139D
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134D
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1HWV
| MOLECULAR TOPOLOGY OF POLYCYCLIC AROMATIC CARCINOGENS DETERMINES DNA ADDUCT CONFORMATION: A LINK TO TUMORIGENIC ACTIVITY | Descriptor: | (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL, 5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3' | Authors: | Patel, D.J, Lin, C.H, Geacintov, N.E, Broyde, S, Huang, X, Kolbanovskii, A, Hingerty, B.E, Amin, S. | Deposit date: | 2001-01-10 | Release date: | 2001-03-21 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity. J.Mol.Biol., 306, 2001
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1HX4
| MOLECULAR TOPOLOGY OF POLYCYCLIC AROMATIC CARCINOGENS DETERMINES DNA ADDUCT CONFORMATION: A LINK TO TUMORIGENIC ACTIVITY | Descriptor: | (1R)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL, 5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3' | Authors: | Patel, D.J, Lin, C.H, Geacintov, N.E, Broyde, S, Huang, X, Kolbanovskii, A, Hingerty, B.E, Amin, S. | Deposit date: | 2001-01-11 | Release date: | 2001-03-21 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity. J.Mol.Biol., 306, 2001
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4IUR
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1D6D
| SOLUTION DNA STRUCTURE CONTAINING (A-A)-T TRIADS INTERDIGITATED BETWEEN A-T BASE PAIRS AND GGGG TETRADS; NMR, 8 STRUCT. | Descriptor: | 5'-D(*AP*AP*GP*GP*TP*TP*TP*TP*AP*AP*GP*G)-3' | Authors: | Kuryavyi, V.V, Kettani, A, Wang, W, Jones, R, Patel, D.J. | Deposit date: | 1999-10-13 | Release date: | 2000-01-17 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | A diamond-shaped zipper-like DNA architecture containing triads sandwiched between mismatches and tetrads. J.Mol.Biol., 295, 2000
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1CR3
| SOLUTION CONFORMATION OF THE (+)TRANS-ANTI-BENZO[G]CHRYSENE-DA ADDUCT OPPOSITE DT IN A DNA DUPLEX | Descriptor: | BENZO[G]CHRYSENE, DNA (5'-D(*CP*TP*CP*TP*CP*AP*CP*TP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*TP*GP*AP*GP*AP*G)-3') | Authors: | Suri, A.K, Mao, B, Amin, S, Geacintov, N.E, Patel, D.J. | Deposit date: | 1999-08-12 | Release date: | 2000-02-18 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution conformation of the (+)-trans-anti-benzo[g]chrysene-dA adduct opposite dT in a DNA duplex. J.Mol.Biol., 292, 1999
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1D83
| STRUCTURE REFINEMENT OF THE CHROMOMYCIN DIMER/DNA OLIGOMER COMPLEX IN SOLUTION | Descriptor: | (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... | Authors: | Gao, X, Mirau, P, Patel, D.J. | Deposit date: | 1992-07-22 | Release date: | 1993-07-15 | Last modified: | 2023-08-02 | Method: | SOLUTION NMR | Cite: | Structure refinement of the chromomycin dimer-DNA oligomer complex in solution. J.Mol.Biol., 223, 1992
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149D
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136D
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7VKJ
| Structure of ESRP1 qRRM3 domain | Descriptor: | Epithelial splicing regulatory protein 1 | Authors: | Wu, B.X, Patel, D.J. | Deposit date: | 2021-09-30 | Release date: | 2022-10-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure of ESRP1 qRRM3 domain To Be Published
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135D
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7WRN
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7R76
| Cryo-EM structure of DNMT5 in apo state | Descriptor: | DNA repair protein Rad8, ZINC ION | Authors: | Wang, J, Patel, D.J. | Deposit date: | 2021-06-24 | Release date: | 2022-02-23 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
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8T8F
| Smc5/6 8mer | Descriptor: | DNA repair protein KRE29, Non-structural maintenance of chromosome element 4, Non-structural maintenance of chromosome element 5, ... | Authors: | Yu, Y, Patel, D.J. | Deposit date: | 2023-06-22 | Release date: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions. Proc.Natl.Acad.Sci.USA, 120, 2023
