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2J7L
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BU of 2j7l by Molmil
E. coli P Pilus chaperone PapD in complex with a pilus biogenesis inhibitor, pilicide 2c
Descriptor: (3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID, CHAPERONE PROTEIN PAPD
Authors:Remaut, H, Pinkner, J.S, Hultgren, S.J, Almqvist, F, Waksman, G.
Deposit date:2006-10-12
Release date:2006-11-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Rationally Designed Small Compounds Inhibit Pilus Biogenesis in Uropathogenic Bacteria.
Proc.Natl.Acad.Sci.USA, 103, 2006
2WMP
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BU of 2wmp by Molmil
Structure of the E. coli chaperone PapD in complex with the pilin domain of the PapGII adhesin
Descriptor: CHAPERONE PROTEIN PAPD, PAPG PROTEIN
Authors:Ford, B.A, Verger, D, Elam, J.S, Dodson, K.W, Pinkner, J.S, Hultgren, S.J.
Deposit date:2009-07-02
Release date:2010-08-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Papd-Papgii Pilin Complex Reveals an Open and Flexible P5 Pocket.
J.Bacteriol., 194, 2012
4UV2
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BU of 4uv2 by Molmil
Structure of the curli transport lipoprotein CsgG in a non-lipidated, pre-pore conformation
Descriptor: CURLI PRODUCTION TRANSPORT COMPONENT CSGG
Authors:Goyal, P, Krasteva, P.V, Gerven, N.V, Gubellini, F, Broeck, I.V.D, Troupiotis-Tsailaki, A, Jonckheere, W, Pehau-Arnaudet, G, Pinkner, J.S, Chapman, M.R, Hultgren, S.J, Howorka, S, Fronzes, R, Remaut, H.
Deposit date:2014-08-04
Release date:2014-09-24
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg.
Nature, 516, 2014
4UV3
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BU of 4uv3 by Molmil
Structure of the curli transport lipoprotein CsgG in its membrane- bound conformation
Descriptor: CURLI PRODUCTION ASSEMBLY/TRANSPORT COMPONENT CSGG
Authors:Goyal, P, Krasteva, P.V, Gerven, N.V, Gubellini, F, Broeck, I.V.D, Troupiotis-Tsailaki, A, Jonckheere, W, Pehau-Arnaudet, G, Pinkner, J.S, Chapman, M.R, Hultgren, S.J, Howorka, S, Fronzes, R, Remaut, H.
Deposit date:2014-08-04
Release date:2014-09-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg.
Nature, 516, 2014
2VQI
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BU of 2vqi by Molmil
Structure of the P pilus usher (PapC) translocation pore
Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, LAURYL DIMETHYLAMINE-N-OXIDE, OUTER MEMBRANE USHER PROTEIN PAPC
Authors:Remaut, H, Tang, C, Henderson, N.S, Pinkner, J.S, Wang, T, Hultgren, S.J, Thanassi, D.G, Li, H, Waksman, G.
Deposit date:2008-03-16
Release date:2008-05-27
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Fiber formation across the bacterial outer membrane by the chaperone/usher pathway.
Cell, 133, 2008
2XG4
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BU of 2xg4 by Molmil
E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 2c
Descriptor: (3R)-8-CYCLOPROPYL-6-(MORPHOLIN-4-YLMETHYL)-7-(1-NAPHTHYLMETHYL)-5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID, CHAPERONE PROTEIN PAPD, COBALT (II) ION, ...
Authors:Remaut, H, Phan, G, Buelens, F, Chorell, E, Pinkner, J.S, Edvinsson, S, Almqvist, F, Hultgren, S.J, Waksman, G.
Deposit date:2010-05-30
Release date:2010-07-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity.
J.Med.Chem., 53, 2010
2XG5
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BU of 2xg5 by Molmil
E. coli P pilus chaperone-subunit complex PapD-PapH bound to pilus biogenesis inhibitor, pilicide 5d
Descriptor: (2R)-2-[5-CYCLOPROPYL-6-(HYDROXYSULFANYL)-4-(NAPHTHALEN-1-YLMETHYL)-2-OXOPYRIDIN-1(2H)-YL]-3-PHENYLPROPANOIC ACID, (2R,3R)-8-CYCLOPROPYL-7-(NAPHTHALEN-1-YLMETHYL)-5-OXO-2-PHENYL-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID, CHAPERONE PROTEIN PAPD, ...
