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1VY4
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING ACYLATED TRNA-SUBSTRATES IN THE A AND P SITES.
分子名称:16S Ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
著者Polikanov, Y.S., Steitz, T.A., Innis, C.A.
登録日2014-05-13
公開日2014-08-20
最終更新日2017-05-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
1VY5
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE POST-CATALYSIS STATE OF PEPTIDE BOND FORMATION CONTAINING DIPEPTYDIL-TRNA IN THE A SITE AND DEACYLATED TRNA IN THE P SITE.
分子名称:16S Ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
著者Polikanov, Y.S., Steitz, T.A., Innis, C.A.
登録日2014-05-13
公開日2014-08-20
最終更新日2017-05-31
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
1VY6
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING SHORT SUBSTRATE-MIMIC CYTIDINE-PUROMYCIN IN THE A SITE AND ACYLATED TRNA IN THE P SITE.
分子名称:16S Ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
著者Polikanov, Y.S., Steitz, T.A., Innis, C.A.
登録日2014-05-13
公開日2014-08-20
最終更新日2015-01-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
1VY7
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING SHORT SUBSTRATE-MIMIC CYTIDINE-CYTIDINE-PUROMYCIN IN THE A SITE AND ACYLATED TRNA IN THE P SITE.
分子名称:16S Ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
著者Polikanov, Y.S., Steitz, T.A., Innis, C.A.
登録日2014-05-13
公開日2014-08-20
最終更新日2015-01-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014
4V8G
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CRYSTAL STRUCTURE OF RMF BOUND TO THE 70S RIBOSOME.
分子名称:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
著者Polikanov, Y.S., Blaha, G.M., Steitz, T.A.
登録日2011-12-11
公開日2014-07-09
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
Science, 336, 2012
4V8H
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CRYSTAL STRUCTURE OF HPF BOUND TO THE 70S RIBOSOME.
分子名称:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
著者Polikanov, Y.S., Blaha, G.M., Steitz, T.A.
登録日2011-12-11
公開日2014-07-09
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis.
Science, 336, 2012
4V8I
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CRYSTAL STRUCTURE OF YFIA BOUND TO THE 70S RIBOSOME.
分子名称:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
著者Polikanov, Y.S., Blaha, G.M., Steitz, T.A.
登録日2011-12-12
公開日2014-07-09
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
Science, 336, 2012
4W2F
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH AMICOUMACIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
分子名称:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
著者Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
登録日2014-09-12
公開日2014-10-15
最終更新日2015-01-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2G
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (SOAKED), MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
分子名称:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
著者Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
登録日2014-09-12
公開日2014-10-15
最終更新日2015-01-14
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2H
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (CO-CRYSTALLIZED), MRNA AND DEACYLATED TRNA IN THE P SITE
分子名称:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
著者Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
登録日2014-09-12
公開日2014-10-15
最終更新日2015-01-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2I
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH NEGAMYCIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
分子名称:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
著者Polikanov, Y.S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T.A., Vazquez-Laslop, N., Mankin, A.S.
登録日2014-09-12
公開日2014-10-15
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA.
Mol.Cell, 56, 2014
4Y4O
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO PROTEIN Y (YFIA) AT 2.3A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
登録日2015-02-10
公開日2015-03-18
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
4Y4P
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.5A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A.
登録日2015-02-10
公開日2015-03-18
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat.Struct.Mol.Biol., 22, 2015
4Z3S
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC A201A, MRNA AND THREE TRNAS IN THE A, P AND E SITES AT 2.65A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N.
登録日2015-03-31
公開日2015-06-03
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
5DOX
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH HYGROMYCIN-A AT 3.1A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N.
登録日2015-09-11
公開日2015-12-30
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
5DOY
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC HYGROMYCIN A, MRNA AND THREE TRNAS IN THE A, P AND E SITES AT 2.6A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ...
著者Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N.
登録日2015-09-11
公開日2015-12-30
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
4V9R
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CRYSTAL STRUCTURE OF ANTIBIOTIC DITYROMYCIN BOUND TO 70S RIBOSOME
分子名称:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
著者Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A.
登録日2013-12-05
公開日2014-07-09
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
4V9S
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CRYSTAL STRUCTURE OF ANTIBIOTIC GE82832 BOUND TO 70S RIBOSOME
分子名称:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
著者Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A.
登録日2013-12-05
公開日2014-07-09
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
5J4B
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (CO-CRYSTALLIZED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION
分子名称:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
著者Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
登録日2016-03-31
公開日2016-04-27
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5J4C
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (SOAKED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION
分子名称:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
著者Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
登録日2016-03-31
公開日2016-04-27
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5KCR
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CRYO-EM STRUCTURE OF THE ESCHERICHIA COLI 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC AVILAMYCIN C, MRNA AND P-SITE TRNA AT 3.6A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Arenz, S., Juette, M.F., Graf, M., Nguyen, F., Huter, P., Polikanov, Y.S., Blanchard, S.C., Wilson, D.N.
登録日2016-06-06
公開日2016-08-17
最終更新日2018-07-18
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KCS
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CRYO-EM STRUCTURE OF THE ESCHERICHIA COLI 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC EVERNIMYCIN, MRNA, TETM AND P-SITE TRNA AT 3.9A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Arenz, S., Juette, M.F., Graf, M., Nguyen, F., Huter, P., Polikanov, Y.S., Blanchard, S.C., Wilson, D.N.
登録日2016-06-06
公開日2016-08-17
最終更新日2018-07-18
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5VP2
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH MADUMYCIN II AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION
分子名称:23S Ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
著者Osterman, I.A., Khabibullina, N.F., Komarova, E.S., Kasatsky, P., Kartsev, V.G., Bogdanov, A.A., Dontsova, O.A., Konevega, A.L., Sergiev, P.V., Polikanov, Y.S.
登録日2017-05-04
公開日2017-06-28
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.
Nucleic Acids Res., 45, 2017
5W4K
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH KLEBSAZOLICIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Metelev, M., Osterman, I.A., Ghilarov, D., Khabibullina, N.F., Yakimov, A., Shabalin, K., Utkina, I., Travin, D.Y., Komarova, E.S., Serebryakova, M., Artamonova, T., Khodorkovskii, M., Konevega, A.L., Sergiev, P.V., Severinov, K., Polikanov, Y.S.
登録日2017-06-12
公開日2017-08-30
最終更新日2018-06-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.
Nat. Chem. Biol., 13, 2017
5WIS
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH METHYMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION
分子名称:23S ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S.
登録日2017-07-20
公開日2018-02-14
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (2.703 Å)
主引用文献Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
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