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3V0C
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BU of 3v0c by Molmil
4.3 angstrom crystal structure of an inactive BoNT/A (E224Q/R363A/Y366F)
Descriptor: BoNT/A, ZINC ION
Authors:Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
3V0B
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BU of 3v0b by Molmil
3.9 angstrom crystal structure of BoNT/Ai in complex with NTNHA
Descriptor: BoNT/A, CALCIUM ION, NTNH, ...
Authors:Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
3V0A
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BU of 3v0a by Molmil
2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BoNT/A, CALCIUM ION, ...
Authors:Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
7NA9
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BU of 7na9 by Molmil
Crystal structure of BoNT/B-LC-JSG-C1
Descriptor: 1,2-ETHANEDIOL, Botulinum neurotoxin type B, JSG-C1, ...
Authors:Lam, K, Jin, R.
Deposit date:2021-06-20
Release date:2021-12-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022
5E1H
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BU of 5e1h by Molmil
Ricin toxin in complex with neutralizing single chain monoclonal antibodies (VHHs)
Descriptor: CHLORIDE ION, F8(JOB10) VHH antibody, Ricin
Authors:Rudolph, M.J, Vance, D, Shoemaker, C, Mantis, N.
Deposit date:2015-09-29
Release date:2016-08-03
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.032 Å)
Cite:Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.
Proteins, 84, 2016
4Z9K
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BU of 4z9k by Molmil
Ricin A chain bound to camelid nanobody (VHH2)(F5)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Ricin, ...
Authors:Rudolph, M.J.
Deposit date:2015-04-10
Release date:2016-07-20
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.
Proteins, 84, 2016
5L21
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BU of 5l21 by Molmil
Crystal structure of BoNT/A receptor binding domain in complex with VHH C2
Descriptor: Botulinum neurotoxin type A, VHH-C2
Authors:Yao, G, Jin, R.
Deposit date:2016-07-29
Release date:2017-08-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.
Sci Rep, 7, 2017
7K7Y
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BU of 7k7y by Molmil
Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E9
Descriptor: Botulinum neurotoxin type E, JLE-E9
Authors:Lam, K, Jin, R.
Deposit date:2020-09-24
Release date:2020-10-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells.
Toxins, 12, 2020
7K84
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BU of 7k84 by Molmil
Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E5
Descriptor: Botulinum neurotoxin type E, JLE-E5, SULFATE ION, ...
Authors:Lam, K, Jin, R.
Deposit date:2020-09-25
Release date:2020-10-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells.
Toxins, 12, 2020
7UIB
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BU of 7uib by Molmil
Crystal structure of BoNT/E receptor binding domain in complex with SV2, VHH, and sialic acid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-beta-neuraminic acid, ...
Authors:Liu, Z, Jin, R, Chen, P.
Deposit date:2022-03-29
Release date:2023-04-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2.
Nat Commun, 14, 2023
7UIA
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BU of 7uia by Molmil
Crystal structure of BoNT/E receptor binding domain in complex with SV2 and VHH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:Liu, Z, Jin, R, Chen, P.
Deposit date:2022-03-28
Release date:2023-04-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2.
Nat Commun, 14, 2023
7UIE
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BU of 7uie by Molmil
Crystal structure of HcE-JLE-G6
Descriptor: Botulinum neurotoxin E heavy chain, JLE-G6
Authors:Jin, R, Lam, K.
Deposit date:2022-03-29
Release date:2023-04-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2.
Nat Commun, 14, 2023
7L6V
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BU of 7l6v by Molmil
Crystal structure of BoNT/A-LC-JPU-A5-JPU-C1-JPU-H7-JPU-D12-ciA-F12
Descriptor: 1,2-ETHANEDIOL, BoNT/A, JPU-A5, ...
Authors:Lam, K, Jin, R.
Deposit date:2020-12-24
Release date:2021-12-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022
7LZP
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BU of 7lzp by Molmil
LC/A-JPU-B9-JPU-A11-JPU-G11
Descriptor: Botulinum neurotoxin A light chain, JPU-A11, JPU-B9, ...
