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7KIR
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BU of 7kir by Molmil
Crystal structure of inositol polyphosphate 1-phosphatase (INPP1) D54A mutant in complex with inositol (1,4)-bisphosphate
Descriptor: CALCIUM ION, D-MYO-INOSITOL-1,4-BISPHOSPHATE, Inositol polyphosphate 1-phosphatase
Authors:Dollins, D.E, Xiong, J.-P, Ren, Y, York, J.D.
Deposit date:2020-10-24
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A structural basis for lithium and substrate binding of an inositide phosphatase.
J.Biol.Chem., 296, 2020
6PCK
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BU of 6pck by Molmil
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 1-IP7
Descriptor: (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ...
Authors:Dollins, D.E, Neubauer, J, Dong, J, York, J.D.
Deposit date:2019-06-17
Release date:2020-04-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.
Proc.Natl.Acad.Sci.USA, 117, 2020
6PCL
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BU of 6pcl by Molmil
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 5-IP7
Descriptor: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ...
Authors:Dollins, D.E, Neubauer, J, Dong, J, York, J.D.
Deposit date:2019-06-17
Release date:2020-04-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.
Proc.Natl.Acad.Sci.USA, 117, 2020
6X25
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BU of 6x25 by Molmil
CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 1-PHOSPHATASE INPP1 IN COMPLEX GADOLINIUM AFTER ADDITION OF INOSITOL 1,3,4-TRISPHOSPHATE AND LITHIUM AT 3.2 ANGSTROM RESOLUTION
Descriptor: GADOLINIUM ATOM, Inositol polyphosphate 1-phosphatase, SULFATE ION
Authors:Dollins, D.E, Endo-Streeter, S, Ren, Y, York, J.D.
Deposit date:2020-05-20
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A structural basis for lithium and substrate binding of an inositide phosphatase.
J.Biol.Chem., 296, 2020
6WRO
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BU of 6wro by Molmil
CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 1-PHOSPHATASE INPP1 IN COMPLEX GADOLINIUM BUT NO LITHIUM AT 3 ANGSTROM RESOLUTION
Descriptor: GADOLINIUM ATOM, Inositol polyphosphate 1-phosphatase, SULFATE ION
Authors:Dollins, D.E, Endo-Streeter, S, York, J.D.
Deposit date:2020-04-29
Release date:2020-11-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:A structural basis for lithium and substrate binding of an inositide phosphatase.
J.Biol.Chem., 296, 2020
1YT2
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BU of 1yt2 by Molmil
Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N APO CRYSTAL
Descriptor: Endoplasmin, TETRAETHYLENE GLYCOL
Authors:Dollins, D.E, Immormino, R.M, Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YSZ
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BU of 1ysz by Molmil
Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH NECA
Descriptor: Endoplasmin, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, TETRAETHYLENE GLYCOL
Authors:Dollins, D.E, Immormino, R.M, Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
2O1T
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BU of 2o1t by Molmil
Structure of Middle plus C-terminal domains (M+C) of GRP94
Descriptor: Endoplasmin
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1U
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BU of 2o1u by Molmil
Structure of full length GRP94 with AMP-PNP bound
Descriptor: Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1V
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BU of 2o1v by Molmil
Structure of full length GRP94 with ADP bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1W
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BU of 2o1w by Molmil
Structure of N-terminal plus middle domains (N+M) of GRP94
Descriptor: Endoplasmin
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
1YT0
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BU of 1yt0 by Molmil
Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
Authors:Dollins, D.E, Immormino, R.M, Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT1
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BU of 1yt1 by Molmil
Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL
Descriptor: Endoplasmin, PENTAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL
Authors:Dollins, D.E, Immormino, R.M, Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
7KIO
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BU of 7kio by Molmil
Crystal structure of inositol polyphosphate 1-phosphatase (INPP1) D54A mutant
Descriptor: CALCIUM ION, Inositol polyphosphate 1-phosphatase, SULFATE ION
Authors:Xiong, J.-P, Dollins, D.E, Ren, Y, York, J.D.
Deposit date:2020-10-24
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A structural basis for lithium and substrate binding of an inositide phosphatase.
J.Biol.Chem., 296, 2020
1R4I
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BU of 1r4i by Molmil
Crystal Structure of Androgen Receptor DNA-Binding Domain Bound to a Direct Repeat Response Element
Descriptor: 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*TP*CP*AP*AP*GP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*CP*TP*TP*GP*AP*TP*GP*TP*TP*CP*TP*GP*G)-3', Androgen receptor, ...
