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5UMD
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BU of 5umd by Molmil
Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine
Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Wong, W, Bai, X.-C, Brown, A, Scheres, S, Baum, J.
Deposit date:2017-01-27
Release date:2017-03-01
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Nat Microbiol, 2, 2017
6OKK
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BU of 6okk by Molmil
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Wong, W, Scheres, S.H.W.
Deposit date:2019-04-13
Release date:2019-05-22
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3TI9
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BU of 3ti9 by Molmil
Crystal structure of the basic protease BprB from the ovine footrot pathogen, Dichelobacter nodosus
Descriptor: CALCIUM ION, CHLORIDE ION, GLYCEROL, ...
Authors:Wong, W, Whisstock, J.C, Porter, C.J.
Deposit date:2011-08-20
Release date:2011-10-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction.
J.Biol.Chem., 286, 2011
3TI7
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BU of 3ti7 by Molmil
Crystal structure of the basic protease BprV from the ovine footrot pathogen, Dichelobacter nodosus
Descriptor: Basic extracellular subtilisin-like protease BprV, CALCIUM ION
Authors:Wong, W, Whisstock, J.C, Porter, C.J.
Deposit date:2011-08-20
Release date:2011-10-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction.
J.Biol.Chem., 286, 2011
3Q2B
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BU of 3q2b by Molmil
Crystal Structure of an Actin Depolymerizing Factor
Descriptor: BETA-MERCAPTOETHANOL, Cofilin/actin-depolymerizing factor homolog 1, D(-)-TARTARIC ACID
Authors:Wong, W, Clarke, O.B, Gulbis, J.M, Baum, J.
Deposit date:2010-12-19
Release date:2011-06-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1
Proc.Natl.Acad.Sci.USA, 108, 2011
3J7A
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BU of 3j7a by Molmil
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit
Descriptor: 18S ribosomal RNA, 40S ribosomal protein eS1, 40S ribosomal protein eS10, ...
Authors:Wong, W, Bai, X.C, Brown, A, Fernandez, I.S, Hanssen, E, Condron, M, Tan, Y.H, Baum, J, Scheres, S.H.W.
Deposit date:2014-06-03
Release date:2014-07-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3J79
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BU of 3j79 by Molmil
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit
Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Wong, W, Bai, X.C, Brown, A, Fernandez, I.S, Hanssen, E, Condron, M, Tan, Y.H, Baum, J, Scheres, S.H.W.
Deposit date:2014-06-02
Release date:2014-07-16
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3LPA
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BU of 3lpa by Molmil
Crystal structure of a subtilisin-like protease
Descriptor: Acidic extracellular subtilisin-like protease AprV2, CALCIUM ION
Authors:Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M.
Deposit date:2010-02-05
Release date:2010-12-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Plos Pathog., 6, 2010
3LPD
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BU of 3lpd by Molmil
Crystal structure of a subtilisin-like protease
Descriptor: Acidic extracellular subtilisin-like protease AprV2, CALCIUM ION
Authors:Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M.
Deposit date:2010-02-05
Release date:2010-12-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Plos Pathog., 6, 2010
3LPC
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BU of 3lpc by Molmil
Crystal structure of a subtilisin-like protease
Descriptor: ACETATE ION, AprB2, CALCIUM ION, ...
Authors:Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M.
Deposit date:2010-02-05
Release date:2010-12-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Plos Pathog., 6, 2010
4N9L
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BU of 4n9l by Molmil
crystal structure of beta-lactamse PenP_E166S in complex with meropenem
Descriptor: (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase
Authors:Pan, X, Wong, W, Zhao, Y.
Deposit date:2013-10-21
Release date:2014-09-10
Last modified:2022-02-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
4N9K
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BU of 4n9k by Molmil
crystal structure of beta-lactamse PenP_E166S in complex with cephaloridine
Descriptor: 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase
Authors:Pan, X, Wong, W, Zhao, Y.
