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2GNU
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BU of 2gnu by Molmil
The crystallization of reaction center from Rhodobacter sphaeroides occurs via a new route
Descriptor: BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ...
Authors:Wadsten, P, Woehri, A.B, Snijder, A, Katona, G, Gardiner, A.T, Cogdell, R.J, Neutze, R, Engstroem, S.
Deposit date:2006-04-11
Release date:2006-11-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Lipidic sponge phase crystallization of membrane proteins
J.Mol.Biol., 364, 2006
2BNP
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BU of 2bnp by Molmil
Lipidic cubic phase grown reaction centre from Rhodobacter sphaeroides, ground state
Descriptor: 2-T-BUTYLAMINO-4-ETHYLAMINO-6-METHYLTHIO-S-TRIAZINE, BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, ...
Authors:Katona, G, Snijder, A, Gourdon, P, Andreasson, U, Hansson, O, Andreasson, L.E, Neutze, R.
Deposit date:2005-03-31
Release date:2005-05-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational Regulation of Charge Recombination Reactions in a Photosynthetic Bacterial Reaction Centre
Nat.Struct.Mol.Biol., 12, 2005
2BNS
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BU of 2bns by Molmil
Lipidic cubic phase grown reaction centre from Rhodobacter sphaeroides, excited state
Descriptor: 2-T-BUTYLAMINO-4-ETHYLAMINO-6-METHYLTHIO-S-TRIAZINE, BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, ...
Authors:Katona, G, Snijder, A, Gourdon, P, Andreasson, U, Hansson, O, Andreasson, L.E, Neutze, R.
Deposit date:2005-03-31
Release date:2005-05-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformational Regulation of Charge Recombination Reactions in a Photosynthetic Bacterial Reaction Centre
Nat.Struct.Mol.Biol., 12, 2005
4CTH
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BU of 4cth by Molmil
Neprilysin variant G399V,G714K in complex with phosphoramidon
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, ...
Authors:Webster, C.I, Burrell, M, Olsson, L, Fowler, S.B, Digby, S, Sandercock, A, Snijder, A, Tebbe, J, Haupts, U, Grudzinska, J, Jermutus, L, Andersson, C.
Deposit date:2014-03-13
Release date:2014-08-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer'S Disease.
Plos One, 9, 2014
5NJ6
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BU of 5nj6 by Molmil
Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in ternary complex with Fab3949 and AZ7188 at 4.0 angstrom resolution
Descriptor: Fab3949 H, Fab3949 L, Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2
Authors:Cheng, R.K.Y, Fiez-Vandal, C, Schlenker, O, Edman, K, Aggeler, B, Brown, D.G, Brown, G, Cooke, R.M, Dumelin, C.E, Dore, A.S, Geschwindner, S, Grebner, C, Hermansson, N.-O, Jazayeri, A, Johansson, P, Leong, L, Prihandoko, R, Rappas, M, Soutter, H, Snijder, A, Sundstrom, L, Tehan, B, Thornton, P, Troast, D, Wiggin, G, Zhukov, A, Marshall, F.H, Dekker, N.
Deposit date:2017-03-28
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
5NDD
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BU of 5ndd by Molmil
Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ8838 at 2.8 angstrom resolution
Descriptor: (~{S})-(4-fluoranyl-2-propyl-phenyl)-(1~{H}-imidazol-2-yl)methanol, Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, PHOSPHATE ION, ...
Authors:Cheng, R.K.Y, Fiez-Vandal, C, Schlenker, O, Edman, K, Aggeler, B, Brown, D.G, Brown, G, Cooke, R.M, Dumelin, C.E, Dore, A.S, Geschwindner, S, Grebner, C, Hermansson, N.-O, Jazayeri, A, Johansson, P, Leong, L, Prihandoko, R, Rappas, M, Soutter, H, Snijder, A, Sundstrom, L, Tehan, B, Thornton, P, Troast, D, Wiggin, G, Zhukov, A, Marshall, F.H, Dekker, N.
Deposit date:2017-03-08
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
5NDZ
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BU of 5ndz by Molmil
Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 angstrom resolution
Descriptor: 2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide, Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, SODIUM ION
Authors:Cheng, R.K.Y, Fiez-Vandal, C, Schlenker, O, Edman, K, Aggeler, B, Brown, D.G, Brown, G, Cooke, R.M, Dumelin, C.E, Dore, A.S, Geschwindner, S, Grebner, C, Hermansson, N.-O, Jazayeri, A, Johansson, P, Leong, L, Prihandoko, R, Rappas, M, Soutter, H, Snijder, A, Sundstrom, L, Tehan, B, Thornton, P, Troast, D, Wiggin, G, Zhukov, A, Marshall, F.H, Dekker, N.
Deposit date:2017-03-09
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
5LAE
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BU of 5lae by Molmil
Crystal structure of murine N1-acetylpolyamine oxidase
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Authors:Sjogren, T, Aagaard, A, Snijder, A, Barlind, L.
Deposit date:2016-06-14
Release date:2017-03-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5LFO
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BU of 5lfo by Molmil
Crystal structure of murine N1-acetylpolyamine oxidase in complex with N1-acetylspermine
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide, ...
Authors:Sjogren, T, Aagaard, A, Wassvik, C, Snijder, A, Barlind, L.