Authors:Shaffer, P.L, Jivan, A, Dollins, D.E, Claessens, F, Gewirth, D.T.
Deposit date:2003-10-06
Release date:2004-06-29
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of androgen receptor binding to selective androgen response elements.
Proc.Natl.Acad.Sci.USA, 101, 2004
4HNW
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BU of 4hnw by Molmil
The NatA Acetyltransferase Complex Bound To Inositol Hexakisphosphate
Descriptor: INOSITOL HEXAKISPHOSPHATE, N-terminal acetyltransferase A complex catalytic subunit ARD1, N-terminal acetyltransferase A complex subunit NAT1, ...
Authors:Neubauer, J.L, Immormino, R.M, Dollins, D.E, Endo-Streeter, S.T, Pemble IV, C.W, York, J.D.
Deposit date:2012-10-21
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
4HNY
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BU of 4hny by Molmil
Apo N-terminal acetyltransferase complex A
Descriptor: GLYCEROL, N-terminal acetyltransferase A complex catalytic subunit ARD1, N-terminal acetyltransferase A complex subunit NAT1, ...
Authors:Neubauer, J.L, Immormino, R.M, Dollins, D.E, Endo-Streeter, S.T, Pemble IV, C.W, York, J.D.
Deposit date:2012-10-21
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
4HNX
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BU of 4hnx by Molmil
The NatA Acetyltransferase Complex Bound To ppGpp
Descriptor: GUANOSINE-5',3'-TETRAPHOSPHATE, N-terminal acetyltransferase A complex catalytic subunit ARD1, N-terminal acetyltransferase A complex subunit NAT1
Authors:Neubauer, J.L, Immormino, R.M, Dollins, D.E, Endo-Streeter, S.T, Pemble IV, C.W, York, J.D.
Deposit date:2012-10-21
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.339 Å)
Cite:The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
1TBW
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BU of 1tbw by Molmil
Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation
Descriptor: ADENOSINE MONOPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
Authors:Gewirth, D.T, Immormino, R.M, Dollins, D.E, Shaffer, P.L, Walker, M.A, Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC0
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BU of 1tc0 by Molmil
Ligand Induced Conformational Shifts in the N-terminal Domain of GRP94, Open Conformation Complexed with the physiological partner ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
Authors:Gewirth, D.T, Immormino, R.M, Dollins, D.E, Shaffer, P.L, Walker, M.A, Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC6
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BU of 1tc6 by Molmil
Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation ADP-Complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
Authors:Gewirth, D.T, Immormino, R.M, Dollins, D.E, Shaffer, P.L, Walker, M.A, Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
6WRR
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BU of 6wrr by Molmil
CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 1-PHOSPHATASE INPP1 IN COMPLEX GADOLINIUM AND LITHIUM AT 2.5 ANGSTROM RESOLUTION
Descriptor: GADOLINIUM ATOM, Inositol polyphosphate 1-phosphatase, SULFATE ION
Authors:Dollins, D.R, Endo-Streeter, S, York, J.D.
Deposit date:2020-04-30
Release date:2020-11-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structural basis for lithium and substrate binding of an inositide phosphatase.
J.Biol.Chem., 296, 2020
6WRY
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BU of 6wry by Molmil
CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 1-PHOSPHATASE INPP1 IN COMPLEX GADOLINIUM AFTER ADDITION OF INOSITOL 1,3,4-TRISPHOSPHATE AT 2.5 ANGSTROM RESOLUTION
Descriptor: GADOLINIUM ATOM, Inositol polyphosphate 1-phosphatase, SULFATE ION
Authors:Dollins, D.R, Endo-Streeter, S, York, J.D.
Deposit date:2020-04-30
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A structural basis for lithium and substrate binding of an inositide phosphatase.
J.Biol.Chem., 296, 2020
2EXL
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BU of 2exl by Molmil
GRP94 N-terminal Domain bound to geldanamycin
Descriptor: Endoplasmin, GELDANAMYCIN, PENTAETHYLENE GLYCOL, ...
Authors:Reardon, P.N, Immormino, R.M, Gewirth, D.T.
Deposit date:2005-11-08
Release date:2006-10-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
J.Mol.Biol., 388, 2009
2FXS
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BU of 2fxs by Molmil
Yeast HSP82 in complex with the novel HSP90 Inhibitor Radamide
Descriptor: ATP-dependent molecular chaperone HSP82, GLYCEROL, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE
Authors:Immormino, R.M, Gewirth, D.T.
Deposit date:2006-02-06
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
J.Mol.Biol., 388, 2009

 

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