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3GT8
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BU of 3gt8 by Molmil
Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP
Descriptor: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jura, N, Endres, N.F, Engel, K, Deindl, S, Das, R, Lamers, M.H, Wemmer, D.E, Zhang, X, Kuriyan, J.
Deposit date:2009-03-27
Release date:2009-07-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.955 Å)
Cite:Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
Cell(Cambridge,Mass.), 137, 2009
3KEX
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BU of 3kex by Molmil
Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Receptor tyrosine-protein kinase erbB-3
Authors:Jura, N, Shan, Y, Cao, X, Shaw, D.E, Kuriyan, J.
Deposit date:2009-10-26
Release date:2009-12-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
Proc.Natl.Acad.Sci.USA, 106, 2009
8DS6
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BU of 8ds6 by Molmil
Structure of the PEAK3 pseudokinase homodimer
Descriptor: Protein PEAK3
Authors:Torosyan, H, Paul, M, Jura, N, Verba, K.A.
Deposit date:2022-07-21
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
Nat Commun, 14, 2023
8DP5
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BU of 8dp5 by Molmil
Structure of the PEAK3/14-3-3 complex
Descriptor: 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ...
Authors:Torosyan, H, Paul, M, Jura, N, Verba, K.A.
Deposit date:2022-07-14
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
Nat Commun, 14, 2023
5WNO
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BU of 5wno by Molmil
Crystal structure of C. elegans LET-23 kinase domain complexed with AMP-PNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Receptor tyrosine-protein kinase let-23
Authors:Liu, L, Thaker, T.M, Jura, N.
Deposit date:2017-08-01
Release date:2018-01-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.386 Å)
Cite:Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.
Structure, 26, 2018
8U4K
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BU of 8u4k by Molmil
Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betacellulin, ...
Authors:Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N.
Deposit date:2023-09-10
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (4.27 Å)
Cite:Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain
To Be Published
8U4L
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BU of 8u4l by Molmil
Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ...
Authors:Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N.
Deposit date:2023-09-10
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
To Be Published
8U4J
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BU of 8u4j by Molmil
Structure of the HER4/BTC Homodimer Extracellular Domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betacellulin, ...
Authors:Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N.
Deposit date:2023-09-10
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of the HER4/BTC Homodimer Extracellular Domain
To Be Published
8U4I
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BU of 8u4i by Molmil
Structure of the HER4/NRG1b Homodimer Extracellular Domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ...
Authors:Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N.
Deposit date:2023-09-10
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
To Be Published
6OP9
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BU of 6op9 by Molmil
HER3 pseudokinase domain bound to bosutinib
Descriptor: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Receptor tyrosine-protein kinase erbB-3
Authors:Littlefield, P, Agnew, C, Jura, N.
Deposit date:2019-04-24
Release date:2019-08-21
Last modified:2022-02-16
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers.
Cell Rep, 38, 2022
6P5S
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BU of 6p5s by Molmil
HIPK2 kinase domain bound to CX-4945
Descriptor: 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, Homeodomain-interacting protein kinase 2
Authors:Agnew, C, Liu, L, Jura, N.
Deposit date:2019-05-30
Release date:2019-07-31
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.194 Å)
Cite:The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.
J.Biol.Chem., 294, 2019
6CNL
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BU of 6cnl by Molmil
Crystal Structure of H105A PGAM5 Dodecamer
Descriptor: MAGNESIUM ION, PGAM5 Multimerization Motif Peptide, Serine/threonine-protein phosphatase PGAM5, ...
Authors:Ruiz, K, Agnew, C, Jura, N.
Deposit date:2018-03-08
Release date:2019-02-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.
Nat Commun, 10, 2019
6CNI
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BU of 6cni by Molmil
Crystal structure of H105A PGAM5 dimer
Descriptor: PHOSPHATE ION, SODIUM ION, Serine/threonine-protein phosphatase PGAM5, ...
Authors:Ruiz, K, Agnew, C, Jura, N.
Deposit date:2018-03-08
Release date:2019-02-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.
Nat Commun, 10, 2019
5CNO
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BU of 5cno by Molmil
Crystal structure of the EGFR kinase domain mutant V924R
Descriptor: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Kovacs, E, Das, R, Mirza, A, Jura, N, Barros, T, Kuriyan, J.
Deposit date:2015-07-17
Release date:2015-07-29
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.
Mol.Cell.Biol., 35, 2015
5CNN
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BU of 5cnn by Molmil
Crystal structure of the EGFR kinase domain mutant I682Q
Descriptor: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Kovacs, E, Das, R, Mirza, A, Jura, N, Barros, T, Kuriyan, J.
Deposit date:2015-07-17
Release date:2015-07-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.
Mol.Cell.Biol., 35, 2015
4RIW
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BU of 4riw by Molmil
Crystal structure of an EGFR/HER3 kinase domain heterodimer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Littlefield, P, Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
4RIY
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BU of 4riy by Molmil
Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Littlefield, P, Liu, L, Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.981 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
4RIX
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BU of 4rix by Molmil
Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Littlefield, P, Liu, L, Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
2RFD
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BU of 2rfd by Molmil
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Descriptor: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor, SULFATE ION
Authors:Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2RF9
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BU of 2rf9 by Molmil
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Descriptor: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor
Authors:Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2RFE
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BU of 2rfe by Molmil
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Descriptor: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor
Authors:Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
6OWV
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BU of 6owv by Molmil
Crystal structure of a Human Cardiac Calsequestrin Filament
Descriptor: CHLORIDE ION, Calsequestrin-2, SULFATE ION
Authors:Titus, E.W, Deiter, F.H, Shi, C, Jura, N, Deo, R.C.
Deposit date:2019-05-12
Release date:2020-07-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.
Nat.Struct.Mol.Biol., 27, 2020
6OWW
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BU of 6oww by Molmil
Crystal structure of a Human Cardiac Calsequestrin Filament Complexed with Ytterbium
Descriptor: Calsequestrin-2, SULFATE ION, YTTERBIUM (III) ION
Authors:Titus, E.W, Deiter, F.H, Shi, C, Jura, N, Deo, R.C.
Deposit date:2019-05-12
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.84 Å)
Cite:The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.
Nat.Struct.Mol.Biol., 27, 2020
6UNQ
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BU of 6unq by Molmil
Kinase domain of ALK2-K493A with AMPPNP
Descriptor: Activin receptor type-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Agnew, C, Jura, N.
Deposit date:2019-10-13
Release date:2021-07-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
Nat Commun, 12, 2021
6UNR
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BU of 6unr by Molmil
Kinase domain of ALK2-K492A/K493A with AMPPNP
Descriptor: Activin receptor type-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Agnew, C, Jura, N.
Deposit date:2019-10-13
Release date:2021-07-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
Nat Commun, 12, 2021

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