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5PEP
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BU of 5pep by Molmil
X-RAY ANALYSES OF ASPARTIC PROTEASES. II. THREE-DIMENSIONAL STRUCTURE OF THE HEXAGONAL CRYSTAL FORM OF PORCINE PEPSIN AT 2.3 ANGSTROMS RESOLUTION
Descriptor: PEPSIN
Authors:Cooper, J.B, Khan, G, Taylor, G, Tickle, I.J, Blundell, T.L.
Deposit date:1990-05-30
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution.
J.Mol.Biol., 214, 1990
1IDS
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BU of 1ids by Molmil
X-RAY STRUCTURE ANALYSIS OF THE IRON-DEPENDENT SUPEROXIDE DISMUTASE FROM MYCOBACTERIUM TUBERCULOSIS AT 2.0 ANGSTROMS RESOLUTIONS REVEALS NOVEL DIMER-DIMER INTERACTIONS
Descriptor: FE (III) ION, IRON SUPEROXIDE DISMUTASE
Authors:Cooper, J.B, Mcintyre, K, Wood, S.P, Zhang, Y, Young, D.
Deposit date:1994-09-29
Release date:1994-12-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure analysis of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis at 2.0 Angstroms resolution reveals novel dimer-dimer interactions.
J.Mol.Biol., 246, 1995
5ER1
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BU of 5er1 by Molmil
A rational approach to the design of antihypertensives. X-ray studies of complexes between aspartic proteinases and aminoalcohol renin inhibitors
Descriptor: ENDOTHIAPEPSIN, methyl N-[(2S,3S)-3-amino-2-hydroxy-5-methylhexyl]-L-valyl-L-isoleucyl-L-phenylalaninate
Authors:Cooper, J.B, Foundling, S.I, Blundell, T.L.
Deposit date:1990-11-07
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Rational Approach to the Design of Antihypertensives. X-Ray Studies of Complexes between Aspartic Proteinases and Aminoalcohol Renin Inhibitors
Topics in Medicinal Chemistry, 1988
2ER9
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BU of 2er9 by Molmil
X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES.
Descriptor: ENDOTHIAPEPSIN, L363,564
Authors:Cooper, J.B, Foundling, S.I, Boger, J, Blundell, T.L.
Deposit date:1990-10-20
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
2ER0
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BU of 2er0 by Molmil
X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES
Descriptor: ENDOTHIAPEPSIN, L364,099
Authors:Cooper, J.B, Foundling, S.I, Boger, J, Blundell, T.L.
Deposit date:1990-10-20
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
1GN6
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BU of 1gn6 by Molmil
G152A mutant of Mycobacterium tuberculosis iron-superoxide dismutase.
Descriptor: FE (III) ION, SUPEROXIDE DISMUTASE
Authors:Bunting, K.A, Cooper, J.B, Saward, S, Erskine, P.T, Badasso, M.O, Wood, S.P, Zhang, Y, Young, D.B.
Deposit date:2001-10-03
Release date:2001-10-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-Ray Structure Analysis of an Engineered Fe-Superoxide Dismutase Gly-Ala Mutant with Significantly Reduced Stability to Denaturant
FEBS Lett., 387, 1996
1AW5
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BU of 1aw5 by Molmil
5-AMINOLEVULINATE DEHYDRATASE FROM SACCHAROMYCES CEREVISIAE
Descriptor: 5-AMINOLEVULINATE DEHYDRATASE, ZINC ION
Authors:Erskine, P.T, Cooper, J.B, Wood, S.P.
Deposit date:1997-10-09
Release date:1998-10-21
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase.
Nat.Struct.Biol., 4, 1997
1B4E
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BU of 1b4e by Molmil
X-ray structure of 5-aminolevulinic acid dehydratase complexed with the inhibitor levulinic acid
Descriptor: GLYCEROL, LAEVULINIC ACID, PROTEIN (5-AMINOLEVULINIC ACID DEHYDRATASE), ...
Authors:Erskine, P.T, Cooper, J.B, Lewis, G, Spencer, P, Wood, S.P, Shoolingin-Jordan, P.M.
Deposit date:1998-12-19
Release date:1999-12-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0 A resolution.
Biochemistry, 38, 1999
5OV5
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BU of 5ov5 by Molmil
Bacillus megaterium porphobilinogen deaminase D82E mutant
Descriptor: 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase
Authors:Guo, J, Erskine, P, Coker, A.R, Wood, S.P, Cooper, J.B.
Deposit date:2017-08-28
Release date:2017-09-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural studies of domain movement in active-site mutants of porphobilinogen deaminase from Bacillus megaterium.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5OT1
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The type III pullulan hydrolase from Thermococcus kodakarensis
Descriptor: CALCIUM ION, Pullulanase type II, GH13 family
Authors:Guo, J, Coker, A.R, Wood, S.P, Cooper, J.B, Keegan, R, Ahmad, N, Muhammad, M.A, Rashid, N, Akhtar, M.
Deposit date:2017-08-18
Release date:2018-04-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of the type III pullulan hydrolase from Thermococcus kodakarensis.
Acta Crystallogr D Struct Biol, 74, 2018
5OV6
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BU of 5ov6 by Molmil
Bacillus megaterium porphobilinogen deaminase D82N mutant
Descriptor: 3-[4-(2-hydroxy-2-oxoethyl)-2,5-dimethyl-1~{H}-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase
Authors:Guo, J, Erskine, P, Coker, A.R, Wood, S.P, Cooper, J.B.
Deposit date:2017-08-28
Release date:2017-09-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural studies of domain movement in active-site mutants of porphobilinogen deaminase from Bacillus megaterium.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5OT0
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BU of 5ot0 by Molmil
The thermostable L-asparaginase from Thermococcus kodakarensis
Descriptor: 1,2-ETHANEDIOL, L-asparaginase, PHOSPHATE ION, ...
Authors:Guo, J, Coker, A.R, Wood, S.P, Cooper, J.B, Rashid, N, Chohan, S.M, Akhtar, M.
Deposit date:2017-08-18
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structure and function of the thermostable L-asparaginase from Thermococcus kodakarensis.
Acta Crystallogr D Struct Biol, 73, 2017
5OV4
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BU of 5ov4 by Molmil
Bacillus megaterium porphobilinogen deaminase D82A mutant
Descriptor: Porphobilinogen deaminase
Authors:Guo, J, Erskine, P, Coker, A.R, Wood, S.P, Cooper, J.B.
Deposit date:2017-08-28
Release date:2017-10-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.692 Å)
Cite:Structural studies of domain movement in active-site mutants of porphobilinogen deaminase from Bacillus megaterium.
Acta Crystallogr F Struct Biol Commun, 73, 2017
4PVN
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BU of 4pvn by Molmil
Neutron structure of human transthyretin (TTR) at room temperature to 2.3A resolution (monochromatic)
Descriptor: Transthyretin
Authors:Fisher, S.J, Blakeley, M.P, Haupt, M, Mason, S.A, Cooper, J.B, Mitchell, E.P, Forsyth, V.T.
Deposit date:2014-03-18
Release date:2014-11-12
Last modified:2024-03-20
Method:NEUTRON DIFFRACTION (2.3 Å), X-RAY DIFFRACTION
Cite:Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein
IUCrJ, 1, 2014
7OL1
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BU of 7ol1 by Molmil
The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.
Descriptor: L-threonine 3-dehydrogenase
Authors:Guo, J, Cooper, J.B.
Deposit date:2021-05-18
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.
Acta Crystallogr.,Sect.F, 77, 2021
7P4R
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BU of 7p4r by Molmil
Ultra High Resolution X-ray Structure of Orthorhombic Bovine Pancreatic Ribonuclease at 100K
Descriptor: ETHANOL, Ribonuclease pancreatic, SULFATE ION
Authors:Lisgarten, D.R, Palmer, R.A, Cooper, J.B, Naylor, C.E, Howlin, B.J, Lisgarten, J.N, Najmudin, S, Lobley, C.M.C.
Deposit date:2021-07-12
Release date:2022-07-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Ultra-high resolution X-ray structure of orthorhombic bovine pancreatic Ribonuclease A at 100K.
BMC Chem, 17, 2023
5A92
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BU of 5a92 by Molmil
15K X-ray structure with Cefotaxime: Exploring the Mechanism of beta- Lactam Ring Protonation in the Class A beta-lactamase Acylation Mechanism Using Neutron and X-ray Crystallography
Descriptor: BETA-LACTAMASE CTX-M-97, CEFOTAXIME, C3' cleaved, ...
Authors:Vandavasi, V.G, Weiss, K.L, Cooper, J.B, Erskine, P.T, Tomanicek, S.J, Ostermann, A, Schrader, T.E, Ginell, S.L, Coates, L.
Deposit date:2015-07-17
Release date:2015-12-16
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Exploring the Mechanism of Beta-Lactam Ring Protonation in the Class a Beta-Lactamase Acylation Mechanism Using Neutron and X-Ray Crystallography.
