Author results

1F0J
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B
分子名称:PHOSPHODIESTERASE 4B, ZINC ION, MAGNESIUM ION, ...
著者Xu, R.X., Hassell, A.M., Vanderwall, D., Lambert, M.H., Holmes, W.D., Luther, M.A., Rocque, W.J., Milburn, M.V., Zhao, Y., Ke, H., Nolte, R.T.
登録日2000-05-16
公開日2000-07-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity.
Science, 288, 2000
1RO6
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CRYSTAL STRUCTURE OF PDE4B2B COMPLEXED WITH ROLIPRAM (R & S)
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MANGANESE (II) ION, ...
著者Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.
登録日2003-12-01
公開日2004-12-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J.Mol.Biol., 337, 2004
1RO9
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CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-BR-AMP
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE
著者Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.
登録日2003-12-01
公開日2004-12-07
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J.Mol.Biol., 337, 2004
1ROR
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CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, ADENOSINE MONOPHOSPHATE
著者Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.
登録日2003-12-02
公開日2004-12-07
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J.Mol.Biol., 337, 2004
1TBN
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NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
分子名称:PROTEIN KINASE C, GAMMA TYPE, ZINC ION
著者Xu, R.X., Pawelczyk, T., Xia, T., Brown, S.C.
登録日1997-04-15
公開日1998-04-29
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions.
Biochemistry, 36, 1997
1TBO
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NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, 30 STRUCTURES
分子名称:PROTEIN KINASE C, GAMMA TYPE, ZINC ION
著者Xu, R.X., Pawelczyk, T., Xia, T., Brown, S.C.
登録日1997-04-15
公開日1998-04-29
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions.
Biochemistry, 36, 1997
1XV9
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CRYSTAL STRUCTURE OF CAR/RXR HETERODIMER BOUND WITH SRC1 PEPTIDE, FATTY ACID, AND 5B-PREGNANE-3,20-DIONE.
分子名称:Retinoic acid receptor RXR-alpha, Orphan nuclear receptor NR1I3, nuclear receptor coactivator 1 isoform 1, ...
著者Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Moore, L.B., Willson, T.M., Moore, J.T.
登録日2004-10-27
公開日2004-12-28
最終更新日2016-11-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer.
Mol.Cell, 16, 2004
1XVP
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CRYSTAL STRUCTURE OF CAR/RXR HETERODIMER BOUND WITH SRC1 PEPTIDE, FATTY ACID AND CITCO
分子名称:Retinoic acid receptor RXR-alpha, Orphan nuclear receptor NR1I3, nuclear receptor coactivator 1 isoform 1, ...
著者Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Moore, L.B., Willson, T.M., Moore, J.T.
登録日2004-10-28
公開日2004-12-28
最終更新日2016-11-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer.
Mol.Cell, 16, 2004
2P54
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A CRYSTAL STRUCTURE OF PPAR ALPHA BOUND WITH SRC1 PEPTIDE AND GW735
分子名称:Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID
著者Xu, R.X., Xu, H.E., Sierra, M.L., Montana, V.G., Lambert, M.H., Pianetti, P.M.
登録日2007-03-14
公開日2007-04-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPAR Agonists. 1.Discovery of a Novel Series of Potent HDLc Raising Agents.
J.Med.Chem., 50, 2007
1HCS
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NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
分子名称:ACETYL-PYEEIE-OH, HUMAN SRC
著者Gampe Junior, R.T., Xu, R.X.
登録日1994-09-02
公開日1995-09-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
1HCT
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NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
分子名称:ACETYL-PYEEIE-OH, HUMAN SRC
著者Gampe Junior, R.T., Xu, R.X.
登録日1994-09-02
公開日1995-09-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
2FDD
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CRYSTAL STRUCTURE OF HIV PROTEASE D545701 BOUND WITH GW0385
分子名称:Gag-Pol polyprotein, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-3-[(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO]-2-HYDROXY-1-{4-[(2-METHYL-1,3-THIAZOL-4-YL)METHOXY]BENZYL}PROPYL]CARBAMATE
著者Xu, R.X.
