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1JBU
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BU of 1jbu by Molmil
Coagulation Factor VII Zymogen (EGF2/Protease) in Complex with Inhibitory Exosite Peptide A-183
Descriptor: BENZAMIDINE, COAGULATION FACTOR VII, Peptide exosite inhibitor A-183, ...
Authors:Eigenbrot, C, Kirchhofer, D, Dennis, M.S, Santell, L, Lazarus, R.A, Stamos, J, Ultsch, M.H.
Deposit date:2001-06-06
Release date:2001-07-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:The factor VII zymogen structure reveals reregistration of beta strands during activation.
Structure, 9, 2001
1SI5
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BU of 1si5 by Molmil
Protease-like domain from 2-chain hepatocyte growth factor
Descriptor: hepatocyte growth factor
Authors:Kirchhofer, D, Yao, X, Peek, M, Eigenbrot, C, Lipari, M.T, Billeci, K.L, Maun, H.R, Moran, P, Santell, L, Lazarus, R.A.
Deposit date:2004-02-27
Release date:2004-12-28
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling
J.Biol.Chem., 279, 2004
4AWN
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BU of 4awn by Molmil
Structure of recombinant human DNase I (rhDNaseI) in complex with Magnesium and Phosphate.
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Parsiegla, G, Noguere, C, Santell, L, Lazarus, R.A, Bourne, Y.
Deposit date:2012-06-04
Release date:2013-01-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-Like Superfamily.
Biochemistry, 51, 2012
1YBW
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BU of 1ybw by Molmil
Protease domain of HGFA with no inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hepatocyte growth factor activator precursor
Authors:Shia, S, Stamos, J, Kirchhofer, D, Fan, B, Wu, J, Corpuz, R.T, Santell, L, Lazarus, R.A, Eigenbrot, C.
Deposit date:2004-12-21
Release date:2005-02-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.
J.Mol.Biol., 346, 2005
1YC0
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BU of 1yc0 by Molmil
short form HGFA with first Kunitz domain from HAI-1
Descriptor: Hepatocyte growth factor activator, Kunitz-type protease inhibitor 1, PHOSPHATE ION
Authors:Shia, S, Stamos, J, Kirchhofer, D, Fan, B, Wu, J, Corpuz, R.T, Santell, L, Lazarus, R.A, Eigenbrot, C.
Deposit date:2004-12-21
Release date:2005-02-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.
J.Mol.Biol., 346, 2005
1DVA
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BU of 1dva by Molmil
Crystal Structure of the Complex Between the Peptide Exosite Inhibitor E-76 and Coagulation Factor VIIA
Descriptor: CACODYLATE ION, CALCIUM ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide, ...
Authors:Eigenbrot, C, Ultsch, M.H.
Deposit date:2000-01-20
Release date:2000-05-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Peptide exosite inhibitors of factor VIIa as anticoagulants.
Nature, 404, 2000
4K3J
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BU of 4k3j by Molmil
Crystal structure of Onartuzumab Fab in complex with MET and HGF-beta
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor beta chain, ...
Authors:Ma, X, Starovasnik, M.A.
Deposit date:2013-04-10
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
Proc.Natl.Acad.Sci.USA, 110, 2013
4O3U
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BU of 4o3u by Molmil
Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP2.3
Descriptor: Hepatocyte growth factor, Hepatocyte growth factor receptor, ZAP 2.3
Authors:Eigenbrot, C, Landgraf, K.E, Steffek, M.
Deposit date:2013-12-18
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
Nat.Chem.Biol., 10, 2014
4O3T
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BU of 4o3t by Molmil
Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP.14
Descriptor: Hepatocyte growth factor, Hepatocyte growth factor receptor, PENTAETHYLENE GLYCOL, ...
Authors:Eigenbrot, C, Landgraf, K.E, Steffek, M.
Deposit date:2013-12-18
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
Nat.Chem.Biol., 10, 2014
1SHY
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BU of 1shy by Molmil
The Crystal Structure of HGF beta-chain in Complex with the Sema Domain of the Met Receptor.
Descriptor: Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Stamos, J, Wiesmann, C.
Deposit date:2004-02-26
Release date:2004-06-15
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor.
Embo J., 23, 2004

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