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4TNT
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BU of 4tnt by Molmil
Structure of the human mineralocorticoid receptor in complex with DNA
Descriptor: DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), Mineralocorticoid receptor, ...
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2014-06-04
Release date:2014-09-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3938 Å)
Cite:Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.
Plos One, 9, 2014
4MCE
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BU of 4mce by Molmil
Crystal structure of the Gas5 GRE Mimic
Descriptor: Gas5 GREM Fwd, Gas5 GREM Rev, SULFATE ION
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2013-08-21
Release date:2014-09-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
Nat Commun, 5, 2014
4MCF
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BU of 4mcf by Molmil
Crystal structure of the Gas5 GRE Mimic
Descriptor: Gas5 GREM Fwd, Gas5 GREM Rev, SULFATE ION
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2013-08-21
Release date:2014-11-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
Nat Commun, 5, 2014
5CC1
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BU of 5cc1 by Molmil
S425G Glucocorticoid receptor DNA binding domain - (+)GRE complex
Descriptor: DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Weikum, E.A, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBX
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BU of 5cbx by Molmil
AncGR DNA Binding Domain - (+)GRE Complex
Descriptor: AncGR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBY
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BU of 5cby by Molmil
AncGR2 DNA Binding Domain - (+)GRE Complex
Descriptor: AncGR2 DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBZ
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BU of 5cbz by Molmil
AncMR DNA Binding Domain - (+)GRE Complex
Descriptor: AncMR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CC0
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BU of 5cc0 by Molmil
AncSR2 - TSLP nGRE complex
Descriptor: AncSR2 DNA Binding Domain, DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), ...
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5E6A
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BU of 5e6a by Molmil
Glucocorticoid receptor DNA binding domain - PLAU NF-kB response element complex
Descriptor: DNA (5'-D(*AP*TP*CP*AP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*TP*GP*AP*T)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E69
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BU of 5e69 by Molmil
Glucocorticoid receptor DNA binding domain - IL8 NF-kB response element complex
Descriptor: DNA (5'-D(*AP*TP*CP*GP*TP*GP*GP*AP*AP*TP*TP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*AP*AP*TP*TP*CP*CP*AP*CP*GP*AP*T)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E6D
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BU of 5e6d by Molmil
Glucocorticoid receptor DNA binding domain - ICAM1 NF-kB response element complex
Descriptor: DNA (5'-D(*GP*CP*TP*CP*CP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*GP*GP*AP*GP*C)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E6C
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BU of 5e6c by Molmil
Glucocorticoid receptor DNA binding domain - CCL2 NF-kB response element complex
Descriptor: DNA (5'-D(*AP*GP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*CP*T)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E6B
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BU of 5e6b by Molmil
Glucocorticoid receptor DNA binding domain - RELB NF-kB response element complex
Descriptor: DNA (5'-D(*CP*CP*GP*GP*GP*GP*AP*AP*TP*TP*CP*CP*GP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*CP*GP*GP*AP*AP*TP*TP*CP*CP*CP*CP*GP*G)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
4HN6
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BU of 4hn6 by Molmil
GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex
Descriptor: DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Youn, C.E, Ortlund, E.A.
Deposit date:2012-10-18
Release date:2012-12-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.549 Å)
Cite:The structural basis of direct glucocorticoid-mediated transrepression.
Nat.Struct.Mol.Biol., 20, 2013
4HN5
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BU of 4hn5 by Molmil
GR DNA Binding Domain - TSLP nGRE Complex
Descriptor: DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Youn, C.E, Ortlund, E.A.
Deposit date:2012-10-18
Release date:2012-12-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:The structural basis of direct glucocorticoid-mediated transrepression.
Nat.Struct.Mol.Biol., 20, 2013
5VA0
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BU of 5va0 by Molmil
Glucocorticoid Receptor DNA Binding Domain in complex with AP-1 response element from VCAM-1 Promoter
Descriptor: DNA (5'-D(*CP*GP*GP*CP*TP*GP*AP*CP*TP*CP*AP*TP*CP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*GP*AP*TP*GP*AP*GP*TP*CP*AP*GP*CP*CP*G)-3'), Glucocorticoid receptor, ...
Authors:Weikum, E.R, Ortlund, E.A.
Deposit date:2017-03-24
Release date:2017-08-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Nucleic Acids Res., 45, 2017
5VA7
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BU of 5va7 by Molmil
Glucocorticoid Receptor DNA Binding Domain - IL11 AP-1 recognition element Complex
Descriptor: DNA (5'-D(*AP*GP*GP*GP*TP*GP*AP*GP*TP*CP*AP*GP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*CP*TP*GP*AP*CP*TP*CP*AP*CP*CP*CP*T)-3'), Glucocorticoid receptor, ...
Authors:Weikum, E.R, Ortlund, E.A.
Deposit date:2017-03-24
Release date:2017-08-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Nucleic Acids Res., 45, 2017
4DOR
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BU of 4dor by Molmil
Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, in its apo State Bound to a Fragment of Human SHP Box1
Descriptor: L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, Nuclear receptor subfamily 0 group B member 2, Nuclear receptor subfamily 5 group A member 2
Authors:Musille, P.M, Ortlund, E.A.
Deposit date:2012-02-10
Release date:2012-04-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
Nat.Struct.Mol.Biol., 19, 2012
4DOS
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BU of 4dos by Molmil
Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to DLPC and a Fragment of TIF-2
Descriptor: DIUNDECYL PHOSPHATIDYL CHOLINE, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2, ...
Authors:Musille, P.M, Ortlund, E.A.
Deposit date:2012-02-10
Release date:2012-04-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
Nat.Struct.Mol.Biol., 19, 2012

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PDB entries from 2024-03-27

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