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1ABO
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BU of 1abo by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF THE ABL TYROSINE KINASE SH3 DOMAIN WITH 3BP-1 SYNTHETIC PEPTIDE
Descriptor: 3BP-1 SYNTHETIC PEPTIDE, 10 RESIDUES, ABL TYROSINE KINASE, ...
Authors:Musacchio, A, Wilmanns, M, Saraste, M.
Deposit date:1995-05-19
Release date:1995-10-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Nat.Struct.Biol., 1, 1994
1ABQ
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BU of 1abq by Molmil
CRYSTAL STRUCTURE OF THE UNLIGANDED ABL TYROSINE KINASE SH3 DOMAIN
Descriptor: ABL TYROSINE KINASE SRC-HOMOLOGY 3 (SH3) DOMAIN
Authors:Musacchio, A, Wilmanns, M, Saraste, M.
Deposit date:1995-05-19
Release date:1995-10-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Nat.Struct.Biol., 1, 1994
1PBW
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BU of 1pbw by Molmil
STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE
Authors:Musacchio, A, Cantley, L.C, Harrison, S.C.
Deposit date:1996-10-17
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.
Proc.Natl.Acad.Sci.USA, 93, 1996
1FYN
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BU of 1fyn by Molmil
PHOSPHOTRANSFERASE
Descriptor: 3BP-2, PHOSPHOTRANSFERASE FYN
Authors:Musacchio, A, Saraste, M, Wilmanns, M.
Deposit date:1995-05-17
Release date:1996-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Nat.Struct.Biol., 1, 1994
1SHG
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BU of 1shg by Molmil
CRYSTAL STRUCTURE OF A SRC-HOMOLOGY 3 (SH3) DOMAIN
Descriptor: ALPHA-SPECTRIN SH3 DOMAIN
Authors:Noble, M, Pauptit, R, Musacchio, A, Saraste, M, Wierenga, R.K.
Deposit date:1993-05-19
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a Src-homology 3 (SH3) domain.
Nature, 359, 1992
8Q5H
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BU of 8q5h by Molmil
Human KMN network (outer kinetochore)
Descriptor: Kinetochore protein Spc24, Kinetochore protein Spc25, Kinetochore scaffold 1, ...
Authors:Raisch, T, Polley, S, Vetter, I, Musacchio, A, Raunser, S.
Deposit date:2023-08-09
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Insights into human outer kinetochore assembly and force transmission from a structure-function analysis of the KMN network
To Be Published
7QPG
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BU of 7qpg by Molmil
Human RZZ kinetochore corona complex.
Descriptor: Centromere/kinetochore protein zw10 homolog, Kinetochore-associated protein 1, Protein zwilch homolog
Authors:Raisch, T, Ciossani, G, d'Amico, E, Cmetowski, V, Carmignani, S, Maffini, S, Merino, F, Wohlgemuth, S, Vetter, I.R, Raunser, S, Musacchio, A.
Deposit date:2022-01-04
Release date:2022-03-16
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores.
Embo J., 41, 2022
5DMZ
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BU of 5dmz by Molmil
Structure of human Bub1 kinase domain phosphorylated at Ser969
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitotic checkpoint serine/threonine-protein kinase BUB1
Authors:Breit, C, Weir, J.R, Musacchio, A.
Deposit date:2015-09-09
Release date:2015-12-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1.
Plos One, 10, 2015
6C0W
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BU of 6c0w by Molmil
Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing CENP-A
Descriptor: 147 mer DNA, Centromere protein N, Histone H2A, ...
Authors:Zhou, K, Pentakota, S, Vetter, I.R, Morgan, G.P, Petrovic, A, Musacchio, A, Luger, K.
Deposit date:2018-01-02
Release date:2018-01-17
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Decoding the centromeric nucleosome through CENP-N.
Elife, 6, 2017
1BPO
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BU of 1bpo by Molmil
CLATHRIN HEAVY-CHAIN TERMINAL DOMAIN AND LINKER
Descriptor: PROTEIN (CLATHRIN)
Authors:Harr, E.T, Musacchio, A, Harrison, S.C, Kirchhausen, T.
Deposit date:1998-08-11
Release date:1998-12-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.
Cell(Cambridge,Mass.), 95, 1998
6EQT
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BU of 6eqt by Molmil
CRYSTAL STRUCTURE OF THE HUMAN KINETOCHORE PROTEIN CENP-N
Descriptor: Centromere protein N
Authors:Pentakota, S, Vetter, I.R, Petrovic, A, Musacchio, A.
Deposit date:2017-10-15
Release date:2018-01-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.735 Å)
Cite:Decoding the centromeric nucleosome through CENP-N.
Elife, 6, 2017
3IF8
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BU of 3if8 by Molmil
Crystal Structure of ZWILCH, a member of the RZZ kinetochore complex
Descriptor: Protein zwilch homolog
Authors:Wehenkel, A, Civril, F, Musacchio, A.
Deposit date:2009-07-24
Release date:2010-06-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.
Structure, 18, 2010
3ZTX
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BU of 3ztx by Molmil
Aurora kinase selective inhibitors identified using a Taxol-induced checkpoint sensitivity screen.
Descriptor: 2-((4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL)AMINO)-5,11-DIMETHYL-5H-BENZO[E]PYRIMIDO [5,4-B][1,4]DIAZEPIN-6(11H)-ONE, INNER CENTROMERE PROTEIN A, SERINE/THREONINE-PROTEIN KINASE 12-A
Authors:Kwiatkowski, N, Villa, F, Musacchio, A, Gray, N.
