Author results

6NXE
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CRYO-EM RECONSTRUCTION OF PROTEASE-ACTIVATEABLE ADENO-ASSOCIATED VIRUS 9 (AAV9-L001)
Descriptor:Capsid protein VP1
Authors:Bennett, A.B., Agbandje-Mckenna, M.
Deposit date:2019-02-08
Release date:2019-03-13
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue.
Mol. Ther., 27, 2019
6E9D
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SUB-2 ANGSTROM EWALD CURVATURE-CORRECTED SINGLE-PARTICLE CRYO-EM RECONSTRUCTION OF AAV-2 L336C
Descriptor:Capsid protein VP1
Authors:Tan, Y.Z., Aiyer, S., Mietzsch, M., Hull, J.A., McKenna, R., Baker, T.S., Agbandje-McKenna, M., Lyumkis, D.
Deposit date:2018-07-31
Release date:2018-08-15
Last modified:2018-09-19
Method:ELECTRON MICROSCOPY (1.86 Å)
Cite:Sub-2 angstrom Ewald curvature corrected structure of an AAV2 capsid variant.
Nat Commun, 9, 2018
6CBE
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ATOMIC STRUCTURE OF A RATIONALLY ENGINEERED GENE DELIVERY VECTOR, AAV2.5
Descriptor:Capsid protein VP1
Authors:Burg, M., Rosebrough, C., Drouin, L., Bennett, A., Mietzsch, M., Chipman, P., McKenna, R., Sousa, D., Potter, M., Byrne, B., Kozyreva, O.G., Samulski, R.J., Agbandje-McKenna, M.
Deposit date:2018-02-02
Release date:2018-05-30
Last modified:2018-08-29
Method:ELECTRON MICROSCOPY (2.78 Å)
Cite:Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
J. Struct. Biol., 203, 2018
6BX1
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ATOMIC RESOLUTION STRUCTURE OF HUMAN BUFAVIRUS 3
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-12-15
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses, 10, 2018
6BX0
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ATOMIC RESOLUTION STRUCTURE OF HUMAN BUFAVIRUS 2
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-12-15
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (3.79 Å)
Cite:Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses, 10, 2018
6BWX
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ATOMIC RESOLUTION STRUCTURE OF HUMAN BUFAVIRUS 1
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-12-15
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses, 10, 2018
6B9Q
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SINGLE PARTICLE CRYO-EM STRUCTURE DETERMINATION OF THE LUIII CAPSID PROTEIN
Descriptor:Capsid protein VP2
Authors:Pittman, N.C., Agbandje-McKenna, M.
Deposit date:2017-10-11
Release date:2017-11-15
Last modified:2017-12-06
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction.
Viruses, 9, 2017
5US9
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HUMAN BOCAVIRUS 4
Descriptor:Capsid protein VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-02-13
Release date:2017-03-29
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017
5US7
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HUMAN BOCAVIRUS 3
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-02-13
Release date:2017-03-29
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017
5URF
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THE STRUCTURE OF HUMAN BOCAVIRUS 1
Descriptor:viral protein 3
Authors:Mietzsch, M., Kailasan, S., Garrison, J., Ilyas, M., Chipman, P., Kandola, K., Jansen, M., Spear, J., Sousa, D., McKenna, R., Soderlund-Venermo, M., Baker, T., Agbandje-McKenna, M.
Deposit date:2017-02-10
Release date:2017-03-29
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017
5JJ8
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CRYSTAL STRUCTURE OF THE BETA CARBONIC ANHYDRASE PSCA3 ISOLATED FROM PSEUDOMONAS AERUGINOSA - ALTERNATE CRYSTAL PACKING FORM
Descriptor:Carbonic anhydrase, ZINC ION
Authors:Pinard, M.A., Kurian, J.J., Aggarwal, M., Agbandje-McKenna, M., McKenna, R.
Deposit date:2016-04-22
Release date:2016-07-06
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.585 Å)
Cite:Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3.
Acta Crystallogr.,Sect.F, 72, 2016
5IPK
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STRUCTURE OF THE R432A VARIANT OF ADENO-ASSOCIATED VIRUS TYPE 2 VLP
Descriptor:Capsid protein VP1
Authors:Drouin, L.M., Lins, B., Janssen, M.E., Bennet, A., Chipman, P., McKenna, R., Chen, W., Muzyczka, N., Cardone, G., Baker, T.S., Agbandje-McKenna, M.
Deposit date:2016-03-09
Release date:2016-07-20
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
J.Virol., 90, 2016
5IPI
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STRUCTURE OF ADENO-ASSOCIATED VIRUS TYPE 2 VLP
Descriptor:Capsid protein VP1
Authors:Drouin, L.M., Lins, B., Janssen, M.E., Bennet, A., Chipman, P., McKenna, R., Chen, W., Muzyczka, N., Cardone, G., Baker, T.S., Agbandje-McKenna, M.
Deposit date:2016-03-09
Release date:2016-07-20
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
J.Virol., 90, 2016
5EGC
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STRUCTURE OF THE ADENO-ASSOCIATED VIRUS SEROTYPE 1 SIALIC ACID COMPLEX
Descriptor:Capsid protein, O-SIALIC ACID, MAGNESIUM ION
Authors:Huang, L.Y., Agbandje-McKenna, M.
