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1GKO
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BU of 1gko by Molmil
An Engineered Transthyretin Monomer that is Non-amyloidogenic - Unless Partially Denatured
Descriptor: TRANSTHYRETIN
Authors:Jiang, X, Smith, C.S, Petrassi, H.M, Hammarstrom, P, White, J.T, Sacchettini, J.C, Kelly, J.W.
Deposit date:2001-08-17
Release date:2001-11-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An Engineered Transthyretin Monomer that is Nonamyloidogenic, Unless It is Partially Denatured
Biochemistry, 40, 2001
7CLA
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BU of 7cla by Molmil
Crystal structure of HTH-type transcriptional regulator SkgA from Caulobacter crescentus
Descriptor: HTH-type transcriptional regulator SkgA
Authors:Jiang, X, Zhang, L, Teng, M, Li, X.
Deposit date:2020-07-20
Release date:2020-10-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Antibiotic binding releases autoinhibition of the TipA multidrug-resistance transcriptional regulator.
J.Biol.Chem., 295, 2020
4AY9
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BU of 4ay9 by Molmil
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FOLLICLE-STIMULATING HORMONE RECEPTOR, FOLLITROPIN SUBUNIT BETA, ...
Authors:Jiang, X, Liu, H, Chen, X, He, X.
Deposit date:2012-06-19
Release date:2012-08-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Follicle-Stimulating Hormone in Complex with the Entire Ectodomain of its Receptor.
Proc.Natl.Acad.Sci.USA, 109, 2012
1SCF
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BU of 1scf by Molmil
HUMAN RECOMBINANT STEM CELL FACTOR
Descriptor: CALCIUM ION, PENTAETHYLENE GLYCOL, STEM CELL FACTOR
Authors:Jiang, X, Gurel, O, Langley, K.E, Hendrickson, W.A.
Deposit date:1998-06-04
Release date:2000-07-07
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the active core of human stem cell factor and analysis of binding to its receptor kit.
EMBO J., 19, 2000
6IZO
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BU of 6izo by Molmil
Crystal structure of DNA polymerase sliding clamp from Caulobacter crescentus
Descriptor: 1,2-ETHANEDIOL, Beta sliding clamp, DI(HYDROXYETHYL)ETHER
Authors:Jiang, X, Zhang, L, Teng, M, Li, X.
Deposit date:2018-12-20
Release date:2019-11-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Caulobacter crescentus beta sliding clamp employs a noncanonical regulatory model of DNA replication.
Febs J., 287, 2020
4MQW
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BU of 4mqw by Molmil
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Follicle-stimulating hormone receptor, ...
Authors:Jiang, X, Liu, H, Chen, X, He, X.
Deposit date:2013-09-16
Release date:2014-04-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer.
J.Biol.Chem., 289, 2014
5AX8
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BU of 5ax8 by Molmil
Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase
Descriptor: Aspartate aminotransferase, mitochondrial
Authors:Jiang, X, Wang, J, Chang, H, Zhou, Y.
Deposit date:2015-07-20
Release date:2016-03-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.989 Å)
Cite:Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase
Biosci Trends, 10, 2016
3WZF
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BU of 3wzf by Molmil
Crystal structure of human cytoplasmic aspartate aminotransferase
Descriptor: Aspartate aminotransferase, cytoplasmic
Authors:Jiang, X, Chang, H, Zhou, Y, Chen, L, Yang, Q.
Deposit date:2014-09-24
Release date:2015-10-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.991 Å)
Cite:Recombinant expression, purification and Preliminary crystallographic studies of human cytoplasmic aspartate aminotransferase
To be Published
6JK6
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BU of 6jk6 by Molmil
Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 2-8-s2
Descriptor: 6-azanyl-11-methyl-2-oxidanylidene-7-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)-1,9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,6,9,11,13-hexaene-5-carboxamide, Chitotriosidase-1
Authors:Jiang, X, Yang, Q.
Deposit date:2019-02-27
Release date:2020-02-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.571 Å)
Cite:A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.
J.Med.Chem., 63, 2020
6JMN
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BU of 6jmn by Molmil
Crystal structure of Ostrinia furnacalis Chitinase h complexed with compound 2-8-s2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-11-methyl-2-oxidanylidene-7-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)-1,9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,6,9,11,13-hexaene-5-carboxamide, Chitinase
Authors:Jiang, X, Yang, Q.
Deposit date:2019-03-12
Release date:2020-05-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.
J.Med.Chem., 63, 2020
5GXB
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BU of 5gxb by Molmil
crystal structure of a LacY/Nanobody complex
Descriptor: Lactose permease, nanobody
Authors:Jiang, X, Wu, J.P, Yan, N, Kaback, H.R.
Deposit date:2016-09-16
Release date:2016-10-26
Last modified:2022-10-12
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.
Proc.Natl.Acad.Sci.USA, 113, 2016
4G9Z
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BU of 4g9z by Molmil
Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression
Descriptor: Nucleoprotein, RNA (5'-R(P*GP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*C)-3'), ...
