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8D3F
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BU of 8d3f by Molmil
Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST
Descriptor: Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST
Authors:Huang, Z, Liu, H, Nix, J.C, Amarasinghe, G.K, Sibley, L.D.
Deposit date:2022-06-01
Release date:2022-07-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment.
Nat Commun, 13, 2022
4QQ5
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BU of 4qq5 by Molmil
Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex With FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations
Descriptor: Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide
Authors:Huang, Z, Mohammadi, M.
Deposit date:2014-06-26
Release date:2014-10-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
4QQJ
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BU of 4qqj by Molmil
Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain Harboring the V550L Gate-Keeper Mutation
Descriptor: Fibroblast growth factor receptor 4, SULFATE ION
Authors:Huang, Z, Mohammadi, M.
Deposit date:2014-06-27
Release date:2014-10-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.682 Å)
Cite:DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
4QQT
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BU of 4qqt by Molmil
Crystal Structure of FGF Receptor (FGFR) 4 Tyrosine Kinase Domain
Descriptor: Fibroblast growth factor receptor 4, SULFATE ION
Authors:Huang, Z, Mohammadi, M.
Deposit date:2014-06-29
Release date:2014-10-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
4QRC
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BU of 4qrc by Molmil
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib
Descriptor: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Fibroblast growth factor receptor 4, SULFATE ION
Authors:Huang, Z, Mohammadi, M.
Deposit date:2014-06-30
Release date:2014-10-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
5EG3
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BU of 5eg3 by Molmil
Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Fibroblast growth factor receptor 2, MAGNESIUM ION, ...
Authors:Huang, Z, Li, X, Mohammadi, M.
Deposit date:2015-10-26
Release date:2016-02-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.606 Å)
Cite:Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma.
Mol.Cell, 61, 2016
4K33
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BU of 4k33 by Molmil
Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma
Descriptor: Fibroblast growth factor receptor 3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Huang, Z, Chen, H, Mohammadi, M.
Deposit date:2013-04-10
Release date:2013-09-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3405 Å)
Cite:Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation.
Structure, 21, 2013
7ZE9
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BU of 7ze9 by Molmil
Structure of an AA16 LPMO-like protein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, COPPER (II) ION, ...
Authors:Huang, Z, Banerjee, S, Muderspach, S.J, Sun, P, van Berkel, W.J.H, Kabel, M.A, Lo Leggio, L.
Deposit date:2022-03-30
Release date:2023-03-15
Last modified:2023-04-26
Method:X-RAY DIFFRACTION (2.646 Å)
Cite:AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila.
Acs Catalysis, 13, 2023
3DOR
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BU of 3dor by Molmil
Crystal Structure of mature CPAF
Descriptor: Protein CT_858, SULFATE ION
Authors:Chai, J, Huang, Z.
Deposit date:2008-07-06
Release date:2009-01-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
3DPM
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BU of 3dpm by Molmil
Structure of mature CPAF complexed with lactacystin
Descriptor: N-acetyl-S-({(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)cysteine, Protein CT_858
Authors:Chai, J, Huang, Z.
Deposit date:2008-07-09
Release date:2009-01-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
3DJA
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BU of 3dja by Molmil
Crystal Structure of cpaf solved with MAD
Descriptor: Protein CT_858
Authors:Chai, J, Huang, Z.
Deposit date:2008-06-22
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
3DPN
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BU of 3dpn by Molmil
Crystal Structure of cpaf s499a mutant
Descriptor: Protein CT_858
Authors:Chai, J, Huang, Z.
Deposit date:2008-07-09
Release date:2009-01-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
1Z7I
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BU of 1z7i by Molmil
2'-Me-Se Derivitation of A-DNA Octamer G(UMSe)GTACAC
Descriptor: 5'-D(*GP*(UMS)P*GP*TP*AP*CP*AP*C)-3', SPERMINE
Authors:Huang, Z, Carrasco, N, Jiang, J.
Deposit date:2005-03-24
Release date:2005-04-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Selenium derivatization of nucleic acids for crystallography.
Nucleic Acids Res., 35, 2007
8QAO
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BU of 8qao by Molmil
Crystal structure of TP901-1 CI-NTD89 repressor N-terminal domain
Descriptor: CI
Authors:Huang, Z, Hamad, G.M, Lo Leggio, L, Varming, A.K.
