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7OTS
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BU of 7ots by Molmil
Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside
Descriptor: GLYCEROL, Monoacylglycerol lipase ABHD6, OLEIC ACID, ...
Authors:Nawrotek, A, Talagas, A, Vuillard, L, Miallau, L.
Deposit date:2021-06-10
Release date:2021-06-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside
To Be Published
6FNE
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BU of 6fne by Molmil
Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain
Descriptor: (2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one, IQ motif and SEC7 domain-containing protein 1, NONAETHYLENE GLYCOL
Authors:Nawrotek, A, Zeghouf, M, Cherfils, J.
Deposit date:2018-02-03
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.
Nat.Chem.Biol., 15, 2019
8QEL
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BU of 8qel by Molmil
PKR kinase domain- eIF2alpha in complex with compound
Descriptor: (3~{Z})-3-[(4-methyl-1~{H}-imidazol-5-yl)methylidene]-2-oxidanylidene-1~{H}-indole-5-carboxamide, Eukaryotic translation initiation factor 2 subunit alpha, Interferon-induced, ...
Authors:Nawrotek, A, Vuillard, L, Miallau, L.
Deposit date:2023-08-31
Release date:2023-09-13
Method:X-RAY DIFFRACTION (2.451 Å)
Cite:PKR kinase domain- eIF2alpha in complex with compound
To Be Published
4P3Z
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BU of 4p3z by Molmil
Chlamydia pneumoniae CopN (D29 construct)
Descriptor: CopN, GLYCEROL, SULFATE ION
Authors:Nawrotek, A, Guimaraes, B.G, Knossow, M, Gigant, B.
Deposit date:2014-03-10
Release date:2014-07-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Biochemical and Structural Insights into Microtubule Perturbation by CopN from Chlamydia pneumoniae.
J.Biol.Chem., 289, 2014
4P40
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BU of 4p40 by Molmil
Chlamydia pneumoniae CopN
Descriptor: CHLORIDE ION, CopN, DIMETHYLAMINE, ...
Authors:Nawrotek, A, Guimaraes, B.G, Knossow, M, Gigant, B.
Deposit date:2014-03-10
Release date:2014-07-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Biochemical and Structural Insights into Microtubule Perturbation by CopN from Chlamydia pneumoniae.
J.Biol.Chem., 289, 2014
8AXZ
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BU of 8axz by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with S-adenosylmethionine, adenosin and diphosphono-aminophosphonic acid.
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, ADENOSINE, DI(HYDROXYETHYL)ETHER, ...
Authors:Nawrotek, A, Vuillard, L, Miallau, L.
Deposit date:2022-09-01
Release date:2022-10-05
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.154 Å)
Cite:Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with S-adenosylmethionine, adenosin and diphosphono-aminophosphonic acid.
To Be Published
8B2J
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BU of 8b2j by Molmil
Crystal structure of human STING in complex with ADU-S100
Descriptor: (1~{R},3~{S},6~{R},8~{R},9~{R},10~{S},12~{S},15~{R},17~{R},18~{R})-8,17-bis(6-aminopurin-9-yl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecane-9,18-diol, CALCIUM ION, SODIUM ION, ...
Authors:Nawrotek, A, Vuillard, L, Miallau, L.
Deposit date:2022-09-14
Release date:2022-11-30
Method:X-RAY DIFFRACTION (2.174 Å)
Cite:Crystal structure of human STING in complex with ADU-S100
To Be Published
7AYM
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BU of 7aym by Molmil
Structure of DDR2 Kinase domain in complex with IBZ3
Descriptor: Discoidin domain-containing receptor 2,Epithelial discoidin domain-containing receptor 1, N-[5-({[(3-fluorophenyl)carbamoyl]amino}methyl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide
Authors:Nawrotek, A, Talagas, A, Vuillard, L.M, Miallau, L.
Deposit date:2020-11-12
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structure of DDR2 Kinase domain in complex with IBZ3
To Be Published
3RYI
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BU of 3ryi by Molmil
GDP-Tubulin: rb3 stathmin-like domain complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nawrotek, A, Knossow, M, Gigant, B.
Deposit date:2011-05-11
Release date:2011-10-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin.
J.Mol.Biol., 412, 2011
3RYC
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BU of 3ryc by Molmil
Tubulin: RB3 stathmin-like domain complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nawrotek, A, Knossow, M, Gigant, B.
Deposit date:2011-05-11
Release date:2011-10-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin.
J.Mol.Biol., 412, 2011
3RYF
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BU of 3ryf by Molmil
GTP-Tubulin: RB3 Stathmin-like domain complex
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ...
Authors:Nawrotek, A, Knossow, M, Gigant, B.