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8T8E
| cryoEM structure of Smc5/6 5mer | Descriptor: | DNA repair protein KRE29, Non-structural maintenance of chromosome element 5, Structural maintenance of chromosomes protein 6 | Authors: | Yu, Y, Patel, D.J. | Deposit date: | 2023-06-22 | Release date: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions. Proc.Natl.Acad.Sci.USA, 120, 2023
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8T66
| cA6 bound Cam1 | Descriptor: | Cam1, RNA (5'-R(P*AP*AP*AP*AP*A)-3') | Authors: | Yu, Y, Patel, D.J. | Deposit date: | 2023-06-15 | Release date: | 2024-01-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The CRISPR effector Cam1 mediates membrane depolarization for phage defence. Nature, 625, 2024
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8T64
| Apo Cam1(42-206) | Descriptor: | Cam1 | Authors: | Yu, Y, Patel, D.J. | Deposit date: | 2023-06-15 | Release date: | 2024-01-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The CRISPR effector Cam1 mediates membrane depolarization for phage defence. Nature, 625, 2024
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8T65
| cA4 bound Cam1 | Descriptor: | Cam1, RNA (5'-R(P*AP*AP*AP*A)-3') | Authors: | Yu, Y, Patel, D.J. | Deposit date: | 2023-06-15 | Release date: | 2024-01-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The CRISPR effector Cam1 mediates membrane depolarization for phage defence. Nature, 625, 2024
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6IEJ
| The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine | Descriptor: | 1,2-dihexanoyl-sn-glycero-3-phosphocholine, CALCIUM ION, Cytosolic phospholipase A2, ... | Authors: | Hirano, Y, Gao, Y.G, Stephenson, D.J, Vu, N.T, Malinina, L, Chalfant, C.E, Patel, D.J, Brown, R.E. | Deposit date: | 2018-09-14 | Release date: | 2019-05-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.206 Å) | Cite: | Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2alpha. Elife, 8, 2019
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7DMQ
| Cryo-EM structure of LshCas13a-crRNA-anti-tag RNA complex | Descriptor: | Anti-tag target RNA, CRISPR RNA, CRISPR/Cas system Cas13a | Authors: | Wang, B, Zhang, T, Ding, J, Patel, D.J, Yang, H. | Deposit date: | 2020-12-05 | Release date: | 2021-02-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems. Mol.Cell, 81, 2021
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4QX7
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4QXP
| Crystal structure of hSTING(G230I) in complex with DMXAA | Descriptor: | (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid, Stimulator of interferon genes protein | Authors: | Gao, P, Patel, D.J. | Deposit date: | 2014-07-21 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA. Cell Rep, 8, 2014
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146D
| SOLUTION STRUCTURE OF THE MITHRAMYCIN DIMER-DNA COMPLEX | Descriptor: | 1,2-HYDRO-1-OXY-3,4-HYDRO-3-(1-METHOXY-2-OXY-3,4-DIHYDROXYPENTYL)-8,9-DIHYROXY-7-METHYLANTHRACENE, 2,6-dideoxy-3-C-methyl-beta-D-ribo-hexopyranose-(1-3)-2,6-dideoxy-beta-D-galactopyranose-(1-3)-beta-D-Olivopyranose, DNA (5'-D(*TP*CP*GP*CP*GP*A)-3'), ... | Authors: | Sastry, M, Patel, D.J. | Deposit date: | 1993-11-09 | Release date: | 1995-03-31 | Last modified: | 2022-01-19 | Method: | SOLUTION NMR | Cite: | Solution structure of the mithramycin dimer-DNA complex. Biochemistry, 32, 1993
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1C0Y
| SOLUTION STRUCTURE OF THE [AF]-C8-DG ADDUCT POSITIONED OPPOSITE DA AT A TEMPLATE-PRIMER JUNCTION | Descriptor: | 2-AMINOFLUORENE, DNA (5'-D(*AP*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*GP*GP*TP*AP*GP*C)-3') | Authors: | Gu, Z, Gorin, A, Hingerty, B.E, Broyde, S, Patel, D.J. | Deposit date: | 1999-07-19 | Release date: | 1999-08-31 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structures of aminofluorene [AF]-stacked conformers of the syn [AF]-C8-dG adduct positioned opposite dC or dA at a template-primer junction. Biochemistry, 38, 1999
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