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3ZIF
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BU of 3zif by Molmil
Cryo-EM structures of two intermediates provide insight into adenovirus assembly and disassembly
Descriptor: HEXON PROTEIN, PENTON PROTEIN, PIX, ...
Authors:Cheng, L, Huang, X, Li, X, Xiong, W, Sun, W, Yang, C, Zhang, K, Wang, Y, Liu, H, Ji, G, Sun, F, Zheng, C, Zhu, P.
Deposit date:2013-01-09
Release date:2014-01-22
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-Em Structures of Two Bovine Adenovirus Type 3 Intermediates
Virology, 450, 2014
3IZ3
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BU of 3iz3 by Molmil
CryoEM structure of cytoplasmic polyhedrosis virus
Descriptor: Structural protein VP1, Structural protein VP3, Viral structural protein 5
Authors:Cheng, L, Sun, J, Zhang, K, Mou, Z, Huang, X, Ji, G, Sun, F, Zhang, J, Zhu, P.
Deposit date:2010-09-14
Release date:2011-03-16
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping.
Proc.Natl.Acad.Sci.USA, 108, 2011
5Z4D
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BU of 5z4d by Molmil
Structure of Tailor in complex with AGUU RNA
Descriptor: RNA (5'-R(*AP*GP*UP*U)-3'), Terminal uridylyltransferase Tailor
Authors:Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q.
Deposit date:2018-01-11
Release date:2018-10-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
5Z4M
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BU of 5z4m by Molmil
Structure of TailorD343A with bound UTP and Mg
Descriptor: MAGNESIUM ION, Terminal uridylyltransferase Tailor, URIDINE 5'-TRIPHOSPHATE
Authors:Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q.
Deposit date:2018-01-11
Release date:2018-10-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
5Z4C
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BU of 5z4c by Molmil
Crystal structure of Tailor
Descriptor: Terminal uridylyltransferase Tailor
Authors:Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q.
Deposit date:2018-01-10
Release date:2018-10-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
5Z4J
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BU of 5z4j by Molmil
Structure of Tailor in complex with U4 RNA
Descriptor: RNA (5'-R(*UP*UP*UP*U)-3'), Terminal uridylyltransferase Tailor
Authors:Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q.
Deposit date:2018-01-11
Release date:2018-10-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
5Z4A
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BU of 5z4a by Molmil
Structure of Tailor in complex with AGU RNA
Descriptor: RNA (5'-R(*AP*GP*U)-3'), Terminal uridylyltransferase Tailor
Authors:Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q.
Deposit date:2018-01-10
Release date:2018-10-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.637 Å)
Cite:Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
7ECA
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BU of 7eca by Molmil
Crystal structure of the Keap1 complex with a peptide base on ETGE motif.
Descriptor: Kelch-like ECH-associated protein 1, LEU-ASP-GLU-GLU-THR-GLY-GLU-PHE-LEU-PRO, SULFATE ION
Authors:Cheng, L, Wang, C.
Deposit date:2021-03-11
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.00006342 Å)
Cite:New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.
Life Sci, 282, 2021
4CIK
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BU of 4cik by Molmil
plasminogen kringle 1 in complex with inhibitor
Descriptor: 5-[(2R,4S)-2-(phenylmethyl)piperidin-4-yl]-1,2-oxazol-3-one, PLASMINOGEN
Authors:Xue, Y, Johansson, C, Cheng, L, Pettersen, D, Gustafsson, D.
Deposit date:2013-12-10
Release date:2014-06-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Discovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction.
Acs Med.Chem.Lett., 5, 2014
7BR3
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BU of 7br3 by Molmil
Crystal structure of the protein 1
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R)-2,3-dihydroxypropyl dodecanoate, 4-[[(1R)-2-[5-(2-fluoranyl-3-methoxy-phenyl)-3-[[2-fluoranyl-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-bis(oxidanylidene)pyrimidin-1-yl]-1-phenyl-ethyl]amino]butanoic acid, ...
Authors:Cheng, L, Shao, Z.
Deposit date:2020-03-26
Release date:2020-10-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode.
