Author results

2JOD
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PAC1-RSHORT N-TERMINAL EC DOMAIN PACAP(6-38) COMPLEX
分子名称:Pituitary adenylate cyclase-activating polypeptide type I receptor, Pituitary adenylate cyclase-activating polypeptide
著者Olejniczak, E.T., Sun, C., Song, D., Davis-Taber, R.A., Barrett, L.W., Scott, V.E., Richardson, P.L., Pereda-lopez, A., Uchic, M.E., Solomon, L.R., Lake, M.R., Walter, K.A., Hajduk, P.J.
登録日2007-03-07
公開日2007-05-22
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2KP8
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LIGAND BOUND TO A MODEL PEPTIDE THAT MIMICS THE OPEN FUSOGENIC FORM
分子名称:Model peptide, 5-{[(4'-methoxybiphenyl-4-yl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid
著者Olejniczak, E.T.
登録日2009-10-09
公開日2010-01-19
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.
Bioorg.Med.Chem.Lett., 2009
1FLI
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DNA-BINDING DOMAIN OF FLI-1
分子名称:FLI-1
著者Liang, H., Mao, X., Olejniczak, E.T., Nettesheim, D.G., Yu, L., Meadows, R.P., Thompson, C.B., Fesik, S.W.
登録日1994-09-15
公開日1995-09-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of the ets domain of Fli-1 when bound to DNA.
Nat.Struct.Biol., 1, 1994
1IRS
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IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:IRS-1, IL-4 RECEPTOR PHOSPHOPEPTIDE
著者Zhou, M.-M., Huang, B., Olejniczak, E.T., Meadows, R.P., Shuker, S.B., Miyazaki, M., Trub, T., Shoelson, S.E., Feisk, S.W.
登録日1996-03-22
公開日1997-05-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
1BC9
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CYTOHESIN-1/B2-1 SEC7 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:CYTOHESIN-1
著者Betz, S.F., Schnuchel, A., Wang, H., Olejniczak, E.T., Meadows, R.P., Fesik, S.W.
登録日1998-05-06
公開日1999-05-11
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1.
Proc.Natl.Acad.Sci.USA, 95, 1998
1G3F
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NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP
分子名称:INHIBITOR OF APOPTOSIS PROTEIN 3, SMAC, ZINC ION
著者Liu, Z., Sun, C., Olejniczak, E.T., Meadows, R.P., Betz, S.F., Oost, T., Herrmann, J., Wu, J.C., Fesik, S.W.
登録日2000-10-24
公開日2001-01-10
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Nature, 408, 2000
1G5J
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COMPLEX OF BCL-XL WITH PEPTIDE FROM BAD
分子名称:APOPTOSIS REGULATOR BCL-X, BAD PROTEIN
著者Petros, A.M., Nettesheim, D.G., Wang, Y., Olejniczak, E.T., Meadows, R.P., Mack, J., Swift, K., Matayoshi, E.D., Zhang, H., Thompson, C.B., Fesik, S.W.
登録日2000-11-01
公開日2001-02-07
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.
Protein Sci., 9, 2000
1IB8
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SOLUTION STRUCTURE AND FUNCTION OF A CONSERVED PROTEIN SP14.3 ENCODED BY AN ESSENTIAL STREPTOCOCCUS PNEUMONIAE GENE
分子名称:CONSERVED PROTEIN SP14.3
著者Yu, L., Gunasekera, A.H., Mack, J., Olejniczak, E.T., Chovan, L.E., Ruan, X., Towne, D.L., Lerner, C.G., Fesik, S.W.
登録日2001-03-27
公開日2002-03-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献SOLUTION STRUCTURE AND FUNCTION OF A CONSERVED PROTEIN SP14.3 ENCODED BY AN ESSENTIAL STREPTOCOCCUS PNEUMONIAE GENE
J.Mol.Biol., 311, 2001
1K3K
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SOLUTION STRUCTURE OF A BCL-2 HOMOLOG FROM KAPOSI'S SARCOMA VIRUS
分子名称:functional anti-apoptotic factor vBCL-2 homolog
著者Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
登録日2001-10-03
公開日2002-04-10
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.
Proc.Natl.Acad.Sci.USA, 99, 2002
1P0R
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SOLUTION STRUCTURE OF UBL5 A HUMAN UBIQUITIN-LIKE PROTEIN
分子名称:ubiquitin-like 5
著者McNally, T., Huang, Q., Janis, R.S., Liu, Z., Olejniczak, E.T., Reilly, R.M.
