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2R59
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BU of 2r59 by Molmil
Leukotriene A4 hydrolase complexed with inhibitor RB3041
Descriptor: ACETIC ACID, Leukotriene A-4 hydrolase, N-{(2S)-3-[(R)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine, ...
Authors:Tholander, F, Haeggstrom, J.Z, Thunnissen, M, Muroya, A, Roques, B.P, Fournie-Zaluski, M.C.
Deposit date:2007-09-03
Release date:2008-08-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
1BJ6
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BU of 1bj6 by Molmil
1H NMR OF (12-53) NCP7/D(ACGCC) COMPLEX, 10 STRUCTURES
Descriptor: DNA (5'-D(*AP*CP*GP*CP*C)-3'), NUCLEOCAPSID PROTEIN 7, ZINC ION
Authors:Demene, H, Morellet, N, Teilleux, V, Huynh-Dinh, T, De Rocquigny, H, Fournie-Zaluski, M.C, Roques, B.P.
Deposit date:1998-07-03
Release date:1999-02-02
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC).
J.Mol.Biol., 283, 1998
1Z9G
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BU of 1z9g by Molmil
Crystal Structure Analysis of Thermolysin Complexed with the Inhibitor (R)-retro-thiorphan
Descriptor: (R)-RETRO-THIORPHAN, CALCIUM ION, Thermolysin, ...
Authors:Roderick, S.L, Fournie-Zaluski, M.C, Roques, B.P, Matthews, B.W.
Deposit date:2005-04-01
Release date:2005-04-19
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin
Biochemistry, 28, 1989
1ZDP
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BU of 1zdp by Molmil
Crystal Structure Analysis of Thermolysin Complexed with the Inhibitor (S)-thiorphan
Descriptor: (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE, CALCIUM ION, Thermolysin, ...
Authors:Roderick, S.L, Fournie-Zaluski, M.C, Roques, B.P, Matthews, B.W.
Deposit date:2005-04-14
Release date:2005-04-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin
Biochemistry, 28, 1989
1QF0
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THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYL-3-PHENYLPROPANOYL)-PHE-TYR. PARAMETERS FOR ZN-BIDENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE
Descriptor: (2-SULFANYL-3-PHENYLPROPANOYL)-PHE-TYR, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Gaucher, J.-F, Selkti, M, Tiraboschi, G, Prange, T, Roques, B.P, Tomas, A, Fournie-Zaluski, M.C.
Deposit date:1999-04-06
Release date:1999-12-29
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
1QF1
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THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYLHEPTANOYL)-PHE-ALA. PARAMETERS FOR ZN-BIDENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE
Descriptor: CALCIUM ION, DIMETHYL SULFOXIDE, PROTEIN (THERMOLYSIN), ...
Authors:Gaucher, J.-F, Selkti, M, Tiraboschi, G, Prange, T, Roques, B.P, Tomas, A, Fournie-Zaluski, M.C.
Deposit date:1999-04-06
Release date:1999-12-29
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
1QF2
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THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYL-3-PHENYLPROPANOYL)-GLY-(5-PHENYLPROLINE). PARAMETERS FOR ZN-MONODENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE
Descriptor: CALCIUM ION, DIMETHYL SULFOXIDE, PROTEIN (THERMOLYSIN), ...
Authors:Gaucher, J.-F, Selkti, M, Tiraboschi, G, Prange, T, Roques, B.P, Tomas, A, Fournie-Zaluski, M.C.
Deposit date:1999-04-06
Release date:1999-12-29
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
1R1I
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BU of 1r1i by Molmil
STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Neprilysin, ZINC ION, ...
Authors:Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E.
Deposit date:2003-09-24
Release date:2004-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis of neprilysin with various specific and potent inhibitors.
Acta Crystallogr.,Sect.D, 60, 2004
1R1H
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BU of 1r1h by Molmil
STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE, Neprilysin, ...
Authors:Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E.
Deposit date:2003-09-24
Release date:2004-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural analysis of neprilysin with various specific and potent inhibitors.
