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4CPI
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BU of 4cpi by Molmil
streptavidin A86D mutant with love-hate ligand 4
Descriptor: 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N'-{2,6-bis[4-(morpholine-4- sulfonyl)phenyl]phenyl}pentanehydrazide, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Fairhead, M, Shen, D, Chan, L.K.M, Lowe, E.D, Donohoe, T.J, Howarth, M.
Deposit date:2014-02-06
Release date:2014-08-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction.
Bioorg.Med.Chem., 22, 2014
4CPF
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BU of 4cpf by Molmil
Wild-type streptavidin in complex with love-hate ligand 3 (LH3)
Descriptor: STREPTAVIDIN, methyl 4-(2-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H- thieno[3,4-d]imidazolidin-4-yl]pentanehydrazido}-3- [4-(methoxycarbonyl)phenyl]phenyl)benzoate
Authors:Fairhead, M, Shen, D, Chan, L.K.M, Lowe, E.D, Donohoe, T.J, Howarth, M.
Deposit date:2014-02-06
Release date:2014-08-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction.
Bioorg.Med.Chem., 22, 2014
4CPE
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BU of 4cpe by Molmil
Wild-type streptavidin in complex with love-hate ligand 1 (LH1)
Descriptor: (3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N-{2-[(2,6- diphenylphenyl)formamido]ethyl}pentanamide, STREPTAVIDIN
Authors:Fairhead, M, Shen, D, Chan, L.K.M, Lowe, E.D, Donohoe, T.J, Howarth, M.
Deposit date:2014-02-06
Release date:2014-08-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction.
Bioorg.Med.Chem., 22, 2014
4CPH
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BU of 4cph by Molmil
trans-divalent streptavidin with love-hate ligand 4
Descriptor: 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N'-{2,6-bis[4-(morpholine-4- sulfonyl)phenyl]phenyl}pentanehydrazide, STREPTAVIDIN
Authors:Fairhead, M, Shen, D, Chan, L.K.M, Lowe, E.D, Donohoe, T.J, Howarth, M.
Deposit date:2014-02-06
Release date:2014-08-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction.
Bioorg.Med.Chem., 22, 2014
7Y36
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BU of 7y36 by Molmil
Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ...
Authors:Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z.
Deposit date:2022-06-10
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
to be published
7Y35
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BU of 7y35 by Molmil
Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
Descriptor: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z.
Deposit date:2022-06-09
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
To Be Published
2N6F
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BU of 2n6f by Molmil
Structure of Pleiotrophin
Descriptor: Pleiotrophin
Authors:Ryan, E.O, Shen, D, Wang, X.
Deposit date:2015-08-20
Release date:2016-04-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural studies reveal an important role for the pleiotrophin C-terminus in mediating interactions with chondroitin sulfate.
Febs J., 283, 2016
2VSN
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BU of 2vsn by Molmil
Structure and topological arrangement of an O-GlcNAc transferase homolog: insight into molecular control of intracellular glycosylation
Descriptor: URIDINE-5'-DIPHOSPHATE, XCOGT
Authors:Martinez-Fleites, C, Macauley, M.S, He, Y, Shen, D, Vocadlo, D, Davies, G.J.
Deposit date:2008-04-28
Release date:2008-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of an O-Glcnac Transferase Homolog Provides Insight Into Intracellular Glycosylation.
Nat.Struct.Mol.Biol., 15, 2008
7BV1
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BU of 7bv1 by Molmil
Cryo-EM structure of the apo nsp12-nsp7-nsp8 complex
Descriptor: Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ...
Authors:Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E.
Deposit date:2020-04-09
Release date:2020-04-22
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Science, 368, 2020
7BV2
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BU of 7bv2 by Molmil
The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP)
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E.
Deposit date:2020-04-09
Release date:2020-04-22
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Science, 368, 2020
7CFM
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BU of 7cfm by Molmil
Cryo-EM structure of the P395-bound GPBAR-Gs complex
Descriptor: 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide, CHOLESTEROL, G-protein coupled bile acid receptor 1, ...
Authors:Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y.
Deposit date:2020-06-27
Release date:2020-09-09
Last modified:2020-12-02
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of GPBAR activation and bile acid recognition.
