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2KQH
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BU of 2kqh by Molmil
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
Descriptor: 5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*GP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3', POTASSIUM ION
Authors:Hsu, S.-T.D, Varnai, P, Bugaut, A, Reszka, A.P, Neidle, S, Balasubramanian, S.
Deposit date:2009-11-05
Release date:2009-11-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
J.Am.Chem.Soc., 131, 2009
2KQG
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BU of 2kqg by Molmil
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
Descriptor: 5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*AP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3', POTASSIUM ION
Authors:Hsu, S.-T.D, Varnai, P, Bugaut, A, Reszka, A.P, Neidle, S, Balasubramanian, S.
Deposit date:2009-11-05
Release date:2009-11-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics
J.Am.Chem.Soc., 131, 2009
4QKK
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BU of 4qkk by Molmil
Crystal structure of an oligonucleotide containing 5-formylcytosine
Descriptor: DNA (5'-D(*CP*TP*AP*(5FC)P*GP*(5FC)P*GP*(5FC)P*GP*TP*AP*G)-3')
Authors:Raiber, E.-A, Murat, P, Chirgadze, D.Y, Luisi, B.F, Balasubramanian, S.
Deposit date:2014-06-06
Release date:2014-12-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:5-Formylcytosine alters the structure of the DNA double helix.
Nat.Struct.Mol.Biol., 22, 2015
6AC7
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BU of 6ac7 by Molmil
Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter
Descriptor: 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*GP*AP*GP*GP*CP*GP*GP*GP*GP*CP*TP*TP*GP*GP*G)-3'
Authors:Sengar, A, Vandana, J.J, Chambers, V.S, Di Antonio, M, Winnerdy, F.R, Balasubramanian, S, Phan, A.T.
Deposit date:2018-07-25
Release date:2019-02-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.
Nucleic Acids Res., 47, 2019
4XK0
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BU of 4xk0 by Molmil
Crystal structure of a tetramolecular RNA G-quadruplex in potassium
Descriptor: BARIUM ION, POTASSIUM ION, RNA (5'-(*UP*GP*GP*GP*GP*U)-3')
Authors:Chen, M.C, Murat, P, Abecassis, K.A, Ferre-D'Amare, A.R, Balasubramanian, S.
Deposit date:2015-01-09
Release date:2015-02-11
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase.
Nucleic Acids Res., 43, 2015
5LS6
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BU of 5ls6 by Molmil
Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor
Descriptor: 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ...
Authors:Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S.
Deposit date:2016-08-22
Release date:2017-02-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
5DNI
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BU of 5dni by Molmil
Crystal structure of Methanocaldococcus jannaschii Fumarate hydratase beta subunit
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Jayaraman, V, Kunala, J, Balaram, H.
Deposit date:2015-09-10
Release date:2016-09-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Revisiting the Burden Borne by Fumarase: Enzymatic Hydration of an Olefin.
Biochemistry, 62, 2023
5VHE
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BU of 5vhe by Molmil
DHX36 in complex with the c-Myc G-quadruplex
Descriptor: DEAH (Asp-Glu-Ala-His) box polypeptide 36, DNA (5'-D(*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*TP*TP*TP*TP*TP*T)-3'), POTASSIUM ION
Authors:Chen, M, Ferre-D'Amare, A.
Deposit date:2017-04-13
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.793 Å)
Cite:Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
5VHD
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BU of 5vhd by Molmil
DHX36 with an N-terminal truncation bound to ADP-AlF4
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DEAH (Asp-Glu-Ala-His) box polypeptide 36, TETRAFLUOROALUMINATE ION
Authors:Chen, M, Ferre-D'Amare, A.
Deposit date:2017-04-13
Release date:2018-06-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
5VHC
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BU of 5vhc by Molmil
DHX36 with an N-terminal truncation bound to ADP-BeF3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DEAH (Asp-Glu-Ala-His) box polypeptide 36, ...
Authors:Chen, M, Ferre-D'Amare, A.
Deposit date:2017-04-12
Release date:2018-06-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
5VHA
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BU of 5vha by Molmil
DHX36 with an N-terminal truncation
Descriptor: DEAH (Asp-Glu-Ala-His) box polypeptide 36
Authors:Chen, M, Ferre-D'Amare, A.