登録日2005-12-13
公開日2006-02-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385.
Bioorg.Med.Chem.Lett., 16, 2006
2FDE
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WILD TYPE HIV PROTEASE BOUND WITH GW0385
分子名称:Gag-Pol polyprotein, POTASSIUM ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-3-[(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO]-2-HYDROXY-1-{4-[(2-METHYL-1,3-THIAZOL-4-YL)METHOXY]BENZYL}PROPYL]CARBAMATE
著者Xu, R.X.
登録日2005-12-13
公開日2006-02-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385.
Bioorg.Med.Chem.Lett., 16, 2006
1URK
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SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
分子名称:PLASMINOGEN ACTIVATOR, ALPHA-L-FUCOSE
著者Hansen, A.P., Petros, A.M., Meadows, R.P., Nettesheim, D.G., Mazar, A.P., Olejniczak, E.T., Xu, R.X., Pederson, T.M., Henkin, J., Fesik, S.W.
登録日1994-01-10
公開日1995-05-08
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry, 33, 1994
1YMT
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MOUSE SF-1 LBD
分子名称:Steroidogenic factor 1, Nuclear receptor 0B2, 1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL PHOSPHATIDYL GLYCEROL
著者Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., Juzumiene, D., Bynum, J.M., Fletterick, R.J., Willson, T.M., Ingraham, H.A.
登録日2005-01-21
公開日2005-03-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
1YOK
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CRYSTAL STRUCTURE OF HUMAN LRH-1 BOUND WITH TIF-2 PEPTIDE AND PHOSPHATIDYLGLYCEROL
分子名称:Orphan nuclear receptor NR5A2, Nuclear receptor coactivator 2, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE
著者Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., MacKay, J.A., Juzumiene, D., Bynum, J.M., Madauss, K., Montana, V., Lebedeva, L., Suzawa, M., Williams, J.D., Williams, S.P., Guy, R.K., Thornton, J.W., Fletterick, R.J., Willson, T.M., Ingraham, H.A.
登録日2005-01-27
公開日2005-07-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Cell(Cambridge,Mass.), 120, 2005
1YOW
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HUMAN STEROIDOGENIC FACTOR 1 LBD WITH BOUND CO-FACTOR PEPTIDE
分子名称:Steroidogenic factor 1, TIF2 peptide, PHOSPHATIDYL ETHANOL
著者Krylova, I.N., Sablin, E.P., Xu, R.X., Waitt, G.M., Juzumiene, D., Williams, J.D., Ingraham, H.A., Willson, T.M., Williams, S.P., Montana, V., Madauss, K.P., Moore, J., Bynum, J.M., Lebedeva, L., MacKay, J.A., Suzawa, M., Guy, R.K., Thornton, J.W.
登録日2005-01-28
公開日2005-05-10
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
3S9S
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LIGAND BINDING DOMAIN OF PPARGAMMA COMPLEXED WITH A BENZIMIDAZOLE PARTIAL AGONIST
分子名称:Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 1-(3,4-dichlorobenzyl)-2-methyl-N-[(1R)-1-phenylpropyl]-1H-benzimidazole-5-carboxamide
著者Lambert, M.H., Xu, R.X.
登録日2011-06-02
公開日2012-06-06
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARgamma partial agonist.
Bioorg.Med.Chem.Lett., 21, 2011
1ARD
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STRUCTURES OF DNA-BINDING MUTANT ZINC FINGER DOMAINS: IMPLICATIONS FOR DNA BINDING
分子名称:YEAST TRANSCRIPTION FACTOR ADR1, ZINC ION
著者Hoffman, R.C., Xu, R.X., Horvath, S.J., Herriott, J.R., Klevit, R.E.
登録日1993-10-01
公開日1994-01-31
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Structures of DNA-binding mutant zinc finger domains: implications for DNA binding.