Acta Crystallogr.,Sect.D, 60, 2004
1R1J
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STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-(3-PHENYL-2-SULFANYLPROPANOYL)PHENYLALANYLALANINE, Neprilysin, ...
Authors:Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E.
Deposit date:2003-09-24
Release date:2004-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural analysis of neprilysin with various specific and potent inhibitors.
Acta Crystallogr.,Sect.D, 60, 2004
2ZXG
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BU of 2zxg by Molmil
Aminopeptidase N complexed with the aminophosphinic inhibitor of PL250, a transition state analogue
Descriptor: Aminopeptidase N, GLYCEROL, N-{(2S)-3-[(1R)-1-aminoethyl](hydroxy)phosphoryl-2-benzylpropanoyl}-L-phenylalanine, ...
Authors:Nakajima, Y, Ito, K, Yoshimoto, T.
Deposit date:2008-12-24
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250
Acta Crystallogr.,Sect.D, 65, 2009
1ESK
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BU of 1esk by Molmil
SOLUTION STRUCTURE OF NCP7 FROM HIV-1
Descriptor: GAG POLYPROTEIN, ZINC ION
Authors:Morellet, N, Demene, H, Teilleux, V, Huynh-Dinh, T, de Rocquigny, H, Fournie-Zaluski, M.-C, Roques, B.P.
Deposit date:2000-04-10
Release date:2000-04-26
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution Structure of (12-53)NCp7 of HIV-1
To be Published
3B7S
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BU of 3b7s by Molmil
[E296Q]LTA4H in complex with RSR substrate
Descriptor: ACETIC ACID, GLYCEROL, Leukotriene A-4 hydrolase, ...
Authors:Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.465 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
3B7U
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BU of 3b7u by Molmil
Leukotriene A4 Hydrolase Complexed with KELatorphan
Descriptor: ACETIC ACID, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
3B7R
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BU of 3b7r by Molmil
Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040
Descriptor: IMIDAZOLE, Leukotriene A-4 hydrolase, N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE, ...
Authors:Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.811 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
3B7T
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BU of 3b7t by Molmil
[E296Q]LTA4H in complex with Arg-Ala-Arg substrate
Descriptor: IMIDAZOLE, Leukotriene A-4 hydrolase, RAR peptide, ...
Authors:Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
1OS0
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BU of 1os0 by Molmil
Thermolysin with an alpha-amino phosphinic inhibitor
Descriptor: CALCIUM ION, DIMETHYL SULFOXIDE, N-{(2R)-3-[(S)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine, ...
Authors:Selkti, M, Tomas, A, Prange, T.
Deposit date:2003-03-18
Release date:2003-03-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Interactions of a new alpha-aminophosphinic derivative inside the active site of TLN (thermolysin): a model for zinc-metalloendopeptidase inhibition.
Acta Crystallogr.,Sect.D, 59, 2003
1Q3Y
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BU of 1q3y by Molmil
NMR structure of the Cys28His mutant (D form) of the nucleocapsid protein NCp7 of HIV-1.
Descriptor: GAG protein, ZINC ION
Authors:Ramboarina, S, Druillennec, S, Morellet, N, Bouaziz, S, Roques, B.P.
Deposit date:2003-08-01
Release date:2004-09-07
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Target specificity of human immunodeficiency virus type 1 NCp7 requires an intact conformation of its CCHC N-terminal zinc finger.
J.Virol., 78, 2004
1Q3Z
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NMR structure of the Cys28His mutant (E form) of the nucleocapsid protein NCp7 of HIV-1.
Descriptor: GAG protein, ZINC ION
Authors:Ramboarina, S, Druillennec, S, Morellet, N, Bouaziz, S, Roques, B.P.
Deposit date:2003-08-01
Release date:2004-09-07
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Target specificity of human immunodeficiency virus type 1 NCp7 requires an intact conformation of its CCHC N-terminal zinc finger.
J.Virol., 78, 2004

217705

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