Deposit date:2015-10-27
Release date:2016-03-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site.
J.Virol., 90, 2016
5DVX
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CRYSTAL STRUCTURE OF THE CATALYTIC-DOMAIN OF HUMAN CARBONIC ANHYDRASE IX AT 1.6 ANGSTROM RESOLUTION
Descriptor:Carbonic anhydrase 9, ZINC ION, GLYCEROL, ...
Authors:Mahon, B.P., Socorro, L., Driscoll, J.M., McKenna, R.
Deposit date:2015-09-21
Release date:2016-08-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis.
Biochemistry, 55, 2016
4XZ5
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STRUCTURE OF THE THERMOSTABLE ALPHA-CARBONIC ANYDRASE FROM THIOMICROSPIRA CRUNOGENA XCL-2 GAMMAPROTEOBACTERIUM
Descriptor:Carbonic anhydrase, alpha family, ZINC ION, ...
Authors:Mahon, B.P., Diaz-Torres, N.A., Pinard, M.A., McKenna, R.
Deposit date:2015-02-03
Release date:2015-07-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Structural and biophysical characterization of the alpha-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration.
Acta Crystallogr.,Sect.D, 71, 2015
4RSO
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THE STRUCTURE OF THE NEUROTROPIC AAVRH.8 VIRAL VECTOR
Descriptor:Capsid protein VP1, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, SODIUM ION, ...
Authors:Halder, S., Van Vliet, K., Smith, J.K., McKenna, R., Wilson, J.M., Agbandje-McKenna, M.
Deposit date:2014-11-10
Release date:2016-04-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of neurotropic adeno-associated virus AAVrh.8.
J.Struct.Biol., 192, 2015
4QC8
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STRUCTURAL ANNOTATION OF PATHOGENIC BOVINE PARVOVIRUS-1
Descriptor:VP2
Authors:Kailasan, S., Halder, S., Gurda, B.L., Bladek, H., Chipman, P.R., McKenna, R., Brown, K., Agbandje-McKenna, M.
Deposit date:2014-05-09
Release date:2015-01-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of an enteric pathogen, bovine parvovirus.
J.Virol., 89, 2015
4IOV
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THE STRUCTURE OF AAVRH32.33, A NOVEL GENE DELIVERY VECTOR
Descriptor:Capsid protein VP1, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE
Authors:Mikalism, K., Nam, H.-J., Van vilet, K., Vandenberghe, L.H., Mays, L.E., McKenna, R., Wilson, J., Agbandje-McKenna, M.
Deposit date:2013-01-08
Release date:2014-04-02
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The structure of AAVrh32.33, a novel gene delivery vector.
J.Struct.Biol., 186, 2014
4GBT
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STRUCTURAL CHARACTERIZATION OF H-1 PARVOVIRUS: COMPARISON OF INFECTIOUS VIRIONS TO REPLICATION DEFECTIVE PARTICLES
Descriptor:Capsid protein VP1, SODIUM ION, CHLORIDE ION
Authors:Halder, S., Nam, H.-J., Govindasamy, L., Vogel, M., Dinsart, C., Salome, N., McKenna, R., Agbandje-McKenna, M.
Deposit date:2012-07-27
Release date:2013-02-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural characterization of h-1 parvovirus: comparison of infectious virions to empty capsids.
J.Virol., 87, 2013
4G0R
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STRUCTURAL CHARACTERIZATION OF H-1 PARVOVIRUS: COMPARISON OF INFECTIOUS VIRIONS TO REPLICATION DEFECTIVE PARTICLES
Descriptor:Capsid protein VP1, DNA (5'-D(P*CP*TP*GP*AP*CP*TP*TP*CP*AP*A)-3'), 1,2-ETHANEDIOL, ...
Authors:Halder, S., Agbandje-McKenna, M., Nam, H.-J., Govindasamy, L., Vogel, M., Dinsart, C., Salome, N., McKenna, R.
Deposit date:2012-07-09
Release date:2013-02-27
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural characterization of h-1 parvovirus: comparison of infectious virions to empty capsids.
J.Virol., 87, 2013
4FIK
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HUMAN CARBONIC ANHYDRASE II H64A COMPLEXED WITH THIOXOLONE HYDROLYSIS PRODUCTS
Descriptor:Carbonic anhydrase 2, ZINC ION, 2,4-dihydroxybenzenesulfenic acid, ...
Authors:Sippel, K.H., Genis, C., Govindasamy, L., Agbandje-McKenna, M., Tripp, B.C., McKenna, R.
Deposit date:2012-06-08
Release date:2012-06-27
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.
J Phys Chem Lett, 1, 2010
3V3J
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KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II.
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Boone, C.D., Fisher, S.Z., McKenna, R.
Deposit date:2011-12-13
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein Eng.Des.Sel., 25, 2012
3V3I
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KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II.
Descriptor:Carbonic anhydrase 2, ZINC ION, CHLORIDE ION
Authors:Boone, C.D., Fisher, S.Z., McKenna, R.
Deposit date:2011-12-13
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein Eng.Des.Sel., 25, 2012
3V3H
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KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II.
Descriptor:Carbonic anhydrase 2, ZINC ION, CHLORIDE ION
Authors:Boone, C.D., Fisher, S.Z., McKenna, R.
Deposit date:2011-12-13
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein Eng.Des.Sel., 25, 2012