Author results

1FP8
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STRUCTURE OF THE AMYLOMALTASE FROM THERMUS THERMOPHILUS HB8 IN SPACE GROUP P21212
分子名称:4-ALPHA-GLUCANOTRANSFERASE, MERCURY (II) ION, CHLORIDE ION
著者Uitdehaag, J.C.M., Euverink, G.J., van der Veen, B.A., van der Maarel, M., Dijkstra, B.W.
登録日2000-08-31
公開日2003-09-02
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure and mechanism of the amylomaltase from Thermus thermophilus HB8
To be Published
1FP9
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STRUCTURE OF AMYLOMALTASE FROM THERMUS THERMOPHILUS HB8 IN SPACE GROUP C2
分子名称:4-ALPHA-GLUCANOTRANSFERASE
著者Uitdehaag, J.C.M., Euverink, G.J., van der Veen, B.A., van der Maarel, M., Dijkstra, B.W.
登録日2000-08-31
公開日2003-09-02
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of the amylomaltase from Thermus thermophilus HB8 in space group C2
To be Published
5NAD
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TTK KINASE DOMAIN IN COMPLEX WITH BAY 1217389
分子名称:Dual specificity protein kinase TTK, BAY 1217389
著者Uitdehaag, J.C.M., Willemsen-Seegers, N., Sterrenburg, J.G., de Man, J., Buijsman, R.C., Zaman, G.J.R.
登録日2017-02-27
公開日2017-05-31
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
1EO5
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BACILLUS CIRCULANS STRAIN 251 CYCLODEXTRIN GLYCOSYLTRANSFERASE IN COMPLEX WITH MALTOHEPTAOSE
分子名称:PROTEIN (CYCLODEXTRIN GLYCOSYLTRANSFERASE), BETA-D-GLUCOSE, ALPHA-D-GLUCOSE, ...
著者Uitdehaag, J.C.M., Dijkstra, B.W.
登録日2000-03-22
公開日2000-11-22
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of maltohexaose and maltoheptaose bound at the donor sites of cyclodextrin glycosyltransferase give insight into the mechanisms of transglycosylation activity and cyclodextrin size specificity.
Biochemistry, 39, 2000
1EO7
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BACILLUS CIRCULANS STRAIN 251 CYCLODEXTRIN GLYCOSYLTRANSFERASE IN COMPLEX WITH MALTOHEXAOSE
分子名称:PROTEIN (CYCLODEXTRIN GLYCOSYLTRANSFERASE), ALPHA-D-GLUCOSE, CALCIUM ION
著者Uitdehaag, J.C.M., Dijkstra, B.W.
登録日2000-03-22
公開日2000-11-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Structures of maltohexaose and maltoheptaose bound at the donor sites of cyclodextrin glycosyltransferase give insight into the mechanisms of transglycosylation activity and cyclodextrin size specificity.
Biochemistry, 39, 2000
1CXK
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COMPLEX BETWEEN A MALTONONAOSE SUBSTRATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q/D229N
分子名称:PROTEIN (CYCLODEXTRIN-GLYCOSYLTRANSFERASE), ALPHA-D-GLUCOSE, CALCIUM ION
著者Uitdehaag, J.C.M., Kalk, K.H., Dijkstra, B.W.
登録日1999-02-24
公開日1999-05-03
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family.
Nat.Struct.Biol., 6, 1999
1CXL
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COMPLEX BETWEEN A COVALENT INTERMEDIATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q
分子名称:PROTEIN (CYCLODEXTRIN-GLYCOSYLTRANSFERASE), ALPHA-D-GLUCOSE, 4-DEOXY-ALPHA-D-GLUCOSE, ...
著者Uitdehaag, J.C.M., Dijkstra, B.W.
登録日1999-02-27
公開日1999-05-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family.
Nat.Struct.Biol., 6, 1999
1D3C
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MICHAELIS COMPLEX OF BACILLUS CIRCULANS STRAIN 251 CYCLODEXTRIN GLYCOSYLTRANSFERASE WITH GAMMA-CYCLODEXTRIN
分子名称:CYCLODEXTRIN GLYCOSYLTRANSFERASE, ALPHA-D-GLUCOSE, CALCIUM ION, ...
著者Uitdehaag, J.C.M., Kalk, K.H., van der Veen, B.A., Dijkhuizen, L., Dijkstra, B.W.
登録日1999-09-29
公開日1999-12-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献The cyclization mechanism of cyclodextrin glycosyltransferase (CGTase) as revealed by a gamma-cyclodextrin-CGTase complex at 1.8-A resolution.