Authors:Remaut, H, Phan, G, Buelens, F, Chorell, E, Pinkner, J.S, Edvinsson, S, Almqvist, F, Hultgren, S.J, Waksman, G.
Deposit date:2010-05-30
Release date:2010-07-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity.
J.Med.Chem., 53, 2010
5VQ5
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BU of 5vq5 by Molmil
Crystal Structure of the Lectin Domain From the F17-like Adhesin, UclD
Descriptor: Adhesin, IODIDE ION
Authors:Klein, R.D, Spaulding, C.N, Dodson, K.W, Pinkner, J.S, Hultgren, S.J, Fremont, D.
Deposit date:2017-05-08
Release date:2017-05-24
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
Nature, 546, 2017
8DKA
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BU of 8dka by Molmil
Abp2D receptor binding domain R86E
Descriptor: Abp2D Receptor Binding Domain R86E
Authors:Tamadonfar, K.O, Pinkner, J.S, Dodson, K.W, Hultgren, S.J.
Deposit date:2022-07-05
Release date:2023-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-function correlates of fibrinogen binding by Acinetobacter adhesins critical in catheter-associated urinary tract infections.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DF0
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BU of 8df0 by Molmil
Abp1D receptor binding domain
Descriptor: Abp1D Receptor Binding Domain
Authors:Tamadonfar, K.O, Pinkner, J.S, Dodson, K.W, Hultgren, S.J.
Deposit date:2022-06-21
Release date:2023-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-function correlates of fibrinogen binding by Acinetobacter adhesins critical in catheter-associated urinary tract infections.
Proc.Natl.Acad.Sci.USA, 120, 2023
5LNG
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BU of 5lng by Molmil
Lectin domain of E. coli F9 pilus adhesin FmlH
Descriptor: Putative Fml fimbrial adhesin FmlD, SULFATE ION
Authors:Ruer, S, Conover, M.S, Kalas, V, Taganna, J, De Greve, H, Pinkner, J.S, Dodson, K.W, Hultgren, S.J, Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
5LNE
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BU of 5lne by Molmil
E. coli F9 pilus adhesin FmlH bound to the Thomsen-Friedenreich (TF) antigen
Descriptor: NICKEL (II) ION, Putative Fml fimbrial adhesin FmlD, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose
Authors:Ruer, S, Conover, M.S, Kalas, V, Taganna, J, De Greve, H, Pinkner, J.S, Dodson, K.W, Hultgren, S.J, Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
3ME0
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BU of 3me0 by Molmil
Structure of the E. coli chaperone PAPD in complex with the pilin domain of the PapGII adhesin
Descriptor: Chaperone protein papD, PapG protein
Authors:Ford, B.A, Elam, J.S, Dodson, K.W, Pinkner, J.S, Hultgren, S.J.
Deposit date:2010-03-31
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structure of the E. Coli Chaperone PapD in Complex with the Pilin Domain of the PapGII Adhesin
To be Published
1J8S
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BU of 1j8s by Molmil
PAPG ADHESIN RECEPTOR BINDING DOMAIN-UNBOUND FORM
Descriptor: PYELONEPHRITIC ADHESIN
Authors:Dodson, K.W, Pinkner, J.S, Rose, T, Magnusson, G, Hultgren, S.J, Waksman, G.
Deposit date:2001-05-22
Release date:2001-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell(Cambridge,Mass.), 105, 2001
1J8R
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BU of 1j8r by Molmil
BINARY COMPLEX OF THE PAPG RECEPTOR-BINDING DOMAIN BOUND TO GBO4 RECEPTOR
Descriptor: 2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, PYELONEPHRITIC ADHESIN
Authors:Dodson, K.W, Pinkner, J.S, Rose, T, Magnusson, G, Hultgren, S.J, Waksman, G, Midwest Center for Structural Genomics (MCSG)
Deposit date:2001-05-22
Release date:2001-06-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell(Cambridge,Mass.), 105, 2001
3PNT
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BU of 3pnt by Molmil
Crystal Structure of the Streptococcus pyogenes NAD+ glycohydrolase SPN in complex with IFS, the Immunity Factor for SPN
Descriptor: Immunity factor for SPN, NAD+-glycohydrolase
Authors:Smith, C.L, Stine Elam, J, Ellenberger, T, Ghosh, J, Pinkner, J.S, Hultgren, S.J, Caparon, M.G.
Deposit date:2010-11-19
Release date:2011-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Streptococcus pyogenes Immunity to Its NAD(+) Glycohydrolase Toxin.
