Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
5Y90
DownloadVisualize
BU of 5y90 by Molmil
MAP2K7 mutant -C218S
Descriptor: Dual specificity mitogen-activated protein kinase kinase 7, GLYCEROL
Authors:Kinoshita, T, Hashimoto, T, Sogabe, Y, Matsumoto, T, Sawa, M, Fukada, H.
Deposit date:2017-08-22
Release date:2017-10-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7
Biochem. Biophys. Res. Commun., 493, 2017
5ZZ4
DownloadVisualize
BU of 5zz4 by Molmil
Crystal structure of bruton's tyrosine kinase in complex with inhibitor 2e
Descriptor: N-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide, Tyrosine-protein kinase BTK
Authors:Kawahata, W, Asami, T, Irie, T, Kiyoi, T, Taniguchi, H, Asamitsu, Y, Inoue, T, Miyake, T, Sawa, M.
Deposit date:2018-05-30
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design and Synthesis of Novel Amino-triazine Analogues as Selective Bruton's Tyrosine Kinase Inhibitors for Treatment of Rheumatoid Arthritis.
J. Med. Chem., 61, 2018
5B2L
DownloadVisualize
BU of 5b2l by Molmil
A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Dual specificity mitogen-activated protein kinase kinase 7, GLYCEROL
Authors:Sogabe, Y, Hashimoto, T, Matsumoto, T, Kirii, Y, Sawa, M, Kinoshita, T.
Deposit date:2016-01-19
Release date:2016-04-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7
Biochem.Biophys.Res.Commun., 473, 2016
5B2K
DownloadVisualize
BU of 5b2k by Molmil
A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7
Descriptor: Dual specificity mitogen-activated protein kinase kinase 7
Authors:Sogabe, Y, Hashimoto, T, Matsumoto, T, Kirii, Y, Sawa, M, Kinoshita, T.
Deposit date:2016-01-19
Release date:2016-04-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7
Biochem.Biophys.Res.Commun., 473, 2016
5B2M
DownloadVisualize
BU of 5b2m by Molmil
A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7
Descriptor: Dual specificity mitogen-activated protein kinase kinase 7
Authors:Sogabe, Y, Hashimoto, T, Matsumoto, T, Kirii, Y, Sawa, M, Kinoshita, T.
Deposit date:2016-01-19
Release date:2016-04-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7
Biochem.Biophys.Res.Commun., 473, 2016
6JWA
DownloadVisualize
BU of 6jwa by Molmil
Crystal structure of CK2a1 with 5-iodotubercidin
Descriptor: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 1,2-ETHANEDIOL, Casein kinase II subunit alpha
Authors:Tsuyuguchi, M, Kinoshita, T.
Deposit date:2019-04-19
Release date:2019-07-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.781 Å)
Cite:A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1.
Acta Crystallogr.,Sect.F, 75, 2019
6IQN
DownloadVisualize
BU of 6iqn by Molmil
Crystal structure of TrkA kinase with ligand
Descriptor: 4-[[4-azanyl-3-(4-cyclohexylpiperazin-1-yl)-9,10-bis(oxidanylidene)anthracen-1-yl]amino]benzoic acid, High affinity nerve growth factor receptor
Authors:Noritaka, F.
Deposit date:2018-11-08
Release date:2020-01-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:An isoform-selective inhibitor of tropomyosin receptor kinase A behaves as molecular glue.
Bioorg.Med.Chem.Lett., 30, 2020
5AX9
DownloadVisualize
BU of 5ax9 by Molmil
Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase in complex with compund 9
Descriptor: 4-methoxy-3-[2-[(3-methoxy-4-morpholin-4-yl-phenyl)amino]pyridin-4-yl]benzenecarbonitrile, SULFATE ION, TRAF2 and NCK-interacting protein kinase
Authors:Ohbayashi, N, Kukimoto-Niino, M, Yamada, T, Shirouzu, M.
