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1K4R
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BU of 1k4r by Molmil
Structure of Dengue Virus
Descriptor: MAJOR ENVELOPE PROTEIN E
Authors:Kuhn, R.J, Zhang, W, Rossmann, M.G, Pletnev, S.V, Corver, J, Lenches, E, Jones, C.T, Mukhopadhyay, S, Chipman, P.R, Strauss, E.G, Baker, T.S, Strauss, J.H.
Deposit date:2001-10-08
Release date:2002-03-13
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (24 Å)
Cite:Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.
Cell(Cambridge,Mass.), 108, 2002
4WM7
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BU of 4wm7 by Molmil
Crystal Structure of Human Enterovirus D68 in Complex with Pleconaril
Descriptor: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE, VP1, VP2, ...
Authors:Liu, Y, Sheng, J, Fokine, A, Meng, G, Long, F, Kuhn, R.J, Rossmann, M.G.
Deposit date:2014-10-08
Release date:2015-01-14
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.
Science, 347, 2015
8FE4
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BU of 8fe4 by Molmil
Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody
Descriptor: Envelope protein E, prM protein, prM13 Fab Heavy Chain, ...
Authors:Dowd, A.D, Sirohi, D, Speer, S, Mukherjee, S, Govero, J, Aleshnick, M, Larman, B, Sukupolvi-Petty, S, Sevvana, M, Miller, A.S, Klose, T, Zheng, A, Kielian, M, Kuhn, R.J, Diamond, M.S, Pierson, T.C.
Deposit date:2022-12-05
Release date:2023-02-01
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (9.8 Å)
Cite:prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis.
Proc.Natl.Acad.Sci.USA, 120, 2023
8FE3
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BU of 8fe3 by Molmil
Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody
Descriptor: Envelope protein E, prM protein, prM12 Fab Heavy Chain, ...
Authors:Dowd, A.D, Sirohi, D, Speer, S, Mukherjee, S, Govero, J, Aleshnick, M, Larman, B, Sukupolvi-Petty, S, Sevvana, M, Miller, A.S, Klose, T, Zheng, A, Kielian, M, Kuhn, R.J, Diamond, M.S, Pierson, T.C.
Deposit date:2022-12-05
Release date:2023-02-01
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (10.2 Å)
Cite:prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis.
Proc.Natl.Acad.Sci.USA, 120, 2023
7T17
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BU of 7t17 by Molmil
Zika Virus asymmetric unit bound with IgM antibody DH1017 Fab fragment
Descriptor: Core protein, DH1017.IgM FabC constant domain, DH1017.IgM IgH, ...
Authors:Miller, A.S, Kuhn, R.J.
Deposit date:2021-12-01
Release date:2022-11-23
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (5.26 Å)
Cite:A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization.
Cell, 185, 2022
7V0O
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BU of 7v0o by Molmil
Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a moderately/weakly neutralizing human antibody IgG-94
Descriptor: IgG 94 Fab heavy chain, IgG 94 Fab light chain, Spike glycoprotein E1, ...
Authors:Bandyopadhyay, A, Klose, T, Kuhn, R.J.
Deposit date:2022-05-10
Release date:2023-04-05
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 120, 2023
7V0N
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BU of 7v0n by Molmil
Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a moderately/weakly neutralizing human antibody IgG-21
Descriptor: IgG 21 Fab heavy chain, IgG 21 Fab light chain, Spike glycoprotein E1, ...
Authors:Bandyopadhyay, A, Klose, T, Kuhn, R.J.
Deposit date:2022-05-10
Release date:2023-04-05
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 120, 2023
7V0P
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BU of 7v0p by Molmil
Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a potently neutralizing human antibody IgG-106
Descriptor: IgG 106 Fab heavy chain, IgG 106 Fab light chain, Spike glycoprotein E1, ...
Authors:Bandyopadhyay, A, Klose, T, Kuhn, R.J.
Deposit date:2022-05-10
Release date:2023-04-05
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 120, 2023
7T9P
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BU of 7t9p by Molmil
Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain native virion
Descriptor: viral protein 1, viral protein 2, viral protein 3, ...
Authors:Fu, J, Klose, T, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-12-19
Release date:2023-01-25
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Isoxazole-3-Carboxamide Derivatives of Pleconaril Destabilize the Viral Capsid of Enterovirus-D68
To Be Published
7TAF
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BU of 7taf by Molmil
Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain virion in complex with inhibitor 11526092
Descriptor: N,N-dimethyl-5-(3-{2-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenoxy}propyl)-1,2-oxazole-3-carboxamide, viral protein 1, viral protein 2, ...
Authors:Fu, J, Klose, T, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-12-20
Release date:2023-01-25
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Isoxazole-3-Carboxamide Derivatives of Pleconaril Destabilize the Viral Capsid of Enterovirus-D68
To Be Published
7TAH
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BU of 7tah by Molmil
Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain in complex with inhibitor 11526091 (no/low occupancy-no inhibitor modeled)
Descriptor: viral protein 1, viral protein 2, viral protein 3, ...
Authors:Fu, J, Klose, T, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-12-20
Release date:2023-01-25
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Isoxazole-3-Carboxamide Derivatives of Pleconaril Destabilize the Viral Capsid of Enterovirus-D68
To Be Published
7TAJ
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BU of 7taj by Molmil
Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain in complex with inhibitor 11526093 (no/low occupancy-no inhibitor modeled)
Descriptor: viral protein 1, viral protein 2, viral protein 3, ...
Authors:Fu, J, Klose, T, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-12-20
Release date:2023-01-25
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Isoxazole-3-Carboxamide Derivatives of Pleconaril Destabilize the Viral Capsid of Enterovirus-D68
To Be Published
7TAG
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BU of 7tag by Molmil
Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain virion in complex with pleconaril
Descriptor: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE, viral protein 1, viral protein 2, ...
Authors:Fu, J, Klose, T, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-12-20
Release date:2023-01-25
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Isoxazole-3-Carboxamide Derivatives of Pleconaril Destabilize the Viral Capsid of Enterovirus-D68
To Be Published
2SNW
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BU of 2snw by Molmil
SINDBIS VIRUS CAPSID PROTEIN, TYPE3 CRYSTAL FORM
Descriptor: COAT PROTEIN C
Authors:Choi, H.-K, Lee, S, Zhang, Y.-P, Mckinney, B.R, Wengler, G, Rossmann, M.G, Kuhn, R.J.
Deposit date:1998-02-17
Release date:1998-04-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of Sindbis virus capsid mutants involving assembly and catalysis.
J.Mol.Biol., 262, 1996
4UOM
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BU of 4uom by Molmil
Electron Cryo-microscopy of Venezuelan Equine Encephalitis Virus TC- 83 in complex with neutralizing antibody Fab F5
Descriptor: FAB FRAGMENT HEAVY CHAIN, FAB FRAGMENT LIGHT CHAIN
Authors:Porta, J, Jose, J, Roehrig, J.T, Blair, C.D, Kuhn, R.J, Rossmann, M.G.
Deposit date:2014-06-05
Release date:2014-10-15
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Locking and Blocking the Viral Landscape of an Alphavirus with Neutralizing Antibodies.
J.Virol., 88, 2014
4UOK
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BU of 4uok by Molmil
Electron Cryo-microscopy of Venezuelan Equine Encephalitis Virus TC-83 in complex with neutralizing antibody Fab 3B4C-4
Descriptor: FAB FRAGMENT HEAVY CHAIN, FAB FRAGMENT LIGHT CHAIN
Authors:Porta, J, Jose, J, Roehrig, J.T, Blair, C.D, Kuhn, R.J, Rossmann, M.G.
Deposit date:2014-06-04
Release date:2014-09-17
Last modified:2019-05-29
Method:ELECTRON MICROSCOPY (18 Å)
Cite:Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies.
J.Virol., 88, 2014
3C6R
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BU of 3c6r by Molmil
Low pH Immature Dengue Virus
Descriptor: Envelope protein, Peptide pr
Authors:Yu, I, Zhang, W, Holdway, H.A, Li, L, Kostyuchenko, V.A, Chipman, P.R, Kuhn, R.J, Rossmann, M.G, Chen, J.
Deposit date:2008-02-05
Release date:2008-04-22
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (25 Å)
Cite:Structure of the immature dengue virus at low pH primes proteolytic maturation
Science, 319, 2008
6W2U
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BU of 6w2u by Molmil
Mayaro Virus glycoprotein E1 ectodomain and glycoportien E2 ectodomain asymmetric unit
Descriptor: Spike glycoprotein E1, Spike glycoprotein E2
Authors:Miller, A.S, Kuhn, R.J.
Deposit date:2020-03-08
Release date:2020-10-07
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.
Cell Host Microbe, 28, 2020
6CO8
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BU of 6co8 by Molmil
Structure of Zika virus at a resolution of 3.1 Angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E protein, M protein
Authors:Sevvana, M, Long, F, Miller, A.J, Klose, T, Buda, G, Sun, L, Kuhn, R.J, Rossmann, M.R.
Deposit date:2018-03-12
Release date:2018-07-04
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 angstrom Resolution.
Structure, 26, 2018
1Z7Z
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BU of 1z7z by Molmil
Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Intercellular adhesion molecule-1, human coxsackievirus A21
Authors:Xiao, C, Bator-Kelly, C.M, Rieder, E, Chipman, P.R, Craig, A, Kuhn, R.J, Wimmer, E, Rossmann, M.G.
Deposit date:2005-03-28
Release date:2005-08-02
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (8 Å)
Cite:The crystal structure of coxsackievirus a21 and its interaction with icam-1.
Structure, 13, 2005
1Z7S
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BU of 1z7s by Molmil
The crystal structure of coxsackievirus A21
Descriptor: CALCIUM ION, GUANOSINE-5'-MONOPHOSPHATE, Human COXSACKIEVIRUS A21, ...
Authors:Xiao, C, Bator-Kelly, C.M, Rieder, E, Chipman, P.R, Craig, A, Kuhn, R.J, Wimmer, E, Rossmann, M.G.
Deposit date:2005-03-28
Release date:2005-08-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The crystal structure of coxsackievirus a21 and its interaction with icam-1.
Structure, 13, 2005
1Z8Y
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BU of 1z8y by Molmil
Mapping the E2 Glycoprotein of Alphaviruses
Descriptor: Capsid protein C, Spike glycoprotein E1, Spike glycoprotein E2
Authors:Mukhopadhyay, S, Zhang, W, Gabler, S, Chipman, P.R, Strauss, E.G, Strauss, J.H, Baker, T.S, Kuhn, R.J, Rossmann, M.G.
Deposit date:2005-03-31
Release date:2006-02-07
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses.
Structure, 14, 2006
2B6B
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BU of 2b6b by Molmil
Cryo EM structure of Dengue complexed with CRD of DC-SIGN
Descriptor: CD209 antigen, envelope glycoprotein
Authors:Pokidysheva, E, Zhang, Y, Battisti, A.J, Bator-Kelly, C.M, Chipman, P.R, Gregorio, G, Hendrickson, W.A, Kuhn, R.J, Rossmann, M.G.
Deposit date:2005-09-30
Release date:2006-03-07
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (25 Å)
Cite:Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN
Cell(Cambridge,Mass.), 124, 2006
6W09
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BU of 6w09 by Molmil
Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor: E1 glycoprotein, E2 glycoprotein, E3, ...
Authors:Miller, A.S, Kuhn, R.J.
Deposit date:2020-02-29
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.
Cell Host Microbe, 28, 2020
6W1C
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BU of 6w1c by Molmil
Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor: E1 glycoprotein, E2 glycoprotein, Fab CHK-265 heavy chain, ...
Authors:Miller, A.S, Kuhn, R.J.
Deposit date:2020-03-04
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.
Cell Host Microbe, 28, 2020

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