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2AZX
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BU of 2azx by Molmil
Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase
Descriptor: 72-MER, GLYCEROL, MAGNESIUM ION, ...
Authors:Yang, X.L, Otero, F.J, Ewalt, K.L, Liu, J, Swairjo, M.A, Kohrer, C, RajBhandary, U.L, Skene, R.J, McRee, D.E, Schimmel, P.
Deposit date:2005-09-12
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
Embo J., 25, 2006
4XEO
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BU of 4xeo by Molmil
Crystal Structure of human AlaRS catalytic domain with R329H mutation
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, Alanine--tRNA ligase, cytoplasmic, ...
Authors:Zhou, H, He, W, Yang, X.L.
Deposit date:2014-12-24
Release date:2015-12-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of human AlaRS catalytic domain with R329H mutation
To Be Published
6O76
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BU of 6o76 by Molmil
Human cytosolic Histidyl-tRNA synthetase (HisRS) with WHEP domain
Descriptor: CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic
Authors:Kuhle, B, Yang, X.L.
Deposit date:2019-03-07
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.787 Å)
Cite:CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 116, 2019
2ZT8
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BU of 2zt8 by Molmil
Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Gly-AMP analog
Descriptor: Glycyl-tRNA synthetase, [(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (aminoacetyl)sulfamate
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT5
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BU of 2zt5 by Molmil
Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with ATP)
Descriptor: BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Glycyl-tRNA synthetase
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT7
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BU of 2zt7 by Molmil
Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Glycine and ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCINE, Glycyl-tRNA synthetase
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT6
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BU of 2zt6 by Molmil
Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Glycyl-tRNA synthetase
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZXF
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BU of 2zxf by Molmil
Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with AP4A)
Descriptor: BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Glycyl-tRNA synthetase
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-12-23
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
3BJU
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BU of 3bju by Molmil
Crystal Structure of tetrameric form of human lysyl-tRNA synthetase
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, LYSINE, ...
Authors:Guo, M, Yang, X.L, Schimmel, P.
Deposit date:2007-12-04
Release date:2008-02-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation
Proc.Natl.Acad.Sci.Usa, 105, 2008
4XEM
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BU of 4xem by Molmil
Crystal Structure of wild type human AlaRS catalytic domain
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 1,2-ETHANEDIOL, Alanine--tRNA ligase, ...
Authors:Zhou, H, He, W, Yang, X.L.
Deposit date:2014-12-24
Release date:2016-02-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.278 Å)
Cite:Crystal structure of wild type human AlaRS catalytic domain
To Be Published
5THL
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BU of 5thl by Molmil
Crystal structure of the human tyrosyl-tRNA synthetase mutant G41R
Descriptor: Tyrosine--tRNA ligase, cytoplasmic
Authors:Blocquel, D, Sajish, M, Yang, X.L.
Deposit date:2016-09-29
Release date:2017-06-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5THH
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BU of 5thh by Molmil
Crystal structure of a human tyrosyl-tRNA synthetase mutant
Descriptor: TYROSINE, Tyrosine--tRNA ligase, cytoplasmic
Authors:Blocquel, D, Yang, X.L.
Deposit date:2016-09-29
Release date:2017-05-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.959 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5W6M
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BU of 5w6m by Molmil
Crystal structure of the human histidyl-tRNA synthetase mutant D175E
Descriptor: Histidine--tRNA ligase, cytoplasmic
Authors:Blocquel, D, Yang, X.L.
Deposit date:2017-06-16
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.696 Å)
Cite:CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 2019
3G98
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BU of 3g98 by Molmil
Crystal Structure of the C-Ala domain from Aquifex aeolicus alanyl-tRNA synthetase
Descriptor: Alanyl-tRNA synthetase
Authors:Guo, M, Yang, X.L, Schimmel, P.
Deposit date:2009-02-13
Release date:2009-10-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The C-Ala domain brings together editing and aminoacylation functions on one tRNA.
Science, 325, 2009
5HWL
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BU of 5hwl by Molmil
Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form
Descriptor: GLUTATHIONE, Glutathione S-transferase Mu 2, N,N'-(butane-1,4-diyl)bis{2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetamide}
Authors:Zhang, X, Wei, J, Wu, S, Zhang, H.P, Luo, M, Yang, X.L, Liao, F, Wang, D.Q.
