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1TNF
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BU of 1tnf by Molmil
THE STRUCTURE OF TUMOR NECROSIS FACTOR-ALPHA AT 2.6 ANGSTROMS RESOLUTION. IMPLICATIONS FOR RECEPTOR BINDING
Descriptor: TUMOR NECROSIS FACTOR-ALPHA
Authors:Eck, M.J, Sprang, S.R.
Deposit date:1989-08-25
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
J.Biol.Chem., 264, 1989
4K11
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BU of 4k11 by Molmil
The structure of 1NA in complex with Src T338G
Descriptor: 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
Authors:Eck, M.J, Yun, C.H.
Deposit date:2013-04-04
Release date:2014-04-09
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of 1NA in complex with Src T338G
To be Published
4WYB
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BU of 4wyb by Molmil
Structure of the Bud6 flank domain in complex with actin
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Eck, M.J, Park, E, Zheng, W.
Deposit date:2014-11-17
Release date:2015-08-19
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.493 Å)
Cite:Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.
Structure, 23, 2015
4ZJV
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BU of 4zjv by Molmil
crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
Descriptor: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor
Authors:Eck, M.J, Park, E, Lee, B.
Deposit date:2015-04-29
Release date:2015-08-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
8DGT
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BU of 8dgt by Molmil
Cryo-EM structure of a RAS/RAF complex (state 2)
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Eck, M.J, Jeon, H, Park, E, Rawson, S.
Deposit date:2022-06-24
Release date:2023-07-05
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
8DGS
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BU of 8dgs by Molmil
Cryo-EM structure of a RAS/RAF complex (state 1)
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Eck, M.J, Jeon, H, Park, E, Rawson, S.
Deposit date:2022-06-24
Release date:2023-07-05
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
5U1M
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BU of 5u1m by Molmil
Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor
Descriptor: Insulin receptor, Insulin receptor substrate 1
Authors:Eck, M.J, Dhe-Paganon, S.
Deposit date:2016-11-28
Release date:2017-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.
Nat Commun, 8, 2017
3O4X
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BU of 3o4x by Molmil
Crystal structure of complex between amino and carboxy terminal fragments of mDia1
Descriptor: Protein diaphanous homolog 1
Authors:Eck, M.J, Nezami, A, Toms, A.V.
Deposit date:2010-07-27
Release date:2010-10-13
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins.
Plos One, 5, 2010
1QZY
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BU of 1qzy by Molmil
Human Methionine Aminopeptidase in complex with bengamide inhibitor LAF153 and cobalt
Descriptor: (E)-(2R,3R,4S,5R)-3,4,5-TRIHYDROXY-2-METHOXY-8,8-DIMETHYL-NON-6-ENOIC ACID ((3S,6R)-6-HYDROXY-2-OXO-AZEPAN-3-YL)-AMIDE, COBALT (II) ION, Methionine aminopeptidase 2, ...
Authors:Eck, M.J, Song, H.K, Morollo, A.
Deposit date:2003-09-18
Release date:2003-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.
J.Biol.Chem., 278, 2003
4WD5
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BU of 4wd5 by Molmil
Crystal structure of EGFR 696-1022 T790M in complex with QL-X138
Descriptor: CHLORIDE ION, Epidermal growth factor receptor, N-{2-methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1(2H)-yl]phenyl}propanamide
Authors:Yun, C.H, Eck, M.J.
Deposit date:2014-09-07
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of EGFR 696-1022 T790M in complex with QL-X138
To Be Published
1B47
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BU of 1b47 by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70
Descriptor: CALCIUM ION, CBL
Authors:Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
Deposit date:1999-01-06
Release date:1999-04-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
8TJL
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BU of 8tjl by Molmil
EGFR kinase in complex with pyrazolopyrimidine covalent inhibitor
Descriptor: 1-{3-[(4-amino-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]azetidin-1-yl}propan-1-one, Epidermal growth factor receptor
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2023-07-22
Release date:2024-02-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases.
J.Med.Chem., 67, 2024
4Z16
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BU of 4z16 by Molmil
Crystal Structure of the Jak3 Kinase Domain Covalently Bound to N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide
Descriptor: N-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide, Tyrosine-protein kinase JAK3
Authors:McNally, R, Tan, L, Gray, N.S, Eck, M.J.
Deposit date:2015-03-26
Release date:2016-02-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Development of Selective Covalent Janus Kinase 3 Inhibitors.
J.Med.Chem., 58, 2015
5CZH
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BU of 5czh by Molmil
EGFR L858R MUTANT IN COMPLEX WITH AN OPTIMAL PEPTIDE SUBSTRATE
Descriptor: Epidermal growth factor receptor, Peptide substrate
Authors:Yun, C.H, Eck, M.J.