Protein Sci., 2, 1993
1ARE
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STRUCTURES OF DNA-BINDING MUTANT ZINC FINGER DOMAINS: IMPLICATIONS FOR DNA BINDING
分子名称:YEAST TRANSCRIPTION FACTOR ADR1, ZINC ION
著者Hoffman, R.C., Xu, R.X., Horvath, S.J., Herriott, J.R., Klevit, R.E.
登録日1993-10-01
公開日1994-01-31
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Structures of DNA-binding mutant zinc finger domains: implications for DNA binding.
Protein Sci., 2, 1993
1ARF
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STRUCTURES OF DNA-BINDING MUTANT ZINC FINGER DOMAINS: IMPLICATIONS FOR DNA BINDING
分子名称:YEAST TRANSCRIPTION FACTOR ADR1, ZINC ION
著者Hoffman, R.C., Xu, R.X., Horvath, S.J., Herriott, J.R., Klevit, R.E.
登録日1993-10-01
公開日1994-01-31
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Structures of DNA-binding mutant zinc finger domains: implications for DNA binding.
Protein Sci., 2, 1993
1Y0S
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CRYSTAL STRUCTURE OF PPAR DELTA COMPLEXED WITH GW2331
分子名称:Peroxisome proliferator activated receptor delta, IODIDE ION, (2S)-2-(4-[2-(3-[2,4-DIFLUOROPHENYL]-1-HEPTYLUREIDO)ETHYL]PHENOXY)-2-METHYLBUTYRIC ACID, ...
著者Takada, I., Yu, R.T., Xu, H.E., Xu, R.X., Lambert, M.H., Montana, V.G., Kliewer, S.A., Evans, R.M., Umesono, K.
登録日2004-11-16
公開日2005-03-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Alteration of a Single Amino Acid in Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) Generates a PPAR delta Phenotype
MOL.ENDOCRINOL., 14, 2000
3DY6
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PPARDELTA COMPLEXED WITH AN ANTHRANILIC ACID PARTIAL AGONIST
分子名称:Peroxisome proliferator-activated receptor delta, IODIDE ION, 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid
著者Lambert, M.L., Xu, R., Shearer, B.G., Wilson, T.M.
登録日2008-07-25
公開日2008-10-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery of a novel class of PPARdelta partial agonists
Bioorg.Med.Chem.Lett., 18, 2008
3PEQ
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PPARD COMPLEXED WITH A PHENOXYACETIC ACID PARTIAL AGONIST
分子名称:Peroxisome proliferator-activated receptor delta, [(4-{butyl[2-methyl-4'-(methylsulfanyl)biphenyl-3-yl]sulfamoyl}naphthalen-1-yl)oxy]acetic acid, hexyl beta-D-glucopyranoside, ...
著者Lambert, M.H., Evans, K.A., Shearer, B.G., Wisnoski, D.D., Shi, D., Jin, J., Rivero, R.A., Sparks, S.M., Winegar, D.A., Billin, A.N., Britt, C., Way, J.M., Leesnitzer, L.M., Merrihew, R.V.
登録日2010-10-27
公開日2011-10-12
最終更新日2014-10-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Phenoxyacetic acid PPARd partial agonists for the treatment of type 2 diabetes: synthesis, optimization, and in vivo efficacy
Bioorg.Med.Chem.Lett., 21, 2011
1PAA
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STRUCTURE OF A HISTIDINE-X4-HISTIDINE ZINC FINGER DOMAIN: INSIGHTS INTO ADR1-UAS1 PROTEIN-DNA RECOGNITION
分子名称:YEAST TRANSCRIPTION FACTOR ADR1, ZINC ION
著者Bernstein, B.E., Hoffman, R.C., Horvath, S.J., Herriott, J.R., Klevit, R.E.
登録日1994-07-15
公開日1994-10-15
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Structure of a histidine-X4-histidine zinc finger domain: insights into ADR1-UAS1 protein-DNA recognition.
Biochemistry, 33, 1994