Deposit date:2015-07-21
Release date:2016-07-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:TNIK inhibition abrogates colorectal cancer stemness
Nat Commun, 7, 2016
5D7A
DownloadVisualize
BU of 5d7a by Molmil
Crystal structure of the kinase domain of TRAF2 and NCK-interacting protein kinase with NCB-0846
Descriptor: SULFATE ION, TRAF2 and NCK-interacting protein kinase, cis-4-{[2-(1H-benzimidazol-5-ylamino)quinazolin-8-yl]oxy}cyclohexanol
Authors:Ohbayashi, N, Kukimoto-Niino, M, Yamada, T, Shirouzu, M.
Deposit date:2015-08-13
Release date:2016-08-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:TNIK inhibition abrogates colorectal cancer stemness
Nat Commun, 7, 2016
5CWZ
DownloadVisualize
BU of 5cwz by Molmil
Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase
Descriptor: TRAF2 and NCK-interacting protein kinase
Authors:Ohbayashi, N, Kukimoto-Niino, M, Yamada, T, Shirouzu, M.
Deposit date:2015-07-28
Release date:2016-07-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:TNIK inhibition abrogates colorectal cancer stemness
Nat Commun, 7, 2016
7W5O
DownloadVisualize
BU of 7w5o by Molmil
Crystal structure of ERK2 with an allosteric inhibitor
Descriptor: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 13-[4-({Imidazo[1,2-a]pyridin-2-yl}methoxy)phenyl]-4,8-dioxa-12,14,16,18-tetraazatetracyclo[9.7.0.0^{3,9}.0^{12,17}]octadeca-1(11),2,9,15,17-pentaen-15-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Yoshida, M, Kinoshita, T.
Deposit date:2021-11-30
Release date:2022-02-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Identification of a novel target site for ATP-independent ERK2 inhibitors.
Biochem.Biophys.Res.Commun., 593, 2022
7X4H
DownloadVisualize
BU of 7x4h by Molmil
Crystal structure of CK2a1 complexed with AG1112
Descriptor: 5-azanyl-3-[(~{Z})-1-cyano-2-(1~{H}-indol-3-yl)ethenyl]-1~{H}-pyrazole-4-carbonitrile, Casein Kinase 2 subunit alpha
Authors:Ikeda, A, Kinoshita, T, Tsuyuguchi, M.
Deposit date:2022-03-02
Release date:2023-01-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2 alpha 1-selective inhibitors.
Biochem.Biophys.Res.Commun., 630, 2022
7XYH
DownloadVisualize
BU of 7xyh by Molmil
Crystal structure of CK2a2 complexed with AG1112
Descriptor: 1,2-ETHANEDIOL, 5-azanyl-3-[(~{Z})-1-cyano-2-(1~{H}-indol-3-yl)ethenyl]-1~{H}-pyrazole-4-carbonitrile, Casein kinase II subunit alpha'
Authors:Ikeda, A, Kinoshita, T, Tsuyuguchi, M.
Deposit date:2022-06-01
Release date:2023-01-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2 alpha 1-selective inhibitors.
Biochem.Biophys.Res.Commun., 630, 2022
3W8Q
DownloadVisualize
BU of 3w8q by Molmil
Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1)
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Nakae, S, Kitamura, M, Shirai, T, Tada, T.
Deposit date:2013-03-20
Release date:2014-03-26
Last modified:2021-12-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation.
Acta Crystallogr.,Sect.F, 77, 2021
5Y8U
DownloadVisualize
BU of 5y8u by Molmil
Crystal structure of the C276S mutant of MAP2K7
Descriptor: Dual specificity mitogen-activated protein kinase kinase 7
Authors:Kinoshita, T.
Deposit date:2017-08-21
Release date:2017-10-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7
Biochem. Biophys. Res. Commun., 493, 2017
3WZU
DownloadVisualize
BU of 3wzu by Molmil
THE STRUCTURE OF MAP2K7 IN COMPLEX WITH 5Z-7-oxozeaenol
Descriptor: (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, Dual specificity mitogen-activated protein kinase kinase 7
Authors:Sogabe, Y, Hashimoto, Y, Matsumoto, T, Kinoshita, T.
Deposit date:2014-10-07
Release date:2015-01-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner.
Bioorg.Med.Chem.Lett., 25, 2015

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon