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1OW1
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BU of 1ow1 by Molmil
Crystal structure of the SPOC domain of the human transcriptional corepressor, SHARP.
Descriptor: SMART/HDAC1 associated repressor protein
Authors:Schwabe, J.W, Ariyoshi, M.
Deposit date:2003-03-28
Release date:2003-08-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling
Genes Dev., 17, 2003
4AA6
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BU of 4aa6 by Molmil
The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation
Descriptor: 5'-D(*CP*TP*AP*AP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP *CP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*GP*TP*GP*AP *CP*TP*TP*A)-3', ESTROGEN RECEPTOR, ...
Authors:Schwabe, J.W, Chapman, L, Rhodes, D.
Deposit date:2011-11-30
Release date:2011-12-14
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation.
Structure, 3, 1995
1HCQ
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BU of 1hcq by Molmil
THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS
Descriptor: DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP*CP*CP*T P*G)-3'), DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*TP*GP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (ESTROGEN RECEPTOR), ...
Authors:Schwabe, J.W.R, Chapman, L, Finch, J.T, Rhodes, D.
Deposit date:1995-01-04
Release date:1995-11-23
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements.
Cell(Cambridge,Mass.), 75, 1993
1HCP
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BU of 1hcp by Molmil
DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL
Descriptor: HUMAN/CHICKEN ESTROGEN RECEPTOR, ZINC ION
Authors:Schwabe, J.W.R, Rhodes, D, Neuhaus, D.
Deposit date:1993-11-23
Release date:1995-11-23
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:DNA recognition by the oestrogen receptor: from solution to the crystal.
Structure, 1, 1993
6G16
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BU of 6g16 by Molmil
Structure of the human RBBP4:MTA1(464-546) complex showing loop exchange
Descriptor: Histone-binding protein RBBP4, Metastasis-associated protein MTA1
Authors:Millard, C.J, Varma, N, Fairall, L, Schwabe, J.W.R.
Deposit date:2018-03-20
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structure of the core NuRD repression complex provides insights into its interaction with chromatin.
Elife, 5, 2016
5ICN
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BU of 5icn by Molmil
HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4
Descriptor: GLY-ALA-6A0-ARG-HIS, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Millard, C.J, Robertson, N.S, Watson, P.J, Jameson, A.G, Schwabe, J.W.R.
Deposit date:2016-02-23
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.
Nat Commun, 7, 2016
8AU4
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BU of 8au4 by Molmil
Structural insights reveal a heterotetramer between oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
Descriptor: Ral guanine nucleotide dissociation stimulator-like 2
Authors:Tariq, M, Ikeya, T, Togashi, N, Fairall, L, Alejo, C.B, Kamei, S, Alonso, B.R, Campillo, M.A.M, Hudson, A, Ito, Y, Schwabe, J, Dominguez, C, Tanaka, K.
Deposit date:2022-08-25
Release date:2023-08-23
Last modified:2023-10-25
Method:SOLUTION NMR
Cite:Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator.
Life Sci Alliance, 7, 2024
5FXY
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BU of 5fxy by Molmil
Structure of the human RBBP4:MTA1(464-546) complex
Descriptor: HISTONE-BINDING PROTEIN RBBP4, METASTASIS-ASSOCIATED PROTEIN MTA1
Authors:Millard, C.J, Varma, N, Fairall, L, Schwabe, J.W.R.
Deposit date:2016-03-03
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structure of the core NuRD repression complex provides insights into its interaction with chromatin.
Elife, 5, 2016
8B69
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BU of 8b69 by Molmil
Heterotetramer of K-Ras4B(G12V) and Rgl2(RBD)
Descriptor: Isoform 2B of GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tariq, M, Fairall, L, Romartinez-Alonso, B, Dominguez, C, Schwabe, J.W.R, Tanaka, K.
Deposit date:2022-09-26
Release date:2023-08-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator.
Life Sci Alliance, 7, 2024
2MWI
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BU of 2mwi by Molmil
The structure of the carboxy-terminal domain of DNTTIP1
Descriptor: Deoxynucleotidyltransferase terminal-interacting protein 1
Authors:Schwabe, J.W.R, Muskett, F.W, Itoh, T.
Deposit date:2014-11-11
Release date:2015-02-18
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.
Nucleic Acids Res., 43, 2015
1ZFD
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BU of 1zfd by Molmil
SWI5 ZINC FINGER DOMAIN 2, NMR, 45 STRUCTURES
Descriptor: SWI5, ZINC ION
Authors:Neuhaus, D, Nakaseko, Y, Schwabe, J.W.R, Rhodes, D, Klug, A.
Deposit date:1996-04-04
Release date:1996-10-14
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy. A zinc-finger structure with a third strand of beta-sheet.
J.Mol.Biol., 228, 1992
2DRP
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BU of 2drp by Molmil
THE CRYSTAL STRUCTURE OF A TWO ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER/DNA RECOGNITION
Descriptor: DNA (5'-D(*CP*TP*AP*AP*TP*AP*AP*GP*GP*AP*TP*AP*AP*CP*GP*TP*C P*CP*G)-3'), DNA (5'-D(*TP*CP*GP*GP*AP*CP*GP*TP*TP*AP*TP*CP*CP*TP*TP*AP*T P*TP*A)-3'), PROTEIN (TRAMTRACK DNA-BINDING DOMAIN), ...
Authors:Fairall, L, Schwabe, J.W.R, Chapman, L, Finch, J.T, Rhodes, D.
Deposit date:1994-06-06
Release date:1994-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition.
Nature, 366, 1993
2L5G
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BU of 2l5g by Molmil
Co-ordinates and 1H, 13C and 15N chemical shift assignments for the complex of GPS2 53-90 and SMRT 167-207
Descriptor: G protein pathway suppressor 2, Putative uncharacterized protein NCOR2
Authors:Oberoi, J, Yang, J, Neuhaus, D, Schwabe, J.W.R.
Deposit date:2010-11-01
Release date:2011-02-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Nat.Struct.Mol.Biol., 18, 2011
2YHO
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BU of 2yho by Molmil
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor
Descriptor: ACETATE ION, E3 UBIQUITIN-PROTEIN LIGASE MYLIP, UBIQUITIN-CONJUGATING ENZYME E2 D1, ...
Authors:Fairall, L, Goult, B.T, Millard, C.J, Tontonoz, P, Schwabe, J.W.R.
Deposit date:2011-05-04
Release date:2011-06-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Idol-Ube2D Complex Mediates Sterol-Dependent Degradation of the Ldl Receptor.
Genes Dev., 25, 2011
1NCS
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BU of 1ncs by Molmil
NMR STUDY OF SWI5 ZINC FINGER DOMAIN 1
Descriptor: TRANSCRIPTIONAL FACTOR SWI5, ZINC ION
Authors:Dutnall, R.N, Neuhaus, D, Rhodes, D.
Deposit date:1996-02-26
Release date:1996-06-10
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:The solution structure of the first zinc finger domain of SWI5: a novel structural extension to a common fold.
Structure, 4, 1996
1MEY
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BU of 1mey by Molmil
CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA
Descriptor: CHLORIDE ION, CONSENSUS ZINC FINGER, DNA (5'-D(*AP*TP*GP*AP*GP*GP*CP*AP*GP*AP*AP*CP*T)-3'), ...
Authors:Kim, C.A, Berg, J.M.
Deposit date:1996-09-27
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A 2.2 A Resolution Crystal Structure of a Designed Zinc Finger Protein Bound to DNA
Nat.Struct.Biol., 3, 1996

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