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8U0P
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BU of 8u0p by Molmil
Synaptic complex of human DNA polymerase Lambda DL variant engaged on a noncomplementary DNA double-strand break
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ...
Authors:Kaminski, A.M, Pedersen, L.C, Bebenek, K, Kunkel, T.A, Chiruvella, K.K, Ramsden, D.A.
Deposit date:2023-08-29
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:DNA polymerase lambda Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining.
DNA Repair (Amst), 136, 2024
8U0O
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BU of 8u0o by Molmil
Synaptic complex of human DNA polymerase Lambda DL variant engaged on a DNA double-strand break containing an unpaired 3' primer terminus
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*AP*CP*GP*CP*GP*GP*CP*A)-3'), ...
Authors:Kaminski, A.M, Pedersen, L.C, Bebenek, K, Kunkel, T.A, Chiruvella, K.K, Ramsden, D.A.
Deposit date:2023-08-29
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:DNA polymerase lambda Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining.
DNA Repair (Amst), 136, 2024
6BKG
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BU of 6bkg by Molmil
Human LigIV catalytic domain with bound DNA-adenylate intermediate in closed conformation
Descriptor: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ...
Authors:Moon, A.F, Tumbale, P.P, Schellenberg, M.J, Williams, R.S, Williams, J.G, Kunkel, T.A, Pedersen, L.C, Bebenek, B.
Deposit date:2017-11-08
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
Nat Commun, 9, 2018
6BKF
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BU of 6bkf by Molmil
Lysyl-adenylate form of human LigIV catalytic domain with bound DNA substrate in open conformation
Descriptor: ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Moon, A.F, Tumbale, P.P, Schellenberg, M.J, Williams, R.S, Williams, J.G, Kunkel, T.A, Pedersen, L.C, Bebenek, B.
Deposit date:2017-11-08
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
Nat Commun, 9, 2018
1XSL
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BU of 1xsl by Molmil
Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap
Descriptor: 5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
1XSP
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BU of 1xsp by Molmil
Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate
Descriptor: 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*TP*AP*CP*TP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
1XSN
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BU of 1xsn by Molmil
Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP
Descriptor: 1,2-ETHANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*(2DT))-3', ...
Authors:Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
4YD1
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BU of 4yd1 by Molmil
Ternary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate and an incoming nonhydrolyzable dUMPNPP
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K.
Deposit date:2015-02-20
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Creative template-dependent synthesis by human polymerase mu.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YD2
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BU of 4yd2 by Molmil
Nicked complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate
Descriptor: CHLORIDE ION, DNA (5'-D(*CP*GP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ...
Authors:Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K.
Deposit date:2015-02-20
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.471 Å)
Cite:Creative template-dependent synthesis by human polymerase mu.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YCX
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BU of 4ycx by Molmil
Binary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate
Descriptor: DNA (5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), DNA (5'-D(P*GP*CP*CP*G)-3'), ...
Authors:Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K.
Deposit date:2015-02-20
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Creative template-dependent synthesis by human polymerase mu.
Proc.Natl.Acad.Sci.USA, 112, 2015
3UPQ
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BU of 3upq by Molmil
Crystal structure of the pre-catalytic ternary complex of polymerase lambda with an rATP analog opposite a templating T.
Descriptor: 5'-D(*CP*AP*GP*TP*AP*C)-3', 5'-D(*CP*GP*GP*CP*TP*GP*TP*AP*CP*TP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Gosavi, R.A, Moon, A.F, Kunkel, T.A, Pedersen, L.C, Bebenek, K.
Deposit date:2011-11-18
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda
Nucleic Acids Res., 40, 2012
3UQ0
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BU of 3uq0 by Molmil
Crystal structure of the post-catalytic product complex of polymerase lambda with an rAMP at the primer terminus.
Descriptor: 1,2-ETHANEDIOL, 5'-D(*CP*AP*GP*TP*AP*CP)-R(P*A)-3', 5'-D(*CP*GP*GP*CP*TP*GP*TP*AP*CP*TP*G)-3', ...
Authors:Gosavi, R.A, Moon, A.F, Kunkel, T.A, Pedersen, L.C, Bebenek, K.
Deposit date:2011-11-18
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda
Nucleic Acids Res., 40, 2012
3UQ2
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BU of 3uq2 by Molmil
Crystal structure of the post-catalytic product complex of polymerase lambda with an rCMP inserted opposite a templating G and dAMP inserted opposite a templating T at the primer terminus.
Descriptor: 5'-D(*CP*AP*GP*TP*AP)-R(P*CP*A)-3', 5'-D(*CP*GP*GP*CP*TP*GP*TP*AP*CP*TP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Gosavi, R.A, Moon, A.F, Kunkel, T.A, Pedersen, L.C, Bebenek, K.
Deposit date:2011-11-18
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda
Nucleic Acids Res., 40, 2012
6WIE
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BU of 6wie by Molmil
Post-catalytic nicked complex of human Polymerase Mu on a complementary DNA double-strand break substrate
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*AP*CP*G)-3'), ...
Authors:Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K.
Deposit date:2020-04-09
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break.
Nat Commun, 11, 2020
6WIC
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BU of 6wic by Molmil
Pre-catalytic quaternary complex of human Polymerase Mu on a complementary DNA double-strand break substrate
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K.
Deposit date:2020-04-09
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break.