Deposit date:2017-04-12
Release date:2018-06-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.227 Å)
Cite:Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
7D40
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BU of 7d40 by Molmil
Crystal structure of GATase subunit of Methanocaldococcus jannaschii GMP synthetase
Descriptor: GMP synthase [glutamine-hydrolyzing] subunit A
Authors:Bellur, A, Dongre, A, Kumar, S, Balaram, H.
Deposit date:2020-09-21
Release date:2021-08-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural basis for the hyperthermostability of an archaeal enzyme induced by succinimide formation.
Biophys.J., 120, 2021
7D96
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BU of 7d96 by Molmil
Crystal structure of D110G mutant of GATase subunit of Methanocaldococcus jannaschii GMP synthetase
Descriptor: GMP synthase [glutamine-hydrolyzing] subunit A
Authors:Bellur, A, Dongre, A, Aggarwal, R, Balaram, H.
Deposit date:2020-10-12
Release date:2021-08-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural basis for the hyperthermostability of an archaeal enzyme induced by succinimide formation.
Biophys.J., 120, 2021
7D97
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BU of 7d97 by Molmil
Crystal structure of N109P mutant of GATase subunit of Methanocaldococcus jannaschii GMP synthetase
Descriptor: GMP synthase [glutamine-hydrolyzing] subunit A
Authors:Bellur, A, Dongre, A, Kavya, J, Balaram, H.
Deposit date:2020-10-12
Release date:2021-08-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural basis for the hyperthermostability of an archaeal enzyme induced by succinimide formation.
Biophys.J., 120, 2021
7D95
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BU of 7d95 by Molmil
Crystal structure of acivicin-bound GATase subunit of Methanocaldococcus jannaschii GMP synthetase
Descriptor: GMP synthase [glutamine-hydrolyzing] subunit A
Authors:Bellur, A, Dongre, A, Kumar, S, Balaram, H.
Deposit date:2020-10-12
Release date:2021-08-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural basis for the hyperthermostability of an archaeal enzyme induced by succinimide formation.
Biophys.J., 120, 2021
7NAC
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BU of 7nac by Molmil
State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-21
Release date:2022-11-09
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7NAF
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BU of 7naf by Molmil
State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb1-MTD local model
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-21
Release date:2022-11-09
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7NAD
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BU of 7nad by Molmil
State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb4 local refinement model
Descriptor: 25S rRNA, 5.8S rRNA, 60S ribosomal protein L17-A, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-21
Release date:2022-11-09
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
8E2M
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BU of 8e2m by Molmil
Bruton's tyrosine kinase (BTK) with compound 13
Descriptor: (5P)-5-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-4-oxo-N-[(1R,2S)-2-propanamidocyclopentyl]-4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide, TRIETHYLENE GLYCOL, Tyrosine-protein kinase BTK
Authors:Alexander, R, Milligan, C.M.
Deposit date:2022-08-15
Release date:2022-11-16
Last modified:2022-11-23
Method:X-RAY DIFFRACTION (1.904 Å)
Cite:Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J.Med.Chem., 65, 2022
7R7O
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BU of 7r7o by Molmil
Structure of methyltransferase domain of Spb1 boudn to SAM
Descriptor: AdoMet-dependent rRNA methyltransferase SPB1, S-ADENOSYLMETHIONINE
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-25
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Post-catalytic rRNA binding by the DEAD-box ATPase Spb4 and methyltransferase Spb1 guide the late nucleolar assembly of 60S ribosomes
To Be Published
7R6K
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BU of 7r6k by Molmil
State E2 nucleolar 60S ribosomal intermediate - Model for Noc2/Noc3 region
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-22
Release date:2022-11-09
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7R6Q
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BU of 7r6q by Molmil
State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model
Descriptor: 25S rRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-23
Release date:2022-11-09
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7R72
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BU of 7r72 by Molmil
State E1 nucleolar 60S ribosome biogenesis intermediate - Spb4 local model
Descriptor: 25S rRNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, 5.8S rRNA, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-24
Release date:2022-11-09
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7R7A
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BU of 7r7a by Molmil
State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-24
Release date:2022-11-09
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7R7C
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BU of 7r7c by Molmil
State E2 nucleolar 60S ribosomal biogenesis intermediate - L1 stalk local model
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-24
Release date:2022-11-09
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022

 

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