Author results

2NDJ
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STRUCTURAL BASIS FOR KCNE3 AND ESTROGEN MODULATION OF THE KCNQ1 CHANNEL
分子名称:Potassium voltage-gated channel subfamily E member 3
著者Sanders, C.R., Van Horn, W.D., Kroncke, B.M., Sisco, N.J., Meiler, J., Vanoye, C.G., Song, Y., Nannemann, D.P., Welch, R.C., Kang, C., Smith, J., George, A.L.
登録日2016-06-09
公開日2016-09-21
最終更新日2017-12-20
実験手法SOLUTION NMR
主引用文献Structural basis for KCNE3 modulation of potassium recycling in epithelia.
Sci Adv, 2, 2016
6F27
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NMR SOLUTION STRUCTURE OF NON-BOUND [DES-ARG10]-KALLIDIN (DAKD)
分子名称:DAKD
著者Richter, C., Jonker, H.R.A., Schwalbe, H., Joedicke, L., Mao, J., Kuenze, G., Reinhart, C., Kalavacherla, T., Meiler, J., Preu, J., Michel, H., Glaubitz, C.
登録日2017-11-23
公開日2018-01-10
最終更新日2019-05-08
実験手法SOLUTION NMR
主引用文献The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3V
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BACKBONE STRUCTURE OF BRADYKININ (BK) PEPTIDE BOUND TO HUMAN BRADYKININ 2 RECEPTOR (B2R) DETERMINED BY MAS SSNMR
分子名称:Bradykinin (BK)
著者Mao, J., Lopez, J.J., Shukla, A.K., Kuenze, G., Meiler, J., Schwalbe, H., Michel, H., Glaubitz, C.
登録日2017-11-29
公開日2018-01-10
最終更新日2018-02-21
実験手法SOLID-STATE NMR
主引用文献The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3W
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BACKBONE STRUCTURE OF FREE BRADYKININ (BK) IN DDM/CHS DETERGENT MICELLE DETERMINED BY MAS SSNMR
分子名称:Kininogen-1
著者Mao, J., Lopez, J.J., Shukla, A.K., Kuenze, G., Meiler, J., Schwalbe, H., Michel, H., Glaubitz, C.
登録日2017-11-29
公開日2018-01-10
最終更新日2018-02-21
実験手法SOLID-STATE NMR
主引用文献The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3X
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BACKBONE STRUCTURE OF DES-ARG10-KALLIDIN (DAKD) PEPTIDE IN FROZEN DDM/CHS DETERGENT MICELLE SOLUTION DETERMINED BY DNP-ENHANCED MAS SSNMR
分子名称:Kininogen-1
著者Mao, J., Kuenze, G., Joedicke, L., Meiler, J., Michel, H., Glaubitz, C.
登録日2017-11-29
公開日2018-01-10
最終更新日2018-02-21
実験手法SOLID-STATE NMR
主引用文献The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3Y
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BACKBONE STRUCTURE OF DES-ARG10-KALLIDIN (DAKD) PEPTIDE BOUND TO HUMAN BRADYKININ 1 RECEPTOR (B1R) DETERMINED BY DNP-ENHANCED MAS SSNMR
分子名称:Kininogen-1
著者Mao, J., Kuenze, G., Joedicke, L., Meiler, J., Michel, H., Glaubitz, C.
登録日2017-11-29
公開日2018-01-10
最終更新日2018-02-21
実験手法SOLID-STATE NMR
主引用文献The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
3TDN
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COMPUTATIONALLY DESIGNED TWO-FOLD SYMMETRIC TIM-BARREL PROTEIN, FLR
分子名称:FLR SYMMETRIC ALPHA-BETA TIM BARREL
著者Harp, J.M., Fortenberry, C., Bowman, E., Profitt, W., Dorr, B., Mizoue, L., Meiler, J.
登録日2011-08-11
公開日2011-11-16
最終更新日2011-11-23
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133, 2011
4PAM
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
分子名称:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ...
著者Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
登録日2014-04-09
公開日2014-07-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAN
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
分子名称:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ...
著者Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
登録日2014-04-09
公開日2014-07-30
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAO
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
分子名称:Guanine nucleotide-binding protein G(i) subunit alpha-1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
著者Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
登録日2014-04-09
公開日2014-07-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.003 Å)
主引用文献A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAQ
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
分子名称:Guanine nucleotide-binding protein G(i) subunit alpha-1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
著者Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
登録日2014-04-09
公開日2014-07-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
5KDL
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CRYSTAL STRUCTURE OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT BOUND TO GTPGAMMAS
分子名称:Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
著者Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
登録日2016-06-08
公開日2016-08-03
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.665 Å)
主引用文献A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
5KDO
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HETEROTRIMERIC COMPLEX OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT AND THE GBETA1-GGAMMA1
分子名称:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
著者Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
登録日2016-06-08
公開日2016-08-03
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
2K21
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NMR STRUCTURE OF HUMAN KCNE1 IN LMPG MICELLES AT PH 6.0 AND 40 DEGREE C
分子名称:Potassium voltage-gated channel subfamily E member
著者Kang, C., Tian, C., Sonnichsen, F.D., Smith, J.A., Meiler, J., George, A.L., Vanoye, C.G., Sanders, C.R., Kim, H.
登録日2008-03-19
公開日2008-12-09
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel.
Biochemistry, 47, 2008
2K39
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RECOGNITION DYNAMICS UP TO MICROSECONDS REVEALED FROM RDC DERIVED UBIQUITIN ENSEMBLE IN SOLUTION
分子名称:Ubiquitin
著者Lange, O.F., Lakomek, N.A., Fares, C., Schroder, G., Walter, K., Becker, S., Meiler, J., Grubmuller, H., Griesinger, C., de Groot, B.L.
登録日2008-04-25
公開日2008-06-24
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution.
Science, 320, 2008
2LLE
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COMPUTATIONAL DESIGN OF AN EIGHT-STRANDED (BETA/ALPHA)-BARREL FROM FRAGMENTS OF DIFFERENT FOLDS
分子名称:Chemotaxis protein CheY, Imidazole glycerol phosphate synthase subunit HisF chimera
著者Coles, M., Truffault, V., Eisenbeis, S., Proffitt, W., Meiler, J., Hocker, B.
登録日2011-11-07
公開日2012-03-21
実験手法SOLUTION NMR
主引用文献Potential of fragment recombination for rational design of proteins.
J.Am.Chem.Soc., 134, 2012
5TQL
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CRYSTAL STRUCTURE OF TIM-BARREL PROTEIN HISF-C9S
分子名称:Imidazole glycerol phosphate synthase subunit HisF, PHOSPHATE ION
著者Bender, B.J., Meiler, J.
登録日2016-10-24
公開日2016-11-16
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Experimental and Computational Identification of Naive Binders to a TIM-Barrel Protein Scaffold
To Be Published
6BP2
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THERAPEUTIC HUMAN MONOCLONAL ANTIBODY MR191 BOUND TO A MARBURGVIRUS GLYCOPROTEIN
分子名称:Envelope glycoprotein, Envelope glycoprotein GP2, MR191 Fab Heavy Chain, ...
著者King, L.B., Fusco, M.L., Flyak, A.I., Ilinykh, P.A., Huang, K., Gunn, B., Kirchdoerfer, R.N., Hastie, K.M., Sangha, A.K., Meiler, J., Alter, G., Bukreyev, A., Crowe, J.E.J., Saphire, E.O.
登録日2017-11-21
公開日2018-01-17
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (3.172 Å)
主引用文献The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Cell Host Microbe, 23, 2018
5BOP
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CRYSTAL STRUCTURE OF THE ARTIFICIAL NANOBODY OCTARELLINV.1 COMPLEX
分子名称:Nanobody, Octarellin V.1
著者Figueroa, M., Sleutel, M., Pardon, E., Steyaert, J., Martial, J.A., van de Weerdt, C.
登録日2015-05-27
公開日2016-05-25
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
5JRP
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CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY MR78 FAB
分子名称:marberg virus monoclonal antibody MR78 Fab light chain, marberg virus monoclonal antibody MR78 Fab heavy chain, SODIUM ION
著者Dong, J., Crowe, J.
登録日2016-05-06
公開日2017-11-08
最終更新日2018-04-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
4ZV6
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CRYSTAL STRUCTURE OF THE ARTIFICIAL ALPHAREP-7 OCTARELLINV.1 COMPLEX
分子名称:AlphaRep-7, Octarellin V.1
著者Figueroa, M., Sleutel, M., Urvoas, A., Valerio-Lepiniec, M., Minard, P., Martial, J.A., van de Weerdt, C.
登録日2015-05-18
公開日2016-05-25
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
5WEQ
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THE CRYSTAL STRUCTURE OF A MR78 MUTANT
分子名称:MR78 mutant light chain, MR78 mutant Fab heavy chain
著者Dong, J., Williamson, L.E., Crowe, J.E.
登録日2017-07-10
公開日2018-04-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
3TDM
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COMPUTATIONALLY DESIGNED TIM-BARREL PROTEIN, HALFFLR
分子名称:Computationally designed two-fold symmetric TIM-barrel protein, FLR (half molecule), PHOSPHATE ION
著者Harp, J.M., Fortenberry, C., Bowman, E., Profitt, W., Dorr, B., Mizoue, L.
登録日2011-08-11
公開日2011-11-16
最終更新日2011-11-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133, 2011
2KN5
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A CORRESPONDENCE BETWEEN SOLUTION-STATE DYNAMICS OF AN INDIVIDUAL PROTEIN AND THE SEQUENCE AND CONFORMATIONAL DIVERSITY OF ITS FAMILY
分子名称:Ubiquitin
著者Friedland, G.D.
登録日2009-08-14
公開日2009-11-17
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献A correspondence between solution-state dynamics of an individual protein and the sequence and conformational diversity of its family.
PLOS COMPUT.BIOL., 5, 2009
3MF6
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
分子名称:Endo-1,4-beta-xylanase, SULFATE ION
著者Morin, A., Harp, J.M.
登録日2010-04-01
公開日2010-11-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
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