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3CST
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BU of 3cst by Molmil
Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2
Descriptor: Methylated Ruthenium Pyridocarbazole, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Xie, P, Marmorstein, R.
Deposit date:2008-04-10
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3CSF
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BU of 3csf by Molmil
Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor DW2
Descriptor: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, RU-PYRIDOCARBAZOLE-2
Authors:Xie, P, Marmorstein, R.
Deposit date:2008-04-09
Release date:2008-05-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3Q4C
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BU of 3q4c by Molmil
Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292
Descriptor: Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+)
Authors:Xie, P, Streu, C, Qin, J, Pregman, H, Pagano, N, Meggers, E, Marmorstein, R.
Deposit date:2010-12-23
Release date:2011-03-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.
Biochemistry, 48, 2009
1AGN
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BU of 1agn by Molmil
X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE
Descriptor: ACETATE ION, HUMAN SIGMA ALCOHOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Hurley, T.D, Xie, P.
Deposit date:1996-06-04
Release date:1997-03-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.
J.Biol.Chem., 272, 1997
4E26
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BU of 4e26 by Molmil
BRAF in complex with an organic inhibitor 7898734
Descriptor: 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol, Serine/threonine-protein kinase B-raf
Authors:Qin, J, Xie, P, Ventocilla, C, Zhou, G, Vultur, A, Chen, Q, Herlyn, M, Winkler, J, Marmorstein, R.
Deposit date:2012-03-07
Release date:2012-05-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Identification of a Novel Family of BRAF(V600E) Inhibitors.
J.Med.Chem., 55, 2012
3KVQ
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BU of 3kvq by Molmil
Crystal structure of VEGFR2 extracellular domain D7
Descriptor: Vascular endothelial growth factor receptor 2
Authors:Yang, Y, Opatowsky, Y, Xie, P, Schlessinger, J.
Deposit date:2009-11-30
Release date:2010-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
Proc.Natl.Acad.Sci.USA, 107, 2010
1ZMS
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BU of 1zms by Molmil
LMP1 Protein binds to TRAF3 as a structural CD40
Descriptor: Latent membrane protein 1, TNF receptor associated factor 3
Authors:Wu, S.D, Xie, P, Welsh, K, Li, C, Ni, C.-Z, Zhu, X, Reed, J.C, Satterthwait, A.C, Bishop, G.A, Ely, K.R.
Deposit date:2005-05-10
Release date:2005-07-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:LMP1 protein from the Epstein Barr virus is a structural CD40 decoy in B lymphocytes fro binding to TRAF3
J.Biol.Chem., 39, 2005
1AG8
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BU of 1ag8 by Molmil
ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA
Descriptor: ALDEHYDE DEHYDROGENASE
Authors:Steinmetz, C.G, Hurley, T.D.
Deposit date:1997-04-03
Release date:1997-10-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.
Structure, 5, 1997
1A4Z
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BU of 1a4z by Molmil
ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA COMPLEX WITH NAD (REDUCED) AND SAMARIUM (III)
Descriptor: ALDEHYDE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SAMARIUM (III) ION
Authors:Steinmetz, C.G, Hurley, T.D.
Deposit date:1998-02-10
Release date:1998-04-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.
Structure, 5, 1997
1CW3
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BU of 1cw3 by Molmil
HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE COMPLEXED WITH NAD+ AND MN2+
Descriptor: MAGNESIUM ION, MANGANESE (II) ION, MITOCHONDRIAL ALDEHYDE DEHYDROGENASE, ...
Authors:Ni, L, Zhou, J, Hurley, T.D, Weiner, H.
Deposit date:1999-08-25
Release date:1999-08-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms.
Protein Sci., 8, 1999

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