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1PQZ
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MURINE CYTOMEGALOVIRUS IMMUNOMODULATORY PROTEIN M144
分子名称:MCMV M144, Beta-2-microglobulin
著者Miley, M.J., Fremont, D.H., Midwest Center for Structural Genomics (MCSG)
登録日2003-06-19
公開日2004-07-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献MURINE CYTOMEGALOVIRUS IMMUNOMODULATORY PROTEIN M144
To be Published
1RJY
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MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND HERPES SIMPLEX VIRUS GLYCOPROTEIN B PEPTIDE
分子名称:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
著者Miley, M.J., Messaoudi, I., Nikolich-Zugich, J., Fremont, D.H.
登録日2003-11-20
公開日2004-12-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
J.Exp.Med., 200, 2004
1RJZ
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MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND HERPIES SIMPLEX VIRUS MUTANT GLYCOPROTEIN B PEPTIDE
分子名称:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
著者Miley, M.J., Messaoudi, I., Nikolich-Zugich, J., Fremont, D.H.
登録日2003-11-20
公開日2004-12-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
J.Exp.Med., 200, 2004
1RK0
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MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND HERPES SIMPLEX VIRUS GLYCOPROTEIN B PEPTIDE
分子名称:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
著者Miley, M.J., Messaoudi, I., Nikolich-Zugich, J., Fremont, D.H.
登録日2003-11-20
公開日2004-12-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
J.Exp.Med., 200, 2004
1RK1
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MHC CLASS I NATURAL H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND HERPES SIMPLEX VIRUS MUTANT GLYCOPROTEIN B PEPTIDE
分子名称:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
著者Miley, M.J., Messaoudi, I., Nikolich-Zugich, J., Fremont, D.H.
登録日2003-11-20
公開日2004-12-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
J.Exp.Med., 200, 2004
2O6L
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CRYSTAL STRUCTURE OF THE UDP-GLUCURONIC ACID BINDING DOMAIN OF THE HUMAN DRUG METABOLIZING UDP-GLUCURONOSYLTRANSFERASE 2B7
分子名称:UDP-glucuronosyltransferase 2B7
著者Miley, M.J., Redinbo, M.R.
登録日2006-12-07
公開日2007-05-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of the Cofactor-Binding Domain of the Human Phase II Drug-Metabolism Enzyme UDP-Glucuronosyltransferase 2B7.
J.Mol.Biol., 369, 2007
1FNE
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HISTOCOMPATIBILITY ANTIGEN
分子名称:PROTEIN (MHC CLASS II I-EK, ALPHA CHAIN), BETA CHAIN), ...
著者Miley, M.J., Nelson, C.A., Fremont, D.H.
登録日2000-08-21
公開日2001-03-07
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional consequences of altering a peptide MHC anchor residue.
J.Immunol., 166, 2001
1FNG
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HISTOCOMPATIBILITY ANTIGEN
分子名称:PROTEIN (MHC CLASS II I-EK, ALPHA CHAIN), BETA CHAIN), ...
著者Miley, M.J., Nelson, C.A., Fremont, D.H.
登録日2000-08-21
公開日2001-03-07
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional consequences of altering a peptide MHC anchor residue.
J.Immunol., 166, 2001
3ONW
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STRUCTURE OF A G-ALPHA-I1 MUTANT WITH ENHANCED AFFINITY FOR THE RGS14 GOLOCO MOTIF.
分子名称:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
著者Bosch, D., Kimple, A.J., Sammond, D.W., Miley, M.J., Machius, M., Kuhlman, B., Willard, F.S., Siderovski, D.P.
登録日2010-08-30
公開日2010-11-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
3V1A
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-APO1
分子名称:Computational design, MID1-apo1
著者Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
登録日2011-12-09
公開日2012-01-11
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1B
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-APO2
分子名称:Computational design, MID1-apo2, GLYCEROL
著者Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
登録日2011-12-09
公開日2012-01-11
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1C
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-ZINC
分子名称:Computational design, MID1-zinc, ZINC ION, ...
著者Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
登録日2011-12-09
公開日2012-01-11
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (1.129 Å)
主引用文献Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1D
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-COBALT
分子名称:Computational design, MID1-cobalt, COBALT (II) ION, ...
著者Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
登録日2011-12-09
公開日2012-01-11
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (1.239 Å)
主引用文献Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1E
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-ZINC H12E MUTANT
分子名称:Computational design, MID1-zinc H12E mutant, ZINC ION
著者Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
登録日2011-12-09
公開日2012-01-11
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (1.073 Å)
主引用文献Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1F
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-ZINC H35E MUTANT
分子名称:Computational design, MID1-zinc H35E mutant, ZINC ION, ...
