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1A2K
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GDPRAN-NTF2 COMPLEX
分子名称:NUCLEAR TRANSPORT FACTOR 2, RAN, MAGNESIUM ION, ...
著者Stewart, M., Kent, H.M., Mccoy, A.J.
登録日1998-01-06
公開日1998-04-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran.
J.Mol.Biol., 277, 1998
1BYU
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CANINE GDP-RAN
分子名称:PROTEIN (GTP-BINDING PROTEIN RAN), MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
著者Stewart, M., Kent, H.M., Mccoy, A.J.
登録日1998-10-18
公開日1998-12-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2).
J.Mol.Biol., 284, 1998
1EQ6
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1.9 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE SACCHAROMYCES CEREVISIAE RAN-BINDING PROTEIN MOG1P
分子名称:MOG1P
著者Stewart, M., Baker, R.P.
登録日2000-04-03
公開日2000-05-27
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献1.9 A resolution crystal structure of the Saccharomyces cerevisiae Ran-binding protein Mog1p.
J.Mol.Biol., 299, 2000
3RAN
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CANINE GDP-RAN Q69L MUTANT
分子名称:PROTEIN (GTP-BINDING NUCLEAR PROTEIN RAN), MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
著者Stewart, M., Kent, H.M., Mccoy, A.J.
登録日1998-10-19
公開日1998-12-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2).
J.Mol.Biol., 284, 1998
5BXQ
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STRUCTURE OF THE NTF2:RANGDP COMPLEX
分子名称:Nuclear transport factor 2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ...
著者Stewart, M.
登録日2015-06-09
公開日2015-07-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran.
J. Mol. Biol., 277, 1998
2BVU
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D83R MUTANT OF ASARIS SUUM MAJOR SPERM PROTEIN (MSP)
分子名称:MAJOR SPERM PROTEIN, ISOFORM ALPHA
著者Stewart, M., Grant, R.P., Roberts, T.M.
登録日2005-07-04
公開日2006-10-25
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Role of Filament-Packing Dynamics in Powering Amoeboid Cell Motility.
Proc.Natl.Acad.Sci.USA, 105, 2008
3FWB
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SAC3:SUS1:CDC31 COMPLEX
分子名称:Cell division control protein 31, Nuclear mRNA export protein SAC3, Protein SUS1
著者Stewart, M., Jani, D.
登録日2009-01-17
公開日2009-04-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export.
Mol.Cell, 33, 2009
3FWC
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SAC3:SUS1:CDC31 COMPLEX
分子名称:Cell division control protein 31, Nuclear mRNA export protein SAC3, Protein SUS1, ...
著者Stewart, M., Jani, D.
登録日2009-01-17
公開日2009-04-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export.
Mol.Cell, 33, 2009
3KIK
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SGF11:SUS1 COMPLEX
分子名称:Protein SUS1, SAGA-associated factor 11
著者Stewart, M., Ellisdon, A.M.
登録日2009-11-02
公開日2009-12-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1
J.Biol.Chem., 285, 2010
3KJL
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SGF11:SUS1 COMPLEX
分子名称:Protein SUS1, SAGA-associated factor 11
著者Stewart, M., Ellisdon, A.M.
登録日2009-11-03
公開日2009-12-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.
J.Biol.Chem., 285, 2010
3KND
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TPX2:IMPORTIN-ALPHA COMPLEX
分子名称:Importin subunit alpha-2, Targeting protein for Xklp2, SULFATE ION
著者Stewart, M.
登録日2009-11-12
公開日2010-03-23
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.151 Å)
主引用文献Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha.
J.Biol.Chem., 285, 2010
3LCN
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NAB2:GFD1 COMPLEX
分子名称:Nuclear polyadenylated RNA-binding protein NAB2, mRNA transport factor GFD1, ZINC ION
著者Stewart, M.
