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4KMC
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BU of 4kmc by Molmil
Structure analysis of M. Tuberculosis rRNA transcriptional regulator CarD and its interaction with T. Aquaticus RNA polymerase-BETA1 domain
Descriptor: RNA polymerase-binding transcription factor CarD
Authors:Gangwar, S.P, Meena, S.R, Saxena, A.K.
Deposit date:2013-05-08
Release date:2014-02-19
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the carboxy-terminal domain of Mycobacterium tuberculosis CarD protein: an essential rRNA transcriptional regulator.
Acta Crystallogr.,Sect.F, 70, 2014
4NDW
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BU of 4ndw by Molmil
Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR)
Descriptor: Nucleoid-associated protein EspR
Authors:Gangwar, S.P, Meena, S.R, Saxena, A.K.
Deposit date:2013-10-28
Release date:2014-04-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Comparison of four different crystal forms of the Mycobacterium tuberculosis ESX-1 secreted protein regulator EspR
Acta Crystallogr.,Sect.F, 70, 2014
6VEA
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BU of 6vea by Molmil
Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Glycine
Descriptor: BETA-MERCAPTOETHANOL, GLYCINE, Glutamate receptor 3.2, ...
Authors:Gangwar, S.P, Green, M.N, Yoder, J.B, Sobolevsky, A.I.
Deposit date:2019-12-30
Release date:2020-09-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain.
Structure, 29, 2021
6VE8
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BU of 6ve8 by Molmil
Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain in complex with Methionine
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, GLYCEROL, ...
Authors:Gangwar, S.P, Green, M.N, Yoder, J.B, Sobolevsky, A.I.
Deposit date:2019-12-30
Release date:2020-09-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain.
Structure, 29, 2021
5V5V
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BU of 5v5v by Molmil
Complex of NLGN2 with MDGA1 Ig1-Ig2
Descriptor: MAM domain-containing glycosylphosphatidylinositol anchor protein 1, Neuroligin-2
Authors:Gangwar, S.P, Machius, M, Rudenko, G.
Deposit date:2017-03-15
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.11 Å)
Cite:Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.
Neuron, 94, 2017
8FWQ
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BU of 8fwq by Molmil
Structure of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-01-23
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.
Cell Rep, 42, 2023
8FWV
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BU of 8fwv by Molmil
Structure of the amino-terminal domain of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and noncompetitive inhibitor perampanel
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-01-23
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.
Cell Rep, 42, 2023
8FWR
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BU of 8fwr by Molmil
Structure of the amino-terminal domain of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-01-23
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.
Cell Rep, 42, 2023
8FWW
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BU of 8fww by Molmil
Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and noncompetitive inhibitor perampanel
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-01-23
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.
Cell Rep, 42, 2023
8FWS
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BU of 8fws by Molmil
Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-01-23
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.
Cell Rep, 42, 2023
8SS8
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BU of 8ss8 by Molmil
Structure of AMPA receptor GluA2 complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, CHOLESTEROL, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
8SS9
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BU of 8ss9 by Molmil
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, CHOLESTEROL, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.72 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
8SS7
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BU of 8ss7 by Molmil
Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, CHOLESTEROL, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
8SS2
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BU of 8ss2 by Molmil
Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, Digitonin, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
8SS3
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BU of 8ss3 by Molmil
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, Digitonin, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
8SSA
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BU of 8ssa by Molmil
Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
8SS6
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BU of 8ss6 by Molmil
Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, CHOLESTEROL, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
8SSB
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BU of 8ssb by Molmil
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
5V5W
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BU of 5v5w by Molmil
Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges
Descriptor: MAM domain-containing glycosylphosphatidylinositol anchor protein 1, SULFATE ION
Authors:Machius, M, Gangwar, S.P, Rudenko, G.
Deposit date:2017-03-15
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.718 Å)
Cite:Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.
Neuron, 94, 2017
8FWU
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BU of 8fwu by Molmil
Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and competitive antagonist DNQX
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yen, L.Y, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-01-23
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.
Cell Rep, 42, 2023
8FWT
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BU of 8fwt by Molmil
Structure of the amino terminal domain of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and competitive antagonist DNQX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
Authors:Yen, L.Y, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-01-23
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.
Cell Rep, 42, 2023
8SS4
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BU of 8ss4 by Molmil
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 (apo state)
Descriptor: Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, Protein cornichon homolog 2, ...
Authors:Yen, L.Y, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
8SS5
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BU of 8ss5 by Molmil
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 (apo state)
Descriptor: Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, SODIUM ION
Authors:Yen, L.Y, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2023-05-08
Release date:2023-09-06
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Nat.Struct.Mol.Biol., 30, 2023
7RZ5
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BU of 7rz5 by Molmil
Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK 200775
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Gangwar, S.P, Klykov, O.V, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-27
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021
7RZA
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BU of 7rza by Molmil
Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 2
Authors:Gangwar, S.P, Klykov, O.V, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2021-08-27
Release date:2021-10-27
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.26 Å)
Cite:Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L.
Mol.Cell, 81, 2021

 

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