著者Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
登録日2011-12-09
公開日2012-01-11
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (1.151 Å)
主引用文献Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3ZY7
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CRYSTAL STRUCTURE OF COMPUTATIONALLY REDESIGNED GAMMA-ADAPTIN APPENDAGE DOMAIN FORMING A SYMMETRIC HOMODIMER
分子名称:AP-1 COMPLEX SUBUNIT GAMMA-1, ISOPROPYL ALCOHOL, DI(HYDROXYETHYL)ETHER
著者Stranges, P.B., Machius, M., Miley, M.J., Tripathy, A., Kuhlman, B.
登録日2011-08-17
公開日2011-12-28
最終更新日2012-01-11
実験手法X-RAY DIFFRACTION (1.09 Å)
主引用文献Computational Design of a Symmetric Homodimer Using Beta-Strand Assembly.
Proc.Natl.Acad.Sci.USA, 108, 2011
4MH7
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1896
分子名称:Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ...
著者Zhang, W., McIver, A., Stashko, M.A., Deryckere, D., Branchford, B.R., Hunter, D., Kireev, D.B., Miley, M.J., Norris-Drouin, J., Stewart, W.M., Lee, M., Sather, S., Zhou, Y., DiPaola, J.A., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
登録日2013-08-29
公開日2014-05-21
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013
5K0K
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC2434
分子名称:Tyrosine-protein kinase Mer, CHLORIDE ION, 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3H)-one, ...
著者Wang, X., Liu, J., Zhang, W., Stashko, M.A., Nichols, J., DeRyckere, D., Miley, M.J., Norris-Drouin, J., Chen, Z., Machius, M., Wood, E., Graham, D.K., Earp, H.S., Graham, K., Kireev, D., Frye, S.V.
登録日2016-05-17
公開日2017-01-11
実験手法X-RAY DIFFRACTION (2.545 Å)
主引用文献Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
ACS Med Chem Lett, 7, 2016
5K0X
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC2541
分子名称:Tyrosine-protein kinase Mer, CHLORIDE ION, (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide
著者McIver, A.L., Zhang, W., Liu, Q., Jiang, X., Stashko, M.A., Nichols, J., Miley, M.J., Norris-Drouin, J., Machius, M., DeRyckere, D., Wood, E., Graham, D.K., Earp, H.S., Kireev, D., Frye, S.V., Wang, X.
登録日2016-05-17
公開日2017-02-22
実験手法X-RAY DIFFRACTION (2.231 Å)
主引用文献Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
ChemMedChem, 12, 2017
3TCP
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC569
分子名称:Tyrosine-protein kinase Mer, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, CHLORIDE ION, ...
著者Liu, J., Yang, C., Simpson, C., DeRyckere, D., Van Deusen, A., Miley, M., Kireev, D.B., Norris-Drouin, J., Sather, S., Hunter, D., Patel, H.S., Janzen, W.P., Machius, M., Johnson, G., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
登録日2011-08-09
公開日2012-06-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS Med Chem Lett, 3, 2012
4M3Q
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1917
分子名称:Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ...
著者Zhang, W., Zhang, D., Stashko, M.A., DeRyckere, D., Hunter, D., Kireev, D.B., Miley, M., Cummings, C., Lee, M., Norris-Drouin, J., Stewart, W.M., Sather, S., Zhou, Y., Kirkpatrick, G., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
登録日2013-08-06
公開日2013-11-27
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.718 Å)
主引用文献Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors.
J.Med.Chem., 56, 2013
4MHA
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1817
分子名称:Tyrosine-protein kinase Mer, CHLORIDE ION, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, ...
著者Zhang, W., Mciver, A., Stashko, M.A., Deryckere, D., Branchford, B.R., Hunter, D., Kireev, D.B., Miley, D.B.M., Norris-Drouin, J., Stewart, W.M., Lee, M., Sather, S., Zhou, Y., Dipaola, J.A., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
登録日2013-08-29
公開日2014-05-21
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013
6MEP
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC3437
分子名称:Tyrosine-protein kinase Mer, CHLORIDE ION, cis-4-[(2-[(4-{[4-(1,3-dioxolan-2-yl)pyridin-2-yl]ethynyl}phenyl)amino]-5-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}pyrimidin-4-yl)amino]cyclohexan-1-ol, ...
著者Da, C., Zhang, D., Stashko, M.A., Cheng, A., Hunter, D., Norris-Drouin, J., Graves, L., Machius, M., Miley, M.J., DeRyckere, D., Earp, H.S., Graham, D.K., Frye, S.V., Wang, X., Kireev, D.
登録日2018-09-06
公開日2019-09-11
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (2.893 Å)
主引用文献Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.
J.Am.Chem.Soc., 141, 2019
3QE0
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A GALPHA-I1 P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE
分子名称:Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, MAGNESIUM ION, ...
著者Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
登録日2011-01-19
公開日2012-01-25
最終更新日2012-03-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3QI2
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A GALPHA P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE: G42R BOUND TO RGS14 GOLOCO
分子名称:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
著者Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
登録日2011-01-26
公開日2012-02-01
最終更新日2012-03-14
実験手法X-RAY DIFFRACTION (2.797 Å)
主引用文献A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
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