登録日2010-01-11
公開日2010-05-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the function of the Saccharomyces cerevisiae Gfd1 protein in mRNA nuclear export.
J.Biol.Chem., 285, 2010
3T5V
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SAC3:THP1:SEM1 COMPLEX
分子名称:Nuclear mRNA export protein SAC3, Nuclear mRNA export protein THP1, 26S proteasome complex subunit SEM1
著者Stewart, M., Ellisdon, A.M.
登録日2011-07-28
公開日2012-02-22
最終更新日2012-03-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex.
Nat.Struct.Mol.Biol., 19, 2012
3T5X
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PCID2:DSS1 STRUCTURE
分子名称:PCI domain-containing protein 2, 26S proteasome complex subunit DSS1
著者Stewart, M., Ellisdon, A.M.
登録日2011-07-28
公開日2012-02-22
最終更新日2012-03-21
実験手法X-RAY DIFFRACTION (2.123 Å)
主引用文献Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex.
Nat.Struct.Mol.Biol., 19, 2012
4C31
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NUP1:SAC3:SUS1 COMPLEX
分子名称:NUCLEAR MRNA EXPORT PROTEIN SAC3, PROTEIN SUS1, NUCLEOPORIN NUP1
著者Stewart, M., Jani, D.
登録日2013-08-21
公開日2014-04-16
最終更新日2014-06-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis for Binding the Trex2 Complex to Nuclear Pores, Gal1 Localisation and Mrna Export.
Nucleic Acids Res., 42, 2014
4DHX
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ENY2:GANP COMPLEX
分子名称:80 kDa MCM3-associated protein, Enhancer of yellow 2 transcription factor homolog
著者Stewart, M., Jani, D.
登録日2012-01-30
公開日2012-06-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export.
Nucleic Acids Res., 40, 2012
4LJ0
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NAB2 ZN FINGERS COMPLEXED WITH POLYADENOSINE
分子名称:Nab2, polyadenosine RNA, ZINC ION, ...
著者Stewart, M., Kuhlmann, S.I., Valkov, E.
登録日2013-07-04
公開日2013-10-09
最終更新日2014-01-22
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers.
Nucleic Acids Res., 42, 2014
4U54
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
分子名称:Importin subunit alpha-1, N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine
著者Stewart, M., Valkov, E., Holvey, R.S.
登録日2014-07-24
公開日2015-05-13
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U58
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
分子名称:Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzoyl]-L-lysinamide
著者Stewart, M., Valkov, E., Holvey, R.S.
登録日2014-07-24
公開日2015-05-13
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5L
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
分子名称:Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysinamide
著者Stewart, M., Valkov, E., Holvey, R.S.
登録日2014-07-25
公開日2015-05-13
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5N
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
分子名称:Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysyl-N-[(1R,2S,3R)-1-{[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino}-1,3-dihydroxybutan-2-yl]glycinamide
著者Stewart, M., Valkov, E., Holvey, R.S.
登録日2014-07-25
公開日2015-05-13
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5O
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
分子名称:Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-D-lysinamide
著者Stewart, M., Valkov, E., Holvey, R.S.
登録日2014-07-25
公開日2015-05-13
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5S
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
分子名称:Importin subunit alpha-1, N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide
著者Stewart, M., Valkov, E., Holvey, R.S.
登録日2014-07-25
公開日2015-05-13
最終更新日2017-06-21
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5U
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
分子名称:Importin subunit alpha-1, N~2~-[3-(pyridin-3-yl)benzyl]-L-lysinamide
著者Stewart, M., Valkov, E., Holvey, R.S.
登録日2014-07-25
公開日2015-05-13
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5V
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
分子名称:Importin subunit alpha-1, N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide
著者Stewart, M., Valkov, E., Holvey, R.S.
登録日2014-07-25
公開日2015-05-13
最終更新日2015-07-08
実験手法X-RAY DIFFRACTION (1.968 Å)
主引用文献Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015