2-yl]piperazin-1-ium-1-yl]propanoate, CALCIUM ION, ...
Authors:Dahms, S.O, Brandstetter, H, Pautsch, A.
Deposit date:2022-01-27
Release date:2022-04-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.
Acs Chem.Biol., 17, 2022
7QY2
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BU of 7qy2 by Molmil
X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 2
Descriptor: (2R)-4-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyrimidin-2-yl]piperazin-1-ium-1-yl]-2-methyl-butanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Dahms, S.O, Brandstetter, H, Pautsch, A.
Deposit date:2022-01-27
Release date:2022-04-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.
Acs Chem.Biol., 17, 2022
7QXY
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BU of 7qxy by Molmil
X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 3
Descriptor: 3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyrimidin-2-yl]piperazin-1-ium-1-yl]propanoate, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Brandstetter, H, Pautsch, A.
Deposit date:2022-01-27
Release date:2022-04-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.478 Å)
Cite:Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.
Acs Chem.Biol., 17, 2022
3UMK
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BU of 3umk by Molmil
X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with copper
Descriptor: ACETATE ION, Amyloid beta A4 protein, CADMIUM ION, ...
Authors:Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E.
Deposit date:2011-11-13
Release date:2012-01-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
3UMH
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BU of 3umh by Molmil
X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium
Descriptor: ACETATE ION, Amyloid beta A4 protein, CADMIUM ION
Authors:Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E.
Deposit date:2011-11-13
Release date:2012-01-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
3UMI
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BU of 3umi by Molmil
X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc
Descriptor: ACETATE ION, Amyloid beta A4 protein, CADMIUM ION, ...
Authors:Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E.
Deposit date:2011-11-13
Release date:2012-01-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
4OMC
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BU of 4omc by Molmil
X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba
Descriptor: CALCIUM ION, FORMIC ACID, Furin, ...
Authors:Dahms, S.O, Than, M.E.
Deposit date:2014-01-27
Release date:2014-04-09
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9, 2014
4OMD
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BU of 4omd by Molmil
X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba
Descriptor: CALCIUM ION, FORMIC ACID, Furin, ...
Authors:Dahms, S.O, Than, M.E.
Deposit date:2014-01-27
Release date:2014-04-09
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9, 2014
7O1U
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BU of 7o1u by Molmil
X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 1 (BEV241)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Brandstetter, H.
Deposit date:2021-03-30
Release date:2021-09-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
Acs Chem.Biol., 16, 2021
7O22
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BU of 7o22 by Molmil
X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 4 (mi359)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Brandstetter, H.
Deposit date:2021-03-30
Release date:2021-09-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
Acs Chem.Biol., 16, 2021
7O20
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BU of 7o20 by Molmil
X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (mi300)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Brandstetter, H.
Deposit date:2021-03-30
Release date:2021-09-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
Acs Chem.Biol., 16, 2021
7O1W
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BU of 7o1w by Molmil
X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 1 M NaCl
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Brandstetter, H.
Deposit date:2021-03-30
Release date:2021-09-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
Acs Chem.Biol., 16, 2021
7O1Y
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BU of 7o1y by Molmil
X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 0.25 M NaCl
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Dahms, S.O, Brandstetter, H.
Deposit date:2021-03-30
Release date:2021-09-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
Acs Chem.Biol., 16, 2021
5JMR
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BU of 5jmr by Molmil
X-ray structure of the furin inhibitory antibody Nb14
Descriptor: CHLORIDE ION, camelid VHH fragment
Authors:Dahms, S.O, Than, M.E.
Deposit date:2016-04-29
Release date:2016-12-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Sci Rep, 6, 2016

 

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