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3N3Z
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BU of 3n3z by Molmil
Crystal structure of PDE9A (E406A) mutant in complex with IBMX
Descriptor: 3-ISOBUTYL-1-METHYLXANTHINE, CHLORIDE ION, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ...
Authors:Hou, J, Luo, H.-B, Chen, Y, Xu, J, Zhao, R, Zou, L.
Deposit date:2010-05-21
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of PDE9A (E406A) mutation in complex with IBMX
To be Published
6KZE
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BU of 6kze by Molmil
The crystal structue of PDE10A complexed with 4d
Descriptor: 8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline, MAGNESIUM ION, ZINC ION, ...
Authors:Yang, Y, Zhang, S, Zhou, Q, Huang, Y.-Y, Guo, L, Luo, H.-B.
Deposit date:2019-09-24
Release date:2020-09-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.50003481 Å)
Cite:Novel Potent and Highly Selective Benzoimidazole-based Phosphodiesterase 10 Inhibitors with Improved Solubility and Pharmacokinetic Properties for the Treatment of Pulmonary Arterial Hypertension
To Be Published
7VTV
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BU of 7vtv by Molmil
Crystal structure of PDE8A catalytic domain in complex with 15
Descriptor: 2-chloro-9-(3-(2,2-difluoroethoxy)-5-(difluoromethoxy)benzyl)-9H-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ...
Authors:Wu, X.-N, Zhou, Q, Huang, Y.-D, Li, Z, Wu, Y, Luo, H.-B.
Deposit date:2021-10-31
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia
To Be Published
7VSL
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BU of 7vsl by Molmil
Crystal structure of PDE8A catalytic domain in complex with 10
Descriptor: 2-chloro-9-(3-(2,2-difluoroethoxy)benzyl)-9H-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ...
Authors:Wu, X.-N, Zhou, Q, Huang, Y.-D, Li, Z, Wu, Y, Luo, H.-B.
Deposit date:2021-10-26
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.500069 Å)
Cite:Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia
To Be Published
7VTX
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BU of 7vtx by Molmil
Crystal structure of PDE8A catalytic domain in complex with 22
Descriptor: 2-chloro-9-(3-(2,2-difluoroethoxy)-5-(pyridin-4-yl)benzyl)-9H-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ...
Authors:Wu, X.-N, Zhou, Q, Huang, Y.-D, Li, Z, Wu, Y, Luo, H.-B.
Deposit date:2021-10-31
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.50010943 Å)
Cite:Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia
To Be Published
7VTW
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BU of 7vtw by Molmil
Crystal structure of PDE8A catalytic domain in complex with 17
Descriptor: 2-chloro-9-(3-(2,2-difluoroethoxy)-5-isopropoxybenzyl)-9H-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ...
Authors:Wu, X.-N, Zhou, Q, Huang, Y.-D, Li, Z, Wu, Y, Luo, H.-B.
Deposit date:2021-10-31
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.79971337 Å)
Cite:Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia
To Be Published
3EEF
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BU of 3eef by Molmil
Crystal structure of N-carbamoylsarcosine amidase from thermoplasma acidophilum
Descriptor: N-carbamoylsarcosine amidase related protein, ZINC ION
Authors:Luo, H.-B, Zheng, H, Chruszcz, M, Zimmerman, M.D, Skarina, T, Egorova, O, Savchenko, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2008-09-04
Release date:2008-09-16
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum.
J.Struct.Biol., 169, 2010
3ICC
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BU of 3icc by Molmil
Crystal structure of a putative 3-oxoacyl-(acyl carrier protein) reductase from Bacillus anthracis at 1.87 A resolution
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Hou, J, Chruszcz, M, Zheng, H, Cymborowski, M, Luo, H.-B, Skarina, T, Gordon, S, Savchenko, A, Edwards, A.M, Anderson, W, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2009-07-17
Release date:2009-07-28
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.
Acta Crystallogr.,Sect.F, 68, 2012
3V4E
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BU of 3v4e by Molmil
Crystal Structure of the galactoside O-acetyltransferase in complex with CoA
Descriptor: COENZYME A, DI(HYDROXYETHYL)ETHER, Galactoside O-acetyltransferase, ...
Authors:Knapik, A.A, Shumilin, I.A, Luo, H.-B, Chruszcz, M, Zimmerman, M.D, Cymborowski, M, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-12-14
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus.
J.Struct.Funct.Genom., 14, 2013
7BPI
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BU of 7bpi by Molmil
The crystal structue of PDE10A complexed with 14
Descriptor: 8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline, MAGNESIUM ION, ZINC ION, ...
Authors:Yang, Y, Zhang, S, Zhou, Q, Huang, Y.-Y, Guo, L, Luo, H.-B.
Deposit date:2020-03-22
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4000864 Å)
Cite:Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension.
Acta Pharm Sin B, 10, 2020
6KJZ
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BU of 6kjz by Molmil
Crystal structure of PDE4D catalytic domain complexed with compound 1
Descriptor: 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, MAGNESIUM ION, ZINC ION, ...
Authors:Huang, Y.-Y, He, X, Luo, H.-B.
Deposit date:2019-07-23
Release date:2020-03-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.200001 Å)
Cite:Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia.
J.Med.Chem., 63, 2020
6KK0
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BU of 6kk0 by Molmil
Crystal structure of PDE4D catalytic domain complexed with compound 4e
Descriptor: 7-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-9-yl]oxyheptanoic acid, MAGNESIUM ION, ZINC ION, ...
Authors:Huang, Y.-Y, He, X, Luo, H.-B.
Deposit date:2019-07-23
Release date:2020-03-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.20008755 Å)
Cite:Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia.
J.Med.Chem., 63, 2020
6KO0
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BU of 6ko0 by Molmil
The crystal structue of PDE10A complexed with 1i
Descriptor: 3-[2-(5-methyl-1-phenyl-benzimidazol-2-yl)ethyl]chromen-4-one, MAGNESIUM ION, ZINC ION, ...
Authors:Huang, Y.-Y, Yu, Y.F, Zhang, C, Guo, L, Wu, D, Luo, H.-B.
Deposit date:2019-08-07
Release date:2020-04-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.600029 Å)
Cite:Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors.
Acs Chem Neurosci, 11, 2020
6KO1
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BU of 6ko1 by Molmil
The crystal structue of PDE10A complexed with 2d
Descriptor: 6-chloranyl-3-[2-(5-methyl-1-phenyl-benzimidazol-2-yl)ethyl]chromen-4-one, MAGNESIUM ION, ZINC ION, ...
Authors:Huang, Y.-Y, Yu, Y.F, Zhang, C, Guo, L, Wu, D, Luo, H.-B.
Deposit date:2019-08-07
Release date:2020-04-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors.
Acs Chem Neurosci, 11, 2020
7CWF
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BU of 7cwf by Molmil
Crystal structure of PDE8A catalytic domain in complex with 2c
Descriptor: 9-[[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]methyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ...
Authors:Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B.
Deposit date:2020-08-28
Release date:2021-09-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.
J.Med.Chem., 63, 2020
7CWG
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BU of 7cwg by Molmil
Crystal structure of PDE8A catalytic domain in complex with 3a
Descriptor: 9-[(1~{S})-1-[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]ethyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ...
Authors:Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B.
Deposit date:2020-08-28
Release date:2021-09-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.
J.Med.Chem., 63, 2020
7CWA
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BU of 7cwa by Molmil
Crystal structure of PDE8A catalytic domain in complex with clofarabine
Descriptor: 2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ...
Authors:Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B.
Deposit date:2020-08-27
Release date:2021-09-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.
J.Med.Chem., 63, 2020
7F2M
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BU of 7f2m by Molmil
Crystal structure of PDE4D catalytic domain complexed with compound 18d
Descriptor: (~{Z})-4-[9-[(4-fluorophenyl)methoxy]-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-6-oxidanylidene-pyrano[3,2-b]xanthen-5-yl]oxybut-2-enoic acid, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ...