J.Biol.Chem., 274, 1999
1DTU
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BACILLUS CIRCULANS STRAIN 251 CYCLODEXTRIN GLYCOSYLTRANSFERASE: A MUTANT Y89D/S146P COMPLEXED TO AN HEXASACCHARIDE INHIBITOR
分子名称:PROTEIN (CYCLODEXTRIN GLYCOSYLTRANSFERASE), ALPHA-D-GLUCOSE, 6-DEOXY-ALPHA-D-GLUCOSE, ...
著者Uitdehaag, J.C.M., Kalk, K.H., Dijkstra, B.W.
登録日2000-01-13
公開日2000-03-06
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase alpha-cyclodextrin production.
J.Mol.Biol., 296, 2000
1NT0
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CRYSTAL STRUCTURE OF THE CUB1-EGF-CUB2 REGION OF MASP2
分子名称:mannose-binding protein associated serine protease-2, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
著者Feinberg, H., Uitdehaag, J.C.M., Davies, J.M., Wallis, R., Drickamer, K., Weis, W.I.
登録日2003-01-28
公開日2003-05-20
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2
Embo J., 22, 2003
2DIJ
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COMPLEX OF A Y195F MUTANT CGTASE FROM B. CIRCULANS STRAIN 251 COMPLEXED WITH A MALTONONAOSE INHIBITOR AT PH 9.8 OBTAINED AFTER SOAKING THE CRYSTAL WITH ACARBOSE AND MALTOHEXAOSE
分子名称:CYCLODEXTRIN GLYCOSYLTRANSFERASE, ALPHA-D-GLUCOSE, 6-DEOXY-ALPHA-D-GLUCOSE, ...
著者Strokopytov, B.V., Knegtel, R.M.A., Uitdehaag, J.C.M., Dijkstra, B.W.
登録日1998-05-27
公開日1998-12-09
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of cyclodextrin glycosyltransferase complexed with a maltononaose inhibitor at 2.6 angstrom resolution. Implications for product specificity.
Biochemistry, 35, 1996
2W8Y
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RU486 BOUND TO THE PROGESTERONE RECEPTOR IN A DESTABILIZED AGONISTIC CONFORMATION
分子名称:PROGESTERONE RECEPTOR, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, SULFATE ION, ...
著者Raaijmakers, H.C.A., Versteeg, J., Uitdehaag, J.C.M.
登録日2009-01-20
公開日2009-04-28
最終更新日2017-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The X-Ray Structure of Ru486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation.
J.Biol.Chem., 284, 2009
2CXG
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CYCLODEXTRIN GLYCOSYLTRANSFERASE COMPLEXED TO THE INHIBITOR ACARBOSE
分子名称:CYCLODEXTRIN GLYCOSYLTRANSFERASE, ALPHA-D-GLUCOSE, 6-DEOXY-ALPHA-D-GLUCOSE, ...
著者Strokopytov, B.V., Uitdehaag, J.C.M., Ruiterkamp, R., Dijkstra, B.W.
登録日1998-05-08
公開日1998-10-14
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-ray structure of cyclodextrin glycosyltransferase complexed with acarbose. Implications for the catalytic mechanism of glycosidases.
Biochemistry, 34, 1995
5N84
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TTK KINASE DOMAIN IN COMPLEX WITH MPS-BAY2B
分子名称:Dual specificity protein kinase TTK, ~{N}-cyclopropyl-4-[8-(2-methylpropylamino)imidazo[1,2-a]pyrazin-3-yl]benzamide, SODIUM ION, ...
著者Uitdehaag, J., Willemsen-Seegers, N., de Man, J., Buijsman, R.C., Zaman, G.J.R.
登録日2017-02-22
公開日2017-05-31
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
1A47
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CGTASE FROM THERMOANAEROBACTERIUM THERMOSULFURIGENES EM1 IN COMPLEX WITH A MALTOHEXAOSE INHIBITOR
分子名称:CYCLODEXTRIN GLYCOSYLTRANSFERASE, ALPHA-D-GLUCOSE, 6-DEOXY-ALPHA-D-GLUCOSE, ...
著者Uitdehaag, J.C.M., Kalk, K.H., Rozeboom, H.J., Dijkstra, B.W.
登録日1998-02-11
公開日1998-06-17
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Engineering of cyclodextrin product specificity and pH optima of the thermostable cyclodextrin glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1.
J.Biol.Chem., 273, 1998
3KW9
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X-RAY STRUCTURE OF CATHEPSIN K COVALENTLY BOUND TO A TRIAZINE LIGAND
分子名称:Cathepsin K, 4-(cyclohexylamino)-6-piperazin-1-yl-1,3,5-triazine-2-carbonitrile, trifluoroacetic acid
著者Uitdehaag, J.C.M., van Zeeland, M.
