Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1H5P
DownloadVisualize
BU of 1h5p by Molmil
Solution structure of the human Sp100b SAND domain by heteronuclear NMR.
Descriptor: NUCLEAR AUTOANTIGEN SP100-B
Authors:Bottomley, M.J, Liu, Z, Collard, M.W, Huggenvik, J.I, Gibson, T.J, Sattler, M.
Deposit date:2001-05-24
Release date:2001-07-06
Last modified:2018-03-28
Method:SOLUTION NMR
Cite:The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation.
Nat. Struct. Biol., 8, 2001
2UV0
DownloadVisualize
BU of 2uv0 by Molmil
Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer
Descriptor: N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, TRANSCRIPTIONAL ACTIVATOR PROTEIN LASR
Authors:Bottomley, M.J, Muraglia, E, Bazzo, R, Carfi, A.
Deposit date:2007-03-08
Release date:2007-03-27
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Insights Into Quorum Sensing in the Human Pathogen Pseudomonas Aeruginosa from the Structure of the Virulence Regulator Lasr Bound to its Autoinducer.
J.Biol.Chem., 282, 2007
1XWH
DownloadVisualize
BU of 1xwh by Molmil
NMR structure of the first phd finger of autoimmune regulator protein (AIRE1): insights into apeced
Descriptor: Autoimmune regulator, ZINC ION
Authors:Bottomley, M.J, Stier, G, Krasotkina, J, Legube, G, Simon, B, Akhtar, A, Sattler, M, Musco, G.
Deposit date:2004-11-01
Release date:2005-01-25
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease
J.Biol.Chem., 280, 2005
2W2M
DownloadVisualize
BU of 2w2m by Molmil
WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR
Descriptor: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
Authors:Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2VQM
DownloadVisualize
BU of 2vqm by Molmil
Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor
Descriptor: HISTONE DEACETYLASE 4, N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide, POTASSIUM ION, ...
Authors:Bottomley, M.J, Lo Surdo, P, Di Giovine, P, Cirillo, A, Scarpelli, R, Ferrigno, F, Jones, P, Neddermann, P, De Francesco, R, Steinkuhler, C, Gallinari, P, Carfi, A.
Deposit date:2008-03-17
Release date:2008-07-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2W2Q
DownloadVisualize
BU of 2w2q by Molmil
PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR
Descriptor: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
Authors:Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2VQW
DownloadVisualize
BU of 2vqw by Molmil
Structure of inhibitor-free HDAC4 catalytic domain (with gain-of- function mutation His332Tyr)
Descriptor: HISTONE DEACETYLASE 4, POTASSIUM ION, ZINC ION
Authors:Bottomley, M.J, Lo Surdo, P, Di Giovine, P, Cirillo, A, Scarpelli, R, Ferrigno, F, Jones, P, Neddermann, P, De Francesco, R, Steinkuhler, C, Gallinari, P, Carfi, A.
Deposit date:2008-03-19
Release date:2008-08-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQV
DownloadVisualize
BU of 2vqv by Molmil
Structure of HDAC4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor
Descriptor: HISTONE DEACETYLASE 4, N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide, POTASSIUM ION, ...
Authors:Bottomley, M.J, Lo Surdo, P, Di Giovine, P, Cirillo, A, Scarpelli, R, Ferrigno, F, Jones, P, Neddermann, P, De Francesco, R, Steinkuhler, C, Gallinari, P, Carfi, A.
Deposit date:2008-03-19
Release date:2008-07-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2W2P
DownloadVisualize
BU of 2w2p by Molmil
PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR
Descriptor: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
Authors:Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2N
DownloadVisualize
BU of 2w2n by Molmil
WT PCSK9-deltaC bound to EGF-A H306Y mutant of LDLR
Descriptor: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
Authors:Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2VQQ
DownloadVisualize
BU of 2vqq by Molmil
Structure of HDAC4 catalytic domain (a double cysteine-to-alanine mutant) bound to a trifluoromethylketone inhbitor
Descriptor: 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL, HISTONE DEACETYLASE 4, POTASSIUM ION, ...
Authors:Bottomley, M.J, Lo Surdo, P, Di Giovine, P, Cirillo, A, Scarpelli, R, Ferrigno, F, Jones, P, Neddermann, P, De Francesco, R, Steinkuhler, C, Gallinari, P, Carfi, A.
Deposit date:2008-03-18
Release date:2008-07-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2W2O
DownloadVisualize
BU of 2w2o by Molmil
PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR
Descriptor: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
Authors:Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
Deposit date:2008-11-03
Release date:2008-11-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2VQO
DownloadVisualize
BU of 2vqo by Molmil
Structure of HDAC4 catalytic domain with a gain-of-function muation bound to a trifluoromethylketone inhbitor
Descriptor: 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL, HISTONE DEACETYLASE 4, POTASSIUM ION, ...
Authors:Bottomley, M.J, Lo Surdo, P, Di Giovine, P, Cirillo, A, Scarpelli, R, Ferrigno, F, Jones, P, Neddermann, P, De Francesco, R, Steinkuhler, C, Gallinari, P, Carfi, A.
Deposit date:2008-03-18
Release date:2008-07-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
2VQJ
DownloadVisualize
BU of 2vqj by Molmil
Structure of HDAC4 catalytic domain bound to a trifluoromethylketone inhbitor
Descriptor: 1,4-DIETHYLENE DIOXIDE, 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL, HISTONE DEACETYLASE 4, ...
Authors:Bottomley, M.J, Lo Surdo, P, Di Giovine, P, Cirillo, A, Scarpelli, R, Ferrigno, F, Jones, P, Neddermann, P, De Francesco, R, Steinkuhler, C, Gallinari, P, Carfi, A.
