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6PEW
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BU of 6pew by Molmil
CryoEM Plasmodium falciparum glutamine synthetase
Descriptor: Glutamine synthetase
Authors:Ho, C.M, Lai, M, Zhou, Z.H.
Deposit date:2019-06-21
Release date:2019-12-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu.
Nat.Methods, 17, 2020
6PEV
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BU of 6pev by Molmil
CryoEM Plasmodium falciparum M18 aspartyl aminopeptidase
Descriptor: M18 aspartyl aminopeptidase, ZINC ION
Authors:Ho, C, Lai, M, Zhou, Z.H.
Deposit date:2019-06-21
Release date:2019-12-11
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu.
Nat.Methods, 17, 2020
6BP8
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BU of 6bp8 by Molmil
Recombinant major vault protein [Rattus norvegicus] structure in solution: conformation 1
Descriptor: Major vault protein
Authors:Ding, K, Zhang, X, Mrazek, J, Kickhoefer, V.A, Lai, M, Ng, H.L, Yang, O.O, Rome, L.H, Zhou, Z.H.
Deposit date:2017-11-22
Release date:2018-04-04
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Solution Structures of Engineered Vault Particles.
Structure, 26, 2018
6E10
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BU of 6e10 by Molmil
PTEX Core Complex in the Engaged (Extended) State
Descriptor: Endogenous cargo polypeptide, Exported protein 2, Heat shock protein 101, ...
Authors:Ho, C, Lai, M, Zhou, Z.H.
Deposit date:2018-07-08
Release date:2018-08-22
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (4.16 Å)
Cite:Malaria parasite translocon structure and mechanism of effector export.
Nature, 561, 2018
6E11
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BU of 6e11 by Molmil
PTEX Core Complex in the Resetting (Compact) State
Descriptor: Endogenous cargo polypeptide, Exported protein 2, Heat shock protein 101, ...
Authors:Ho, C, Lai, M, Zhou, Z.H.
Deposit date:2018-07-08
Release date:2018-08-22
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (4.23 Å)
Cite:Malaria parasite translocon structure and mechanism of effector export.
Nature, 561, 2018
7MRW
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BU of 7mrw by Molmil
Native RhopH complex of the malaria parasite Plasmodium falciparum
Descriptor: Cytoadherence linked asexual protein 3.1, High molecular weight rhoptry protein 2, High molecular weight rhoptry protein 3
Authors:Ho, C.M, Jih, J, Lai, M, Li, X.R, Goldberg, D.E, Beck, J.R, Zhou, Z.H.
Deposit date:2021-05-10
Release date:2021-09-15
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition.
Proc.Natl.Acad.Sci.USA, 118, 2021
5T2A
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BU of 5t2a by Molmil
CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution
Descriptor: 18S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Zhang, X, Lai, M, Zhou, Z.H.
Deposit date:2016-08-23
Release date:2017-01-25
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Nat Commun, 7, 2016
5T2C
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BU of 5t2c by Molmil
CryoEM structure of the human ribosome at 3.6 Angstrom resolution
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
Authors:Zhang, X, Lai, M, Zhou, Z.H.
Deposit date:2016-08-23
Release date:2017-01-25
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Nat Commun, 7, 2016
5TC1
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BU of 5tc1 by Molmil
In situ structures of the genome and genome-delivery apparatus in ssRNA bacteriophage MS2
Descriptor: Capsid protein, Maturation protein, phage MS2 genome
Authors:Dai, X.H, Li, Z.H, Lai, M, Shu, S, Du, Y.S, Zhou, Z.H, Sun, R.
Deposit date:2016-09-13
Release date:2016-12-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus.
Nature, 541, 2017
6N9Y
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BU of 6n9y by Molmil
Atomic structure of Non-Structural protein 1 of bluetongue virus
Descriptor: Non-structural protein 1
Authors:Kerviel, A, Ge, P, Lai, M, Jih, J, Boyce, M, Zhang, X, Zhou, Z.H, Roy, P.
Deposit date:2018-12-04
Release date:2019-03-13
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Atomic structure of the translation regulatory protein NS1 of bluetongue virus.
Nat Microbiol, 4, 2019
6BP7
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BU of 6bp7 by Molmil
Recombinant major vault protein [Rattus norvegicus] structure in solution: conformation 2
Descriptor: Major vault protein
Authors:Ding, K, Zhang, X, Mrazek, J, Kickhoefer, V.A, Lai, M, Ng, H.L, Yang, O.O, Rome, L.H, Zhou, Z.H.
Deposit date:2017-11-22
Release date:2018-04-04
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Solution Structures of Engineered Vault Particles.
Structure, 26, 2018
6JRK
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BU of 6jrk by Molmil
The structure of co-crystals of 8r-B-EGFR WT complex
Descriptor: 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one, Epidermal growth factor receptor
Authors:Zhu, S.J, Yun, C.H.
Deposit date:2019-04-04
Release date:2020-04-15
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.796 Å)
Cite:Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S).
J.Med.Chem., 62, 2019
6JRJ
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BU of 6jrj by Molmil
The structure of co-crystals of 8r-B-EGFR T790M/C797S complex
Descriptor: 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one, Epidermal growth factor receptor
Authors:Zhu, S.J, Yun, C.H.
Deposit date:2019-04-04
Release date:2020-04-15
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.943 Å)
Cite:Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S).
J.Med.Chem., 62, 2019
6CCY
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BU of 6ccy by Molmil
Crystal structure of Akt1 in complex with a selective inhibitor
Descriptor: (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one, RAC-alpha serine/threonine-protein kinase,PIFtide
Authors:Wang, Y, Stout, S.
Deposit date:2018-02-07
Release date:2018-05-02
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Bioorg. Med. Chem. Lett., 28, 2018
7ER2
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BU of 7er2 by Molmil
Crystal structure of EGFR 696-1022 T790M/C797S in complex with LS_2_40
Descriptor: 5-chloranyl-N2-[3-chloranyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine, Epidermal growth factor receptor
Authors:Zhu, S.J, Yun, C.H.
Deposit date:2021-05-05
Release date:2022-04-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.662 Å)
Cite:Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR T790M/C797S Mutants.
Acs Med.Chem.Lett., 13, 2022
3FKT
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BU of 3fkt by Molmil
Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor
Descriptor: Beta-secretase 1, N-(4-{[4-(cyclohexylamino)-1-(3-fluorophenyl)-2-oxo-1,3,8-triazaspiro[4.5]dec-3-en-8-yl]methyl}phenyl)acetamide
Authors:Munshi, S.
Deposit date:2008-12-17
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and X-ray Crystallographic Analysis of a Iminohydantoin Inhibitor of beta-Secretase
J.Med.Chem., 51, 2008
7VRE
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BU of 7vre by Molmil
The crystal structure of EGFR T790M/C797S with the inhibitor HCD2892
Descriptor: 5-chloranyl-N-[5-chloranyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-(1-ethylsulfonylindol-3-yl)pyrimidin-2-amine, Epidermal growth factor receptor
Authors:Zhu, S.J.
Deposit date:2021-10-22
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.507 Å)
Cite:Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.
J.Med.Chem., 65, 2022
7VRA
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BU of 7vra by Molmil
The crystal structure of EGFR T790M/C797S with the inhibitor HC5476
Descriptor: 25-chloro-11-(ethylsulfonyl)-44-morpholino-11H-5,12-dioxa-3-aza-1(3,6)-indola-2(4,2)-pyrimidina-4(1,3)-benzenacyclododecaphane, Epidermal growth factor receptor
Authors:Zhu, S.J.
Deposit date:2021-10-22
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.
J.Med.Chem., 65, 2022
5OSG
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BU of 5osg by Molmil
Structure of KSRP in context of Leishmania donovani 80S
Descriptor: 18S rRNA, 40S ribosomal protein S6, RNA binding protein, ...
Authors:Brito Querido, J, Mancera-Martinez, E, Vicens, Q, Bochler, A, Chicher, J, Simonetti, A, Hashem, Y.
Deposit date:2017-08-17
Release date:2017-11-15
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.
Structure, 25, 2017

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