登録日2009-12-01
公開日2010-03-02
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3KWB
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STRUCTURE OF CATK COVALENTLY BOUND TO A DIOXO-TRIAZINE INHIBITOR
分子名称:Cathepsin K, 3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
著者Uitdehaag, J.C.M., van Zeeland, M.
登録日2009-12-01
公開日2010-04-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Dioxo-triazines as a novel series of cathepsin K inhibitors
Bioorg.Med.Chem.Lett., 20, 2010
5N7V
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TTK KINASE DOMAIN IN COMPLEX WITH MPI-0479605
分子名称:Dual specificity protein kinase TTK, ~{N}6-cyclohexyl-~{N}2-(2-methyl-4-morpholin-4-yl-phenyl)-7~{H}-purine-2,6-diamine, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
著者Uitdehaag, J., Willemsen-Seegers, N., Zaman, G.J.R.
登録日2017-02-21
公開日2017-05-31
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5N87
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TTK KINASE DOMAIN IN COMPLEX WITH NTRC 0066-0
分子名称:Dual specificity protein kinase TTK, ~{N}-(2,6-diethylphenyl)-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide, 2,5,8,11-TETRAOXATRIDECANE, ...
著者Uitdehaag, J., Willemsen-Seegers, N., Sterrenburg, J.G., de Man, J., Buijsman, R.C., Zaman, G.J.R.
登録日2017-02-23
公開日2017-05-31
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5N93
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TTK KINASE DOMAIN IN COMPLEX WITH TC-MPS1-12
分子名称:Dual specificity protein kinase TTK, 4-[[4-azanyl-6-(~{tert}-butylamino)-5-cyano-pyridin-2-yl]amino]benzamide
著者Uitdehaag, J., Willemsen-Seegers, N., de Man, J., Buijsman, R.C., Zaman, G.J.R.
登録日2017-02-24
公開日2017-05-31
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5N9S
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TTK KINASE DOMAIN IN COMPLEX WITH BAY 1161909
分子名称:Dual specificity protein kinase TTK, (2~{R})-2-(4-fluorophenyl)-~{N}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide
著者Uitdehaag, J., Willemsen-Seegers, N., de Man, J., Buijsman, R.C., Zaman, G.J.R.
登録日2017-02-27
公開日2017-05-31
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
5NA0
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TTK KINASE DOMAIN IN COMPLEX WITH A PEG-LINKED PYRIMIDO-INDOLIZINE
分子名称:Dual specificity protein kinase TTK, ~{N}-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]pyrazol-4-yl]-2-[[2-methoxy-4-[4-(2-methoxyethanoyl)piperazin-1-yl]phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide
著者Uitdehaag, J., Willemsen-Seegers, N., de Man, J., Buijsman, R.C., Zaman, G.J.R.
登録日2017-02-27
公開日2017-05-31
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
1KCK
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BACILLUS CIRCULANS STRAIN 251 CYCLODEXTRIN GLYCOSYL TRANSFERASE MUTANT N193G
分子名称:CYCLODEXTRIN GLYCOSYLTRANSFERASE, ALPHA-D-GLUCOSE, 6-DEOXY-ALPHA-D-GLUCOSE, ...
著者Rozeboom, H.J., Uitdehaag, J.C.M., Dijkstra, B.W.
登録日2001-11-09
公開日2002-01-16
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献The remote substrate binding subsite -6 in cyclodextrin-glycosyltransferase controls the transferase activity of the enzyme via an induced-fit mechanism.
J.Biol.Chem., 277, 2002
1KCL
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BACILLUS CIRUCLANS STRAIN 251 CYCLODEXTRIN GLYCOSYL TRANSFERASE MUTANT G179L
分子名称:Cyclodextrin glycosyltransferase, MALTOSE, ALPHA-D-GLUCOSE, ...
著者Rozeboom, H.J., Uitdehaag, J.C.M., Dijkstra, B.W.
登録日2001-11-09
公開日2002-01-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献The remote substrate binding subsite -6 in cyclodextrin-glycosyltransferase controls the transferase activity of the enzyme via an induced-fit mechanism.
J.Biol.Chem., 277, 2002
3IPQ
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X-RAY STRUCTURE OF GW3965 SYNTHETIC AGONIST BOUND TO THE LXR-ALPHA
分子名称:Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, [3-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid, ...
著者Fradera, X., Vu, D., Nimz, O., Skene, R., Hosfield, D., Wijnands, R., Cooke, A.J., Haunso, A., King, A., Bennet, D.J., McGuire, R., Uitdehaag, J.C.M.
登録日2009-08-18
公開日2010-06-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
J.Mol.Biol., 399, 2010
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