Deposit date:2013-10-21
Release date:2014-09-10
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
2QP2
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BU of 2qp2 by Molmil
Structure of a MACPF/perforin-like protein
Descriptor: CALCIUM ION, Unknown protein
Authors:Rosado, C.J, Buckle, A.M, Law, R.H.P, Butcher, R.E, Kan, W.T, Bird, C.H, Ung, K, Browne, K.A, Baran, K, Bashtannyk-Puhalovich, T.A, Faux, N.G, Wong, W, Porter, C.J, Pike, R.N, Ellisdon, A.M, Pearce, M.C, Bottomley, S.P, Emsley, J, Smith, A.I, Rossjohn, J, Hartland, E.L, Voskoboinik, I, Trapani, J.A, Bird, P.I, Dunstone, M.A, Whisstock, J.C.
Deposit date:2007-07-22
Release date:2007-09-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A common fold mediates vertebrate defense and bacterial attack
Science, 317, 2007
4N92
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BU of 4n92 by Molmil
Crystal structure of beta-lactamse PenP_E166S
Descriptor: Beta-lactamase
Authors:Pan, X, Wong, W, Zhao, Y.
Deposit date:2013-10-19
Release date:2014-09-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
6MPV
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BU of 6mpv by Molmil
Cryo-electron microscopy structure of Plasmodium falciparum Rh5/CyRPA/Ripr invasion complex
Descriptor: Cysteine-rich protective antigen, PfRipr, Reticulocyte binding protein 5
Authors:Wilson, W, Zhiheng, Y, Cowman, A.F.
Deposit date:2018-10-08
Release date:2018-12-12
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (7.17 Å)
Cite:Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.
Nature, 565, 2019
5TIH
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BU of 5tih by Molmil
Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA
Descriptor: ACETATE ION, CyRPA antibody Fab Heavy Chain, CyRPA antibody Fab Light Chain, ...
Authors:Chen, L, Xu, Y, Wang, W, Thompson, J.K, Goddard-Borger, E, Lawrence, M.C, Cowman, A.F.
Deposit date:2016-10-03
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural basis for inhibition of erythrocyte invasion by antibodies toPlasmodium falciparumprotein CyRPA.
Elife, 6, 2017
5TIK
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BU of 5tik by Molmil
Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA
Descriptor: Cysteine-rich protective antigen
Authors:Chen, L, Xu, Y, Wang, W, Thompson, J.K, Goddard-Borger, E, Lawrence, M.C, Cowman, A.F.
Deposit date:2016-10-03
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structural basis for inhibition of erythrocyte invasion by antibodies toPlasmodium falciparumprotein CyRPA.
Elife, 6, 2017
6BPE
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BU of 6bpe by Molmil
Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 6H1
Descriptor: Monoclonal antibody 6H1 Fab heavy chain, Monoclonal antibody 6H1 Fab light chain, Reticulocyte binding protein 2, ...
Authors:Gruszczyk, J, Chan, L.J, Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6D03
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BU of 6d03 by Molmil
Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; one molecule of parasite ligand.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(2-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gruszczyk, J, Huang, R.K, Hong, C, Yu, Z, Tham, W.H.
Deposit date:2018-04-10
Release date:2018-06-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6D05
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BU of 6d05 by Molmil
Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 2.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Gruszczyk, J, Huang, R.K, Hong, C, Yu, Z, Tham, W.H.
Deposit date:2018-04-10
Release date:2018-06-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6D04
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BU of 6d04 by Molmil
Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 1.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Gruszczyk, J, Huang, R.K, Hong, C, Yu, Z, Tham, W.H.
Deposit date:2018-04-10
Release date:2018-06-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6DFK
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BU of 6dfk by Molmil
Crystal structure of the 11S subunit of the Plasmodium falciparum proteasome, PA28
Descriptor: SULFATE ION, Subunit of proteaseome activator complex,putative
Authors:Xie, S.C, Metcalfe, R.D, Gillett, D.L, Tilley, L, Griffin, M.D.W.
Deposit date:2018-05-15
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
Nat Microbiol, 4, 2019
6MUW
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BU of 6muw by Molmil
The structure of the Plasmodium falciparum 20S proteasome.
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2018-10-23
Release date:2019-08-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
Nat Microbiol, 4, 2019
6MUV
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BU of 6muv by Molmil
The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2018-10-23
Release date:2019-08-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
Nat Microbiol, 4, 2019
6MUX
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BU of 6mux by Molmil
The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2018-10-23
Release date:2019-08-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
Nat Microbiol, 4, 2019

 

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