Deposit date:2016-01-29
Release date:2017-11-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form
To Be Published
4HVC
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BU of 4hvc by Molmil
Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Bifunctional glutamate/proline--tRNA ligase, MAGNESIUM ION, ...
Authors:Zhou, H, Sun, L, Yang, X.L, Schimmel, P.
Deposit date:2012-11-06
Release date:2013-01-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature, 494, 2012
1BE5
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BU of 1be5 by Molmil
STRUCTURAL STUDIES OF A STABLE PARALLEL-STRANDED DNA DUPLEX INCORPORATING ISOGUANINE:CYTOSINE AND ISOCYTOSINE:GUANINE BASE PAIRS BY NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: DNA DUPLEX (TGCACGGACT)
Authors:Yang, X.-L, Sugiyama, H, Ikeda, S, Saito, I, Wang, A.H.-J.
Deposit date:1998-05-19
Release date:1998-08-12
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy.
Biophys.J., 75, 1998
1B0S
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BU of 1b0s by Molmil
BINDING OF AR-1-144, A TRI-IMIDAZOLE DNA MINOR GROOVE BINDER, TO CCGG SEQUENCE ANALYZED BY NMR SPECTROSCOPY
Descriptor: (2-{[4-({4-[(4-FORMYLAMINO-1-METHYL-1H-IMIDAZOLE-2-CARBONYL)-AMINO]-1-METHYL-1H-IMIDAZOLE-2-CARBONYL}-AMINO)-1-METHYL-1 H-IMIDAZOLE-2-CARBONYL]-AMINO}-ETHYL)-DIMETHYL-AMMONIUM, DNA (5'-D(*GP*AP*AP*CP*CP*GP*GP*TP*TP*C)-3')
Authors:Yang, X.-L, Kaenzig, C, Lee, M, Wang, A.H.-J.
Deposit date:1998-11-12
Release date:1999-08-31
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Binding of AR-1-144, a tri-imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopy.
Eur.J.Biochem., 263, 1999
1FDG
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BU of 1fdg by Molmil
BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (AMETANTRONE COMPLEX)
Descriptor: 1,4-BIS-[2-(2-HYDROXY-ETHYLAMINO)-ETHYLAMINO]-ANTHRAQUINONE, COBALT (II) ION, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), ...
Authors:Yang, X.-L, Robinson, H, Gao, Y.-G, Wang, A.H.-J.
Deposit date:2000-07-20
Release date:2000-08-07
Last modified:2022-09-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.
Biochemistry, 39, 2000
1FD5
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BU of 1fd5 by Molmil
BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (BISACRIDINE COMPLEX)
Descriptor: COBALT (II) ION, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), MACROCYCLIC-BIS-9-AMINO-ACRIDINE, ...
Authors:Yang, X.-L, Robinson, H, Gao, Y.-G, Wang, A.H.-J.
Deposit date:2000-07-19
Release date:2000-08-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.
Biochemistry, 39, 2000
7WQZ
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BU of 7wqz by Molmil
Structure of Active-mutEP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain
Authors:Yang, X.L, Ding, Z.Y, Huang, H.J.
Deposit date:2022-01-26
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
7WQW
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BU of 7wqw by Molmil
Structure of Active-EP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain
Authors:Yang, X.L, Ding, Z.Y, Huang, H.J.
Deposit date:2022-01-26
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
7WR7
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BU of 7wr7 by Molmil
Structure of Inhibited-EP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, Enteropeptidase catalytic light chain, ...
Authors:Yang, X.L, Ding, Z.Y, Huang, H.J.
Deposit date:2022-01-26
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
7WQX
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BU of 7wqx by Molmil
Structure of Inactive-EP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Enteropeptidase
Authors:Yang, X.L, Ding, Z.Y, Huang, H.J.
Deposit date:2022-01-26
Release date:2022-10-26
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
3VBB
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BU of 3vbb by Molmil
Crystal Structure of Seryl-tRNA Synthetase from Human at 2.9 angstroms
Descriptor: MAGNESIUM ION, PHOSPHATE ION, Seryl-tRNA synthetase, ...
Authors:Xu, X.L, Yang, X.-L.
Deposit date:2012-01-02
Release date:2012-02-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.891 Å)
Cite:Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.
Nat Commun, 3, 2012

 

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