Deposit date:2011-05-11
Release date:2011-10-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin.
J.Mol.Biol., 412, 2011
3RYH
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BU of 3ryh by Molmil
GMPCPP-Tubulin: RB3 Stathmin-like domain complex
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Nawrotek, A, Knossow, M, Gigant, B.
Deposit date:2011-05-11
Release date:2011-10-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin.
J.Mol.Biol., 412, 2011
7Z4V
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BU of 7z4v by Molmil
Structure of Serine-Threonine kinase STK25 in complex with compound
Descriptor: 1,2-ETHANEDIOL, Serine/threonine-protein kinase 25, ~{N}-(5-~{tert}-butyl-1~{H}-pyrazol-3-yl)-4-pyrrolidin-1-ylsulfonyl-benzamide
Authors:Nawrotek, A, Vuillard, L, Miallau, L.
Deposit date:2022-03-04
Release date:2022-04-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.644 Å)
Cite:Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25.
Bioorg.Med.Chem.Lett., 75, 2022
8A66
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BU of 8a66 by Molmil
Crystal structure of MST2 in complex with XMU-MP-1
Descriptor: 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, SODIUM ION, Serine/threonine-protein kinase 3 36kDa subunit
Authors:Nawrotek, A, Vuillard, L, Miallau, L, Weber, C.
Deposit date:2022-06-16
Release date:2022-07-20
Last modified:2022-12-07
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Crystal structure of the Kelch domain of human Keap1in complex with ligand S217879
To Be Published
5NLV
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BU of 5nlv by Molmil
Brag2 Sec7-PH (390-763)
Descriptor: IQ motif and SEC7 domain-containing protein 1
Authors:Nawrotek, A, Cherfils, J.
Deposit date:2017-04-05
Release date:2017-09-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NLY
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BU of 5nly by Molmil
Brag2 Sec7-PH (390-763), P212121
Descriptor: IQ motif and SEC7 domain-containing protein 1, PHOSPHATE ION
Authors:Nawrotek, A, Cherfils, J.
Deposit date:2017-04-05
Release date:2017-09-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4UX8
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BU of 4ux8 by Molmil
RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF FAMILY RECEPTOR ALPHA-1, ...
Authors:Goodman, K, Kjaer, S, Beuron, F, Knowles, P, Nawrotek, A, Burns, E, Purkiss, A, George, R, Santoro, M, Morris, E.P, McDonald, N.Q.
Deposit date:2014-08-19
Release date:2014-10-01
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (24 Å)
Cite:Ret Recognition of Gdnf-Gfralpha1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association.
Cell Rep., 8, 2014
7AZB
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BU of 7azb by Molmil
Structure of DDR2 DS domain in complex with VHH
Descriptor: Discoidin domain-containing receptor 2, VHH
Authors:Talagas, A, Nawrotek, A, Arrial, A, Vuillard, L.M, Miallau, L.
Deposit date:2020-11-16
Release date:2020-11-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure of DDR2 DS domain in complex with VHH
To Be Published
8A5J
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BU of 8a5j by Molmil
Crystal structure of Human STE20-like kinase 1, MST1 in complex with compound XMU-MP-1
Descriptor: 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, Serine/threonine-protein kinase 4 37kDa subunit
Authors:Nawrotek, A, Vuillard, L, Miallau, L.
Deposit date:2022-06-15
Release date:2022-07-13
Method:X-RAY DIFFRACTION (2.123 Å)
Cite:Crystal structure of the Kelch domain of human Keap1in complex with ligand S217879
To Be Published
7AMK
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BU of 7amk by Molmil
Zebrafish RET Cadherin Like Domains 1 to 4.
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Purkiss, A.G, McDonald, N.Q, Goodman, K.M, Narowtek, A, Knowles, P.P.
Deposit date:2020-10-09
Release date:2021-02-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
7AB8
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BU of 7ab8 by Molmil
Crystal structure of a GDNF-GFRalpha1 complex
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q.
Deposit date:2020-09-07
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
7AML
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BU of 7aml by Molmil
RET/GDNF/GFRa1 extracellular complex Cryo-EM structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha, ...
Authors:Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q.
Deposit date:2020-10-09
Release date:2021-01-13
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
6U3E
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BU of 6u3e by Molmil
Best fitting antiparallel model for Volume 1 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)
Descriptor: Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Das, S, Lambright, D.G.
Deposit date:2019-08-21
Release date:2019-09-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (53 Å)
Cite:Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.
Structure, 27, 2019
6U3G
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BU of 6u3g by Molmil
Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)
Descriptor: Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Das, S, Lambright, D.G.
Deposit date:2019-08-21
Release date:2019-09-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (53 Å)
Cite:Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.
Structure, 27, 2019

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