Nature, 587, 2020
4D3E
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BU of 4d3e by Molmil
Tetramer of IpaD, modified from 2J0O, fitted into negative stain electron microscopy reconstruction of the wild type tip complex from the type III secretion system of Shigella flexneri
Descriptor: INVASIN IPAD
Authors:Cheung, M, Shen, D.-K, Makino, F, Kato, T, Roehrich, D, Martinez-Argudo, I, Walker, M.L, Murillo, I, Liu, X, Pain, M, Brown, J, Frazer, G, Mantell, J, Mina, P, Todd, T, Sessions, R.B, Namba, K, Blocker, A.J.
Deposit date:2014-10-21
Release date:2014-12-10
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (2.12 Å)
Cite:Three-Dimensional Electron Microscopy Reconstruction and Cysteine-Mediated Crosslinking Provide a Model of the T3Ss Needle Tip Complex.
Mol.Microbiol., 95, 2015
7C7Q
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BU of 7c7q by Molmil
Cryo-EM structure of the baclofen/BHFF-bound human GABA(B) receptor in active state
Descriptor: (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ...
Authors:Mao, C, Shen, C, Li, C, Shen, D, Xu, C, Zhang, S, Zhou, R, Shen, Q, Chen, L, Jiang, Z, Liu, J, Zhang, Y.
Deposit date:2020-05-26
Release date:2020-07-01
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM structures of inactive and active GABABreceptor.
Cell Res., 30, 2020
7VLA
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BU of 7vla by Molmil
Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex
Descriptor: C-C chemokine receptor type 1, CCL15(27-92), CHOLESTEROL, ...
Authors:Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H.
Deposit date:2021-10-02
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
7F55
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BU of 7f55 by Molmil
Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F54
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BU of 7f54 by Molmil
Cryo-EM structure of afamelanotide-MC4R-Gs_Nb35 complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F53
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BU of 7f53 by Molmil
Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F58
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BU of 7f58 by Molmil
Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex
Descriptor: (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxidanylidene-propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7NWG
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BU of 7nwg by Molmil
Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.
Descriptor: 18S Ribosomal RNA, 28S Ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C.
Deposit date:2021-03-16
Release date:2021-07-07
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
7NWI
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BU of 7nwi by Molmil
Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA+BlaS, 40S ribosomal protein S11, ...
Authors:Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C.
Deposit date:2021-03-16
Release date:2021-07-07
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
7NWH
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BU of 7nwh by Molmil
Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S.
Descriptor: 18S Ribosomal RNA, 28S Ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C.
Deposit date:2021-03-16
Release date:2021-07-07
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
8IKJ
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BU of 8ikj by Molmil
Cryo-EM structure of the inactive CD97
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G protein-coupled receptor E5,Soluble cytochrome b562,Adhesion G protein-coupled receptor E5 subunit beta
Authors:Mao, C, Zhao, R, Dong, Y, Gao, M, Chen, L, Zhang, C, Xiao, P, Guo, J, Qin, J, Shen, D, Ji, S, Zang, S, Zhang, H, Wang, W, Shen, Q, Sun, P, Zhang, Y.
Deposit date:2023-02-28
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Conformational transitions and activation of the adhesion receptor CD97.
Mol.Cell, 84, 2024
5Y9O
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BU of 5y9o by Molmil
The apo structure of Legionella pneumophila WipA
Descriptor: IODIDE ION, WipA
Authors:Xie, W, Jia, Q.
Deposit date:2017-08-26
Release date:2018-05-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.554 Å)
Cite:Legionella pneumophila effector WipA, a bacterial PPP protein phosphatase with PTP activity
Acta Biochim. Biophys. Sin. (Shanghai), 50, 2018
7DFG
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BU of 7dfg by Molmil
Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir
Descriptor: 6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide, MAGNESIUM ION, Non-structural protein 7, ...
Authors:Li, Z, Zhou, Z, Yu, X.
Deposit date:2020-11-08
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for repurpose and design of nucleotide drugs for treating COVID-19
To Be Published
7DFH
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BU of 7dfh by Molmil
Structure of COVID-19 RNA-dependent RNA polymerase bound to ribavirin
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Li, Z, Zhou, Z, Yu, X.
Deposit date:2020-11-08
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structural basis for repurpose and design of nucleotide drugs for treating COVID-19
To Be Published

 

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