Deposit date:2016-07-04
Release date:2017-03-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5LGB
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BU of 5lgb by Molmil
Crystal structure of murine N1-acetylpolyamine oxidase in complex with MDL72527
Descriptor: FAD-MDL72527 adduct, N,N'-BIS(2,3-BUTADIENYL)-1,4-BUTANE-DIAMINE, Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Authors:Sjogren, T, Aagaard, A, Wassvik, C, Snijder, A, Barlind, L.
Deposit date:2016-07-06
Release date:2017-08-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5MBX
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BU of 5mbx by Molmil
Crystal structure of reduced murine N1-acetylpolyamine oxidase in complex with N1-acetylspermine
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide, Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, ...
Authors:Sjogren, T, Aagaard, A, Wassvik, C, Snijder, A, Barlind, L.
Deposit date:2016-11-09
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5JNQ
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BU of 5jnq by Molmil
MraY tunicamycin complex
Descriptor: PALMITIC ACID, Phospho-N-acetylmuramoyl-pentapeptide-transferase, Tunicamycin, ...
Authors:Johansson, P.
Deposit date:2016-04-30
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:MraY-antibiotic complex reveals details of tunicamycin mode of action.
Nat. Chem. Biol., 13, 2017
6QZR
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BU of 6qzr by Molmil
14-3-3 sigma in complex with FOXO1 pT24 peptide
Descriptor: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Forkhead box protein O1, ...
Authors:Ottmann, C, Wolter, M, Lau, R.A.
Deposit date:2019-03-12
Release date:2019-07-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
J.Biol.Chem., 294, 2019
6QZS
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BU of 6qzs by Molmil
14-3-3 sigma in complex with FOXO1 pS256 peptide
Descriptor: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FOXO1 pS256 site, ...
Authors:Ottmann, C, Wolter, M, Lau, R.A.
Deposit date:2019-03-12
Release date:2019-07-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
J.Biol.Chem., 294, 2019
8ANS
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BU of 8ans by Molmil
Crystal structure of D1228V c-MET bound by compound 1.
Descriptor: 3-[bis(fluoranyl)methyl]-~{N}-methyl-~{N}-[(1~{R})-8-methyl-5-(3-methyl-1~{H}-indazol-6-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-2-carboxamide, GLYCEROL, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2022-08-05
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Discovery of a selective c-MET inhibitor with a novel binding mode.
Bioorg.Med.Chem.Lett., 75, 2022
8AN8
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BU of 8an8 by Molmil
Crystal structure of wild-type c-MET bound by compound 7.
Descriptor: 3-[bis(fluoranyl)methyl]-~{N}-methyl-~{N}-[(1~{R})-8-methyl-5-(3-methyl-1~{H}-indazol-6-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-2-carboxamide, Hepatocyte growth factor receptor, SULFATE ION
Authors:Collie, G.W.
Deposit date:2022-08-04
Release date:2022-08-31
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.394 Å)
Cite:Discovery of a selective c-MET inhibitor with a novel binding mode.
Bioorg.Med.Chem.Lett., 75, 2022
2RDD
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BU of 2rdd by Molmil
X-ray crystal structure of AcrB in complex with a novel transmembrane helix.
Descriptor: (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, Acriflavine resistance protein B, UPF0092 membrane protein yajC
Authors:Tornroth-Horsefield, S, Gourdon, P, Horsefield, R, Neutze, R.
Deposit date:2007-09-22
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist.
Structure, 15, 2007
6YOS
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BU of 6yos by Molmil
Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 pS617 peptide
Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor,Glucocorticoid receptor
Authors:Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C.
Deposit date:2020-04-15
Release date:2021-03-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
J.Biol.Chem., 296, 2021
6YO8
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BU of 6yo8 by Molmil
Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide
Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor
Authors:Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C.
Deposit date:2020-04-14
Release date:2021-03-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
J.Biol.Chem., 296, 2021
6YMO
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BU of 6ymo by Molmil
Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide
Descriptor: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ...
Authors:Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C.
Deposit date:2020-04-09
Release date:2021-03-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
J.Biol.Chem., 296, 2021
6SD9
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BU of 6sd9 by Molmil
Crystal structure of wild-type cMET bound by foretinib
Descriptor: CHLORIDE ION, Hepatocyte growth factor receptor, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Authors:Collie, G.W, Phillips, C.
Deposit date:2019-07-26
Release date:2019-08-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6SDC
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BU of 6sdc by Molmil
Crystal structure of D1228V cMET bound by foretinib
Descriptor: Hepatocyte growth factor receptor, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Authors:Collie, G.W, Phillips, C.
Deposit date:2019-07-26
Release date:2019-08-14
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6SDD
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BU of 6sdd by Molmil
Crystal structure of D1228V cMET bound by BMS-777607
Descriptor: GLYCEROL, Hepatocyte growth factor receptor, N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Authors:Collie, G.W, Phillips, C.
Deposit date:2019-07-26
Release date:2019-08-14
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6SDE
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BU of 6sde by Molmil
Crystal structure of wild-type cMET bound by savolitinib
Descriptor: Hepatocyte growth factor receptor, volitinib
Authors:Collie, G.W, Phillips, C.
Deposit date:2019-07-26
Release date:2019-08-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Acs Med.Chem.Lett., 10, 2019
8OWG
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BU of 8owg by Molmil
Crystal structure of D1228V c-MET bound by compound 2
Descriptor: 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2023-04-27
Release date:2023-07-05
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
J.Med.Chem., 66, 2023

 

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