Deposit date:2023-08-23
Release date:2024-02-28
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:CI:Mor interactions in the lysogeny switches of Lactococcus lactis TP901-1 and Staphylococcus aureus phi 13 bacteriophages
Microbiome Res Rep, 2024
4QQC
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BU of 4qqc by Molmil
Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations
Descriptor: Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, SULFATE ION
Authors:Huang, Z, Mohammadi, M.
Deposit date:2014-06-27
Release date:2014-10-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc.Natl.Acad.Sci.USA, 111, 2014
4R6V
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BU of 4r6v by Molmil
Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations
Descriptor: Fibroblast growth factor receptor 4, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide, SULFATE ION
Authors:Huang, Z, Mohammadi, M.
Deposit date:2014-08-26
Release date:2014-10-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.353 Å)
Cite:Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc.Natl.Acad.Sci.USA, 111, 2014
3CXB
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BU of 3cxb by Molmil
Crystal Structure of sifa and skip
Descriptor: Pleckstrin homology domain-containing family M member 2, Protein sifA
Authors:Huang, Z, Chai, J.
Deposit date:2008-04-24
Release date:2008-12-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation
Cell Host Microbe, 4, 2008
3GCG
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BU of 3gcg by Molmil
crystal structure of MAP and CDC42 complex
Descriptor: Cell division control protein 42 homolog, L0028 (Mitochondria associated protein)
Authors:Chai, J, Huang, Z, Feng, Y, Wu, X.
Deposit date:2009-02-22
Release date:2009-07-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics
Nat.Struct.Mol.Biol., 16, 2009
4J98
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BU of 4j98 by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Huang, Z, Chen, H, Mohammadi, M.
Deposit date:2013-02-15
Release date:2013-08-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3067 Å)
Cite:Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
5Y2F
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BU of 5y2f by Molmil
Human SIRT6 in complex with allosteric activator MDL-801
Descriptor: 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid, 9-mer peptide QTARKSTGG, DI(HYDROXYETHYL)ETHER, ...
Authors:Zhang, J, Huang, Z, Song, K.
Deposit date:2017-07-25
Release date:2018-11-07
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Identification of a cellularly active SIRT6 allosteric activator.
Nat. Chem. Biol., 14, 2018
6X5D
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BU of 6x5d by Molmil
Structure of Dickerson-Drew Dodecamer with 2'-MeSe-ara-T modification
Descriptor: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*(UWJ)P*CP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Chen, C, Fang, Z, Huang, Z.
Deposit date:2020-05-25
Release date:2021-06-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:2'-Beta-Selenium Atom on Thymidine to Control Beta-Form DNA Conformation and Large Crystal Formation
Cryst.Growth Des., 22, 2022
1MA8
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BU of 1ma8 by Molmil
A-DNA decamer GCGTA(UMS)ACGC with incorporated 2'-methylseleno-uridine
Descriptor: 5'-D(*GP*CP*GP*TP*AP*UMSP*AP*CP*GP*C)-3'
Authors:Teplova, M, Wilds, C.J, Wawrzak, Z, Tereshko, V, Du, Q, Carrasco, N, Huang, Z, Egli, M.
Deposit date:2002-08-01
Release date:2002-12-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle
BIOCHIMIE, 84, 2002
7BTN
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BU of 7btn by Molmil
Crystal structure of human inorganic pyrophosphatase with metal ions
Descriptor: Inorganic pyrophosphatase, MAGNESIUM ION
Authors:Hu, F, Huang, Z, Li, L.
Deposit date:2020-04-02
Release date:2020-10-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:Structural and biochemical characterization of inorganic pyrophosphatase from Homo sapiens.
Biochem.Biophys.Res.Commun., 533, 2020
5USG
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BU of 5usg by Molmil
5-Se-T2/4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant
Descriptor: DNA (5'-D(*AP*(T5S)P*GP*(T5S)P*CP*G)-3'), MAGNESIUM ION, RNA (5'-R(*UP*CP*GP*AP*CP*A)-3'), ...
Authors:Fang, Z, Qin, L, Huang, Z.
Deposit date:2017-02-13
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate
Chemistryselect, 8, 2023
5US2
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BU of 5us2 by Molmil
2-Se-T2-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant
Descriptor: DNA (5'-D(*AP*(US3)P*GP*TP*CP*G)-3'), MAGNESIUM ION, RNA (5'-R(*UP*CP*GP*AP*CP*A)-3'), ...
Authors:Fang, Z, Yang, F, Huang, Z.
Deposit date:2017-02-13
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:2-Se-T-modified-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant
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PDB entries from 2024-03-27

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