Deposit date:2008-03-17
Release date:2008-07-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
J.Biol.Chem., 283, 2008
6H2Y
DownloadVisualize
BU of 6h2y by Molmil
human Fab 1E6 bound to fHbp variant 3 from Neisseria meningitidis serogroup B
Descriptor: 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Veggi, D, Bianchi, F, Cozzi, R, Malito, E, Bottomley, M.J.
Deposit date:2018-07-17
Release date:2019-08-14
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Cocrystal structure of meningococcal factor H binding protein variant 3 reveals a new crossprotective epitope recognized by human mAb 1E6.
Faseb J., 33, 2019
7NRU
DownloadVisualize
BU of 7nru by Molmil
Structure of a natural chimera of meningococcal factor H binding protein belonging to NL096 strain
Descriptor: Factor H binding protein variant 1-2,3.x, SULFATE ION
Authors:Veggi, D, Malito, E, Bottomley, M.J.
Deposit date:2021-03-04
Release date:2022-06-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.21998358 Å)
Cite:Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096.
Comput Struct Biotechnol J, 20, 2022
1D8B
DownloadVisualize
BU of 1d8b by Molmil
NMR STRUCTURE OF THE HRDC DOMAIN FROM SACCHAROMYCES CEREVISIAE RECQ HELICASE
Descriptor: SGS1 RECQ HELICASE
Authors:Liu, Z, Macias, M.J, Bottomley, M.J, Stier, G, Linge, J.P, Nilges, M, Bork, P, Sattler, M.
Deposit date:1999-10-21
Release date:2000-01-10
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Structure Fold.Des., 7, 1999
1VCA
DownloadVisualize
BU of 1vca by Molmil
CRYSTAL STRUCTURE OF AN INTEGRIN-BINDING FRAGMENT OF VASCULAR CELL ADHESION MOLECULE-1 AT 1.8 ANGSTROMS RESOLUTION
Descriptor: HUMAN VASCULAR CELL ADHESION MOLECULE-1
Authors:Jones, E.Y, Harlos, K, Bottomley, M.J, Robinson, R.C, Driscoll, P.C, Edwards, R.M, Clements, J.M, Dudgeon, T.J, Stuart, D.I.
Deposit date:1995-03-21
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.
Nature, 373, 1995
5AIQ
DownloadVisualize
BU of 5aiq by Molmil
Crystal structure of ligand-free NadR
Descriptor: TRANSCRIPTIONAL REGULATOR, MARR FAMILY
Authors:Liguori, A, Malito, E, Bottomley, M.J.
Deposit date:2015-02-16
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.716 Å)
Cite:Molecular Basis of Ligand-Dependent Regulation of Nadr, the Transcriptional Repressor of Meningococcal Virulence Factor Nada.
Plos Pathog., 12, 2016
5AIP
DownloadVisualize
BU of 5aip by Molmil
Crystal structure of NadR in complex with 4-hydroxyphenylacetate
Descriptor: 4-HYDROXYPHENYLACETATE, TRANSCRIPTIONAL REGULATOR, MARR FAMILY
Authors:Liguori, A, Malito, E, Bottomley, M.J.
Deposit date:2015-02-16
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Basis of Ligand-Dependent Regulation of Nadr, the Transcriptional Repressor of Meningococcal Virulence Factor Nada.
Plos Pathog., 12, 2016
7SBZ
DownloadVisualize
BU of 7sbz by Molmil
JAR5 Fab bound to fHbp v1.1 crystallized in space group I422
Descriptor: CADMIUM ION, Factor H-binding protein, JAR5 Heavy Chain, ...
Authors:Chesterman, C, Malito, E, Bottomley, M.J.
Deposit date:2021-09-26
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Active Learning for Rapid Design: An iterative AI approach for accelerated vaccine design that combines active machine learning and high-throughput experimental evaluation
To Be Published
7SA6
DownloadVisualize
BU of 7sa6 by Molmil
fHbp mutant 2416 bound to Fab JAR5
Descriptor: Factor H-binding protein 2416, JAR5 Heavy Chain, JAR5 Light Chain
Authors:Chesterman, C, Malito, E, Bottomley, M.J.
Deposit date:2021-09-22
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Active Learning for Rapid Design: An iterative AI approach for accelerated vaccine design that combines active machine learning and high-throughput experimental evaluation
To Be Published
1OQJ
DownloadVisualize
BU of 1oqj by Molmil
Crystal structure of the SAND domain from glucocorticoid modulatory element binding protein-1 (GMEB1)
Descriptor: Glucocorticoid Modulatory Element Binding protein-1, ZINC ION
Authors:Surdo, P.L, Bottomley, M.J, Sattler, M, Scheffzek, K.
Deposit date:2003-03-10
Release date:2003-11-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions
MOL.ENDOCRINOL., 17, 2003
6EUN
DownloadVisualize
BU of 6eun by Molmil
Crystal structure of Neisseria meningitidis vaccine antigen NadA variant 3
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ...
Authors:Dello Iacono, L, Liguori, A, Malito, E, Bottomley, M.J.
Deposit date:2017-10-30
Release date:2018-10-10
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies.
MBio, 9, 2018
6EUP
DownloadVisualize
BU of 6eup by Molmil
Crystal structure of Neisseria meningitidis NadA variant 3 double mutant A33I-I38L
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Adhesin A, ...
Authors:Dello Iacono, L, Liguori, A, Malito, E, Bottomley, M.J.
Deposit date:2017-10-31
Release date:2018-10-10
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies.
MBio, 9, 2018

 

123>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon