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5TGE
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BU of 5tge by Molmil
Thermus Phage P74-26 Large Terminase Nuclease Domain
Descriptor: Phage terminase large subunit
Authors:Hilbert, B.J, Hayes, J.A, Stone, N.P, Kelch, B.A.
Deposit date:2016-09-27
Release date:2017-01-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain.
Nucleic Acids Res., 45, 2017
4ZNI
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BU of 4zni by Molmil
Thermus Phage P74-26 Large Terminase ATPase domain (I 2 3 space group)
Descriptor: Phage terminase large subunit, SULFATE ION
Authors:Hilbert, B.J, Hayes, J.A, Stone, N.P, Duffy, C.M, Sankaran, B, Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZNL
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BU of 4znl by Molmil
Thermus Phage P74-26 Large Terminase ATPase domain bound to ADP Beryllium Fluoride
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Hilbert, B.J, Hayes, J.A, Stone, N.P, Duffy, C.M, Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.068 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZNJ
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BU of 4znj by Molmil
Thermus Phage P74-26 Large Terminase ATPase domain mutant R139A (I 2 3 space group)
Descriptor: Phage terminase large subunit, SULFATE ION
Authors:Hilbert, B.J, Hayes, J.A, Stone, N.P, Duffy, C.M, Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.532 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZNK
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BU of 4znk by Molmil
Thermus Phage P74-26 Large Terminase ATPase domain from (P 32 2 1 space group)
Descriptor: Phage terminase large subunit, SULFATE ION
Authors:Hilbert, B.J, Hayes, J.A, Stone, N.P, Duffy, C.M, Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.931 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
4LCE
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BU of 4lce by Molmil
CtBP1 in complex with substrate MTOB
Descriptor: 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID, C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hilbert, B.J, Schiffer, C.A, Royer Jr, W.E.
Deposit date:2013-06-21
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Febs Lett., 588, 2014
4LCJ
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BU of 4lcj by Molmil
CtBP2 in complex with substrate MTOB
Descriptor: 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID, C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hilbert, B.J, Schiffer, C.A, Royer Jr, W.E.
Deposit date:2013-06-21
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Febs Lett., 588, 2014
4U6S
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BU of 4u6s by Molmil
CtBP1 in complex with substrate phenylpyruvate
Descriptor: 3-PHENYLPYRUVIC ACID, C-terminal-binding protein 1, CALCIUM ION, ...
Authors:Hilbert, B.J, Morris, B.L, Ellis, K.C, Paulsen, J.L, Schiffer, C.A, Grossman, S.R, Royer Jr, W.E.
Deposit date:2014-07-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Guided Design of a High Affinity Inhibitor to Human CtBP.
Acs Chem.Biol., 10, 2015
4U6Q
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BU of 4u6q by Molmil
CtBP1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid
Descriptor: (2E)-2-(hydroxyimino)-3-phenylpropanoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C-terminal-binding protein 1, ...
Authors:Hilbert, B.J, Morris, B.L, Ellis, K.C, Paulsen, J.L, Schiffer, C.A, Grossman, S.R, Royer Jr, W.E.
Deposit date:2014-07-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Guided Design of a High Affinity Inhibitor to Human CtBP.
Acs Chem.Biol., 10, 2015
7KS4
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BU of 7ks4 by Molmil
Thermus Phage P74-26 Large Terminase ATPase domain with partially bound ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phage terminase large subunit, ...
Authors:Hilbert, B.J, Kelch, B.A.
Deposit date:2020-11-20
Release date:2021-05-05
Method:X-RAY DIFFRACTION (1.887 Å)
Cite:Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation.
Proc.Natl.Acad.Sci.USA, 118, 2021
6BL5
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BU of 6bl5 by Molmil
Head decoration protein from the hyperthermophilic phage P74-26
Descriptor: Head decoration protein
Authors:Stone, N.P, Hilbert, B.J, Hidalgo, D, Halloran, K.T, Kelch, B.A.
Deposit date:2017-11-09
Release date:2018-02-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein.
Structure, 26, 2018
6V1I
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BU of 6v1i by Molmil
Cryo-EM reconstruction of the thermophilic bacteriophage P74-26 small terminase- symmetric
Descriptor: Small terminase protein
Authors:Hayes, J.A, Hilbert, B.J, Gaubitz, C, Stone, N.P, Kelch, B.A.
Deposit date:2019-11-20
Release date:2020-02-12
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry.
J.Biol.Chem., 295, 2020
5KEG
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BU of 5keg by Molmil
Crystal structure of APOBEC3A in complex with a single-stranded DNA
Descriptor: CALCIUM ION, CHLORIDE ION, DNA (5'-D(*TP*TP*CP*TP*T)-3'), ...
Authors:Kouno, T, Hilbert, B.J, Silvas, T, Royer, W.E, Matsuo, H, Schiffer, C.A.
Deposit date:2016-06-09
Release date:2017-05-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Nat Commun, 8, 2017
5E0U
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BU of 5e0u by Molmil
Human PCNA variant (S228I) complexed with p21 at 1.9 Angstroms
Descriptor: Cyclin-dependent kinase inhibitor 1, Proliferating cell nuclear antigen
Authors:Duffy, C.M, Hilbert, B.J, Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
5E0V
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BU of 5e0v by Molmil
Human PCNA variant (S228I) complexed with FEN1 at 2.1 Angstroms
Descriptor: Flap endonuclease 1, Proliferating cell nuclear antigen
Authors:Duffy, C.M, Hilbert, B.J, Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.074 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
5E0T
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BU of 5e0t by Molmil
Human PCNA mutant - S228I
Descriptor: Proliferating cell nuclear antigen
Authors:Duffy, C.M, Hilbert, B.J, Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6653 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
8TDU
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BU of 8tdu by Molmil
STX-478, a Mutant-Selective, Allosteric Inhibitor bound to PI3Kalpha
Descriptor: N-(2-aminopyrimidin-5-yl)-N'-[(1R)-1-(5,7-difluoro-3-methyl-1-benzofuran-2-yl)-2,2,2-trifluoroethyl]urea, N~2~-{(4S,11aP)-2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-alaninamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, ...
Authors:Hilbert, B.J, Brooijmans, N, Buckbinder, L, St.Jean Jr, D.J.
Deposit date:2023-07-05
Release date:2023-09-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:STX-478, a Mutant-Selective, Allosteric PI3K alpha Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3K alpha-Mutant Xenografts.
Cancer Discov, 13, 2023

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PDB entries from 2024-03-27

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