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6NMY
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BU of 6nmy by Molmil
A Cytokine-receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, ...
Authors:Dhagat, U, Kan, W.L, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W.
Deposit date:2019-01-13
Release date:2020-01-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Signalling conformation of cell surface receptor
To Be Published
6BFQ
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BU of 6bfq by Molmil
The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies
Descriptor: Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
3GUG
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BU of 3gug by Molmil
Crystal structure of AKR1C1 L308V mutant in complex with NADP and 3,5-dichlorosalicylic acid
Descriptor: 3,5-dichloro-2-hydroxybenzoic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Dhagat, U, El-Kabbani, O.
Deposit date:2009-03-30
Release date:2010-02-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of AKR1C1 L308V mutant in complex with NADP and 3,5-dichlorosalicylic acid
To be Published
6EF5
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BU of 6ef5 by Molmil
14-3-3 with peptide
Descriptor: 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN
Authors:Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W.
Deposit date:2018-08-16
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:14-3-3 with peptide
To Be Published
6BFS
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BU of 6bfs by Molmil
The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies
Descriptor: Fab Heavy Chain, Fab light Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
3C3U
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BU of 3c3u by Molmil
Crystal structure of AKR1C1 in complex with NADP and 3,5-dichlorosalicylic acid
Descriptor: 3,5-dichloro-2-hydroxybenzoic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Dhagat, U, El-Kabbani, O.
Deposit date:2008-01-28
Release date:2008-08-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid
J.Med.Chem., 51, 2008
3CV6
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BU of 3cv6 by Molmil
The crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase GG225.226PP mutant in complex with inhibitor and cofactor NADP+.
Descriptor: 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol, Aldo-keto reductase family 1 member C21, BETA-MERCAPTOETHANOL, ...
Authors:Dhagat, U, El-Kabbani, O.
Deposit date:2008-04-17
Release date:2009-03-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.
Acta Crystallogr.,Sect.D, 65, 2009
3FJN
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BU of 3fjn by Molmil
The crystal structure of 17-alpha hydroxysteroid dehydrogenase Y224D mutant.
Descriptor: ACETATE ION, Aldo-keto reductase family 1 member C21
Authors:Dhagat, U, El-Kabbani, O.
Deposit date:2008-12-14
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme
Acta Crystallogr.,Sect.D, 66, 2010
2P5N
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BU of 2p5n by Molmil
Crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase in complex with coenzyme NADPH
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Aldo-keto reductase family 1, member C21, ...
Authors:El-Kabbani, O, Dhagat, U.
Deposit date:2007-03-15
Release date:2007-10-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.
Acta Crystallogr.,Sect.F, 63, 2007
5DWU
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BU of 5dwu by Molmil
Beta common receptor in complex with a Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, Fab - Heavy Chain, ...
Authors:Dhagat, U, Parker, M.W.
Deposit date:2015-09-23
Release date:2015-12-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.97 Å)
Cite:CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors.
Mabs, 8, 2016
3NTY
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BU of 3nty by Molmil
Crystal structure of AKR1C1 in complex with NADP and 5-Phenyl,3-chlorosalicylic acid
Descriptor: 5-chloro-4-hydroxybiphenyl-3-carboxylic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Dhagat, U, El-Kabbani, O.
Deposit date:2010-07-06
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis
Bioorg.Med.Chem.Lett., 21, 2011
4RS1
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BU of 4rs1 by Molmil
Crystal structure of receptor-cytokine complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Granulocyte-macrophage colony-stimulating factor, ...
Authors:Broughton, S.E, Parker, M.W, Dhagat, U.
Deposit date:2014-11-06
Release date:2015-11-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
3O3R
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BU of 3o3r by Molmil
Crystal Structure of AKR1B14 in complex with NADP
Descriptor: Aldo-keto reductase family 1, member B7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sundaram, K, Dhagat, U, El-Kabbani, O.
Deposit date:2010-07-26
Release date:2011-01-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis
Bioorg.Med.Chem.Lett., 21, 2011
5UWC
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BU of 5uwc by Molmil
Cytokine-receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, ...
Authors:Broughton, S.E, Parker, M.W.
Deposit date:2017-02-21
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
5UV8
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BU of 5uv8 by Molmil
Interleukin-3 Receptor Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Interleukin-3, ...
Authors:Broughton, S.E, Parker, M.W.
Deposit date:2017-02-19
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
4NKQ
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BU of 4nkq by Molmil
Structure of a Cytokine Receptor Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, ...
Authors:Parker, M.W, Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
4JZJ
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BU of 4jzj by Molmil
Crystal Structure of Receptor-Fab Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy Chain, Fab Light Chain, ...
Authors:Broughton, S.E, Parker, M.W.
Deposit date:2013-04-03
Release date:2014-04-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody
Cell Rep, 8, 2014

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