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6C9F
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AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R734
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Hitoshi, Y., Brunzelle, J.S., Griffin, P.R., Xu, H.E., Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.924 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9G
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AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R739
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Hitoshi, Y., Brunzelle, J.S., Griffin, P.R., Xu, H.E., Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9H
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NON-PHOSPHORYLATED AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R734
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Hitoshi, Y., Brunzelle, J.S., Griffin, P.R., Xu, H.E., Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9J
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AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R734
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Brunzelle, J.S., Hitoshi, Y., Griffin, P.R., Xu, H.E., Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6CMO
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RHODOPSIN-GI COMPLEX
Descriptor:chimera protein of Soluble cytochrome b562 and Rhodopsin, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kang, Y., Kuybeda, O., de Waal, P.W., Mukherjee, S., Van Eps, N., Dutka, P., Zhou, X.E., Bartesaghi, A., Erramilli, S., Morizumi, T., Gu, X., Yin, Y., Liu, P., Jiang, Y., Meng, X., Zhao, G., Melcher, K., Earnst, O.P., Kossiakoff, A.A., Subramaniam, S., Xu, H.E.
Deposit date:2018-03-05
Release date:2018-06-20
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
4PW2
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5 EPIMERASE
Descriptor:D-glucuronyl C5 epimerase B, CITRIC ACID
Authors:Ke, J., Qin, Y., Gu, X., Brunzelle, J.S., Xu, H.E., Ding, K.
Deposit date:2014-03-18
Release date:2015-01-14
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
4PXQ
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5-EPIMERASE IN COMPLEX WITH HEPARIN HEXASACCHARIDE
Descriptor:D-glucuronyl C5 epimerase B, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Ke, J., Qin, Y., Gu, X., Tan, J., Brunzelle, J.S., Xu, H.E., Ding, K.
Deposit date:2014-03-24
Release date:2015-01-14
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
4XAI
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CRYSTAL STRUCTURE OF RED FLOUR BEETLE NR2E1/TLX
Descriptor:Maltose-binding periplasmic protein,Tailless ortholog, Grunge, isoform J, ...
Authors:Zhi, X., Zhou, E., Xu, E.
Deposit date:2014-12-14
Release date:2015-03-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
Genes Dev., 29, 2015
4XAJ
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CRYSTAL STRUCTURE OF HUMAN NR2E1/TLX
Descriptor:Maltose-binding periplasmic protein,Nuclear receptor subfamily 2 group E member 1, Atrophin/grunge, MALTOSE
Authors:Zhi, X., Zhou, E., Xu, E.
Deposit date:2014-12-14
Release date:2015-03-04
Last modified:2015-07-29
Method:X-RAY DIFFRACTION (3.551 Å)
Cite:Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
Genes Dev., 29, 2015
5J9F
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (4-{[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)ETHYL]AMINO}BENZOYL)-L-GLUTAMIC ACID (AGF183)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid
Authors:Wong, J., Deis, S.M., Dann III, C.E.
Deposit date:2016-04-09
Release date:2016-08-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J.Med.Chem., 59, 2016
6BD4
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CRYSTAL STRUCTURE OF HUMAN APO-FRIZZLED4 RECEPTOR
Descriptor:Frizzled-4/Rubredoxin chimeric protein, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Yang, S., Wu, Y., Pu, M., Chen, Y., Dong, S., Guo, Y., Han, G.Y., Stevens, R.C., Zhao, S., Xu, F.
Deposit date:2017-10-21
Release date:2018-08-22
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
5CL1
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COMPLEX STRUCTURE OF NORRIN WITH HUMAN FRIZZLED 4
Descriptor:Maltose-binding periplasmic protein,Norrin, Frizzled-4, N-ACETYL-D-GLUCOSAMINE
Authors:Wang, Z., Ke, J., Shen, G., Cheng, Z., Xu, H.E., Xu, W.
Deposit date:2015-07-16
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural basis of the Norrin-Frizzled 4 interaction.
Cell Res., 25, 2015
5EJN
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CRYSTAL STRUCTURE OF JUNO, THE MAMMALIAN EGG RECEPTOR FOR SPERM IZUMO1
Descriptor:Sperm-egg fusion protein Juno, N-ACETYL-D-GLUCOSAMINE
Authors:Nishimura, K., Han, L., Jovine, L.
Deposit date:2015-11-02
Release date:2016-02-24
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes.
Curr.Biol., 26, 2016