Deposit date:2015-07-31
Release date:2015-09-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.
Nat.Struct.Mol.Biol., 22, 2015
5CZI
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BU of 5czi by Molmil
EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE
Descriptor: Epidermal growth factor receptor, SHC Peptide substrate
Authors:Yun, C.H, Eck, M.J.
Deposit date:2015-07-31
Release date:2015-09-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.
Nat.Struct.Mol.Biol., 22, 2015
4R3R
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BU of 4r3r by Molmil
Crystal structures of EGFR in complex with Mig6
Descriptor: Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1'
Authors:Park, E, Kim, N, Yi, Z, Cho, A, Kim, K, Ficarro, S.B, Park, A, Park, W.Y, Murray, B, Meyerson, M, Beroukim, R, Marto, J.A, Cho, J, Eck, M.J.
Deposit date:2014-08-17
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
4R3P
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BU of 4r3p by Molmil
Crystal structures of EGFR in complex with Mig6
Descriptor: Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1
Authors:Park, E, Kim, N, Yi, Z, Cho, A, Kim, K, Ficarro, S.B, Park, A, Park, W.Y, Murray, B, Meyerson, M, Beroukim, R, Marto, J.A, Cho, J, Eck, M.J.
Deposit date:2014-08-17
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.905 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
3ZDT
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BU of 3zdt by Molmil
Crystal structure of basic patch mutant FAK FERM domain FAK31- 405 K216A, K218A, R221A, K222A
Descriptor: FOCAL ADHESION KINASE 1
Authors:Goni, G.M, Epifano, C, Boskovic, J, Camacho-Artacho, M, Zhou, J, Martin, M.T, Eck, M.J, Kremer, L, Graeter, F, Gervasio, F.L, Perez-Moreno, M, Lietha, D.
Deposit date:2012-11-30
Release date:2012-12-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CYE
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BU of 4cye by Molmil
Crystal structure of avian FAK FERM domain FAK31-405 at 3.2A
Descriptor: FOCAL ADHESION KINASE 1
Authors:Goni, G.M, Epifano, C, Boskovic, J, Camacho-Artacho, M, Zhou, J, Martin, M.T, Eck, M.J, Kremer, L, Graeter, F, Gervasio, F.L, Perez-Moreno, M, Lietha, D.
Deposit date:2014-04-10
Release date:2014-04-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes.
Proc.Natl.Acad.Sci.USA, 111, 2014
4Z32
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BU of 4z32 by Molmil
Crystal Structure of the FERM-SH2 Domains of Jak2
Descriptor: Tyrosine-protein kinase JAK2
Authors:McNally, R, Eck, M.J.
Deposit date:2015-03-30
Release date:2016-06-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Crystal Structure of the FERM-SH2 Module of Human Jak2.
Plos One, 11, 2016
7U98
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BU of 7u98 by Molmil
EGFR(T790M/V948R) in complex with a macrocyclic inhibitor
Descriptor: 19-chloro-18-fluoro-22-methoxy-8,9,11,12,14,15-hexahydro-21H-4,6-ethenopyrimido[5,4-m][1,4,7,10,15]benzotetraoxazacycloheptadecine, Epidermal growth factor receptor
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2022-03-10
Release date:2022-11-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
J.Med.Chem., 65, 2022
7U9A
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BU of 7u9a by Molmil
EGFR in complex with a macrocyclic inhibitor
Descriptor: 4-(5-chloro-4-fluoro-2-hydroxyanilino)-7-methoxyquinazolin-6-ol, CITRATE ANION, Epidermal growth factor receptor
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2022-03-10
Release date:2022-11-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
J.Med.Chem., 65, 2022
7U99
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BU of 7u99 by Molmil
EGFR kinase in complex with a macrocyclic inhibitor
Descriptor: 19-chloro-22-methoxy-8,9,11,12,14,15-hexahydro-21H-4,6-ethenopyrimido[5,4-m][1,4,7,10,15]benzotetraoxazacycloheptadecine, CITRATE ANION, Epidermal growth factor receptor
Authors:Beyett, T.S, Eck, M.J.
Deposit date:2022-03-10
Release date:2022-11-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
J.Med.Chem., 65, 2022
5D41
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BU of 5d41 by Molmil
EGFR kinase domain in complex with mutant selective allosteric inhibitor
Descriptor: (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Yun, C.-H, Park, E, Eck, M.J.
Deposit date:2015-08-07
Release date:2016-06-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Nature, 534, 2016
3IKA
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BU of 3ika by Molmil
Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002
Descriptor: Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
Authors:Yun, C.-H, Eck, M.J.
Deposit date:2009-08-05
Release date:2010-01-12
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Nature, 462, 2009

217705

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