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1PXX
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CRYSTAL STRUCTURE OF DICLOFENAC BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
分子名称:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
著者Kiefer, J.R., Rowlinson, S.W., Prusakiewicz, J.J., Pawlitz, J.L., Kozak, K.R., Kalgutkar, A.S., Stallings, W.C., Marnett, L.J., Kurumbail, R.G.
登録日2003-07-07
公開日2003-09-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385.
J.Biol.Chem., 278, 2003
1CVU
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CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
分子名称:PROSTAGLANDIN H2 SYNTHASE-2, PROTEIN (9-MER), N-ACETYL-D-GLUCOSAMINE, ...
著者Kiefer, J.R., Pawlitz, J.L., Moreland, K.T., Stegeman, R.A., Gierse, J.K., Stevens, A.M., Goodwin, D.C., Rowlinson, S.W., Marnett, L.J., Stallings, W.C., Kurumbail, R.G.
登録日1999-08-24
公開日2000-05-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405, 2000
1DDX
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CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE
分子名称:PROTEIN (PROSTAGLANDIN H2 SYNTHASE-2), N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
著者Kiefer, J.R., Pawlitz, J.L., Moreland, K.T., Stegeman, R.A., Gierse, J.K., Stevens, A.M., Goodwin, D.C., Rowlinson, S.W., Marnett, L.J., Stallings, W.C., Kurumbail, R.G.
登録日1999-11-11
公開日2000-05-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405, 2000
4RRW
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CRYSTAL STRUCTURE OF APO MURINE CYCLOOXYGENASE-2
分子名称:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
著者Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
登録日2014-11-06
公開日2015-04-08
最終更新日2015-06-03
実験手法X-RAY DIFFRACTION (2.569 Å)
主引用文献Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRX
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CRYSTAL STRUCTURE OF APO MURINE V89W CYCLOOXYGENASE-2 COMPLEXED WITH LUMIRACOXIB
分子名称:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
著者Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
登録日2014-11-06
公開日2015-04-08
最終更新日2015-06-03
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRY
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2
分子名称:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE
著者Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
登録日2014-11-06
公開日2015-04-08
最終更新日2015-06-03
実験手法X-RAY DIFFRACTION (2.429 Å)
主引用文献Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRZ
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH LUMIRACOXIB
分子名称:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
著者Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
登録日2014-11-06
公開日2015-04-08
最終更新日2015-06-03
実験手法X-RAY DIFFRACTION (2.569 Å)
主引用文献Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RS0
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CRYSTAL STRUCTURE OF MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH S-IBUPROFEN
分子名称:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
著者Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
登録日2014-11-06
公開日2015-04-08
最終更新日2015-06-03
実験手法X-RAY DIFFRACTION (2.807 Å)
主引用文献Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015