Nat Commun, 11, 2020
6WID
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BU of 6wid by Molmil
Nucleotide incorporation intermediate into quaternary complex of human Polymerase Mu on a complementary DNA double-strand break substrate
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K.
Deposit date:2020-04-09
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break.
Nat Commun, 11, 2020
2GWS
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BU of 2gws by Molmil
Crystal Structure of human DNA Polymerase lambda with a G/G mismatch in the primer terminus
Descriptor: 1,2-ETHANEDIOL, 5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*G)-3', ...
Authors:Garcia-Diaz, M, Picher, A.J, Bebenek, K, Pedersen, L.C, Kunkel, T.A, Blanco, L.
Deposit date:2006-05-05
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Promiscuous mismatch extension by human DNA polymerase lambda.
Nucleic Acids Res., 34, 2006
2IHM
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BU of 2ihm by Molmil
Polymerase mu in ternary complex with gapped 11mer DNA duplex and bound incoming nucleotide
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*T)-3', 5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*TP*G)-3', ...
Authors:Moon, A.F, Pedersen, L.C, Kunkel, T.A.
Deposit date:2006-09-26
Release date:2006-12-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insight into the substrate specificity of DNA Polymerase mu.
Nat.Struct.Mol.Biol., 14, 2007
3C5F
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BU of 3c5f by Molmil
Structure of a binary complex of the R517A Pol lambda mutant
Descriptor: DNA (5'-D(*DCP*DAP*DGP*DTP*DAP*DC)-3'), DNA (5'-D(*DCP*DGP*DGP*DCP*DCP*DGP*DTP*DAP*DCP*DTP*DG)-3'), DNA (5'-D(P*DGP*DCP*DCP*DG)-3'), ...
Authors:Garcia-Diaz, M, Bebenek, K, Foley, M.C, Pedersen, L.C, Schlick, T, Kunkel, T.A.
Deposit date:2008-01-31
Release date:2008-09-02
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda.
Embo Rep., 9, 2008
3C5G
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BU of 3c5g by Molmil
Structure of a ternary complex of the R517K Pol lambda mutant
Descriptor: 1,2-ETHANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*DCP*DAP*DGP*DTP*DAP*(2DT))-3'), ...
Authors:Garcia-Diaz, M, Bebenek, K, Foley, M.C, Pedersen, L.C, Schlick, T, Kunkel, T.A.
Deposit date:2008-01-31
Release date:2008-07-29
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda.
Embo Rep., 9, 2008
3CQ8
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BU of 3cq8 by Molmil
Ternary complex of the L415F mutant RB69 exo(-)polymerase
Descriptor: CALCIUM ION, DNA (5'-D(*DAP*DCP*DAP*DGP*DGP*DTP*DAP*DAP*DGP*DCP*DAP*DGP*DTP*DCP*DCP*DGP*DCP*DG)-3'), DNA (5'-D(*DGP*DCP*DGP*DGP*DAP*DCP*DTP*DGP*DCP*DTP*DTP*DAP*DCP*DC)-3'), ...
Authors:Zhong, X, Pedersen, L.C, Kunkel, T.A.
Deposit date:2008-04-02
Release date:2008-09-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity.
Nucleic Acids Res., 36, 2008
3H4L
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BU of 3h4l by Molmil
Crystal Structure of N terminal domain of a DNA repair protein
Descriptor: DNA mismatch repair protein PMS1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Arana, M.E, Holmes, S.F, Fortune, J.M, Moon, A.F, Pedersen, L.C, Kunkel, T.A.
Deposit date:2009-04-20
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Functional residues on the surface of the N-terminal domain of yeast Pms1.
Dna Repair, 9, 2010
3HX0
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BU of 3hx0 by Molmil
ternary complex of L277A, H511A, R514 mutant pol lambda bound to a 2 nucleotide gapped DNA substrate with a scrunched dA
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*T)-3', 5'-D(*CP*GP*GP*CP*AP*AP*AP*TP*AP*CP*TP*G)-3', ...
Authors:Garcia-Diaz, M, Bebenek, K, Larrea, A.A, Havener, J.M, Perera, L, Krahn, J.M, Pedersen, L.C, Ramsden, D.A, Kunkel, T.A.
Deposit date:2009-06-19
Release date:2009-08-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Scrunching During DNA Repair Synthesis
To be Published
3HWT
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BU of 3hwt by Molmil
Ternary complex of DNA polymerase lambda bound to a two nucleotide gapped DNA substrate with a scrunched dA
Descriptor: 1,2-ETHANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*(2DT))-3', ...
Authors:Garcia-Diaz, M, Bebenek, K, Larrea, A.A, Pedersen, L.C, Kunkel, T.A.
Deposit date:2009-06-18
Release date:2009-08-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Scrunching during DNA repair synthesis
To be Published
3HW8
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BU of 3hw8 by Molmil
ternary complex of DNA polymerase lambda of a two nucleotide gapped DNA substrate with a C in the scrunch site
Descriptor: 1,2-ETHANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*T)-3', ...
Authors:Garcia-Diaz, M, Bebenek, K, Larrea, A.A, Havener, J.M, Perera, L, Krahn, J.M, Pedersen, L.C, Ramsden, D.A, Kunkel, T.A.
Deposit date:2009-06-17
Release date:2009-08-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Scrunching Durning DNA Repair Synthesis
To be Published

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