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2IEI
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BU of 2iei by Molmil
Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone
Descriptor: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE, Glycogen phosphorylase, ...
Authors:Birch, A.M, Kenny, P.W, Oikonomakos, N.G, Otterbein, L, Schofield, P, Whittamore, P.R.O, Whalley, D.P, Rowsell, S, Pauptit, R, Pannifer, A, Breed, J, Minshull, C.
Deposit date:2006-09-19
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2IEG
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BU of 2ieg by Molmil
Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone
Descriptor: (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Glycogen phosphorylase, ...
Authors:Birch, A.M, Kenny, P.W, Oikonomakos, N.G, Otterbein, L, Schofield, P, Whittamore, P.R.O, Whalley, D.P, Rowsell, S, Pauptit, R, Pannifer, A, Breed, J, Minshull, C.
Deposit date:2006-09-19
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
6BFT
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BU of 6bft by Molmil
Structure of Bevacizumab Fab mutant in complex with VEGF
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Avastin Heavy Chain Fab fragment mutant, Avastin Light Chain Fab fragment mutant, ...
Authors:Christie, M, Christ, D.
Deposit date:2017-10-27
Release date:2018-10-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Stable human IgG antibody therapeutics with native framework structure
To Be Published
6BGT
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BU of 6bgt by Molmil
Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Herceptin heavy chain Fab fragment mutant, Herceptin light chain mutant, ...
Authors:Christie, M, Christ, D.
Deposit date:2017-10-29
Release date:2018-10-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Stable human IgG antibody therapeutics with native framework structure
To Be Published
7RTA
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BU of 7rta by Molmil
Crystal structures of human PYY and NPY
Descriptor: 4A3B2-B Fab heavy chain, 4A3B2-B Fab light chain, Neuropeptide Y, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2021-08-12
Release date:2022-03-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).
Neuropeptides, 92, 2022
7RT9
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BU of 7rt9 by Molmil
Crystal structures of human PYY and NPY
Descriptor: 4A3B2-A Fab heavy chain, 4A3B2-A Fab light chain, GLYCEROL, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2021-08-12
Release date:2022-03-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).
Neuropeptides, 92, 2022
7T72
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BU of 7t72 by Molmil
Epitope-based selection of SARS-CoV-2 neutralizing antibodies from convalescent patients
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody heavy chain, Antibody light chain, ...
Authors:Langley, D.B, Christ, D, Rouet, R.
Deposit date:2021-12-14
Release date:2022-12-21
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (3.177 Å)
Cite:Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients.
Nat Commun, 14, 2023
7T5O
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BU of 7t5o by Molmil
VFLIP Spike Trimer with GAR03
Descriptor: GAR03 Fab heavy chain, GAR03 Fab light chain, Spike glycoprotein
Authors:Sobti, M, Stewart, A.G, Rouet, R, Langley, D.B.
Deposit date:2021-12-12
Release date:2023-01-25
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients.
Nat Commun, 14, 2023
7UEN
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BU of 7uen by Molmil
Genetic and structural basis of the human anti-alpha-galactosyl antibody response
Descriptor: M86 antibody Fab heavy chain, M86 antibody Fab light chain, PHOSPHATE ION, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2022-03-22
Release date:2022-06-29
Last modified:2022-08-03
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Genetic and structural basis of the human anti-alpha-galactosyl antibody response.
Proc.Natl.Acad.Sci.USA, 119, 2022
7UEM
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BU of 7uem by Molmil
Genomic and structural basis for the human anti-alpha-galactosyl antibody response
Descriptor: CHLORIDE ION, Heavy chain Fab arm of antibody HKB7, Light chain Fab of antibody HKB7, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2022-03-22
Release date:2022-06-29
Last modified:2022-08-03
Method:X-RAY DIFFRACTION (2.314 Å)
Cite:Genetic and structural basis of the human anti-alpha-galactosyl antibody response.
Proc.Natl.Acad.Sci.USA, 119, 2022
7UEL
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BU of 7uel by Molmil
Genetic and structural basis for the human anti-alpha-galactosyl antibody response
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Heavy chain Fab of antibody JEC1, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2022-03-22
Release date:2022-06-29
Last modified:2022-08-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Genetic and structural basis of the human anti-alpha-galactosyl antibody response.
Proc.Natl.Acad.Sci.USA, 119, 2022
7KZB
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BU of 7kzb by Molmil
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Fab heavy chain of CR3014-C8 antibody, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2020-12-10
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies.
Mabs, 13
7KZC
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BU of 7kzc by Molmil
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies
Descriptor: CHLORIDE ION, Fab heavy chain of m396-B10 antibody, Fab light chain of m396-B10 antibody
Authors:Langley, D.B, Christ, D.
Deposit date:2020-12-10
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies.
