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1D1Z
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BU of 1d1z by Molmil
CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
Descriptor: SAP SH2 DOMAIN, SULFATE ION
Authors:Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J.
Deposit date:1999-09-22
Release date:1999-10-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4T
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BU of 1d4t by Molmil
CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
Descriptor: SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE, T CELL SIGNAL TRANSDUCTION MOLECULE SAP
Authors:Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4W
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BU of 1d4w by Molmil
CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
Descriptor: SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE, T CELL SIGNAL TRANSDUCTION MOLECULE SAP
Authors:Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1JPW
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BU of 1jpw by Molmil
Crystal Structure of a Human Tcf-4 / beta-Catenin Complex
Descriptor: BETA-CATENIN, transcription factor 7-like 2
Authors:Poy, F, Lepourcelet, M, Shivdasani, R.A, Eck, M.J.
Deposit date:2001-08-03
Release date:2001-12-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a human Tcf4-beta-catenin complex.
Nat.Struct.Biol., 8, 2001
6PGU
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BU of 6pgu by Molmil
Crystal structure of the p300 acetyltransferase domain with allosteric inhibitor CPI-076 and CoA
Descriptor: COENZYME A, Histone acetyltransferase p300, N-(thiophen-2-yl)acetamide
Authors:Gardberg, A.S, Poy, F, Setser, J.
Deposit date:2019-06-24
Release date:2019-10-23
Last modified:2021-12-22
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT.
Struct Dyn., 6, 2019
5DBM
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BU of 5dbm by Molmil
Crystal structure of the CBP bromodomain in complex with CPI703
Descriptor: (4R)-6-(1-tert-butyl-1H-pyrazol-4-yl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, CREB-binding protein
Authors:Setser, J.W, Poy, F, Bellon, S.F.
Deposit date:2015-08-21
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
J.Biol.Chem., 291, 2016
7TAB
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BU of 7tab by Molmil
G-925 bound to the SMARCA4 (BRG1) Bromodomain
Descriptor: 2-(6-amino-5-phenylpyridazin-3-yl)phenol, Isoform 4 of Transcription activator BRG1
Authors:Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F.
Deposit date:2021-12-20
Release date:2022-08-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J.Med.Chem., 65, 2022
7TD9
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BU of 7td9 by Molmil
G-059 bound to the SMARCA4 (BRG1) Bromodomain
Descriptor: 4-phenyl-5H-pyridazino[4,3-b]indol-3-amine, Isoform 4 of Transcription activator BRG1
Authors:Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F.
Deposit date:2021-12-30
Release date:2022-08-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J.Med.Chem., 65, 2022
1I3Z
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BU of 1i3z by Molmil
MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
Descriptor: EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
Authors:Lu, J, Poy, F, Morra, M, Terhorst, C, Eck, M.J.
Deposit date:2001-02-19
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
Eur.J.Biochem., 20, 2001
4LRG
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BU of 4lrg by Molmil
Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide
Descriptor: 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-[1,2]oxazolo[5,4-c]thieno[2,3-e]azepin-6-yl]acetamide, Bromodomain-containing protein 4
Authors:Ravichandran, S, Jayaram, H, Poy, F, Gehling, V, Hewitt, M, Vaswani, R, Leblanc, Y, Cote, A, Nasveschuk, C, Taylor, A, Harmange, J.-C, Audia, J, Pardo, E, Joshi, S, Sandy, P, Mertz, J, Sims, R, Bergeron, L, Bryant, B, Yellapuntala, S, Nandana, B.S, Birudukota, S, Albrecht, B, Bellon, S.
Deposit date:2013-07-19
Release date:2013-08-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
ACS Med Chem Lett, 4, 2013
4LR6
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BU of 4lr6 by Molmil
Structure of BRD4 bromodomain 1 with a 3-methyl-4-phenylisoxazol-5-amine fragment
Descriptor: 3-methyl-4-phenyl-1,2-oxazol-5-amine, Bromodomain-containing protein 4, FORMIC ACID
Authors:Jayaram, H, Poy, F, Gehling, V, Hewitt, M, Vaswani, R, Leblanc, Y, Cote, A, Nasveschuk, C, Taylor, A, Harmange, J.-C, Audia, J, Pardo, E, Joshi, S, Sandy, P, Mertz, J, Sims, R, Bergeron, L, Bryant, B, Ravichandran, S, Yellapuntala, S, Nandana, B.S, Birudukota, S, Albrecht, B, Bellon, S.
Deposit date:2013-07-19
Release date:2013-08-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
ACS Med Chem Lett, 4, 2013
5KR7
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BU of 5kr7 by Molmil
KDM4C bound to pyrazolo-pyrimidine scaffold
Descriptor: 6-ethyl-2,5-dimethyl-7-oxidanylidene-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, CHLORIDE ION, FE (II) ION, ...
Authors:Bellon, S.F, Poy, F, Setser, J.W.
Deposit date:2016-07-07
Release date:2016-08-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of potent, selective KDM5 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5KTU
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BU of 5ktu by Molmil
Crystal structure of the bromodomain of human CREBBP bound to pyrazolopiperidine scaffold
Descriptor: 1-(3-phenylazanyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone, CREB-binding protein, DIMETHYL SULFOXIDE
Authors:Jayaram, H, Poy, F, Setser, J.W, Bellon, S.F.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
2F31
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BU of 2f31 by Molmil
Crystal structure of the autoinhibitory switch in Formin mDia1; the DID/DAD complex
Descriptor: Diaphanous protein homolog 1
Authors:Nezami, A.G, Poy, F, Eck, M.J.