Authors:Huang, Y.-Y, He, X, Luo, H.-B.
Deposit date:2021-06-11
Release date:2021-10-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.20004153 Å)
Cite:Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.
J.Med.Chem., 64, 2021
7F2K
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BU of 7f2k by Molmil
Crystal structure of PDE4D catalytic domain complexed with compound 17a
Descriptor: (~{E})-4-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-9-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-5-yl]oxybut-2-enoic acid, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ...
Authors:Huang, Y.-Y, He, X, Luo, H.-B.
Deposit date:2021-06-11
Release date:2021-10-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.10001969 Å)
Cite:Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.
J.Med.Chem., 64, 2021
7F2L
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BU of 7f2l by Molmil
Crystal structure of PDE4D catalytic domain complexed with compound 18a
Descriptor: (~{E})-4-[9-[(4-fluorophenyl)methoxy]-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-6-oxidanylidene-pyrano[3,2-b]xanthen-5-yl]oxybut-2-enoic acid, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ...
Authors:Huang, Y.-Y, He, X, Luo, H.-B.
Deposit date:2021-06-11
Release date:2021-10-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.10111427 Å)
Cite:Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.
J.Med.Chem., 64, 2021
7W4Y
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BU of 7w4y by Molmil
Crystal structure of PDE4D catalytic domain complexed with 33a
Descriptor: (2R,4S)-6-ethyl-2-(2-hydroxyethyl)-2,8-dimethyl-4-(2-methylprop-1-enyl)-3,4-dihydropyrano[3,2-c][1,8]naphthyridin-5-one, MAGNESIUM ION, ZINC ION, ...
Authors:Huang, Y.-Y, Luo, H.-B.
Deposit date:2021-11-29
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.10002947 Å)
Cite:Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.
J.Med.Chem., 65, 2022
7W4X
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BU of 7w4x by Molmil
Crystal structure of PDE4D catalytic domain complexed with 17
Descriptor: (2R,4S)-2-(2-hydroxyethyl)-2,6-dimethyl-4-(2-methylprop-1-enyl)-3,4-dihydropyrano[3,2-c][1,8]naphthyridin-5-one, MAGNESIUM ION, ZINC ION, ...
Authors:Huang, Y.-Y, Luo, H.-B.
Deposit date:2021-11-29
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.20007324 Å)
Cite:Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.
J.Med.Chem., 65, 2022
7XBB
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BU of 7xbb by Molmil
Crystal structure of PDE4D catalytic domain complexed with compound 23a
Descriptor: (2~{R},4~{S})-6-ethyl-2-[(2~{E})-2-hydroxyiminoethyl]-2,8-dimethyl-4-(2-methylprop-1-enyl)-3,4-dihydropyrano[3,2-c][1,8]naphthyridin-5-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ...
Authors:Huang, Y.-Y, Luo, H.-B.
Deposit date:2022-03-21
Release date:2022-07-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.100009 Å)
Cite:Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects.
Biochem Pharmacol, 202, 2022
7XAB
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BU of 7xab by Molmil
Crystal structure of PDE4D catalytic domain complexed with compound 22d
Descriptor: 9-(cyclopropylmethoxy)-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ...
Authors:Huang, Y.-Y, He, X, Luo, H.-B.
Deposit date:2022-03-17
Release date:2023-02-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.00067449 Å)
Cite:Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.
Eur.J.Med.Chem., 242, 2022
7XAA
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BU of 7xaa by Molmil
Crystal structure of PDE4D catalytic domain complexed with compound 21d
Descriptor: 8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-9-oxidanyl-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ...
Authors:Huang, Y.-Y, He, X, Luo, H.-B.
Deposit date:2022-03-17
Release date:2023-02-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.100414 Å)
Cite:Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.
Eur.J.Med.Chem., 242, 2022

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