Mabs, 13
7KZA
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BU of 7kza by Molmil
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies
Descriptor: CHLORIDE ION, Fab fragment heavy chain of anti-CoV2-RBD antibody variant CR3022-B6, Fab fragment light chain of anti-CoV2-RBD antibody variant CR3022-B6, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2020-12-10
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies.
Mabs, 13
6MH2
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BU of 6mh2 by Molmil
Structure of Herceptin Fab without antigen
Descriptor: Herceptin Fab arm heavy chain, Herceptin Fab arm light chain
Authors:Luthra, A, Langley, D.B, Christie, M, Christ, D.
Deposit date:2018-09-17
Release date:2019-05-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human Antibody Bispecifics through Phage Display Selection.
Biochemistry, 58, 2019
7MSQ
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BU of 7msq by Molmil
Complex between the Fab arm of AB-3467 and the SARS-CoV-2 receptor binding domain (RBD)
Descriptor: AB-3467 Fab Heavy Chain, AB-3467 Fab Light Chain, CHLORIDE ION, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2021-05-12
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability.
Immunity, 54, 2021
5V94
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BU of 5v94 by Molmil
Pekin duck egg lysozyme isoform III (DEL-III), cubic form
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2017-03-22
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis of antigen recognition: crystal structure of duck egg lysozyme.
Acta Crystallogr D Struct Biol, 73, 2017
5V8G
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BU of 5v8g by Molmil
Pekin duck lysozyme isoform I (DEL-I)
Descriptor: CHLORIDE ION, THIOCYANATE ION, lysozyme isoform I
Authors:Langley, D.B, Christ, D.
Deposit date:2017-03-22
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis of antigen recognition: crystal structure of duck egg lysozyme.
Acta Crystallogr D Struct Biol, 73, 2017
5V92
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BU of 5v92 by Molmil
Pekin duck egg lysozyme isoform III (DEL-III), orthorhombic form
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, lysozyme isoform III
Authors:Langley, D.B, Christ, D.
Deposit date:2017-03-22
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Structural basis of antigen recognition: crystal structure of duck egg lysozyme.
Acta Crystallogr D Struct Biol, 73, 2017
5VAS
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BU of 5vas by Molmil
Pekin duck egg lysozyme isoform III (DEL-III), orthorhombic form
Descriptor: GLYCEROL, Lysozyme, PHOSPHATE ION
Authors:Christie, M, Christ, D, Langley, D.B.
Deposit date:2017-03-27
Release date:2018-04-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis of antigen recognition: crystal structure of duck egg lysozyme.
Acta Crystallogr D Struct Biol, 73, 2017
5VJO
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BU of 5vjo by Molmil
Complex between HyHEL10 Fab fragment heavy chain mutant I29F and Pekin duck egg lysozyme isoform I (DEL-I)
Descriptor: CHLORIDE ION, HyHEL10 heavy chain Fab fragment carrying I29F mutation., HyHEL10 light chain Fab fragment, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2017-04-19
Release date:2018-04-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.
Science, 360, 2018
5VJQ
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BU of 5vjq by Molmil
Complex between HyHEL10 Fab fragment heavy chain mutant (I29F, S52T, Y53F) and Pekin duck egg lysozyme isoform I (DEL-I)
Descriptor: CHLORIDE ION, GLYCEROL, HyHEL10 heavy chain Fab fragment carrying three mutations; I29F, ...
Authors:Langley, D.B, Christ, D.
Deposit date:2017-04-19
Release date:2018-04-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.
Science, 360, 2018
3UPC
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BU of 3upc by Molmil
A general strategy for the generation of human antibody variable domains with increased aggregation resistance
Descriptor: DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ...
Authors:Dudgeon, K, Rouet, R, Kokmeijer, I, Langley, D.B, Christ, D.
Deposit date:2011-11-17
Release date:2012-06-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:General strategy for the generation of human antibody variable domains with increased aggregation resistance
Proc.Natl.Acad.Sci.USA, 109, 2012
3UPA
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BU of 3upa by Molmil
A general strategy for the generation of human antibody variable domains with increased aggregation resistance
Descriptor: kappa light chain variable domain
Authors:Dudgeon, K, Rouet, R, Kokmeijer, I, Langley, D.B, Christ, D.
Deposit date:2011-11-17
Release date:2012-06-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:General strategy for the generation of human antibody variable domains with increased aggregation resistance
Proc.Natl.Acad.Sci.USA, 109, 2012
5J7C
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BU of 5j7c by Molmil
A picomolar affinity FN3 domain in complex with hen egg-white lysozyme
Descriptor: FNfn10-anti-lysozyme (DE0.4.1), Lysozyme C
Authors:Porebski, B.T, Drinkwater, N, McGowan, S, Buckle, A.M.
Deposit date:2016-04-06
Release date:2016-08-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.535 Å)
Cite:Circumventing the stability-function trade-off in an engineered FN3 domain.
Protein Eng.Des.Sel., 2016

 

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