登録日2003-04-10
公開日2003-10-28
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural analysis of UBL5, a novel ubiquitin-like modifier
Protein Sci., 12, 2003
1PLS
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SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN
分子名称:PLECKSTRIN HOMOLOGY DOMAIN
著者Yoon, H.S., Hajduk, P.J., Petros, A.M., Olejniczak, E.T., Meadows, R.P., Fesik, S.W.
登録日1994-05-03
公開日1995-06-03
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Solution structure of a pleckstrin-homology domain.
Nature, 369, 1994
1Q3T
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SOLUTION STRUCTURE AND FUNCTION OF AN ESSENTIAL CMP KINASE OF STREPTOCOCCUS PNEUMONIAE
分子名称:Cytidylate kinase
著者Yu, L., Mack, J., Hajduk, P.J., Kakavas, S.J., Saiki, A.Y., Lerner, C.G., Olejniczak, E.T.
登録日2003-07-31
公開日2004-08-03
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and function of an essential CMP kinase of Streptococcus pneumoniae
Protein Sci., 12, 2003
1Q59
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SOLUTION STRUCTURE OF THE BHRF1 PROTEIN FROM EPSTEIN-BARR VIRUS, A HOMOLOG OF HUMAN BCL-2
分子名称:Early antigen protein R
著者Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
登録日2003-08-06
公開日2003-09-23
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
J.Mol.Biol., 332, 2003
1SSK
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STRUCTURE OF THE N-TERMINAL RNA-BINDING DOMAIN OF THE SARS COV NUCLEOCAPSID PROTEIN
分子名称:Nucleocapsid protein
著者Huang, Q., Yu, L., Petros, A.M., Gunasekera, A., Liu, Z., Xu, N., Hajduk, P., Mack, J., Fesik, S.W., Olejniczak, E.T.
登録日2004-03-24
公開日2004-06-08
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein.
Biochemistry, 43, 2004
1TFQ
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
分子名称:Baculoviral IAP repeat-containing protein 4, ZINC ION, N-METHYLALANYL-3-METHYLVALYL-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
著者Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
登録日2004-05-27
公開日2004-09-07
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer.
J.Med.Chem., 47, 2004
1TFT
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
分子名称:Baculoviral IAP repeat-containing protein 4, ZINC ION, 1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE
著者Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A.K., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
登録日2004-05-27
公開日2005-05-03
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
J.Med.Chem., 47, 2004
1URK
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SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
分子名称:PLASMINOGEN ACTIVATOR, ALPHA-L-FUCOSE
著者Hansen, A.P., Petros, A.M., Meadows, R.P., Nettesheim, D.G., Mazar, A.P., Olejniczak, E.T., Xu, R.X., Pederson, T.M., Henkin, J., Fesik, S.W.
登録日1994-01-10
公開日1995-05-08
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry, 33, 1994
1XOX
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SOLUTION STRUCTURE OF HUMAN SURVIVIN
分子名称:Apoptosis inhibitor survivin, ZINC ION
著者Sun, C., Nettesheim, D., Liu, Z., Olejniczak, E.T.
登録日2004-10-07
公開日2005-01-18
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of human survivin and its binding interface with smac/diablo
Biochemistry, 44, 2005
2A9H
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NMR STRUCTURAL STUDIES OF A POTASSIUM CHANNEL / CHARYBDOTOXIN COMPLEX
分子名称:Voltage-gated potassium channel, charybdotoxin
著者Yu, L., Sun, C., Song, D., Shen, J., Xu, N., Gunasekera, A., Hajduk, P.J., Olejniczak, E.T.
登録日2005-07-11
公開日2006-01-10
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.
Biochemistry, 44, 2005
2ABO
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NMR STRUCTURE OF GAMMA HERPESVIRUS 68 A VIRAL BCL-2 HOMOLOG
分子名称:bcl-2 homolog
著者Loh, J., Huang, Q., Petros, A.M., Nettesheim, D., van Dyk, L.F., Labrada, L., Speck, S.H., Levine, B., Olejniczak, E.T., Virgin, H.W.
登録日2005-07-15
公開日2006-05-16
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献A surface groove essential for viral Bcl-2 function during chronic infection in vivo.
Plos Pathog., 1, 2005
2E6W
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SOLUTION STRUCTURE AND CALCIUM BINDING PROPERTIES OF EF-HANDS 3 AND 4 OF CALSENILIN
分子名称:Calsenilin, CALCIUM ION
著者Yu, L., Sun, C., Mendoza, R., Hebert, E., Pereda-Lopez, A., Hajduk, P.J., Olejniczak, E.T.
登録日2007-01-05
公開日2007-11-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin.
Protein Sci., 16, 2007
4EPR
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION.
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
4EPT
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
4EPV
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
4EPW
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012