Nat Commun, 11, 2020
8JZ7
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BU of 8jz7 by Molmil
Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein
Descriptor: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
Deposit date:2023-07-04
Release date:2023-10-04
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2.
Signal Transduct Target Ther, 8, 2023
4WVR
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BU of 4wvr by Molmil
Crystal structure of Dscam1 Ig7 domain, isoform 5
Descriptor: Down syndrome cell adhesion molecule, isoform AK
Authors:Chen, Q, Yu, Y, Li, S, Cheng, L.
Deposit date:2014-11-07
Release date:2015-11-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
8JTS
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BU of 8jts by Molmil
hOCT1 in complex with metformin in outward open conformation
Descriptor: Metformin, Solute carrier family 22 member 1
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTT
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BU of 8jtt by Molmil
hOCT1 in complex with metformin in outward occluded conformation
Descriptor: Metformin, Solute carrier family 22 member 1
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTV
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BU of 8jtv by Molmil
hOCT1 in complex with metformin in inward occluded conformation
Descriptor: Metformin, Solute carrier family 22 member 1
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTW
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BU of 8jtw by Molmil
hOCT1 in complex with nb5660 in inward facing partially open 1 conformation
Descriptor: Solute carrier family 22 member 1, nanobody 56
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTX
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BU of 8jtx by Molmil
hOCT1 in complex with nb5660 in inward facing fully open conformation
Descriptor: Solute carrier family 22 member 1, nanobody 56
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTY
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BU of 8jty by Molmil
hOCT1 in complex with nb5660 in inward facing partially open 2 conformation
Descriptor: Solute carrier family 22 member 1, nanobody 56
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTZ
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BU of 8jtz by Molmil
hOCT1 in complex with spironolactone in outward facing partially occluded conformation
Descriptor: SPIRONOLACTONE, Solute carrier family 22 member 1
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-22
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JU0
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BU of 8ju0 by Molmil
hOCT1 in complex with spironolactone in inward facing occluded conformation
Descriptor: SPIRONOLACTONE, Solute carrier family 22 member 1
Authors:Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
Deposit date:2023-06-23
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
4U6V
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BU of 4u6v by Molmil
Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody
Descriptor: Alpha-hemolysin, Fab, antigen binding fragment, ...
Authors:Oganesyan, V.Y, Peng, L, Damschroder, M.M, Cheng, L, Sadowska, A, Tkaczyk, C, Sellman, B, Wu, H, Dall'Acqua, W.F.
Deposit date:2014-07-29
Release date:2014-09-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody.
J.Biol.Chem., 289, 2014
4RN5
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BU of 4rn5 by Molmil
B1 domain of human Neuropilin-1 with acetate ion in a ligand-binding site
Descriptor: ACETATE ION, GLYCEROL, Neuropilin-1, ...
Authors:Allerston, C.K, Yelland, T.S, Jarvis, A, Jenkins, K, Winfield, N, Cheng, L, Jia, H, Zachary, I, Selwood, D.L, Djordjevic, S.
Deposit date:2014-10-23
Release date:2015-10-28
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Conserved water molecules in a ligand-binding site of neuropilin-1
To be Published
4X83
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BU of 4x83 by Molmil
Crystal structure of Dscam1 isoform 7.44, N-terminal four Ig domains
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Chen, Q, Yu, Y, Li, S.A, Cheng, L.
Deposit date:2014-12-10
Release date:2015-12-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
4X9B
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BU of 4x9b by Molmil
Crystal structure of Dscam1 isoform 4.44, N-terminal four Ig domains
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Down syndrome cell adhesion molecule, isoform 4.44, ...
Authors:Chen, Q, Yu, Y, Li, S.A, Cheng, L.
Deposit date:2014-12-11
Release date:2015-12-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
4X5L
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BU of 4x5l by Molmil
Crystal structure of Dscam1 Ig7 domain, isoform 9
Descriptor: Down syndrome cell adhesion molecule, isoform AM, SODIUM ION
Authors:Chen, Q, Yu, Y, Li, S.A, Cheng, L.
Deposit date:2014-12-05
Release date:2015-12-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.374 Å)
Cite:Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016

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