Authors:Lam, K, Jin, R.
Deposit date:2021-03-10
Release date:2021-12-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022
7M1H
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BU of 7m1h by Molmil
Crystal structure of LC/A-JPU-C10-JPU-D12-JPU-B8-JPU-G3-ciA-F12-ciA-D12
Descriptor: Botulinum neurotoxin A light chain, JPU-B8, JPU-C10, ...
Authors:Lam, K, Jin, R.
Deposit date:2021-03-13
Release date:2021-12-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022
5V8R
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BU of 5v8r by Molmil
Small Molecule Inhibitor ABS-143 Bound to the Botulinum Neurotoxin Serotype A Light Chain
Descriptor: Botulinum neurotoxin type A, N-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-sulfanylacetamide, ZINC ION
Authors:Allen, K.N, Silvaggi, N.R.
Deposit date:2017-03-22
Release date:2017-07-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.
Toxicon, 137, 2017
5V8P
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BU of 5v8p by Molmil
Small Molecule Inhibitor ABS-143 Bound to the Botulinum Neurotoxin Serotype A Light Chain
Descriptor: Botulinum neurotoxin type A, N-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]-2-sulfanylacetamide, ZINC ION
Authors:Allen, K.N, Silvaggi, N.R.
Deposit date:2017-03-22
Release date:2017-07-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.
Toxicon, 137, 2017
5V8U
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BU of 5v8u by Molmil
Small Molecule Inhibitor ABS-143 Bound to the Botulinum Neurotoxin Serotype A Light Chain
Descriptor: Botulinum neurotoxin type A, N-[3-(4-fluorophenyl)-4-methyl-1H-pyrazol-5-yl]-2-sulfanylacetamide, ZINC ION
Authors:Allen, K.N, Silvaggi, N.R.
Deposit date:2017-03-22
Release date:2017-07-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.
Toxicon, 137, 2017
4LGR
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BU of 4lgr by Molmil
Ricin A chain bound to camelid nanobody (VHH3)
Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ...
Authors:Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N.
Deposit date:2013-06-28
Release date:2014-06-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
4LHJ
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BU of 4lhj by Molmil
Ricin A chain bound to camelid nanobody (VHH5)
Descriptor: CHLORIDE ION, Camelid antibody, Ricin
Authors:Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N.
Deposit date:2013-07-01
Release date:2014-06-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
4LGS
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BU of 4lgs by Molmil
Ricin A chain bound to camelid nanobody (VHH4)
Descriptor: Camelid nanobody (VHH4), Ricin
Authors:Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N.
Deposit date:2013-06-28
Release date:2014-06-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
4LGP
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BU of 4lgp by Molmil
Ricin A chain bound to camelid nanobody (VHH1)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Ricin, ...
Authors:Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N.
Deposit date:2013-06-28
Release date:2014-06-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
4LHQ
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BU of 4lhq by Molmil
Ricin A chain bound to camelid nanobody (VHH8)
Descriptor: Camelid nanobody, Ricin
Authors:Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N.
Deposit date:2013-07-01
Release date:2014-06-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
6UFT
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BU of 6uft by Molmil
Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLK-G12
Descriptor: Botulinum neurotoxin type B, JLK-G12, SULFATE ION
Authors:Lam, K, Jin, R.
Deposit date:2019-09-25
Release date:2020-03-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9000814 Å)
Cite:Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins
Cell Rep, 30, 2020
6UL6
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BU of 6ul6 by Molmil
Crystal Structure of BoNT/A-LCHn domain in complex with VNA ciA-D12/11/ciA-B5 and VHH ciA-H7
Descriptor: BoNT/A, ciA-D12/11/ciA-B5, ciA-H7
Authors:Lam, K, Jin, R.
Deposit date:2019-10-07
Release date:2020-03-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.02000213 Å)
Cite:Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins
Cell Rep, 30, 2020

 

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