J.Med.Chem., 59, 2016
5A90
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100K Neutron Ligand Free: Exploring the Mechanism of beta-Lactam Ring Protonation in the Class A beta-lactamase Acylation Mechanism Using Neutron and X-ray Crystallography
Descriptor: BETA-LACTAMASE CTX-M-97
Authors:Vandavasi, V.G, Weiss, K.L, Cooper, J.B, Erskine, P.T, Tomanicek, S.J, Ostermann, A, Schrader, T.E, Ginell, S.L, Coates, L.
Deposit date:2015-07-17
Release date:2015-12-16
Last modified:2017-03-22
Method:NEUTRON DIFFRACTION (1.7 Å)
Cite:Exploring the Mechanism of Beta-Lactam Ring Protonation in the Class a Beta-Lactamase Acylation Mechanism Using Neutron and X-Ray Crystallography.
J.Med.Chem., 59, 2016
5A91
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15K X-ray ligand free: Exploring the Mechanism of beta-Lactam Ring Protonation in the Class A beta-lactamase Acylation Mechanism Using Neutron and X-ray Crystallography
Descriptor: SULFATE ION
Authors:Vandavasi, V.G, Weiss, K.L, Cooper, J.B, Erskine, P.T, Tomanicek, S.J, Ostermann, A, Schrader, T.E, Ginell, S.L, Coates, L.
Deposit date:2015-07-17
Release date:2015-12-16
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Exploring the Mechanism of Beta-Lactam Ring Protonation in the Class a Beta-Lactamase Acylation Mechanism Using Neutron and X-Ray Crystallography.
J.Med.Chem., 59, 2016
5A93
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BU of 5a93 by Molmil
293K Joint X-ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA-LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY
Descriptor: BETA-LACTAMASE CTX-M-97, CEFOTAXIME, C3' cleaved, ...
Authors:Vandavasi, V.G, Weiss, K.L, Cooper, J.B, Erskine, P.T, Tomanicek, S.J, Ostermann, A, Schrader, T.E, Ginell, S.L, Coates, L.
Deposit date:2015-07-17
Release date:2015-12-16
Last modified:2024-01-10
Method:NEUTRON DIFFRACTION (1.598 Å), X-RAY DIFFRACTION
Cite:Exploring the Mechanism of Beta-Lactam Ring Protonation in the Class a Beta-Lactamase Acylation Mechanism Using Neutron and X-Ray Crystallography.
J.Med.Chem., 59, 2016
1EPP
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ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-130,693 (MAS PHE LYS+MTF STA MBA)
Descriptor: ENDOTHIAPEPSIN, N-(dimethylsulfamoyl)-L-phenylalanyl-N-[(1S,2S)-2-hydroxy-4-{[(2S)-2-methylbutyl]amino}-1-(2-methylpropyl)-4-oxobutyl]-N~6~-(methylcarbamothioyl)-L-lysinamide, SULFATE ION
Authors:Wallace, B.A, Cooper, J.B, Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.
J.Med.Chem., 36, 1993
1EPO
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BU of 1epo by Molmil
ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH CP-81,282 (MOR PHE NLE CHF NME)
Descriptor: ENDOTHIAPEPSIN, N-(morpholin-4-ylcarbonyl)-L-phenylalanyl-N-[(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-(methylamino)-4-oxobutyl]-L-norleucinamide
Authors:Veerapandian, B, Cooper, J.B, Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Direct observation by X-ray analysis of the tetrahedral intermediate of aspartic proteinases.
Protein Sci., 1, 1992
1EPQ
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BU of 1epq by Molmil
ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-133,450 (SOT PHE GLY+SCC GCL)
Descriptor: ENDOTHIAPEPSIN, N-[(1S)-2-{[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino}-1-(ethylsulfanyl)-2-oxoethyl]-Nalpha-(morpholin-4-ylsulfonyl)-L-phenylalaninamide, SULFATE ION
Authors:Dealwis, C, Cooper, J.B, Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.
J.Med.Chem., 36, 1993
5K50
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Three-dimensional structure of L-threonine 3-dehydrogenase from Trypanosoma brucei bound to NAD+ and L-allo-threonine refined to 2.23 angstroms
Descriptor: ACETATE ION, ALLO-THREONINE, GLYCEROL, ...
Authors:Adjogatse, E.A, Erskine, P.T, Cooper, J.B.
Deposit date:2016-05-22
Release date:2017-11-15
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4Y
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Three-dimensional structure of L-threonine 3-dehydrogenase from Trypanosoma brucei refined to 1.77 angstroms
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Adjogatse, E.A, Erskine, P.T, Cooper, J.B.
Deposit date:2016-05-22
Release date:2018-01-17
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018

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