Authors:Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C, Scottish Structural Proteomics Facility (SSPF)
Deposit date:2012-07-24
Release date:2013-04-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
4GV6
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BU of 4gv6 by Molmil
Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production
Descriptor: MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ...
Authors:Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
4GVE
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BU of 4gve by Molmil
Tacaribe nucleoprotein structure
Descriptor: MAGNESIUM ION, Nucleoprotein, ZINC ION
Authors:Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
4GV9
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BU of 4gv9 by Molmil
Lassa nucleoprotein C-terminal domain in complex with triphosphated dsRNA soaking for 5 min
Descriptor: MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ...
Authors:Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
4GV3
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BU of 4gv3 by Molmil
Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production
Descriptor: MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ...
Authors:Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
6JIR
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BU of 6jir by Molmil
Crystal structure of C. crescentus beta sliding clamp with PEG bound to putative beta-motif tethering region
Descriptor: 1,2-ETHANEDIOL, Beta sliding clamp, DI(HYDROXYETHYL)ETHER, ...
Authors:Jiang, X, Teng, M, Li, X.
Deposit date:2019-02-23
Release date:2019-11-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Caulobacter crescentus beta sliding clamp employs a noncanonical regulatory model of DNA replication.
Febs J., 287, 2020
6M2L
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BU of 6m2l by Molmil
Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with C3361
Descriptor: (2S,3R,4S,5R,6R)-6-(hydroxymethyl)-4-undec-10-enoxy-oxane-2,3,5-triol, Hexose transporter 1
Authors:Jiang, X, Yuan, Y.Y, Zhang, S, Wang, N, Yan, C.Y, Yan, N.
Deposit date:2020-02-27
Release date:2020-09-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.
Cell, 183, 2020
6M20
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BU of 6m20 by Molmil
Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with glucose
Descriptor: Hexose transporter 1, beta-D-glucopyranose, nonyl beta-D-glucopyranoside
Authors:Jiang, X, Yuan, Y.Y, Zhang, S, Wang, N, Yan, C.Y, Yan, N.
Deposit date:2020-02-26
Release date:2020-09-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.
Cell, 183, 2020
6JJR
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BU of 6jjr by Molmil
Crystal structure of human chitotriosidase-1 (hChit1) catalytic domain in complex with compound 2-8-14
Descriptor: 6-azanyl-2-oxidanylidene-N-[(1S)-1-phenylethyl]-7-(phenylmethyl)-1$l^{4},9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-1(14),3(8),4,6,10,12-hexaene-5-carboxamide, Chitotriosidase-1
Authors:Jiang, X, Yang, Q.
Deposit date:2019-02-26
Release date:2020-02-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.834 Å)
Cite:A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.
J.Med.Chem., 63, 2020
6JK9
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BU of 6jk9 by Molmil
Crystal structure of Serratia marcescens Chitinase B complexed with compound 2-8-14
Descriptor: 6-azanyl-2-oxidanylidene-N-[(1S)-1-phenylethyl]-7-(phenylmethyl)-1$l^{4},9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-1(14),3(8),4,6,10,12-hexaene-5-carboxamide, Chitinase
Authors:Jiang, X, Yang, Q.
Deposit date:2019-02-27
Release date:2020-02-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.312 Å)
Cite:A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.
J.Med.Chem., 63, 2020
6N3I
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BU of 6n3i by Molmil
Crystal structure of a double Trp XylE mutants (G58W/L315W)
Descriptor: D-xylose transporter
Authors:Jiang, X, Wu, J.P, Yan, N.
Deposit date:2018-11-15
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.69 Å)
Cite:Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs.
Cell Discov, 5, 2019
7CB1
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BU of 7cb1 by Molmil
Structure of Serratia marcescens chitinase B complexed with compound 6q
Descriptor: 6-azanyl-11-methyl-2-oxidanylidene-N-[(1S)-1-pyridin-3-ylethyl]-1,7,9-triazatricyclo[8.4.0.0^{3,8}]tetradeca-3,5,7,9,11,13-hexaene-5-carboxamide, Chitinase B
Authors:Jiang, X, Yuan, P.T.
Deposit date:2020-06-10
Release date:2021-06-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery of novel Chitinase Inhibitors with a scaffold of dipyridopyrimidine-3-carboxamide via Structure-based Rational Design
To Be Published
4JAI
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BU of 4jai by Molmil
Crystal Structure of Aurora Kinase A in complex with N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide
Descriptor: Aurora kinase A, N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide
Authors:Jiang, X, Josephson, K, Huck, B, Goutopoulos, A, Karra, S.
Deposit date:2013-02-18
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4JAJ
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BU of 4jaj by Molmil
Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE
Descriptor: Aurora kinase A, benzo[c][1,8]naphthyridin-6(5H)-one
Authors:Jiang, X, Josephson, K, Huck, B, Goutopoulos, A, Karra, S.
Deposit date:2013-02-18
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013

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