Deposit date:2011-07-12
Release date:2012-02-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Selective Aurora Kinase Inhibitors Identified Using a Taxol- Induced Checkpoint Sensitivity Screen.
Acs Chem.Biol., 7, 2012
4NFA
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BU of 4nfa by Molmil
Structure of the C-terminal doamin of Knl1
Descriptor: CHLORIDE ION, GLYCEROL, Protein CASC5
Authors:Petrovic, A, Mosalaganti, S, Keller, J, Mattiuzzo, M, Overlack, K, Wohlgemuth, S, Pasqualato, S, Raunser, S, Musacchio, A.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization.
Mol.Cell, 53, 2014
4NF9
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BU of 4nf9 by Molmil
Structure of the Knl1/Nsl1 complex
Descriptor: CHLORIDE ION, Kinetochore-associated protein NSL1 homolog, Protein CASC5
Authors:Petrovic, A, Mosalaganti, S, Keller, J, Mattiuzzo, M, Overlack, K, Wohlgemuth, S, Pasqualato, S, Raunser, S, Musacchio, A.
Deposit date:2013-10-31
Release date:2014-03-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization.
Mol.Cell, 53, 2014
4P0T
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BU of 4p0t by Molmil
Crystal structure of human centromere protein M
Descriptor: Centromere protein M, GLYCEROL
Authors:Basilico, F, Pasqualato, S, Musacchio, A.
Deposit date:2014-02-22
Release date:2014-07-09
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (1.493 Å)
Cite:The pseudo GTPase CENP-M drives human kinetochore assembly.
Elife, 3, 2014
4A1G
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BU of 4a1g by Molmil
The crystal structure of the human Bub1 TPR domain in complex with the KI motif of Knl1
Descriptor: MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1, PROTEIN CASC5
Authors:Krenn, V, Wehenkel, A, Li, X, Santaguida, S, Musacchio, A.
Deposit date:2011-09-15
Release date:2012-02-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Analysis Reveals Features of the Spindle Checkpoint Kinase Bub1-Kinetochore Subunit Knl1 Interaction.
J.Cell Biol., 196, 2012
4BL0
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BU of 4bl0 by Molmil
Crystal structure of yeast Bub3-Bub1 bound to phospho-Spc105
Descriptor: CELL CYCLE ARREST PROTEIN BUB3, CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1, MAGNESIUM ION, ...
Authors:Primorac, I, Weir, J.R, Musacchio, A.
Deposit date:2013-04-30
Release date:2013-09-18
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Bub3 Reads Phosphorylated Melt Repeats to Promote Spindle Assembly Checkpoint Signaling
Elife, 2, 2013
3IZ0
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BU of 3iz0 by Molmil
Human Ndc80 Bonsai Decorated Microtubule
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Alushin, G.M, Ramey, V.H, Pasqualato, S, Ball, D.A, Grigorieff, N, Musacchio, A, Nogales, E.
Deposit date:2010-08-09
Release date:2010-10-13
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (8.6 Å)
Cite:The Ndc80 kinetochore complex forms oligomeric arrays along microtubules.
Nature, 467, 2010
1H4L
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BU of 1h4l by Molmil
Structure and regulation of the CDK5-p25(nck5a) complex
Descriptor: CELL DIVISION PROTEIN KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR
Authors:Tarricone, C, Dhavan, R, Peng, J, Areces, L.B, Tsai, L.-H, Musacchio, A.
Deposit date:2001-05-11
Release date:2002-08-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure and Regulation of the Cdk5-P25(Nck5A) Complex
Mol.Cell, 8, 2001
1GO4
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BU of 1go4 by Molmil
Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20.
Descriptor: Mitotic spindle assembly checkpoint protein MAD1, Mitotic spindle assembly checkpoint protein MAD2A
Authors:Sironi, L, Mapelli, M, Jeang, K.T, Musacchio, A.
Deposit date:2001-10-17
Release date:2002-05-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.
EMBO J., 21, 2002
2WB8
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BU of 2wb8 by Molmil
Crystal structure of Haspin kinase
Descriptor: SERINE/THREONINE-PROTEIN KINASE HASPIN
Authors:Villa, F, Tortorci, M, Forneris, F, Mattevi, A, Musacchio, A.
Deposit date:2009-02-23
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of the Catalytic Domain of Haspin, an Atypical Kinase Implicated in Chromatin Organization.
Proc.Natl.Acad.Sci.USA, 106, 2009
2VE7
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BU of 2ve7 by Molmil
Crystal structure of a bonsai version of the human Ndc80 complex
Descriptor: GLYCEROL, KINETOCHORE PROTEIN HEC1, KINETOCHORE PROTEIN SPC25, ...
Authors:Ciferri, C, Pasqualato, S, Dos Reis, G, Screpanti, E, Maiolica, A, Polka, J, De Luca, J.G, De Wulf, P, Salek, M, Rappsilber, J, Moores, C.A, Salmon, E.D, Musacchio, A.
Deposit date:2007-10-17
Release date:2008-05-13
Last modified:2022-05-04
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex
Cell(Cambridge,Mass.), 133, 2008
2BFY
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BU of 2bfy by Molmil
Complex of Aurora-B with INCENP and Hesperadin.
Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE
Authors:Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005
2BFX
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BU of 2bfx by Molmil
Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A
Authors:Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005

 

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