Deposit date:2005-11-18
Release date:2006-05-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the Autoinhibitory Switch in Formin mDia1
Structure, 14, 2006
2J1D
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BU of 2j1d by Molmil
Crystallization of hDaam1 C-terminal Fragment
Descriptor: DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 1, GLYCEROL, PHOSPHATE ION
Authors:Lu, J, Meng, W, Poy, F, Eck, M.J.
Deposit date:2006-08-10
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Fh2 Domain of Daam1: Implications for Formin Regulation of Actin Assembly.
J.Mol.Biol., 369, 2007
1EG3
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BU of 1eg3 by Molmil
STRUCTURE OF A DYSTROPHIN WW DOMAIN FRAGMENT IN COMPLEX WITH A BETA-DYSTROGLYCAN PEPTIDE
Descriptor: DYSTROPHIN
Authors:Huang, X, Poy, F, Zhang, R, Joachimiak, A, Sudol, M, Eck, M.J.
Deposit date:2000-02-11
Release date:2000-08-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.
Nat.Struct.Biol., 7, 2000
1EG4
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BU of 1eg4 by Molmil
STRUCTURE OF A DYSTROPHIN WW DOMAIN FRAGMENT IN COMPLEX WITH A BETA-DYSTROGLYCAN PEPTIDE
Descriptor: BETA-DYSTROGLYCAN, DYSTROPHIN
Authors:Huang, X, Poy, F, Zhang, R, Joachimiak, A, Sudol, M, Eck, M.J.
Deposit date:2000-02-11
Release date:2000-08-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.
Nat.Struct.Biol., 7, 2000
2AEH
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BU of 2aeh by Molmil
Focal adhesion kinase 1
Descriptor: Focal adhesion kinase 1
Authors:Ceccarelli, D.F, Song, H.K, Poy, F, Schaller, M.D, Eck, M.J.
Deposit date:2005-07-22
Release date:2005-10-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem., 281, 2006
2AL6
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BU of 2al6 by Molmil
FERM domain of Focal Adhesion Kinase
Descriptor: Focal adhesion kinase 1
Authors:Ceccarelli, D.F, Song, H.K, Poy, F, Schaller, M.D, Eck, M.J.
Deposit date:2005-08-04
Release date:2005-10-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem., 281, 2006
1LAR
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BU of 1lar by Molmil
CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP LAR
Descriptor: PROTEIN (LAR)
Authors:Nam, H.-J, Poy, F, Krueger, N, Saito, H, Frederick, C.A.
Deposit date:1999-04-20
Release date:2000-04-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the tandem phosphatase domains of RPTP LAR.
Cell(Cambridge,Mass.), 97, 1999
1L3E
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BU of 1l3e by Molmil
NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex
Descriptor: ZINC ION, hypoxia inducible factor-1 alpha subunit, p300 protein
Authors:Freedman, S.J, Sun, Z.J, Poy, F, Kung, A.L, Livingston, D.M, Wagner, G, Eck, M.J.
Deposit date:2002-02-26
Release date:2002-04-24
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
Proc.Natl.Acad.Sci.USA, 99, 2002
1M27
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BU of 1m27 by Molmil
Crystal structure of SAP/FynSH3/SLAM ternary complex
Descriptor: CITRATE ANION, Proto-oncogene tyrosine-protein kinase FYN, SH2 domain protein 1A, ...
Authors:Chan, B, Griesbach, J, Song, H.K, Poy, F, Terhorst, C, Eck, M.J.
Deposit date:2002-06-21
Release date:2003-05-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:SAP couples Fyn to SLAM immune receptors.
NAT.CELL BIOL., 5, 2003
5I1Q
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BU of 5i1q by Molmil
Second bromodomain of TAF1 bound to a pyrrolopyridone compound
Descriptor: 3-[6-(but-3-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl]-N,N-dimethylbenzamide, Transcription initiation factor TFIID subunit 1
Authors:Tang, Y, Poy, F, Bellon, S.F.
Deposit date:2016-01-09
Release date:2016-06-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
J.Med.Chem., 59, 2016
5I29
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BU of 5i29 by Molmil
TAF1(2) bound to a pyrrolopyridone compound
Descriptor: CALCIUM ION, N,N-dimethyl-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide, Transcription initiation factor TFIID subunit 1
Authors:Tang, Y, Poy, F, Bellon, S.F.
Deposit date:2016-02-08
Release date:2016-06-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
J.Med.Chem., 59, 2016
1UX4
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BU of 1ux4 by Molmil
Crystal structures of a Formin Homology-2 domain reveal a tethered-dimer architecture
Descriptor: BNI1 PROTEIN
Authors:Xu, Y, Moseley, J.B, Sagot, I, Poy, F, Pellman, D, Goode, B.L, Eck, M.J.
Deposit date:2004-02-19
Release date:2004-03-11
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal Structures of a Formin Homology-2 Domain Reveal a Tethered Dimer Architecture
Cell(Cambridge,Mass.), 116, 2004

 

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