Structure, 19, 2011
1N12
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BU of 1n12 by Molmil
Crystal structure of the PapE (N-terminal-deleted) pilus subunit bound to a peptide corresponding to the N-terminal extension of the PapK pilus subunit (residues 1-11) from uropathogenic E. coli
Descriptor: Peptide corresponding to the N-terminal extension of protein PapK, mature Fimbrial protein PapE
Authors:Sauer, F.G, Pinkner, J.S, Waksman, G, Hultgren, S.J.
Deposit date:2002-10-16
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation
Cell(Cambridge,Mass.), 111, 2002
1N0L
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BU of 1n0l by Molmil
Crystal structure of the PapD chaperone (C-terminally 6x histidine-tagged) bound to the PapE pilus subunit (N-terminal-deleted) from uropathogenic E. coli
Descriptor: Chaperone protein PapD, mature Fimbrial protein PapE
Authors:Sauer, F.G, Pinkner, J.S, Waksman, G, Hultgren, S.J.
Deposit date:2002-10-14
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation
Cell(Cambridge,Mass.), 111, 2002
1QPP
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BU of 1qpp by Molmil
CRYSTAL STRUCTURES OF SELF CAPPING PAPD CHAPERONE HOMODIMERS
Descriptor: PAPD CHAPERONE
Authors:Hung, D.L, Pinkner, J.S, Knight, S.D, Hultgren, S.J.
Deposit date:1999-05-28
Release date:1999-07-07
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of chaperone self-capping in P pilus biogenesis.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QPX
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BU of 1qpx by Molmil
CRYSTAL STRUCTURES OF SELF-CAPPING PAPD CHAPERONE HOMODIMERS
Descriptor: PAPD CHAPERONE
Authors:Hung, D.L, Pinkner, J.S, Knight, S.D, Hultgren, S.J.
Deposit date:1999-05-31
Release date:1999-07-07
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of chaperone self-capping in P pilus biogenesis.
Proc.Natl.Acad.Sci.USA, 96, 1999
8USM
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BU of 8usm by Molmil
FmlH Lectin Domain UTI89 - AM4085
Descriptor: 4'-fluoro-6-(trifluoromethyl)[1,1'-biphenyl]-2-yl 2-acetamido-2-deoxy-beta-D-galactopyranoside, Fimbrial protein (Fragment)
Authors:Tamadonfar, K.O, Pinkner, J.P, Maddirala, A.R, Janetka, J.W, Hultgren, S.J.
Deposit date:2023-10-27
Release date:2024-02-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections.
J.Med.Chem., 67, 2024
8DEZ
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BU of 8dez by Molmil
Abp2D Receptor Binding Domain ACICU
Descriptor: Abp2D Receptor Binding Domain, CITRATE ANION, SULFATE ION
Authors:Tamadonfar, K.O, Pinkner, J.P, Dodson, K.W, Kalas, V, Hultgren, S.J.
Deposit date:2022-06-21
Release date:2023-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Structure-function correlates of fibrinogen binding by Acinetobacter adhesins critical in catheter-associated urinary tract infections.
Proc.Natl.Acad.Sci.USA, 120, 2023
5JR4
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BU of 5jr4 by Molmil
Crystal structure of FimH A27V/V163A from E. coli UTI89 bound to FimG N-terminal extension
Descriptor: CALCIUM ION, FimG N-terminal extension, GLYCEROL, ...
Authors:Kalas, V, Hultgren, S.J.
Deposit date:2016-05-05
Release date:2017-02-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
Sci Adv, 3, 2017
6CD2
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BU of 6cd2 by Molmil
Crystal structure of the PapC usher bound to the chaperone-adhesin PapD-PapG
Descriptor: Chaperone protein PapD, Outer membrane usher protein PapC, PapGII adhesin protein
Authors:Omattage, N.S, Deng, Z, Yuan, P, Hultgren, S.J.
Deposit date:2018-02-07
Release date:2018-10-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli.
Nat Microbiol, 3, 2018
5JQI
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BU of 5jqi by Molmil
Crystal structure of FimH A62S from E. coli UTI89 bound to FimG N-terminal extension
Descriptor: FimG N-terminal extension, GLYCEROL, Type 1 fimbiral adhesin FimH
Authors:Kalas, V, Hultgren, S.J.
Deposit date:2016-05-05
Release date:2017-02-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.962 Å)
Cite:Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
Sci Adv, 3, 2017

 

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